Epigenetics is an area of intense focus in both academia and industry for drug discovery efforts. An expert panel webinar discussed key questions in the epigenetics field, including whether the underlying epigenetic mechanisms are understood, if appropriate in vitro and in vivo models exist, and how to address safety concerns. The webinar featured speakers from Epizyme Inc and AstraZeneca Pharmaceuticals and provided a forum for interaction on challenges and opportunities in epigenetics research.