Located in Northern California, the Lawrence Livermore National Laboratory (LLNL) hosts research projects in a variety of science and technology sectors.
A molecule called Tetrandrine derived from an Asian herb may protect against Ebola infection by turning off two pore channels (TPCs) that the virus uses to enter and infect cells. Researchers found that Tetrandrine inhibited Ebola infection of human white blood cells in dish experiments and protected mice from Ebola without side effects. TPCs were identified as the key calcium sensor involved in Ebola virus infection and needed to be activated for the virus to function properly.
Several research groups hope to create transgenic monkeys with immune or brain disorders to study therapies for humans, as mice models are often inadequate. This work will likely use CRISPR gene editing. A brain-controlled exoskeleton is expected to enable a paralyzed person to kick a ball at the 2014 World Cup. Two competing antibody cancer treatments that harness the immune system showed better responses than existing therapies. Antibodies targeting HIV cleared an HIV-related virus in monkeys and will soon be tested in humans, as was curing a baby born with HIV using high-dose antiretroviral drugs. A miniature DNA sequencer the size of a memory stick aims to sequence longer DNA strands in real-time. The first clinical
The EUCLIDS project is a 5-year, 12 million Euro study funded by the European Commission to research the genetics of bacterial meningitis and sepsis in children. It involves around 5000 participants across Europe and West Africa and 14 partner institutions coordinated by Imperial College London. The project aims to determine which genes affect susceptibility to infection, severity of disease, and immune response to vaccination in order to develop better prevention and treatment strategies for bacterial diseases in children worldwide.
Epigenetics is an area of intense focus in both academia and industry for drug discovery efforts. An expert panel webinar discussed key questions in the epigenetics field, including whether the underlying epigenetic mechanisms are understood, if appropriate in vitro and in vivo models exist, and how to address safety concerns. The webinar featured speakers from Epizyme Inc and AstraZeneca Pharmaceuticals and provided a forum for interaction on challenges and opportunities in epigenetics research.
The document discusses several topics related to biomedical research and human genetics. It notes that the goals of therapeutics, diagnostics, and prognostics are improving fitness. It also discusses themes of eugenics and determinism, media technology and privacy, trends in DNA sequencing costs and capacity, and challenges around data analysis and clinical applications of large-scale human genetics.
Nano Pill is a wearable device being developed by Google that uses nanoparticles to detect cancerous cells in the body. The nanoparticles spread throughout the body, latch onto abnormal cells, and return to the device to indicate if cancer or other diseases are present. They also help cancer cells show up earlier on MRI scans. The device would allow doctors to monitor patients' health daily through cloud-based data and aims to provide early detection of diseases through proactive nanotechnology screening in a non-invasive way.
A wearable device uses nanoparticles in a pill to detect cancerous and abnormal cells throughout the body. The nanoparticles latch onto abnormal cells and return to the device to indicate if cancer is present, helping identify cancer much earlier than traditional methods. The technology is part of Google's health initiatives and will require licensing and clinical trials to test efficacy and safety before being used to allow doctors to monitor patients' health daily through cloud access.
Scientists in London have found that removing cholesterol from HIV's membrane prevents the virus from damaging the immune system. This discovery could lead to a new vaccine approach. The researchers plan to further study how to inactivate HIV using this method and potentially develop a vaccine.
A molecule called Tetrandrine derived from an Asian herb may protect against Ebola infection by turning off two pore channels (TPCs) that the virus uses to enter and infect cells. Researchers found that Tetrandrine inhibited Ebola infection of human white blood cells in dish experiments and protected mice from Ebola without side effects. TPCs were identified as the key calcium sensor involved in Ebola virus infection and needed to be activated for the virus to function properly.
Several research groups hope to create transgenic monkeys with immune or brain disorders to study therapies for humans, as mice models are often inadequate. This work will likely use CRISPR gene editing. A brain-controlled exoskeleton is expected to enable a paralyzed person to kick a ball at the 2014 World Cup. Two competing antibody cancer treatments that harness the immune system showed better responses than existing therapies. Antibodies targeting HIV cleared an HIV-related virus in monkeys and will soon be tested in humans, as was curing a baby born with HIV using high-dose antiretroviral drugs. A miniature DNA sequencer the size of a memory stick aims to sequence longer DNA strands in real-time. The first clinical
The EUCLIDS project is a 5-year, 12 million Euro study funded by the European Commission to research the genetics of bacterial meningitis and sepsis in children. It involves around 5000 participants across Europe and West Africa and 14 partner institutions coordinated by Imperial College London. The project aims to determine which genes affect susceptibility to infection, severity of disease, and immune response to vaccination in order to develop better prevention and treatment strategies for bacterial diseases in children worldwide.
