This document discusses mandibular fractures, including:
- The uniqueness of the mandible as the only mobile bone in the facial region with bilateral joint articulations.
- The biomechanical aspects of fractures, which tend to occur in areas of tension due to irregularities in the mandibular arch.
- Treatment options including closed reduction with fixation, open reduction with rigid fixation using plates, screws or external pin fixation.
- Factors determining the appropriate treatment and length of intermaxillary fixation.
This document summarizes the management of limb length discrepancies and bone gaps. It discusses the etiology, assessment, treatment techniques and complications for each condition. For limb length discrepancies, treatments include shoe lifts for small discrepancies, leg lengthening or shortening procedures, and prosthetics for large discrepancies. Bone gap treatments are tailored based on size and may include grafts, distraction osteogenesis, acute shortening, or amputation. Proper evaluation and a multidisciplinary approach are important to optimize outcomes for these complex orthopedic issues.
Management of Nonunion
This document discusses the management of nonunion fractures. It begins with an introduction defining nonunion and presenting epidemiological data on nonunion rates in Nigeria. It then covers the classification of nonunions based on biological activity and infection status. The main types - atrophic, hypertrophic, and oligotrophic - are described. Treatment approaches are discussed including nonoperative options as well as operative techniques like fixation, bone grafting, and management of infection. Current trends involving prediction of nonunion using telemetric data are also mentioned. The conclusion emphasizes the need for further research on biomarkers for nonunion diagnosis and treatment given higher observed rates in Nigeria compared to developed countries.
The pathology and management of blount’s diseaseAsi-oqua Bassey
This document discusses Blount's disease, a progressive bowleg deformity caused by abnormal growth of the proximal tibial physis. It can be classified as infantile or adolescent based on age of onset. Infantile Blount's is more severe and involves the epiphysis, while adolescent involves the physis. Treatment depends on severity and includes bracing, osteotomies, hemiepiphyseodesis, and physeal bar excision to correct deformities and allow growth. Proper diagnosis and intervention are needed to prevent complications and achieve a good prognosis, as obesity rates rise and more cases are seen.
congenital pseudoarthrosis of tibia or anterolateral bowing of tibia is cause of major morbidity in children with no definitive or curative management.
This document provides information about osteomyelitis, osteomalacia, osteoporosis, and bone tumors. It defines each condition, discusses causes and risk factors, pathophysiology, clinical manifestations, diagnostic tests, and medical and nursing management. Osteomyelitis is an acute bone infection that can be acute, subacute, or chronic. Osteomalacia is a disorder causing inadequate bone mineralization due to vitamin D or phosphate deficiencies. Osteoporosis is a disease where bone density decreases and fragility increases, causing higher fracture risk. Bone tumors can be benign or malignant, and types include osteosarcoma, Ewing's sarcoma, and chondrosarcoma.
Osteochondritis Dessicans is a pathological condition characterized by separation of articular cartilage and subchondral bone from the joint surface. It most commonly affects the knee, especially the medial femoral condyle. The exact etiology is unknown but repetitive trauma is a major risk factor. Diagnosis is made through imaging like MRI and arthroscopy. Treatment depends on the age, location, and stability of the lesion. Conservative treatment is usually attempted first for juvenile OCD while unstable or large lesions in adults typically require surgical intervention such as drilling, fixation, or restorative techniques like microfracture or osteochondral grafting.
This document discusses mandibular fractures, including:
- The uniqueness of the mandible as the only mobile bone in the facial region with bilateral joint articulations.
- The biomechanical aspects of fractures, which tend to occur in areas of tension due to irregularities in the mandibular arch.
- Treatment options including closed reduction with fixation, open reduction with rigid fixation using plates, screws or external pin fixation.
- Factors determining the appropriate treatment and length of intermaxillary fixation.
This document summarizes the management of limb length discrepancies and bone gaps. It discusses the etiology, assessment, treatment techniques and complications for each condition. For limb length discrepancies, treatments include shoe lifts for small discrepancies, leg lengthening or shortening procedures, and prosthetics for large discrepancies. Bone gap treatments are tailored based on size and may include grafts, distraction osteogenesis, acute shortening, or amputation. Proper evaluation and a multidisciplinary approach are important to optimize outcomes for these complex orthopedic issues.
