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Transfusion-related acute lung injury (TRALI)
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INFECTIOUS AGENTS  can be passed along with blood transfusion as well Hepatitis  AIDS  Other viral agents (CMV, EBV, HTLV)  Parasites and bacteria
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About 70% of the blood products are filtered to remove leukocytes (white blood cell) that fight foreign material such as bacteria, viruses and abnormal cells that may cause disease.  When leukocytes are present in donated blood, they may not be tolerated by the person receiving the blood and cause some types of transfusion complications
GUIDELINES FOR TRANSFUSION OF BLOOD COMPONENTS
[object Object],Whole blood Packed red blood cells :  Platelet-rich plasma  Platelet concentrates Platelet-poor plasma   Fresh plasma : Fresh frozen plasma  Cryoprecipitate : Cryoprecipitate is a concentrated source of von Willebrand factor, fibrinogen, factor VIII and fibronectin  Cryosupernant (Cryosuper) :  Cryosupernant is the remaining plasma after removal of the pelleted cryoprecipitate. This is a source of all coagulation and plasma proteins, except for factor VIII, fibrinogen, von Willebrand factor and fibronectin Frozen plasma
Preparation of blood component
[object Object],[object Object],[object Object],[object Object],[object Object],Medical conditions (e.g., GI hemorrhage)
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TRANSFUSION OF  FRESH FROZEN PLASMA   Dilutional coagulopathy (i.e. massive transfusion), active bleeding, surgery or invasive procedure and at least one of the following:  Prothrombin Time (PT) greater than 18 seconds (1.5 times the mid range of normal at UTMB)  Activated Partial Thromboplastin Time (aPTT) greater than 54 seconds (1.5 times the upper range of normal at UTMB)  Specific clotting factor deficiency( <  25% of normal) for which other safer replacement product is not available.
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Bohomolets 3rd year Surgery Blood

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  • 28. INFECTIOUS AGENTS can be passed along with blood transfusion as well Hepatitis AIDS Other viral agents (CMV, EBV, HTLV) Parasites and bacteria
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  • 37. About 70% of the blood products are filtered to remove leukocytes (white blood cell) that fight foreign material such as bacteria, viruses and abnormal cells that may cause disease. When leukocytes are present in donated blood, they may not be tolerated by the person receiving the blood and cause some types of transfusion complications
  • 38. GUIDELINES FOR TRANSFUSION OF BLOOD COMPONENTS
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  • 40. Preparation of blood component
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  • 47. TRANSFUSION OF FRESH FROZEN PLASMA Dilutional coagulopathy (i.e. massive transfusion), active bleeding, surgery or invasive procedure and at least one of the following: Prothrombin Time (PT) greater than 18 seconds (1.5 times the mid range of normal at UTMB) Activated Partial Thromboplastin Time (aPTT) greater than 54 seconds (1.5 times the upper range of normal at UTMB) Specific clotting factor deficiency( < 25% of normal) for which other safer replacement product is not available.
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