Epigenetics is an area of intense focus in both academia and industry for drug discovery efforts. An expert panel webinar discussed key questions in the epigenetics field, including whether the underlying epigenetic mechanisms are understood, if appropriate in vitro and in vivo models exist, and how to address safety concerns. The webinar featured speakers from Epizyme Inc and AstraZeneca Pharmaceuticals and provided a forum for interaction on challenges and opportunities in epigenetics research.
The document discusses several topics related to biomedical research and human genetics. It notes that the goals of therapeutics, diagnostics, and prognostics are improving fitness. It also discusses themes of eugenics and determinism, media technology and privacy, trends in DNA sequencing costs and capacity, and challenges around data analysis and clinical applications of large-scale human genetics.
Nano Pill is a wearable device being developed by Google that uses nanoparticles to detect cancerous cells in the body. The nanoparticles spread throughout the body, latch onto abnormal cells, and return to the device to indicate if cancer or other diseases are present. They also help cancer cells show up earlier on MRI scans. The device would allow doctors to monitor patients' health daily through cloud-based data and aims to provide early detection of diseases through proactive nanotechnology screening in a non-invasive way.
A wearable device uses nanoparticles in a pill to detect cancerous and abnormal cells throughout the body. The nanoparticles latch onto abnormal cells and return to the device to indicate if cancer is present, helping identify cancer much earlier than traditional methods. The technology is part of Google's health initiatives and will require licensing and clinical trials to test efficacy and safety before being used to allow doctors to monitor patients' health daily through cloud access.
Scientists in London have found that removing cholesterol from HIV's membrane prevents the virus from damaging the immune system. This discovery could lead to a new vaccine approach. The researchers plan to further study how to inactivate HIV using this method and potentially develop a vaccine.
Scott Edmunds from GigaScience on 'Publishing in the Open Data Era", at the "Open, Crowdsource and Blockchain Science!" hangout at Hackerspace.sg, 23rd March 2015
This document discusses the moral responsibility of scientists for dangerous research and development. It argues that as technology progresses more rapidly, it is important to consider how to ensure public safety. While scientists have traditionally viewed their role as unrestricted exploration, the document contends they may have a positive duty to refrain from research that could enable catastrophic outcomes. It proposes that scientists consider broader ethical principles of beneficence and justice toward humanity when evaluating new areas of inquiry. Government and institutions also have a role in educating scientists about their social responsibilities.
The document discusses scientists' moral responsibility regarding dangerous research and development (R&D). It argues that scientists have an individual moral duty to consider the broader consequences of their work, not just legal responsibilities. While traditional views see science as value-neutral, the document contends scientists should apply ethical principles like beneficence and justice when their work could endanger humanity. It suggests governments and institutions should provide ethical education for scientists to help cultivate personal moral responsibility regarding potentially catastrophic technologies.
1) The document discusses experiments in the 1970s that injected viruses and cancer-causing materials into primates like monkeys and newborn macaques.
2) It notes that some primates were released back into the wild carrying lab-created viruses, which could have spread to other animals and been ignored as a source of HIV.
3) It examines the possibility that human and animal experiments attempting to induce cancer in primates by suppressing their immune systems could be responsible for unleashing the AIDS pandemic.
COVID-19 : Targeting Cells For TreatmentAPRN World
COVID-19 is still affecting many people worldwide. The precautions to be taken are well known to the society by now. Across the globe, the governments are hard at work establishing the physical infrastructure to fight the andemic. At the same time, many laboratories across the world are working on clinical trials evaluating potential treatments. Researchers at MIT, the Ragon Institute of MGH, and Harvard along with colleagues from around the world have identified specific types of cells that appear to be the targets of the coronavirus, which is causing the Covid-19 pandemic.
A team of scientists at Lund University in Sweden developed a new drug for pulmonary fibrosis by accident while working on a potential cancer treatment. The drug binds to and inhibits a protein called galectin, slowing the progression of lung scarring in pulmonary fibrosis patients. This promising drug was licensed by Bristol-Myers Squibb for $444 million, and approved by the FDA to treat idiopathic pulmonary fibrosis. The success of the drug demonstrates how serendipity can play a role in medical discoveries.
