CAAT - Lush Prize Conference 2014

Knudsen - Lush Prize Conference 2014

This document discusses alternatives to animal testing in three areas: 1. It describes the establishment of the Danish 3R-Center, a collaboration between the government, pharmaceutical industry, and animal welfare organizations aimed at promoting alternatives to animal testing. 2. It discusses the researcher Lisbeth Knudsen's work studying biomarkers to assess human exposure to chemicals as an alternative to animal and cell studies. Her research involves biomonitoring chemicals in humans through samples like blood, urine, and hair. 3. It outlines a EU project that used biomonitoring to study levels of 64 chemicals and their effects in 145 mother-child pairs in Denmark, measuring samples like urine, hair, and blood to assess chemical exposure.

ANAW - Lush Prize Conference 2014

Thit Mørck - Lush Prize Conference 2014

Thit Aarøe Mørck is a PhD student at the University of Copenhagen who studied human exposure to environmental chemicals. Her project involved collecting urine, hair, and blood samples from 145 mother-child pairs in Denmark to measure 64 biomarkers of exposure and early effects from chemicals like phthalates, PBDEs, PCBs, and metals. She plans to use the funding from the LUSH prize to analyze the data for associations between exposure measurements and early effects, and to identify patterns of chemical exposure.

Grafström - Lush Prize Conference 2014

The Karolinska Institute (KI) is the largest centre for medical education and research in Sweden and the home of the Nobel Prize in Physiology or Medicine. KI consists of 22 departments and 600 research groups dedicated to improving human health through research and higher education. The role of the Kohonen/Grafström team has been to guide the application, analysis, interpretation and storage of so called “omics” technology-derived data within the service-oriented subproject “ToxBank”.

Spielmann - Lush Prize Conference 2014

This document summarizes Horst Spielmann's presentation on implementing alternative methods. It discusses his role as State Animal Welfare Officer in Berlin where he provides expert advice on animal welfare issues. The presentation covered topics like ending cosmetics testing in Europe, developing adverse outcome pathways, and alternative methods like embryonic stem cells, organ-on-chip technology, and using human cells for disease and infection models. It also discussed increasing collaboration between international regulatory agencies and researchers to advance alternative methods through information sharing and establishing performance standards.

Anne Krug - Lush Prize Conference 2014

The document discusses using neurite growth as an endpoint for assessing developmental neurotoxicity in vitro. It describes how neurite outgrowth is critical for proper brain wiring and is sensitive to toxicants. A human neuronal cell line called LUHMES can be used to measure neurite growth in automated high-content assays allowing efficient screening of chemicals. Several known neurotoxicants were found to reduce neurite growth in the LUHMES cells. The document proposes applying omics technologies like transcriptomics and metabolomics to the LUHMES model to identify pathways of toxicity and classify chemicals. A proof-of-principle study on MPP+ is described where multi-omics analysis revealed perturbed genes, metabolites and pathways in MPP+-treated

National Program on Prevention and Control of Infection and Antimicrobial Resistance – PPCIRA / PORTUGAL Before 2013, Portugal had a high prevalence of hospital-acquired infections and high antimicrobial consumption compared to other EU countries. Carbapenem and quinolone use was among the highest. Through the PPCIRA program established in 2013, Portugal implemented initiatives like establishing epidemiological surveillance, antimicrobial stewardship programs, and a standard precautions campaign. These efforts led to reductions in antimicrobial consumption in both hospital and community settings, lower rates of methicillin-resistant Staphylococcus aureus, and decreases in some hospital-acquired infections like surgical site infections and infections in neonatal and adult ICUs.

Future Health Challenges: Developing Global Norms for Data and Results Sharin...

Royal Veterinary College Business and International Engagement Presentation

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Phytothreats WP1: Phytophthora diversity, distribution and management in UK n...

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WP1 aims to analyze the distribution and diversity of Phytophthora in UK nursery systems using metabarcoding to improve disease management. The objectives are to (1) use metabarcoding to analyze Phytophthora community structure in nurseries and associated ecosystems, and (2) model variation in Phytophthora communities among nurseries based on trade, management, and ecology. Methods include surveying nurseries, sampling them broadly and at fine scale, detecting and metabarcoding Phytophthora, and using computational analysis and modeling. This will provide insights into Phytophthora problems to advise best practices.