Management of Nonunion
This document discusses the management of nonunion fractures. It begins with an introduction defining nonunion and presenting epidemiological data on nonunion rates in Nigeria. It then covers the classification of nonunions based on biological activity and infection status. The main types - atrophic, hypertrophic, and oligotrophic - are described. Treatment approaches are discussed including nonoperative options as well as operative techniques like fixation, bone grafting, and management of infection. Current trends involving prediction of nonunion using telemetric data are also mentioned. The conclusion emphasizes the need for further research on biomarkers for nonunion diagnosis and treatment given higher observed rates in Nigeria compared to developed countries.
The pathology and management of blount’s diseaseAsi-oqua Bassey
This document discusses Blount's disease, a progressive bowleg deformity caused by abnormal growth of the proximal tibial physis. It can be classified as infantile or adolescent based on age of onset. Infantile Blount's is more severe and involves the epiphysis, while adolescent involves the physis. Treatment depends on severity and includes bracing, osteotomies, hemiepiphyseodesis, and physeal bar excision to correct deformities and allow growth. Proper diagnosis and intervention are needed to prevent complications and achieve a good prognosis, as obesity rates rise and more cases are seen.
congenital pseudoarthrosis of tibia or anterolateral bowing of tibia is cause of major morbidity in children with no definitive or curative management.
This document provides information about osteomyelitis, osteomalacia, osteoporosis, and bone tumors. It defines each condition, discusses causes and risk factors, pathophysiology, clinical manifestations, diagnostic tests, and medical and nursing management. Osteomyelitis is an acute bone infection that can be acute, subacute, or chronic. Osteomalacia is a disorder causing inadequate bone mineralization due to vitamin D or phosphate deficiencies. Osteoporosis is a disease where bone density decreases and fragility increases, causing higher fracture risk. Bone tumors can be benign or malignant, and types include osteosarcoma, Ewing's sarcoma, and chondrosarcoma.
Osteochondritis Dessicans is a pathological condition characterized by separation of articular cartilage and subchondral bone from the joint surface. It most commonly affects the knee, especially the medial femoral condyle. The exact etiology is unknown but repetitive trauma is a major risk factor. Diagnosis is made through imaging like MRI and arthroscopy. Treatment depends on the age, location, and stability of the lesion. Conservative treatment is usually attempted first for juvenile OCD while unstable or large lesions in adults typically require surgical intervention such as drilling, fixation, or restorative techniques like microfracture or osteochondral grafting.
Peri-implantitis is a chronic inflammatory disease affecting the bone and gum tissue around implants. As the number of implants being placed increases and subjected to inflammatory and occlusal demands the incidence of problems associated with Peri-implantitis will also increase. It is essential for practitioners to understand the etiology of Peri-implantitis and their role in preventing, treating and maintaining this growing problem.
Osteomyelitis is an infection of the bone that results in inflammation, necrosis, and new bone formation. It is classified as hematogenous, contiguous focus, or associated with vascular insufficiency. Staphylococcus aureus is the most common causative organism. Clinical manifestations include pain, swelling, and drainage from non-healing ulcers. Diagnosis involves imaging tests and biopsy. Treatment involves antibiotics, surgical debridement, and stabilization of the bone. Nursing care focuses on pain management, preventing complications like sepsis, and educating patients.
This document summarizes the key aspects and findings of a systematic review and meta-analysis comparing the clinical and radiographic outcomes of orthodontic treatment with corticotomy procedures (localized corticotomy, anterior corticotomy-assisted orthodontic treatment (CAOT), and periodontally accelerated osteogenic orthodontics (PAOO)) versus conventional orthodontic treatment. The review found that localized corticotomy may enhance canine distalization compared to conventional treatment, and that PAOO results in reduced active treatment time and greater alveolar bone thickness gain compared to conventional treatment. However, it also noted high heterogeneity across the included studies and a need for more well-standardized randomized controlled trials to draw definitive conclusions.