This document summarizes research being conducted by Christopher Jewell, an assistant professor in the Fischell Department of Bioengineering, to develop a cancer vaccine for neuroblastoma. The vaccine uses biodegradable polymer depots injected into lymph nodes to deliver tumor antigens and immune signals to stimulate T cells and transform them into long-lasting memory T cells. This is hoped to generate an immune response capable of clearing existing tumors and keeping patients in remission by destroying any recurring tumor cells. The research is supported by a grant from the Alex's Lemonade Stand Foundation and a collaboration with Children's National Medical Center. Jewell believes this approach could lead to new cancer therapies and help fight diseases like neuroblastoma that currently have poor
The 16th Annual Scientific Meeting of the Society for Neuro-Oncology and AANS/CNS Section on Tumors was held November 17-20, 2011 in Orange County, CA. Over 1300 participants from 37 countries attended the four day meeting focused on the latest laboratory and clinical research in neuro-oncology. The meeting included education day sessions, morning and afternoon oral presentation sessions on various topics, keynote addresses, award presentations, and poster sessions to facilitate the multidisciplinary exchange of ideas. The successful annual meeting brought together neuro-oncologists, surgeons, pathologists, and other specialists to advance the research, diagnosis, care and treatment of brain tumors.
iOncologi_Pitch Deck_2024 slide show for hostingerssuser9354ce
iOncologi is developing novel cancer immunotherapies including stem cell therapies and mRNA-nanoparticle vaccines. Their stem cell therapy has shown ability to overcome resistance to immune checkpoint inhibitors in preclinical studies and received FDA approval for clinical trials in glioblastoma patients. Their mRNA-NP vaccine platform is in early phase clinical trials for refractory solid cancers. iOncologi seeks capital to further clinical evaluation and develop allogeneic 'off-the-shelf' stem cell therapies.
The document summarizes recent events and projects at the Biomedical Diagnostics Institute in Dublin. It discusses Prof. Richard O'Kennedy and colleagues receiving an innovation award for developing a point-of-care test for bacterial infections. It also describes an undergraduate internship program at BDI and workshops hosted on EU projects involving microfluidic platforms for cancer cell detection and cardiovascular disease diagnosis.
Forensic science and beyond: authenticity, provenance and assurance - evidenc...bis_foresight
This chapter provides an overview of the diverse range of scientific disciplines that constitute forensic science. It discusses how forensic science has developed over the past 150 years to utilize an increasing number of analytical techniques from various scientific fields to answer legal questions. Major developments include fingerprint analysis, DNA profiling, and digital/cyber forensics. The chapter notes both the valuable contributions forensic science makes to justice systems and economic stability, but also issues like potential weaknesses from statistical analysis. It argues that England and Wales would benefit from a national forensic science strategy that considers all stakeholders to help address fragmentation in services.
Biotecnika Times newspaper Dated 1st Jan 2018shekhar suman
Researchers at the Scripps Research Institute have solved the structure of the Piezo1 protein, which is responsible for the sense of touch. Piezo1 converts physical stimuli like touch or blood flow into chemical signals. Understanding the structure of Piezo1 provides insight into how proteins sense mechanical force and which regions can be targeted with drugs. The findings shed light on the fundamental process of touch sensation and may help develop treatments for conditions caused by Piezo1 malfunctions.
El coronavirus, relacionado con el virus que causa el SARS (síndrome respiratorio agudo severo), ha desencadenado un renovado debate sobre si las variantes de laboratorio de ingeniería de virus con posible potencial pandémico valen los riesgos.
En un artículo publicado en Nature Medicine 1 el 9 de noviembre, los científicos investigaron un virus llamado SHC014, que se encuentra en murciélagos de herradura en China. Los investigadores crearon un virus quimérico, compuesto por una proteína de superficie de SHC014 y la columna vertebral de un virus del SARS que se había adaptado para crecer en ratones e imitar una enfermedad humana. La quimera infectó las células de las vías respiratorias humanas, lo que demuestra que la proteína de superficie de SHC014 tiene la estructura necesaria para unirse a un receptor clave en las células e infectarlas. También causó enfermedades en ratones, pero no los mató.
----------------------
Engineered bat virus stirs debate over risky research
Lab-made coronavirus related to SARS can infect human cells.