Borami Seo - Lush Prize Conference 2014

European Center for Disease Prevention and Control (ECDC)

This document summarizes Korea's growing interest in non-animal testing and efforts to end cosmetics testing on animals. It outlines Korea's regulations around animal testing from the 1990s to present and the government bodies involved. It also discusses Korea's increasing development of alternative test methods, including the establishment of KoCVAM in 2009 and CAMSEC in 2013. Finally, it describes efforts to revise laws to ban cosmetics animal testing and increase public awareness campaigns around companies' non-animal testing policies.

Mirjam Maeusezahl: Joint External Evaluations (JEE) – Country experiences: Sw...

THL

The document discusses Switzerland's participation in the Joint External Evaluation (JEE) conducted by the World Health Organization. It provides details on Switzerland's implementation of the International Health Regulations, the timeline and milestones of the JEE process, and lessons learned. Key results showed room for improvement in antimicrobial resistance detection and response as well as strengthening surveillance systems for zoonotic diseases. Switzerland adapted the WHO National Action Plan template to monitor progress in addressing JEE recommendations internally.

European Commission support actions for laboratory preparedness

This document summarizes discussions from a microbiology focal points meeting on health threats and preparedness. Key points include: 1) The European Social Fund Plus for 2021-2027 aims to strengthen crisis preparedness and response to cross-border health threats. 2) Joint actions like SHARP work to improve implementation of the International Health Regulations and enhance laboratory capacity for detecting pathogens. 3) The Horizon Europe programme will support research and innovation to develop new therapies and diagnostics for infectious diseases. 4) Various Commission DGs are collaborating on initiatives related to laboratory networks, digital health, biosafety, and security to improve EU preparedness for health emergencies.

Ovanes Mekenyan - Lush Prize Conference 2014

Brm 1

Umer Farooq

This document summarizes the work of Task 4.1 of the AniBioThreat project, which aimed to implement the Laboratory Biorisk Management CWA 15793 standard across partner institutions. It describes conducting a gap analysis to evaluate current compliance, developing recommendations and tools like training to support full implementation. While institutions already had biorisk programs, the analysis identified gaps to address. Exercises also helped evaluate preparedness and response plans. Full implementation of the CWA 15793 across network laboratories would help strengthen the European response to animal bioterrorism threats by promoting standardized biorisk management.

BioSHaRE - UMCG Close out meeting 20160118

Lisette Giepmans

The document summarizes a close out meeting for the BioSHaRE project. It includes an agenda with summaries of the various work packages, including coordination and management (WP1), data repository and epidemiological harmonization (WP2), and biospecimen harmonization (WP5). The core projects of statistical methods for longitudinal harmonization and data harmonization and federated analysis are also summarized. Participating biobanks and their countries are listed for the Healthy Obese Project and Environmental Core Project. UMCG involvement and realization of budget and publications are provided.

Strengthening data sharing for public health: ethical, legal and political is...

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Establishment of Mobile Laboratories up to Risk Group 4 in combination with C...

The document summarizes the work of the European Mobile Laboratory (EMLab) project from 2012-2015. Key points include: - EMLab units were deployed to test over 10,000 samples for Ebola virus in Guinea and Sierra Leone. - Operational research was conducted on Ebola virus immunology, pathogenesis, and genome sequencing. - The mobile labs provided diagnostic and clinical support to Ebola treatment centers and trials. - Long-term partnerships for disease surveillance and research capacity building were established across Africa.

A vision for a global operation room

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Global and national response to AMR

Murdoch University

This document discusses global and national responses to antimicrobial resistance (AMR). It summarizes various international initiatives in 2014 to address AMR, including a ministerial conference in the Netherlands and a meeting of the Global Health Security Agenda in Washington DC. It also outlines Australia's national response, including establishing a steering group, allocating funding, and developing a national strategy to improve surveillance, prevent infections, promote appropriate antibiotic use, and engage internationally. Gaps in addressing AMR in various settings are identified.