MANDIBLE JOURNAL on complications andnew tratment option .pptxPavanKumar330822
intermuscular septum between the extensor carpi ulnaris and the extensor digiti minimi. After the muscular branches are ligated, retraction of the extensor digiti minimi radially exposes the PIA. With further dissection, the communicating branch with the AIA can also be identified. Flaps are transferred by transposition to the recipient site with direct incision or through a subcutaneous tunnel. The flap is inset without tension; the vascular pedicle must not be compressed. With a skin island of less than 6 cm, primary closure is possible. A larger skin island requires skin grafting.
The document discusses the use of the Jess external fixator for treating recurrent, resistant, and neglected clubfoot deformities. It summarizes a study of 15 patients (18 feet) treated using this method. The results were generally good, with 14 cases rated as satisfactory and only 1 as unsatisfactory. Younger age at treatment and less severe deformities were associated with better outcomes. Complications were minor and manageable. The study concludes that Jess external fixation is an excellent technique for difficult clubfoot cases, especially when performed at an early age.
Used in the right conditions, SFOA is highly successful and has a positive impact on the patients psychosocial status.A combined orthodontic and orthognathic surgery approach is accepted as the standard of care for patients who have a severe skeletal jaw discrepancy with facial asymmetry.
But some disadvantages have been recognized.
One drawback is the long presurgical treatment time that typically worsens facial appearance and exacerbates the malocclusion. In some countries, these disadvantages have caused patients to seek plastic surgeons who are willing to perform orthognathic surgeries without collaboration with orthodontists or consideration for the final occlusion.
Recently, to address patient demand and satisfaction, the surgery-first approach was introduced to overcome some disadvantages associated with the conventional surgical orthodontic approach.1991-Brachvogel et al. suggested the potential advantages of a surgery-first approach.
In that article the advantages of post-surgical orthodontics are outlined as follows:
1) Orthodontic movement does not interfere with compensatory biological responses.
2) Dental movements can be based on an already corrected skeletal pattern.
3) Some surgical relapse can be managed during treatment.
2009: Nagasaka et al., popularized SFOA54. Nagasaka et al1 were among the first to actually carry out SFOA using miniplates for post-surgical orthodontic treatment
The 2011 symposium presented the surgery‑first approach and created broader interest in the complete elimination of time‑consuming preoperative orthodontic treatment
This document discusses tibiotalocalcaneal (TTC) fusion with an intramedullary nail. It provides indications for TTC fusion including arthritis, deformities, and failed fusions. Studies have shown TTC fusion and isolated ankle fusion have similar outcomes in function and pain relief. However, ankle fusion is more likely to lead to subtalar joint arthritis over time. The document then reviews a case of a TTC fusion using an intramedullary nail, including pre-op imaging, surgical technique, and post-op recovery. Tips are provided such as ensuring proper nail entry point and using intraoperative imaging to confirm screw placement.
This document discusses the management of tibial diaphysis gap nonunions. Gap nonunions present a major challenge due to associated infection, previous surgeries, and bone loss. The key principles of treatment include managing any infection through debridement and antibiotics, achieving bone union through techniques like cancellous bone grafting or the Masquelet technique, and addressing soft tissue coverage and deformities. Successful treatment may require multiple reconstructive surgeries using methods like the Ilizarov technique to gradually regenerate bone between fragments.
This document discusses periodontal regeneration and the various factors involved. It begins by defining key terminology related to grafting and regeneration. It then discusses the biology and objectives of periodontal regeneration, including the ideal outcome of new attachment formation and factors that can influence outcomes. The document outlines various techniques for periodontal regeneration including non-graft associated approaches involving removal of epithelium and surgical techniques, as well as graft-associated approaches using various graft materials. Requirements for predictable regeneration and assessment methods are also summarized.
Surgical orthodontics, also known as orthognathic surgery, aims to correct dentofacial deformities through a combination of orthodontic treatment and corrective jaw surgery. It seeks to improve both facial and dental aesthetics as well as create a functional bite. Key developments over time have improved surgical outcomes and patient comfort. Common indications for orthognathic surgery include severe class II or III malocclusions, facial asymmetries, and craniofacial anomalies. Careful examination, investigations, planning and multidisciplinary treatment are required to achieve optimal results.