12 November 2015
An experiment that created a hybrid version of a bat coronavirus — one related to the virus that causes SARS (severe acute respiratory syndrome) — has triggered renewed debate over whether engineering lab variants of viruses with possible pandemic potential is worth the risks.
In an article published in Nature Medicine 1 on 9 November, scientists investigated a virus called SHC014, which is found in horseshoe bats in China. The researchers created a chimaeric virus, made up of a surface protein of SHC014 and the backbone of a SARS virus that had been adapted to grow in mice and to mimic human disease. The chimaera infected human airway cells — proving that the surface protein of SHC014 has the necessary structure to bind to a key receptor on the cells and to infect them. It also caused disease in mice, but did not kill them
The Meunier laboratory at the Queensland Brain Institute had a productive year in 2013. They were awarded two grants to fund their research into neuronal communication and survival. In 2013, the laboratory published eight papers investigating topics like the role of myosin VI in neuroexocytosis and the regulation of neuroexocytosis by Munc18-1. They also demonstrated that inhibition of PIKfyve activity leads to neuronal cell death by disrupting autophagy, implicating this pathway in neurodegenerative diseases. The laboratory continued to study vesicular trafficking and collaborated with other researchers on projects involving neurotoxin transport in neurons and dynamin inhibitors.
In a week when the coronavirus closures and quarantines hit like falling dominoes – the lockdown in Italy, the empty workplaces and college campuses in the U.S., suspended sports seasons, canceled festivals – far less attention fell on the global scientific community's drive to find treatments for the new virus.
Evolution of dental informatics as a major researchGaurav Salunkhe
This document discusses the evolution of dental informatics as a major research tool in oral pathology. It describes how dental informatics incorporates knowledge from various fields like health science, computer science, and information technology. The primary goals are to increase understanding of biological processes and improve patient outcomes. Major areas of research include gene finding, genome assembly, protein structure prediction, and drug design. Applications discussed include using microarrays and genomics/proteomics for early oral cancer detection, identifying genetic factors that influence disease progression, and cataloging proteins in oral fluids. The conclusion states that combining experimental and theoretical approaches from various disciplines like bioinformatics will provide better understanding of oral diseases at the molecular level.
NEW VACCINE HUMAN PAPILLOMAVIRUS DESIGN - BUSINESS PLANCARLOS DUQUE
Carlos Duque, a molecular biologist from Colombia, proposes developing a next-generation vaccine against all mucosal human papillomavirus (HPV) genotypes. The current HPV vaccines only protect against a small number of genotypes and cannot adapt to new emerging genotypes. Duque believes that by applying evolutionary and structural analysis of HPV genotypes using bioinformatics techniques, it is possible to intelligently design a vaccine that protects against all mucosal HPV types. This new broadly protective vaccine could have a major impact on global public health by eradicating HPV infections and decreasing cancer risks. Duque is seeking a financial partner to help fund a one-year project utilizing bioinformatics to identify immunogenic regions of HPV proteins and model vaccine designs
Anti-Universe And Emergent Gravity and the Dark UniverseSérgio Sacani
Recent theoretical progress indicates that spacetime and gravity emerge together from the entanglement structure of an underlying microscopic theory. These ideas are best understood in Anti-de Sitter space, where they rely on the area law for entanglement entropy. The extension to de Sitter space requires taking into account the entropy and temperature associated with the cosmological horizon. Using insights from string theory, black hole physics and quantum information theory we argue that the positive dark energy leads to a thermal volume law contribution to the entropy that overtakes the area law precisely at the cosmological horizon. Due to the competition between area and volume law entanglement the microscopic de Sitter states do not thermalise at sub-Hubble scales: they exhibit memory effects in the form of an entropy displacement caused by matter. The emergent laws of gravity contain an additional ‘dark’ gravitational force describing the ‘elastic’ response due to the entropy displacement. We derive an estimate of the strength of this extra force in terms of the baryonic mass, Newton’s constant and the Hubble acceleration scale a0 = cH0, and provide evidence for the fact that this additional ‘dark gravity force’ explains the observed phenomena in galaxies and clusters currently attributed to dark matter.
Scott Edmunds from GigaScience on 'Publishing in the Open Data Era", at the "Open, Crowdsource and Blockchain Science!" hangout at Hackerspace.sg, 23rd March 2015
This document discusses the moral responsibility of scientists for dangerous research and development. It argues that as technology progresses more rapidly, it is important to consider how to ensure public safety. While scientists have traditionally viewed their role as unrestricted exploration, the document contends they may have a positive duty to refrain from research that could enable catastrophic outcomes. It proposes that scientists consider broader ethical principles of beneficence and justice toward humanity when evaluating new areas of inquiry. Government and institutions also have a role in educating scientists about their social responsibilities.
