Chapter 17
Evoution of Life
The Origin of Life
Did Life on Earth Originate on Mars?
Early Life on Earth
Charles Darwin and The Origin of Species
How Natural Selection Works
Adaptation
Staying Warm and Keeping Cool
Evolution and Genetics
How Species Form
Evidence of Evolution
Fossils: Earth's Tangible Evidence of Evolution
The Evolution of Humans
History of Science: The Peppered Moth
Science and Society: Antibiotic-Resistant Bacteria
Delivered this as talk series on Evolution to some of my colleagues interested in systems thinking. It was a great learning for me and will incorporate it into a sequel later.
Updates:
1. Version 2013.11.23 - Reorganized some slides, added images and credits
2. Version 2013.11.25 - Reorganized presentation around three aspects. Added better intro.
3. Version 2013.11.26 - Updated implications aspect for global warming and behavioral sink.
4. Version 2013.11.27 - Updated taxonomy discussion.
5. V 2013.12.05 - Updated natural selection, convergent evolution and punctuated equilibrium. Reorg of slides.
6. V 2013.12.16 - Added chaos and self-organization slides.
7. V 2013.12.21 - Added extinctions and explosions.
8. V2013.12.23 - Added more chaos explanation and Wikipedia logo.
9. V2014.05.05 - Corrected spelling mistakes and cleaned up slides.
Chapter 17
Evoution of Life
The Origin of Life
Did Life on Earth Originate on Mars?
Early Life on Earth
Charles Darwin and The Origin of Species
How Natural Selection Works
Adaptation
Staying Warm and Keeping Cool
Evolution and Genetics
How Species Form
Evidence of Evolution
Fossils: Earth's Tangible Evidence of Evolution
The Evolution of Humans
History of Science: The Peppered Moth
Science and Society: Antibiotic-Resistant Bacteria
Delivered this as talk series on Evolution to some of my colleagues interested in systems thinking. It was a great learning for me and will incorporate it into a sequel later.
Updates:
1. Version 2013.11.23 - Reorganized some slides, added images and credits
2. Version 2013.11.25 - Reorganized presentation around three aspects. Added better intro.
3. Version 2013.11.26 - Updated implications aspect for global warming and behavioral sink.
4. Version 2013.11.27 - Updated taxonomy discussion.
5. V 2013.12.05 - Updated natural selection, convergent evolution and punctuated equilibrium. Reorg of slides.
6. V 2013.12.16 - Added chaos and self-organization slides.
7. V 2013.12.21 - Added extinctions and explosions.
8. V2013.12.23 - Added more chaos explanation and Wikipedia logo.
9. V2014.05.05 - Corrected spelling mistakes and cleaned up slides.
This pdf is about the Schizophrenia.
For more details visit on YouTube; @SELF-EXPLANATORY;
https://www.youtube.com/channel/UCAiarMZDNhe1A3Rnpr_WkzA/videos
Thanks...!
Nutraceutical market, scope and growth: Herbal drug technologyLokesh Patil
As consumer awareness of health and wellness rises, the nutraceutical market—which includes goods like functional meals, drinks, and dietary supplements that provide health advantages beyond basic nutrition—is growing significantly. As healthcare expenses rise, the population ages, and people want natural and preventative health solutions more and more, this industry is increasing quickly. Further driving market expansion are product formulation innovations and the use of cutting-edge technology for customized nutrition. With its worldwide reach, the nutraceutical industry is expected to keep growing and provide significant chances for research and investment in a number of categories, including vitamins, minerals, probiotics, and herbal supplements.
Cancer cell metabolism: special Reference to Lactate PathwayAADYARAJPANDEY1
Normal Cell Metabolism:
Cellular respiration describes the series of steps that cells use to break down sugar and other chemicals to get the energy we need to function.
Energy is stored in the bonds of glucose and when glucose is broken down, much of that energy is released.
Cell utilize energy in the form of ATP.
The first step of respiration is called glycolysis. In a series of steps, glycolysis breaks glucose into two smaller molecules - a chemical called pyruvate. A small amount of ATP is formed during this process.