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Antibiotic Guardian Leeds Workshop

4 All of Us

Antibiotic resistance is one of the biggest threats facing us today! European Antibiotic Awareness Day (EAAD) is part of the UK 5 Year Antimicrobial Resistance Strategy 2013 to 2018, which focuses on antibiotics and sets out actions to slow the development and spread of antimicrobial resistance. This year, to run in line with EAAD; Public Health England has established the Antibiotic Guardian pledge campaign. It calls on everyone in the UK, the public and healthcare community to become antibiotics guardian by choosing one simple pledge about how they will make better use of these vital medicines. To ensure that the information and knowledge on Antibiotic Stewardship is disseminated to those practising healthcare across the nation, a series of awareness and educational events have been developed. These educational workshop events, to be held in Leeds, Birmingham and London, will provide guidance, resources and information for practitioners on topics associated with antibiotic awareness. The events will provide an opportunity to understand how you and your organisation can support combat the global challenge faced by antibiotic resistance whilst gaining advice, support and resources to inform patients and staff.

UK Diagnostics Summit Presentations

Scott Buckler

The document discusses the key role of diagnostics in addressing the challenge of antimicrobial resistance (AMR). It makes three key points: 1) AMR is a major threat as many infections are becoming increasingly difficult to treat due to drug-resistant bacteria. Without effective antibiotics, common infections and surgeries could become life-threatening. 2) Diagnostics are critical to appropriate antibiotic use by enabling rapid and precise diagnosis of whether a bacterial or viral infection is present and, if bacterial, determining the best antibiotic to use or avoid. This can help reduce unnecessary antibiotic prescribing. 3) The document outlines a vision for AMR diagnostics in the UK to ensure rapid diagnostic technologies are universally available to guide antibiotic

A.2 Galea

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This document summarizes a study methodology that aims to determine pesticide exposure levels in residents living near agricultural land through the analysis of urine samples. The study recruited farmers and residents across 3 regions in the UK. Urine samples were collected from residents on a weekly basis, as well as 1-2 days after pesticide spray events to compare metabolite levels within and outside the spraying season. The study also aims to compare measured urinary levels to exposure estimates from regulatory risk assessments. Over 3,000 urine samples were collected in total. Statistical analysis of the results will help evaluate current risk assessment methods and estimate long-term pesticide exposure levels for residents.

EU Clinical Trials Regulation - IPPOSI perspective

EUPATI 2013 Conference: Vision on Patient involvement in medicines R&D: Here...

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This document discusses increasing patient involvement in medical research and development. It notes that the medical landscape is transforming rapidly through innovations like personalized medicine and biomarkers. While this benefits patients, it also means smaller trial populations and a need for more post-marketing data. The document advocates for increasing patient involvement in areas like clinical trial design, setting research priorities, measuring quality of life, and pharmaceutical policy. It highlights the European Patients' Academy (EUPATI) project, which aims to empower patients through education on medical research and development processes in order to facilitate greater patient engagement.

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Borami Seo - Lush Prize Conference 2014

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Ovanes Mekenyan - Lush Prize Conference 2014

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BioSHaRE - UMCG Close out meeting 20160118

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Seidle - Lush Prize Conference 2014

Work Package (WP) 12 – PEARL Barriers In search for an inventory and assessme...

National Program on Prevention and Control of Infection and Antimicrobial Res...

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The document discusses CO-OP4CBD and its role in increasing the science-policy interface. CO-OP4CBD is a European network that aims to strengthen the role of the EU in implementing the Convention on Biological Diversity. It does this by facilitating dialogue between experts and policymakers, providing training, and producing briefings to support policy positions. An effective science-policy interface is important for biodiversity issues given the failure to reduce biodiversity loss. CO-OP4CBD helps increase the credibility, relevance and legitimacy of the science-policy interface through its activities bringing together experts and decision-makers.

2nd European Conference on Clinical Research

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The document provides information on the organizers, program committee, and agenda for the 2nd European Conference on Clinical Research being held from February 2-4, 2015 in Paris, France. The pre-conference on February 2nd will focus on how clinical procurement can provide strategic value beyond cost reductions. The main conference on February 3rd-4th will involve presentations and debates on key issues in clinical research regulation, new technologies, risk management, and the patient's role. Topics will include the impacts and challenges of the new EU Clinical Trials Regulation and new operational practices in clinical trials.

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This document discusses bringing patient education to the national level through establishing EUPATI National Platforms. It provides background on EUPATI and IPPOSI, and their role in establishing EUPATI National Platforms across Europe to address educational needs of patients and disseminate EUPATI resources at the national level. EUPATI National Platforms are intended to be patient-led, national networks that involve patients, academia, industry and other partners to identify educational opportunities at the national level using EUPATI materials and resources.