The document discusses scientists' moral responsibility regarding dangerous research and development (R&D). It argues that scientists have an individual moral duty to consider the broader consequences of their work, not just legal responsibilities. While traditional views see science as value-neutral, the document contends scientists should apply ethical principles like beneficence and justice when their work could endanger humanity. It suggests governments and institutions should provide ethical education for scientists to help cultivate personal moral responsibility regarding potentially catastrophic technologies.
1) The document discusses experiments in the 1970s that injected viruses and cancer-causing materials into primates like monkeys and newborn macaques.
2) It notes that some primates were released back into the wild carrying lab-created viruses, which could have spread to other animals and been ignored as a source of HIV.
3) It examines the possibility that human and animal experiments attempting to induce cancer in primates by suppressing their immune systems could be responsible for unleashing the AIDS pandemic.
COVID-19 : Targeting Cells For TreatmentAPRN World
COVID-19 is still affecting many people worldwide. The precautions to be taken are well known to the society by now. Across the globe, the governments are hard at work establishing the physical infrastructure to fight the andemic. At the same time, many laboratories across the world are working on clinical trials evaluating potential treatments. Researchers at MIT, the Ragon Institute of MGH, and Harvard along with colleagues from around the world have identified specific types of cells that appear to be the targets of the coronavirus, which is causing the Covid-19 pandemic.
A team of scientists at Lund University in Sweden developed a new drug for pulmonary fibrosis by accident while working on a potential cancer treatment. The drug binds to and inhibits a protein called galectin, slowing the progression of lung scarring in pulmonary fibrosis patients. This promising drug was licensed by Bristol-Myers Squibb for $444 million, and approved by the FDA to treat idiopathic pulmonary fibrosis. The success of the drug demonstrates how serendipity can play a role in medical discoveries.
This document summarizes research being conducted by Christopher Jewell, an assistant professor in the Fischell Department of Bioengineering, to develop a cancer vaccine for neuroblastoma. The vaccine uses biodegradable polymer depots injected into lymph nodes to deliver tumor antigens and immune signals to stimulate T cells and transform them into long-lasting memory T cells. This is hoped to generate an immune response capable of clearing existing tumors and keeping patients in remission by destroying any recurring tumor cells. The research is supported by a grant from the Alex's Lemonade Stand Foundation and a collaboration with Children's National Medical Center. Jewell believes this approach could lead to new cancer therapies and help fight diseases like neuroblastoma that currently have poor
The 16th Annual Scientific Meeting of the Society for Neuro-Oncology and AANS/CNS Section on Tumors was held November 17-20, 2011 in Orange County, CA. Over 1300 participants from 37 countries attended the four day meeting focused on the latest laboratory and clinical research in neuro-oncology. The meeting included education day sessions, morning and afternoon oral presentation sessions on various topics, keynote addresses, award presentations, and poster sessions to facilitate the multidisciplinary exchange of ideas. The successful annual meeting brought together neuro-oncologists, surgeons, pathologists, and other specialists to advance the research, diagnosis, care and treatment of brain tumors.
iOncologi_Pitch Deck_2024 slide show for hostingerssuser9354ce
iOncologi is developing novel cancer immunotherapies including stem cell therapies and mRNA-nanoparticle vaccines. Their stem cell therapy has shown ability to overcome resistance to immune checkpoint inhibitors in preclinical studies and received FDA approval for clinical trials in glioblastoma patients. Their mRNA-NP vaccine platform is in early phase clinical trials for refractory solid cancers. iOncologi seeks capital to further clinical evaluation and develop allogeneic 'off-the-shelf' stem cell therapies.
The document summarizes recent events and projects at the Biomedical Diagnostics Institute in Dublin. It discusses Prof. Richard O'Kennedy and colleagues receiving an innovation award for developing a point-of-care test for bacterial infections. It also describes an undergraduate internship program at BDI and workshops hosted on EU projects involving microfluidic platforms for cancer cell detection and cardiovascular disease diagnosis.