Most healthy cells continue the breakdown in a second process, called the Kreb's cycle. The Kreb's cycle allows cells to “burn” the pyruvates made in glycolysis to get more ATP.
The last step in the breakdown of glucose is called oxidative phosphorylation (Ox-Phos).
It takes place in specialized cell structures called mitochondria. This process produces a large amount of ATP. Importantly, cells need oxygen to complete oxidative phosphorylation.
If a cell completes only glycolysis, only 2 molecules of ATP are made per glucose. However, if the cell completes the entire respiration process (glycolysis - Kreb's - oxidative phosphorylation), about 36 molecules of ATP are created, giving it much more energy to use.
IN CANCER CELL:
Unlike healthy cells that "burn" the entire molecule of sugar to capture a large amount of energy as ATP, cancer cells are wasteful.
Cancer cells only partially break down sugar molecules. They overuse the first step of respiration, glycolysis. They frequently do not complete the second step, oxidative phosphorylation.
This results in only 2 molecules of ATP per each glucose molecule instead of the 36 or so ATPs healthy cells gain. As a result, cancer cells need to use a lot more sugar molecules to get enough energy to survive.
Unlike healthy cells that "burn" the entire molecule of sugar to capture a large amount of energy as ATP, cancer cells are wasteful.
Cancer cells only partially break down sugar molecules. They overuse the first step of respiration, glycolysis. They frequently do not complete the second step, oxidative phosphorylation.
This results in only 2 molecules of ATP per each glucose molecule instead of the 36 or so ATPs healthy cells gain. As a result, cancer cells need to use a lot more sugar molecules to get enough energy to survive.
introduction to WARBERG PHENOMENA:
WARBURG EFFECT Usually, cancer cells are highly glycolytic (glucose addiction) and take up more glucose than do normal cells from outside.
Otto Heinrich Warburg (; 8 October 1883 – 1 August 1970) In 1931 was awarded the Nobel Prize in Physiology for his "discovery of the nature and mode of action of the respiratory enzyme.
WARNBURG EFFECT : cancer cells under aerobic (well-oxygenated) conditions to metabolize glucose to lactate (aerobic glycolysis) is known as the Warburg effect. Warburg made the observation that tumor slices consume glucose and secrete lactate at a higher rate than normal tissues.
Professional air quality monitoring systems provide immediate, on-site data for analysis, compliance, and decision-making.
Monitor common gases, weather parameters, particulates.
(May 29th, 2024) Advancements in Intravital Microscopy- Insights for Preclini...Scintica Instrumentation
Intravital microscopy (IVM) is a powerful tool utilized to study cellular behavior over time and space in vivo. Much of our understanding of cell biology has been accomplished using various in vitro and ex vivo methods; however, these studies do not necessarily reflect the natural dynamics of biological processes. Unlike traditional cell culture or fixed tissue imaging, IVM allows for the ultra-fast high-resolution imaging of cellular processes over time and space and were studied in its natural environment. Real-time visualization of biological processes in the context of an intact organism helps maintain physiological relevance and provide insights into the progression of disease, response to treatments or developmental processes.
In this webinar we give an overview of advanced applications of the IVM system in preclinical research. IVIM technology is a provider of all-in-one intravital microscopy systems and solutions optimized for in vivo imaging of live animal models at sub-micron resolution. The system’s unique features and user-friendly software enables researchers to probe fast dynamic biological processes such as immune cell tracking, cell-cell interaction as well as vascularization and tumor metastasis with exceptional detail. This webinar will also give an overview of IVM being utilized in drug development, offering a view into the intricate interaction between drugs/nanoparticles and tissues in vivo and allows for the evaluation of therapeutic intervention in a variety of tissues and organs. This interdisciplinary collaboration continues to drive the advancements of novel therapeutic strategies.
A brief information about the SCOP protein database used in bioinformatics.
The Structural Classification of Proteins (SCOP) database is a comprehensive and authoritative resource for the structural and evolutionary relationships of proteins. It provides a detailed and curated classification of protein structures, grouping them into families, superfamilies, and folds based on their structural and sequence similarities.