This document summarizes a presentation on malignancy in chronic osteomyelitis given by Dr. Kiran. It discusses chronic osteomyelitis as a long-lasting bone infection caused by biofilm-protected microorganisms. Malignant changes can develop due to factors like chronic inflammation, poor vascularization, and treatment failure. The most common malignancy is aggressive squamous cell carcinoma of the skin near the infected bone. Clinical features include ulceration, bleeding, and bone destruction visible on imaging. Diagnosis involves biopsy and imaging tests. Management may include amputation and adjuvant therapies depending on the malignancy.
This document discusses changing perspectives on the treatment of periodontal disease, from the nonspecific plaque hypothesis (NSPH) to the specific plaque hypothesis (SPH). The NSPH assumed all plaque was equally pathogenic, while studies since the 1970s have demonstrated the microbiological specificity of disease-associated bacteria. The SPH recognizes that only certain "pathogenic" plaques cause infections. Diagnosis under SPH involves detecting these anaerobic bacteria to determine who needs treatment, which is then targeted to eliminate the specific pathogens. Several studies found nonsurgical treatments like scaling and root planing were often as effective as surgical treatments for periodontal pockets. Monitoring treatment success using follow-up bacteriology is important under the SPH.
Dental implant failure / /certified fixed orthodontic courses by Indian dent...Indian dental academy
Welcome to Indian Dental Academy
The Indian Dental Academy is the Leader in continuing dental education , training dentists in all aspects of dentistry and offering a wide range of dental certified courses in different formats.
Indian dental academy has a unique training program & curriculum that provides students with exceptional clinical skills and enabling them to return to their office with high level confidence and start treating patients
State of the art comprehensive training-Faculty of world wide repute &Very affordable.
Dental implant failure /certified fixed orthodontic courses by Indian dental...Indian dental academy
This document discusses various factors that can contribute to dental implant failures. It covers preoperative factors like patient selection and medical conditions, as well as intraoperative errors like improper surgical technique, implant contamination, positioning errors, and errors in maintaining sterility. Postoperative factors discussed include errors in implant exposure timing, as well as prosthetic and soft tissue factors. The document provides details on strategies to avoid common errors and optimize outcomes for dental implant procedures.
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This document is a case study presentation on a patient with impaired right upper limb function as a post-surgical complication of multiple myeloma. It begins with an introduction to multiple myeloma and its epidemiology. It then describes the patient's history, examination findings, and physiotherapy management over 12 sessions. The physiotherapy led to improvements in the patient's right upper limb strength and function, including increased independence with activities of daily living. The presentation concludes with recommendations for promoting awareness of pathological fractures and low-intensity exercise programs for multiple myeloma patients.
Peri-implantitis is a chronic inflammatory disease affecting the bone and gum tissue around implants. As the number of implants being placed increases and subjected to inflammatory and occlusal demands the incidence of problems associated with Peri-implantitis will also increase. It is essential for practitioners to understand the etiology of Peri-implantitis and their role in preventing, treating and maintaining this growing problem.
Osteomyelitis is an infection of the bone that results in inflammation, necrosis, and new bone formation. It is classified as hematogenous, contiguous focus, or associated with vascular insufficiency. Staphylococcus aureus is the most common causative organism. Clinical manifestations include pain, swelling, and drainage from non-healing ulcers. Diagnosis involves imaging tests and biopsy. Treatment involves antibiotics, surgical debridement, and stabilization of the bone. Nursing care focuses on pain management, preventing complications like sepsis, and educating patients.
This document summarizes the key aspects and findings of a systematic review and meta-analysis comparing the clinical and radiographic outcomes of orthodontic treatment with corticotomy procedures (localized corticotomy, anterior corticotomy-assisted orthodontic treatment (CAOT), and periodontally accelerated osteogenic orthodontics (PAOO)) versus conventional orthodontic treatment. The review found that localized corticotomy may enhance canine distalization compared to conventional treatment, and that PAOO results in reduced active treatment time and greater alveolar bone thickness gain compared to conventional treatment. However, it also noted high heterogeneity across the included studies and a need for more well-standardized randomized controlled trials to draw definitive conclusions.
MANDIBLE JOURNAL on complications andnew tratment option .pptxPavanKumar330822
intermuscular septum between the extensor carpi ulnaris and the extensor digiti minimi. After the muscular branches are ligated, retraction of the extensor digiti minimi radially exposes the PIA. With further dissection, the communicating branch with the AIA can also be identified. Flaps are transferred by transposition to the recipient site with direct incision or through a subcutaneous tunnel. The flap is inset without tension; the vascular pedicle must not be compressed. With a skin island of less than 6 cm, primary closure is possible. A larger skin island requires skin grafting.