Forensic science and beyond: authenticity, provenance and assurance - evidenc...bis_foresight
This chapter provides an overview of the diverse range of scientific disciplines that constitute forensic science. It discusses how forensic science has developed over the past 150 years to utilize an increasing number of analytical techniques from various scientific fields to answer legal questions. Major developments include fingerprint analysis, DNA profiling, and digital/cyber forensics. The chapter notes both the valuable contributions forensic science makes to justice systems and economic stability, but also issues like potential weaknesses from statistical analysis. It argues that England and Wales would benefit from a national forensic science strategy that considers all stakeholders to help address fragmentation in services.
Biotecnika Times newspaper Dated 1st Jan 2018shekhar suman
Researchers at the Scripps Research Institute have solved the structure of the Piezo1 protein, which is responsible for the sense of touch. Piezo1 converts physical stimuli like touch or blood flow into chemical signals. Understanding the structure of Piezo1 provides insight into how proteins sense mechanical force and which regions can be targeted with drugs. The findings shed light on the fundamental process of touch sensation and may help develop treatments for conditions caused by Piezo1 malfunctions.
El coronavirus, relacionado con el virus que causa el SARS (síndrome respiratorio agudo severo), ha desencadenado un renovado debate sobre si las variantes de laboratorio de ingeniería de virus con posible potencial pandémico valen los riesgos.
En un artículo publicado en Nature Medicine 1 el 9 de noviembre, los científicos investigaron un virus llamado SHC014, que se encuentra en murciélagos de herradura en China. Los investigadores crearon un virus quimérico, compuesto por una proteína de superficie de SHC014 y la columna vertebral de un virus del SARS que se había adaptado para crecer en ratones e imitar una enfermedad humana. La quimera infectó las células de las vías respiratorias humanas, lo que demuestra que la proteína de superficie de SHC014 tiene la estructura necesaria para unirse a un receptor clave en las células e infectarlas. También causó enfermedades en ratones, pero no los mató.
----------------------
Engineered bat virus stirs debate over risky research
Lab-made coronavirus related to SARS can infect human cells.
12 November 2015
An experiment that created a hybrid version of a bat coronavirus — one related to the virus that causes SARS (severe acute respiratory syndrome) — has triggered renewed debate over whether engineering lab variants of viruses with possible pandemic potential is worth the risks.
In an article published in Nature Medicine 1 on 9 November, scientists investigated a virus called SHC014, which is found in horseshoe bats in China. The researchers created a chimaeric virus, made up of a surface protein of SHC014 and the backbone of a SARS virus that had been adapted to grow in mice and to mimic human disease. The chimaera infected human airway cells — proving that the surface protein of SHC014 has the necessary structure to bind to a key receptor on the cells and to infect them. It also caused disease in mice, but did not kill them
The Meunier laboratory at the Queensland Brain Institute had a productive year in 2013. They were awarded two grants to fund their research into neuronal communication and survival. In 2013, the laboratory published eight papers investigating topics like the role of myosin VI in neuroexocytosis and the regulation of neuroexocytosis by Munc18-1. They also demonstrated that inhibition of PIKfyve activity leads to neuronal cell death by disrupting autophagy, implicating this pathway in neurodegenerative diseases. The laboratory continued to study vesicular trafficking and collaborated with other researchers on projects involving neurotoxin transport in neurons and dynamin inhibitors.
In a week when the coronavirus closures and quarantines hit like falling dominoes – the lockdown in Italy, the empty workplaces and college campuses in the U.S., suspended sports seasons, canceled festivals – far less attention fell on the global scientific community's drive to find treatments for the new virus.
Evolution of dental informatics as a major researchGaurav Salunkhe
This document discusses the evolution of dental informatics as a major research tool in oral pathology. It describes how dental informatics incorporates knowledge from various fields like health science, computer science, and information technology. The primary goals are to increase understanding of biological processes and improve patient outcomes. Major areas of research include gene finding, genome assembly, protein structure prediction, and drug design. Applications discussed include using microarrays and genomics/proteomics for early oral cancer detection, identifying genetic factors that influence disease progression, and cataloging proteins in oral fluids. The conclusion states that combining experimental and theoretical approaches from various disciplines like bioinformatics will provide better understanding of oral diseases at the molecular level.
