The document discusses biomimetic mesotherapy and various dermaheal products. It provides details on: - The history of biomimetic mesotherapy and key developments since 1952. - Five dermaheal products (HSR, SR, HL, SB, LL) and their ingredients, which include vitamins, minerals, peptides and growth factors to target anti-aging, hair regrowth, skin brightening and cellulite reduction. - Treatment protocols involving mesotherapy with the dermaheal products once per week along with a mezoroller or dermaroller. Results are said to look natural.

1. t
Biomimetic Mesotherapy
www.dermagenica.co.uk
Dr Patrick Treacy

2. t
History of Biomimetic Mesotherapy
•1952 - Dr Michel Pistor - the beginning of a
discipline called mesotherapy
•1999 - Nanopeptides
The Nobel Prize in Physiology or Medicine 1999
was awarded to Günter Blobel "for the discovery
that proteins have intrinsic signals that govern
their transport and localization in the cell".
www.dermagenica.co.uk

3. t
History of Biomimetic Mesotherapy
•Since 2002 - Dermaheal the world leader of
research and marketing of Biomimetic Peptides and
Growth Factors & a global supplier of biomimetic
peptides and growth factors to the cosmetic industry
with well established relationships with La Prairie,
Revlon, Dermalogica and Sasa.
•2005 - 2009 - Dermaheal
Introduces biomimetic
mesotherapy
www.dermagenica.co.uk

4. t
Biomimetic peptides
• SynthShort chains of amino-acids responsible for the
proliferation and differentiation of cells
• etic Growth factors
• They are responsible for cellular processes including
wound healing
• Stimulate production of elastin
& collagen
• The latest trend in cosmetology
• A synthetic ingredient
• Repeatable technology
• No irritation or cancerogenic effects

5. t
Platform Technology
The importance of cytokines and growth factors in the regulation
of gene expression and cellular metabolism is well established in
a field of skin biology.
Summarized functions of growth factors and
mimicking peptides.
• Removing damaged skin cells.
• Stimulating skin and hair follicle proliferation.
• Repairing and preventing wrinkle formation and minimizing
scar formation.
• Soothing effect on acne
and pimples.
• Reducing and removing
cellulites.
• Acting as anti-microb agents.
• Preventing hair loss.
• Vitalizing skin and hair cells.

6. t
Skin absorption of Nano-capsulation
Intercellular interval of skin is 70-180nm
Molecules are tiny enough to deeply penetrate
Transport cosmetic components into dermal skin tissue

7. Characteristics of Nano-capsulation
• Multi-layered
• Therapeutic components in each globe layer
• Continuous release effect

10. t
CG-Boostrin / Oligopeptide-72
• Anti-wrinkle, skin firming.
• Reduces and prevents lines and wrinkles by
actively generating new skin cells
• Enhances skin tone that brimms with vitality
and energy
Cell Proliferation
with Fibroblast Cells
Morphological Change of Fibroblast Cells
Anti-aging

11. t
CG-EDP3/ Oligopeptide-24
• Anti-wrinkle, skin lifting, skin firming.
• Reduces and prevents lines and wrinkles by actively generating new
skin cells.
• Enhances skin tone that brimming with vitality and energy.
• Minimize scars on skin by forming new skin cell.
• Up-regulation of cell growth and migration, cell survival, extracellular
matrix expression
Anti-aging
Cell Proliferation with Fibroblast Cells

12. t
CG-EDP3/ Oligopeptide-24
Morphological Change of Fibroblast Cells
Anti-aging

13. t
CG-IDP2/ Decapeptide-4
• Anti-wrinkle, skin lifting, hair growth.
• Strengthens skin elasticity by inducing the synthesis of collagen and
elastin.
• Involves in normal skin growth, healing and wound repair.
• Reduces and prevents lines and wrinkles by actively generating new
skin cells.
Anti-aging
Cell Proliferation with Keratinocyte and Fibroblast Cells

14. t
CG-IDP2/ Decapeptide-4
Anti-aging
Morphological Change of Keratinocyte and Fibroblast Cells
Skin Histology Study of CG-IDP2