The document discusses the use of the Jess external fixator for treating recurrent, resistant, and neglected clubfoot deformities. It summarizes a study of 15 patients (18 feet) treated using this method. The results were generally good, with 14 cases rated as satisfactory and only 1 as unsatisfactory. Younger age at treatment and less severe deformities were associated with better outcomes. Complications were minor and manageable. The study concludes that Jess external fixation is an excellent technique for difficult clubfoot cases, especially when performed at an early age.
Used in the right conditions, SFOA is highly successful and has a positive impact on the patients psychosocial status.A combined orthodontic and orthognathic surgery approach is accepted as the standard of care for patients who have a severe skeletal jaw discrepancy with facial asymmetry.
But some disadvantages have been recognized.
One drawback is the long presurgical treatment time that typically worsens facial appearance and exacerbates the malocclusion. In some countries, these disadvantages have caused patients to seek plastic surgeons who are willing to perform orthognathic surgeries without collaboration with orthodontists or consideration for the final occlusion.
Recently, to address patient demand and satisfaction, the surgery-first approach was introduced to overcome some disadvantages associated with the conventional surgical orthodontic approach.1991-Brachvogel et al. suggested the potential advantages of a surgery-first approach.
In that article the advantages of post-surgical orthodontics are outlined as follows:
1) Orthodontic movement does not interfere with compensatory biological responses.
2) Dental movements can be based on an already corrected skeletal pattern.
3) Some surgical relapse can be managed during treatment.
2009: Nagasaka et al., popularized SFOA54. Nagasaka et al1 were among the first to actually carry out SFOA using miniplates for post-surgical orthodontic treatment
The 2011 symposium presented the surgery‑first approach and created broader interest in the complete elimination of time‑consuming preoperative orthodontic treatment
This document discusses tibiotalocalcaneal (TTC) fusion with an intramedullary nail. It provides indications for TTC fusion including arthritis, deformities, and failed fusions. Studies have shown TTC fusion and isolated ankle fusion have similar outcomes in function and pain relief. However, ankle fusion is more likely to lead to subtalar joint arthritis over time. The document then reviews a case of a TTC fusion using an intramedullary nail, including pre-op imaging, surgical technique, and post-op recovery. Tips are provided such as ensuring proper nail entry point and using intraoperative imaging to confirm screw placement.
This document discusses the management of tibial diaphysis gap nonunions. Gap nonunions present a major challenge due to associated infection, previous surgeries, and bone loss. The key principles of treatment include managing any infection through debridement and antibiotics, achieving bone union through techniques like cancellous bone grafting or the Masquelet technique, and addressing soft tissue coverage and deformities. Successful treatment may require multiple reconstructive surgeries using methods like the Ilizarov technique to gradually regenerate bone between fragments.
This document discusses periodontal regeneration and the various factors involved. It begins by defining key terminology related to grafting and regeneration. It then discusses the biology and objectives of periodontal regeneration, including the ideal outcome of new attachment formation and factors that can influence outcomes. The document outlines various techniques for periodontal regeneration including non-graft associated approaches involving removal of epithelium and surgical techniques, as well as graft-associated approaches using various graft materials. Requirements for predictable regeneration and assessment methods are also summarized.
Surgical orthodontics, also known as orthognathic surgery, aims to correct dentofacial deformities through a combination of orthodontic treatment and corrective jaw surgery. It seeks to improve both facial and dental aesthetics as well as create a functional bite. Key developments over time have improved surgical outcomes and patient comfort. Common indications for orthognathic surgery include severe class II or III malocclusions, facial asymmetries, and craniofacial anomalies. Careful examination, investigations, planning and multidisciplinary treatment are required to achieve optimal results.
This document summarizes a presentation on malignancy in chronic osteomyelitis given by Dr. Kiran. It discusses chronic osteomyelitis as a long-lasting bone infection caused by biofilm-protected microorganisms. Malignant changes can develop due to factors like chronic inflammation, poor vascularization, and treatment failure. The most common malignancy is aggressive squamous cell carcinoma of the skin near the infected bone. Clinical features include ulceration, bleeding, and bone destruction visible on imaging. Diagnosis involves biopsy and imaging tests. Management may include amputation and adjuvant therapies depending on the malignancy.