NEW VACCINE HUMAN PAPILLOMAVIRUS DESIGN - BUSINESS PLANCARLOS DUQUE
Carlos Duque, a molecular biologist from Colombia, proposes developing a next-generation vaccine against all mucosal human papillomavirus (HPV) genotypes. The current HPV vaccines only protect against a small number of genotypes and cannot adapt to new emerging genotypes. Duque believes that by applying evolutionary and structural analysis of HPV genotypes using bioinformatics techniques, it is possible to intelligently design a vaccine that protects against all mucosal HPV types. This new broadly protective vaccine could have a major impact on global public health by eradicating HPV infections and decreasing cancer risks. Duque is seeking a financial partner to help fund a one-year project utilizing bioinformatics to identify immunogenic regions of HPV proteins and model vaccine designs
Similar to Biomedical Research at Lawrence Livermore National Laboratory (20)
Anti-Universe And Emergent Gravity and the Dark UniverseSérgio Sacani
Recent theoretical progress indicates that spacetime and gravity emerge together from the entanglement structure of an underlying microscopic theory. These ideas are best understood in Anti-de Sitter space, where they rely on the area law for entanglement entropy. The extension to de Sitter space requires taking into account the entropy and temperature associated with the cosmological horizon. Using insights from string theory, black hole physics and quantum information theory we argue that the positive dark energy leads to a thermal volume law contribution to the entropy that overtakes the area law precisely at the cosmological horizon. Due to the competition between area and volume law entanglement the microscopic de Sitter states do not thermalise at sub-Hubble scales: they exhibit memory effects in the form of an entropy displacement caused by matter. The emergent laws of gravity contain an additional ‘dark’ gravitational force describing the ‘elastic’ response due to the entropy displacement. We derive an estimate of the strength of this extra force in terms of the baryonic mass, Newton’s constant and the Hubble acceleration scale a0 = cH0, and provide evidence for the fact that this additional ‘dark gravity force’ explains the observed phenomena in galaxies and clusters currently attributed to dark matter.
Candidate young stellar objects in the S-cluster: Kinematic analysis of a sub...Sérgio Sacani
Context. The observation of several L-band emission sources in the S cluster has led to a rich discussion of their nature. However, a definitive answer to the classification of the dusty objects requires an explanation for the detection of compact Doppler-shifted Brγ emission. The ionized hydrogen in combination with the observation of mid-infrared L-band continuum emission suggests that most of these sources are embedded in a dusty envelope. These embedded sources are part of the S-cluster, and their relationship to the S-stars is still under debate. To date, the question of the origin of these two populations has been vague, although all explanations favor migration processes for the individual cluster members. Aims. This work revisits the S-cluster and its dusty members orbiting the supermassive black hole SgrA* on bound Keplerian orbits from a kinematic perspective. The aim is to explore the Keplerian parameters for patterns that might imply a nonrandom distribution of the sample. Additionally, various analytical aspects are considered to address the nature of the dusty sources. Methods. Based on the photometric analysis, we estimated the individual H−K and K−L colors for the source sample and compared the results to known cluster members. The classification revealed a noticeable contrast between the S-stars and the dusty sources. To fit the flux-density distribution, we utilized the radiative transfer code HYPERION and implemented a young stellar object Class I model. We obtained the position angle from the Keplerian fit results; additionally, we analyzed the distribution of the inclinations and the longitudes of the ascending node. Results. The colors of the dusty sources suggest a stellar nature consistent with the spectral energy distribution in the near and midinfrared domains. Furthermore, the evaporation timescales of dusty and gaseous clumps in the vicinity of SgrA* are much shorter ( 2yr) than the epochs covered by the observations (≈15yr). In addition to the strong evidence for the stellar classification of the D-sources, we also find a clear disk-like pattern following the arrangements of S-stars proposed in the literature. Furthermore, we find a global intrinsic inclination for all dusty sources of 60 ± 20◦, implying a common formation process. Conclusions. The pattern of the dusty sources manifested in the distribution of the position angles, inclinations, and longitudes of the ascending node strongly suggests two different scenarios: the main-sequence stars and the dusty stellar S-cluster sources share a common formation history or migrated with a similar formation channel in the vicinity of SgrA*. Alternatively, the gravitational influence of SgrA* in combination with a massive perturber, such as a putative intermediate mass black hole in the IRS 13 cluster, forces the dusty objects and S-stars to follow a particular orbital arrangement. Key words. stars: black holes– stars: formation– Galaxy: center– galaxies: star formation
Sexuality - Issues, Attitude and Behaviour - Applied Social Psychology - Psyc...PsychoTech Services
A proprietary approach developed by bringing together the best of learning theories from Psychology, design principles from the world of visualization, and pedagogical methods from over a decade of training experience, that enables you to: Learn better, faster!
