Making Drugs Smarter

1. V I R U N safe & effective oral delivery © 2009 VIRUN all rights reserved ®

2. A micelle consists of a single lipid monolayer characterized by a thin shell and small particle size usually <100nm A liposome consists of phospholipid bilayers that are characterized by a thicker shell and larger particle size 10nm particle size nanotechnology 1micron particle size V I R U N safe & effective oral delivery © 2009 VIRUN all rights reserved ®

3. a novel drug delivery vehicle can be more than just simple particles composed of lipids… V I R U N safe & effective oral delivery © 2009 VIRUN all rights reserved ®

4. Combining a drug with a thin layered micelle enhances the stability and integrity of the drug while maintaining a fast and effective pk profile. fast and effective V I R U N safe & effective oral delivery © 2009 VIRUN all rights reserved ®

5. Combining a drug with a bilayered liposome enhances the stability and integrity of the drug while maintaining a sustained and basal pk profile. sustained V I R U N safe & effective oral delivery © 2009 VIRUN all rights reserved ®

6. Combining a drug with a micelle, liposome or micelle-lipocomplex enhances the stability, integrity and pk profile… … further comprising the drug delivery vehicle with an intelligent augmentation can increase a drugs pharmacodynamics by focusing on specific cell targets . targeted V I R U N safe & effective oral delivery © 2009 VIRUN all rights reserved ®

7. improved bioavailability and effectiveness of naïve drugs… … a drug can maintain its stability in the body by means of nanoencapsulation while achieving increased bioavailability by small particle manipulation. DNA is an example of a targeted vehicle with small particle size, <100nm. *Image © Dennis Kunkel Microscopy, Inc. * V I R U N safe & effective oral delivery © 2009 VIRUN all rights reserved ®

8. Targeting a specific cell, cell receptor or cell wall can promote better delivery to engage a more pronounced therapeutic effect V I R U N safe & effective oral delivery © 2009 VIRUN all rights reserved ®

9. an inner diverse look into science V I R U N safe & effective oral delivery © 2009 VIRUN all rights reserved ®