15. t
CG-IDP5/ Oligopeptide-20
• Anti-wrinkle, skin lifting, hair growth.
• Strengthens skin elasticity by inducing the synthesis of collagen and
elastin.
• Involves in normal skin growth, healing and wound repair.
• Reduces and prevents lines and wrinkles by actively generating new
skin cells.
Anti-aging
Morphological Change of Keratinocyte and Fibroblast Cells

16. t
CG-IDP5/ Oligopeptide-20
Anti-aging

17. t
CG-Demelarin/ Oligopeptide-58
• Skin Lightening & Brightening
• Sun Protection
• Even Skin Tone
• Photo-aging Prevention
• Aged Spot Treatment
Anti-pigmentation
Morphological Change
Inhibition of Melanin Synthesis
after CG-Demelarin Treatment

18. t
CG-TGP2/ Oligopeptide-34
• Skin Lightening & Brightening
• Sun Protection
• Even Skin Tone
• Photo-aging Prevention
• Aged Spot Treatment
• Skin Trouble Care
Anti-pigmentation
Melanin Synthesis Comparison
With Various Skin Lightening
Ingredients
Morphological Change
Of Melanocyte Cell Line

19. t
CG-Glamerin/ Oligopeptide-50
• Skin Lightening & Brightening
• Sun Protection
• Even Skin Tone
• Photo-aging Prevention
• Aged Spot Treatment
Anti-pigmentation
Morphological Change of Melanocyte Cell Line

20. Melanocytes are First!!
To show signs of damage in the aging
process

21. t
CG-Prohairin-β4/ Octapeptide-2
• Hair growth.
• Increases cell growth and migration.
• Promotes hair growth by activating the stem
cells of hair follicle.
Hair-Growth
Structure of Prohairin- β4
Cell Proliferation with
Keratinocyte - Fibroblast cell nine

22. t
CG-Prohairin-β4/ Octapeptide-2
Hair-Growth
Cell Morphology Analysis after Prohairin-β4 Treatment
Cell Survival Test

23. t
CG-Promkine/ Decapeptide-20
• Promotes hair growth by increasing
proliferation of hair cells.
• Stimulates hair growth through NFkB signaling
Hair-Growth
Morphological Change of fibroblast cell and Keratinocyte cell

24. t
CG-Lipoxyn/ Tripeptide-21
• Lipolysis
• Helps restraining of accumulated lipid and
promotes lipolysis
Lipolysis
Inhibition of Lipid Accumulation by CG-Lipoxyn

25. t
CG-Lipoxyn/ Tripeptide-21
Lipolysis
Lipolysis Mechanism

26. t
Biomimetic Mesotherapy
www.dermagenica.co.uk
Marzena Aniol

27. t
Biomimetic Mesotherapy
www.dermagenica.co.uk

28. t
Dermaheal HSR
Hyaluronic Acid Skin Rejuvenating Mesotherapy
Solution
• Anti-ageing product
• Skin rejuvenating, regenerating and moisturising
effect
• Intended especially for mature, very dry or
dehydrated skin
58 ACTIVE INGREDIENTS:
• 1% of Hyaluronic Acid, 13 Vitamins
• 24 Amino Acids, 5 Minerals,
• 4 Coenzymes, 4 Nucleic Acids,
• 2 Reducing Agents,
• 5 Biomimetic Peptides

29. t
Dermaheal HSR: 5 Biomimetic Peptides
Acetyl Decapeptide-3
Reduces and prevents lines and wrinkles by actively generating
new skin cells
Decapeptide-4
Strengthens skin elasticity by inducing the synthesis
of collagen and elastin
Oligopeptide-24
Minimizes scars on skin by forming new skin cells
Tripeptide-6
Hydrates dry skin and maintain its optimum
moisture balance
Copper Tripeptide-1
Helps blood circulation in the skin and
revitalises by generating new skin cells

30. t
www.dermagenica.co.uk

31. t
Dermaheal SR
Skin Rejuvenating Mesotherapy Solution for face,
neck, hands and strechmarks
• Anti-ageing product
• Skin rejuvenating & regenerating effect
• Recommended for dull, dry, or combination skin
also with acne problems
57 ACTIVE INGREDIENTS:
13 Vitamins, 24 Amino Acids,
5 Minerals, 4 Coenzymes,
4 Nucleic Acids, 2 Reducing Agents,
5 Biomimetic Peptides
www.dermagenica.co.uk