This document discusses changing perspectives on the treatment of periodontal disease, from the nonspecific plaque hypothesis (NSPH) to the specific plaque hypothesis (SPH). The NSPH assumed all plaque was equally pathogenic, while studies since the 1970s have demonstrated the microbiological specificity of disease-associated bacteria. The SPH recognizes that only certain "pathogenic" plaques cause infections. Diagnosis under SPH involves detecting these anaerobic bacteria to determine who needs treatment, which is then targeted to eliminate the specific pathogens. Several studies found nonsurgical treatments like scaling and root planing were often as effective as surgical treatments for periodontal pockets. Monitoring treatment success using follow-up bacteriology is important under the SPH.
Dental implant failure / /certified fixed orthodontic courses by Indian dent...Indian dental academy
Welcome to Indian Dental Academy
The Indian Dental Academy is the Leader in continuing dental education , training dentists in all aspects of dentistry and offering a wide range of dental certified courses in different formats.
Indian dental academy has a unique training program & curriculum that provides students with exceptional clinical skills and enabling them to return to their office with high level confidence and start treating patients
State of the art comprehensive training-Faculty of world wide repute &Very affordable.
Dental implant failure /certified fixed orthodontic courses by Indian dental...Indian dental academy
This document discusses various factors that can contribute to dental implant failures. It covers preoperative factors like patient selection and medical conditions, as well as intraoperative errors like improper surgical technique, implant contamination, positioning errors, and errors in maintaining sterility. Postoperative factors discussed include errors in implant exposure timing, as well as prosthetic and soft tissue factors. The document provides details on strategies to avoid common errors and optimize outcomes for dental implant procedures.
Impaired function of right upperlimb as a post surgical complication in a pat...enweluntaobed
This document is a case study presentation on a patient with impaired right upper limb function as a post-surgical complication of multiple myeloma. It begins with an introduction to multiple myeloma and its epidemiology. It then describes the patient's history, examination findings, and physiotherapy management over 12 sessions. The physiotherapy led to improvements in the patient's right upper limb strength and function, including increased independence with activities of daily living. The presentation concludes with recommendations for promoting awareness of pathological fractures and low-intensity exercise programs for multiple myeloma patients.
Histololgy of Female Reproductive System.pptxAyeshaZaid1
Dive into an in-depth exploration of the histological structure of female reproductive system with this comprehensive lecture. Presented by Dr. Ayesha Irfan, Assistant Professor of Anatomy, this presentation covers the Gross anatomy and functional histology of the female reproductive organs. Ideal for students, educators, and anyone interested in medical science, this lecture provides clear explanations, detailed diagrams, and valuable insights into female reproductive system. Enhance your knowledge and understanding of this essential aspect of human biology.
TEST BANK For An Introduction to Brain and Behavior, 7th Edition by Bryan Kol...rightmanforbloodline
TEST BANK For An Introduction to Brain and Behavior, 7th Edition by Bryan Kolb, Ian Q. Whishaw, Verified Chapters 1 - 16, Complete Newest Versio
TEST BANK For An Introduction to Brain and Behavior, 7th Edition by Bryan Kolb, Ian Q. Whishaw, Verified Chapters 1 - 16, Complete Newest Version
TEST BANK For An Introduction to Brain and Behavior, 7th Edition by Bryan Kolb, Ian Q. Whishaw, Verified Chapters 1 - 16, Complete Newest Version
- Video recording of this lecture in English language: https://youtu.be/kqbnxVAZs-0
- Video recording of this lecture in Arabic language: https://youtu.be/SINlygW1Mpc
- Link to download the book free: https://nephrotube.blogspot.com/p/nephrotube-nephrology-books.html
- Link to NephroTube website: www.NephroTube.com
- Link to NephroTube social media accounts: https://nephrotube.blogspot.com/p/join-nephrotube-on-social-media.html
Adhd Medication Shortage Uk - trinexpharmacy.comreignlana06
The UK is currently facing a Adhd Medication Shortage Uk, which has left many patients and their families grappling with uncertainty and frustration. ADHD, or Attention Deficit Hyperactivity Disorder, is a chronic condition that requires consistent medication to manage effectively. This shortage has highlighted the critical role these medications play in the daily lives of those affected by ADHD. Contact : +1 (747) 209 – 3649 E-mail : sales@trinexpharmacy.com
Muktapishti is a traditional Ayurvedic preparation made from Shoditha Mukta (Purified Pearl), is believed to help regulate thyroid function and reduce symptoms of hyperthyroidism due to its cooling and balancing properties. Clinical evidence on its efficacy remains limited, necessitating further research to validate its therapeutic benefits.