2. Evolution
Charles Robert Darwin (1859)- origin of species by natural selection
1)Species arose from common ancestor (descent with modification)
2)Mechanism is natural selection
Population can change over generations if individuals that possess
certain heritable traits leave more offspring-results in evolutionary
adaptation.
Change in genetic composition over time-new species
Fossil records can be used to test the evolutionary theory
3. Early theories
• Aristotle (384-322 B.C)- species is fixed
Scala nature (scale of nature)-Each form of life is perfect and
permanent and could be arranged on a ladder, or scale of increasing
complexity
Carolus Linnaeus (1707-1778)- founder of taxonomy: instead of linear
hierarchy , he adoped nested classification system (grouping together)
(pattern of creation)
4. Catastrophism
• Most fossils are found in sedimentary rocks (formed from sand and
mud that settle to the bottom of water)-new layer covers old one.
• Georges Cuvier (1769-1832):
1) deeper the strata more dissimilar the fossils are from current form
of life
2) Some species appear and some disappear
Catastrophism : confined to local geographic regions
5. Gradualism
• James Hutton, in 1795: Earth’s Geological change can take place
through the cumulative effect of slow but continuous
processes.
• Charles Lyell- incorporated this into a theory as uniformitarianism.
• Darwin reasoned if that is the case, earth must be older than 6000
years and similar process can act on living organism
6. Darwin’s voyage-HMS Beagle
• Journey began in 1831 with the mission of charting poorly stretches
of south American coastline.
7. OBSERVATIONS
• Various adaptation of plants and animals
• Resemblance of species living in particular region: organisms in
tropic region of south America resembles temperate region of
south America more than the tropic regions of Europe.
• Fossils also resemble living organism of that continent.
• Geological changes (volcanic eruption in Chile)-Marine organism in
Andes mountains
Galapagoas Island: Finches were unique to some island, some are
distributed to one or more island.
Adaptation to environment and origin of new species is related!!!
9. • ALLFRED RUSSEL WALLACE (1823-1913)-Developed similar theory
and send the paper to Darwin
“ORIGIN OF SPECIES”-1859
10. • Earnst Mayr dissected Darwin’s theory into 3 inferences and 5
observations:
• OBSERVATION #1: All species have such great potential fertility that their population size
would increase exponentially if all individuals that are born reproduced successfully.
• OBSERVATION #2: Populations tend to remain stable in size, excepting seasonal
fluctuations.
• OBSERVATION #3: Environmental resources are limited.
• INFERENCE #1: Production of more individuals than the environment can support leads
to a struggle for existence among individuals of a population, with only a fraction of
offspring surviving each generation.
11. • OBSERVATION #4: Individuals of a population vary extensively in their characteristics; no
two individuals are exactly alike.
• OBSERVATION #5: Much of this variation is heritable.
• iNFERENCE #2: Survival in the struggle for existence is not random, but depends in part
on the hereditary constitution of the individuals. Those individuals whose inherited traits
best fit them to their environments are likely to leave more offspring than less fit
individuals.
• INFERENCE #3: This unequal ability of individuals to survive and reproduce will lead to a
gradual change in a population with favorable characteristics accumulating over the
generations
12. Artificial selection
• Artificial selection is the identification by humans of desirable traits in
plants and animals, and the steps taken to enhance and perpetuate
those traits in future generations
14. Drug resistant HIV
-3TC: Blocks reverse transcriptase
-Natural variant that is resistant to
3TC have no advantage, replicate
slower
15. Important points to note
• Individuals don’t evolve, population do.
• Natural selection can amplify or diminish only heritable traits.
• Trait that is favourable in one situation may be detrimental or useless
in another.
16. Explanation for other observations
• Homology : Similarity resulting from common ancestry
Anatomical homologies
19. Biogeography
• Closely related species tend to be in a same geographic region (same
ecological niches in different region may be occupied by similar
looking but very different species)
Convergent
evolution
20. Overview
-Darwins Origin of species
-Earlier theories preceding origin of species
-Examples of Natural selection
-How anatomical homology and convergent evolution is explained by
Darwin’s view of life