EWOCS-I: The catalog of X-ray sources in Westerlund 1 from the Extended Weste...Sérgio Sacani
Context. With a mass exceeding several 104 M⊙ and a rich and dense population of massive stars, supermassive young star clusters
represent the most massive star-forming environment that is dominated by the feedback from massive stars and gravitational interactions
among stars.
Aims. In this paper we present the Extended Westerlund 1 and 2 Open Clusters Survey (EWOCS) project, which aims to investigate
the influence of the starburst environment on the formation of stars and planets, and on the evolution of both low and high mass stars.
The primary targets of this project are Westerlund 1 and 2, the closest supermassive star clusters to the Sun.
Methods. The project is based primarily on recent observations conducted with the Chandra and JWST observatories. Specifically,
the Chandra survey of Westerlund 1 consists of 36 new ACIS-I observations, nearly co-pointed, for a total exposure time of 1 Msec.
Additionally, we included 8 archival Chandra/ACIS-S observations. This paper presents the resulting catalog of X-ray sources within
and around Westerlund 1. Sources were detected by combining various existing methods, and photon extraction and source validation
were carried out using the ACIS-Extract software.
Results. The EWOCS X-ray catalog comprises 5963 validated sources out of the 9420 initially provided to ACIS-Extract, reaching a
photon flux threshold of approximately 2 × 10−8 photons cm−2
s
−1
. The X-ray sources exhibit a highly concentrated spatial distribution,
with 1075 sources located within the central 1 arcmin. We have successfully detected X-ray emissions from 126 out of the 166 known
massive stars of the cluster, and we have collected over 71 000 photons from the magnetar CXO J164710.20-455217.
ESA/ACT Science Coffee: Diego Blas - Gravitational wave detection with orbita...Advanced-Concepts-Team
Presentation in the Science Coffee of the Advanced Concepts Team of the European Space Agency on the 07.06.2024.
Speaker: Diego Blas (IFAE/ICREA)
Title: Gravitational wave detection with orbital motion of Moon and artificial
Abstract:
In this talk I will describe some recent ideas to find gravitational waves from supermassive black holes or of primordial origin by studying their secular effect on the orbital motion of the Moon or satellites that are laser ranged.
When I was asked to give a companion lecture in support of ‘The Philosophy of Science’ (https://shorturl.at/4pUXz) I decided not to walk through the detail of the many methodologies in order of use. Instead, I chose to employ a long standing, and ongoing, scientific development as an exemplar. And so, I chose the ever evolving story of Thermodynamics as a scientific investigation at its best.
Conducted over a period of >200 years, Thermodynamics R&D, and application, benefitted from the highest levels of professionalism, collaboration, and technical thoroughness. New layers of application, methodology, and practice were made possible by the progressive advance of technology. In turn, this has seen measurement and modelling accuracy continually improved at a micro and macro level.
Perhaps most importantly, Thermodynamics rapidly became a primary tool in the advance of applied science/engineering/technology, spanning micro-tech, to aerospace and cosmology. I can think of no better a story to illustrate the breadth of scientific methodologies and applications at their best.
2. Located in Northern California, the
Lawrence Livermore National
Laboratory (LLNL) hosts research
projects in a variety of science and
technology sectors. Initially designed to
ensure the safety and reliability of the
nuclear deterrent, LLNL has since grown
to include many projects in the field of
biomedical sciences.
3. In late 2016, researchers
at LLNL obtained a
$485,000 grant to
develop a vaccine for
chlamydia, one of the
most prevalent sexually
transmitted diseases in
the world.
4. The project focuses on the
synthetic creation of a
major outer membrane
protein vaccine, which
prompts the human
immune system to form
protective antibodies
against the chlamydia
bacterium without actually
contracting the disease.
5. If successful, the
project will help
prevent transmission
from mother to fetus,
which can cause
pneumonia and
conjunctivitis in the
newborn.
6. Meanwhile, members of the in-vitro Chip-
Based Human Investigational Platform
(iCHIP) project have begun using a
microelectrode system to measure activity
in the peripheral nervous system. By
integrating nanotechnology with the
human dorsal root ganglia in the spinal
column, researchers can assess the long-
term effects of chemical and toxic agents
on the human nervous system.
7. Dr. William De La Peña
serves on the Board of
Governors for
Lawrence Livermore
National Security, LLC,
which manages LLNL.