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The document discusses a presentation on the Joint Clinical Assessment (JCA) process under the European HTA Regulation and how it may impact patient experience and involvement in HTA. It begins with an introduction to the JCA process and an overview of a presentation by Sophie Werkö from the Swedish Agency for Health Technology Assessment on their experiences with JCA. It then discusses challenges and opportunities for patient involvement in JCA, including timely involvement, defining PICOs, and ensuring input from both European and national level patient groups. Finally, it provides an overview of EUCAPA and HTA4Patients, two projects aimed at training and building capacity for patient representatives to participate in European HTA processes like JCA

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Derick Mitchell gave a talk on sustaining patient engagement resources through public-private platforms. Some key points: 1. He discussed IPPOSI, a patient-led organization that advocates for patient involvement in health innovation and research. 2. Patient organizations and industry can interact by moving past compliance and instead measuring the value of their interactions through trust and transparency. 3. Generating patient-based evidence through patient registries, mobile apps, and other tools can provide cost-effective, patient-relevant data to inform decision making.

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The document discusses the European Union's support for animal welfare research through its Framework Programme funding. It provides an overview of funded projects from FP5 to FP7 that aim to improve welfare assessment, understand the impacts of upgraded standards, and exchange knowledge between stakeholders. Recent and planned calls focus on indicators for small ruminants, equids and turkeys, networking European researchers, and understanding stress responses and coping behaviors in farmed fish.

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The document discusses the regulatory environment for medicines in Ireland and Europe. It outlines how the Irish Medicines Board operates within the European system, providing resources to the European Medicines Agency and participating in evaluation, supervision, and inspection. It also discusses the IMB's international involvement, including partnerships with other agencies and participation in initiatives to enhance public health protection globally. Finally, it evaluates factors that contribute to the IMB becoming a "world-class" regulatory body.

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The European Cancer Patient Coalition (ECPC) has advocated for harmonized health technology assessment (HTA) in the EU since 2014. Some of their milestones include publishing position papers, participating in EU consultations, and meeting with EU officials. HTA can promote innovation but differences between EU countries result in delays and inequities. Few HTA agencies involve patients systematically. The ECPC calls for mandatory uptake of joint clinical assessments and formal involvement of patient organizations at the EU and national levels. Patients are directly affected by HTA and their preferences on treatment are an important element.

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The best available, up-to-date information on all fishing and related vessels that appear on the illegal, unregulated, and unreported (IUU) fishing vessel lists published by Regional Fisheries Management Organisations (RFMOs) and related organisations. The aim of the site is to improve the effectiveness of the original IUU lists as a tool for a wide variety of stakeholders to better understand and combat illegal fishing and broader fisheries crime. To date, the following regional organisations maintain or share lists of vessels that have been found to carry out or support IUU fishing within their own or adjacent convention areas and/or species of competence: Commission for the Conservation of Antarctic Marine Living Resources (CCAMLR) Commission for the Conservation of Southern Bluefin Tuna (CCSBT) General Fisheries Commission for the Mediterranean (GFCM) Inter-American Tropical Tuna Commission (IATTC) International Commission for the Conservation of Atlantic Tunas (ICCAT) Indian Ocean Tuna Commission (IOTC) Northwest Atlantic Fisheries Organisation (NAFO) North East Atlantic Fisheries Commission (NEAFC) North Pacific Fisheries Commission (NPFC) South East Atlantic Fisheries Organisation (SEAFO) South Pacific Regional Fisheries Management Organisation (SPRFMO) Southern Indian Ocean Fisheries Agreement (SIOFA) Western and Central Pacific Fisheries Commission (WCPFC) The Combined IUU Fishing Vessel List merges all these sources into one list that provides a single reference point to identify whether a vessel is currently IUU listed. Vessels that have been IUU listed in the past and subsequently delisted (for example because of a change in ownership, or because the vessel is no longer in service) are also retained on the site, so that the site contains a full historic record of IUU listed fishing vessels. Unlike the IUU lists published on individual RFMO websites, which may update vessel details infrequently or not at all, the Combined IUU Fishing Vessel List is kept up to date with the best available information regarding changes to vessel identity, flag state, ownership, location, and operations.

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