Basavarajeeyam is a Sreshta Sangraha grantha (Compiled book ), written by Neelkanta kotturu Basavaraja Virachita. It contains 25 Prakaranas, First 24 Chapters related to Rogas& 25th to Rasadravyas.
Cell Therapy Expansion and Challenges in Autoimmune DiseaseHealth Advances
There is increasing confidence that cell therapies will soon play a role in the treatment of autoimmune disorders, but the extent of this impact remains to be seen. Early readouts on autologous CAR-Ts in lupus are encouraging, but manufacturing and cost limitations are likely to restrict access to highly refractory patients. Allogeneic CAR-Ts have the potential to broaden access to earlier lines of treatment due to their inherent cost benefits, however they will need to demonstrate comparable or improved efficacy to established modalities.
In addition to infrastructure and capacity constraints, CAR-Ts face a very different risk-benefit dynamic in autoimmune compared to oncology, highlighting the need for tolerable therapies with low adverse event risk. CAR-NK and Treg-based therapies are also being developed in certain autoimmune disorders and may demonstrate favorable safety profiles. Several novel non-cell therapies such as bispecific antibodies, nanobodies, and RNAi drugs, may also offer future alternative competitive solutions with variable value propositions.
Widespread adoption of cell therapies will not only require strong efficacy and safety data, but also adapted pricing and access strategies. At oncology-based price points, CAR-Ts are unlikely to achieve broad market access in autoimmune disorders, with eligible patient populations that are potentially orders of magnitude greater than the number of currently addressable cancer patients. Developers have made strides towards reducing cell therapy COGS while improving manufacturing efficiency, but payors will inevitably restrict access until more sustainable pricing is achieved.
Despite these headwinds, industry leaders and investors remain confident that cell therapies are poised to address significant unmet need in patients suffering from autoimmune disorders. However, the extent of this impact on the treatment landscape remains to be seen, as the industry rapidly approaches an inflection point.
Cell Therapy Expansion and Challenges in Autoimmune Disease
C. VINAY KUMAR-FDMFJKAS MFJAFL JDAFKLDJFLKSDJFKLDSJ
1. NON UNIONS FOLLOWING PATHOLOGICAL FRACTURES
IN CHRONIC HAEMATOGENOUS OSTEOMYELITIS IN
CHILDREN-A COMPREHENSIVE APPROACH BY ILIZAROV
METHOD
Dr. C. Vinay Kumar
Presenter- Post graduate
Dr. N. Srinivas Reddy
Associate Professor
Dr. M. Nagendra Babu, HOD
Prathima Institute of Medical Sciences,
Karimnagar.
3. WHY DIFFERENT / WHY DIFFICULTY
• Associated with infection – large cavities / sequestrum.
• Limb length discrepancy.*
• Deformities
• Adjacent joint / soft tissue contractures.
*
4. EVALUATION
• Clinical examination
• X-Ray
• Haematological
• MRI / CT
• Physeal damage assessment
• Pus for C/S
• Fitness for anaesthesia / surgery
5. PATIENTS & METHODS
Retrospective clinical study 2006-2018
• Mean age- 5.06 years
– min 1½ year
– max 11 years
• Mean age of nonunion- 3 years
• Limb length discrepancy -3 patients
• Wound exploration – 7 patients but
active infection – 4 patients
• Bone transport – 1 patient
• Free fibular graft + cancellous bone
graft(CBG) – 3 patients,
• CBG – 2 – Iliac crest , 1 – upper tibia
• Average number of surgeries
(Primary) 1.75 / patient.
4 4
0
1
2
3
4
5
MALE FEMALE
NO. PATIENTS
3 3
2
0
0.5
1
1.5
2
2.5
3
3.5
Femur Radius Tibia
BONE SEGMENT
6. TREATMENT
Surgical treatment – Ilizarov fixation
Counseling
Infection control Osteosynthesis Deformity
correction
Limb length
discrepancy
Late reconstruction
Basic function restoration Total function restoration
Priority
of
treatment
PRIORITIZATION OF TREATMENT
7. ILIZAROV APPLICATION
• Single / two stage procedure
• Wound exploration /
debridement
• Mounting the fixator
• Deformity correction
• Corticotomy
• Bone grafting
• Antibiotic protocol.
8. POST OPERATIVE PHASE
• Intensive physiotherapy
• Fixator education- compression / distraction protocol
• Pin tract care / infections
• Bone transport
• Regular followup
9. LONG TERM FOLLOWUP
AND TREATMENT
• Progression of the
deformity
• Limb length discrepancy.
• Deformity correction and
bone transport.
10. COMPLICATIONS & OUTCOME
• Pin tract infection
• Failed osteosynthesis
• Flareup of infection
• Malunion
• Limitation of forearm rotation
Despite complications osteosynthesis
obtained in all the cases.
20. DISCUSSION
• Nonunions – treated at the
earliest.
• Counseling of the patient /
parents. Explanation of the
clinical situation / treatment
methodology /duration of
treatment / inherent
complications/ multiple surgeries.
• Long term followup.
• Late treatment - progressive limb
length discrepancy / angular
deformities.
• Nutritional status.
• Socio-economic aspects of the
family.
• Psychological status of the child.
21. CONCLUSION
• Ilizarov method is very reliable and effective in
these difficult clinical situations, not only because
of its efficacy in osteosynthesis but also because
of its comprehensive approach to address the
associated conditions.
22. REFERENCES
• Tachdjian’s paediatric orthopaedics, 5th Edition
• S Robert Rozbruch & Svetlana ilizarov, Limb
lengthening and reconstruction surgery, 2007
• Vladimir golyakhobsky, Text book of Ilizarov
Surgical techniques-bone correction &
lengthening
• Dror paley, Principles of deformaty correction
• Dianchi maiocci A, Aronson J, Operative principles
of Ilizarov fracture treatment, non union
osteomyelitis. Baltimore, Williams and wilkins,
1991.
23. CONFLICT OF INTEREST
• Informed consent taken from the patient
for inclusion in the study
• Ethical principles of research followed
24. MASTER CHART
Serial
no.
Na
me
Age
Gen
der
Age of
nonunion
Segment
involved
Limb length
discrepancy.
Deformity
No.Of
surgeries
Wound
debridement
Bone
transport
Bone
grafting
Fixator
time in
days
Result Comments
1 Xxx 5 yrs M 4 years Tibia 7cm. Tibia vara 2 Not done
Done. Distal
tibial.
Not
done
218
Union+/bone
transport+
Varus+
2 Xxx 6 yrs M 6 months Femur 3cm. Nil 1 Done Not done
Not
done
222 Union failed
Ilizarov redone
united
3 Xxx
11
yrs
F 8 years Tibia Nil
Procurvatu
m tibia
1 Not done Nil
Not
done
268
Union+/defor
mity
Satisfied
patient.
4 Xxx 3 yrs M 2 years Femur Nil Nil 1 Done Not done
Not
done
192 Successful LLD persisted
5 Xxx 4 yrs M 3 years Radius Nil
Manus
valgus
2 Done. No inf. Not done Fg+cbg 177
Union +
deformity-
Min. Stiffness
6 Xxx 6 yrs F 3 years Radius Nil
Manus
valgus
2 Done.No inf. Not done Fg+cbg 224
Union+
defomity-
Stiffness min.
7 Xxx
1½
yrs
F 6 months Radius Nil
Manus
valgus
2 Done.No inf. Not done Fg+cbg 118
Union+
deformity-
Lost for
followup
8 Xxx 4 yrs F 3 years Femur Nil Deformity+ 3
Done.
Infection+
Not done
Not
done
168 Successful
Deformity
persisted.
• LLD-Limb Length Discrepancy
• FG- Fibular Graft
•CBG- Cancellous Bone Graft