32. t
Acetyl Decapeptide-3
Reduces and prevents lines and wrinkles by actively generating
new skin cells
Decapeptide-4
Strengthens skin elasticity by inducing the synthesis
of collagen and elastin
Oligopeptide-24
Minimizes scars on skin by forming new skin cells
Tripeptide-6
Hydrates dry skin and maintain its optimum
moisture balance
Copper Tripeptide-1
Helps blood circulation in the skin and
revitalises by generating new skin cells
Dermaheal SR: 5 Biomimetic Peptides

33. t
Hair Regain Mesotherapy Solution
• Regenerative product
• Prevents hair loss and alopecia in both men and
women
• Promotes hair regrowth
• Provides scalp care
58 ACTIVE INGREDIENTS:
13 Vitamins, 24 Amino Acids,
5 Minerals, 4 Coenzymes,
4 Nucleic Acids, 2 Reducing Agents,
4 Biomimetic Peptides
Dermaheal HL
www.dermagenica.co.uk

34. t
Dermaheal HL
Decapeptide-4
Strengthens hair while stimulating hair follicles
to produce strong hair shaft
Acetyl Decapeptide-3
Revitalises hair follicles by newly regenerating
hair cells
Oligopeptide-41
Stimulates hair cell proliferation
and migration
Copper Tripeptide-1
Helps blood circulation in the scalp,
revitalises hair follicles

35. t
Dermaheal SB
Skin Brightening
Intended for hyperpigmentation,
melasma, age spots, freckles
www.dermagenica.co.uk

36. t
Dermaheal SB
Oligopeptide-34 + Oligopeptide-50
• reduce the melanin synthesis by blocking the transfer of
melanin to keratinocytes
• prevent pigmentation,
• moisturize the skin
• anti-inflammatory properties
Pentapeptide-13
Brightens and lightens the skin
www.dermagenica.co.uk

37. t
CELLULITE
www.dermagenica.co.uk

38. t
Dermaheal LL
• A unique product that combines fat-burning
capabilities together with the regeneration
and improvement of skin elasticity
• It is both effective in fighting cellulite and local
fat deposits
• Excellent results in slimming the body
& restoring taut facial contours by
breaking down adipose tissue
• By increasing collagen and elastin
production it strengthens the skin,
making it more supple and elastic

39. t
Dermaheal LL
L-Carnitine
Responsible for transport of fat cells into the
mitochondria, where they decompose, detoxifying
action.
Hydrogenated Lecithin
Breakdown & excretion of triglycerides.
Decapeptide 4
Helps to burn & break down
adipose tissue.
Responsible for smoothing the skin.
www.dermagenica.co.uk

40. t
Treatment protocol: Stage 1 - Mesoroller

41. Skin Rejuvenation Treatment Regulate Function Of
1. Keranocytes
2. Melanocytes
3. Fibroblasts

42. Roller & Mesotherapy
Results always look natural

43. t
Treatment protocol: Stage 1 - Mezoroller
ermaheal SR Dermaheal HSR Dermaheal SB Dermaheal HL Dermaheal LL
x 10 vials / Set 5ml x 10 vials / Set 5ml x 10 vials / Set 5ml x 10 vials / Set 5ml x 10 vials / Set
Mesotherapy
ession per week
ial for 1 session
Mesotherapy
1 session per week
1 vial for 1 session
Mesotherapy
1 session per week
1 vial for 1 session
Mesotherapy
1~2 sessions per
week
1 vial for 1 session
Mesotherapy
1 session per week
www.dermagenica.co.uk

44. t

45. t
Biomimetic Mesotherapy
www.dermagenica.co.uk
Dr Gabriela Mercik

51. t
CG-aFGF/ sh-Polypeptide-11
Growth Factors
Tertiary structure of aFGF

52. t
CG-TGF-β3/ sh-Polypeptide-5
Growth Factors
Tertiary structure of TGF-β3

53. t
CG-EGF/ sh-Oligopeptide-1
Growth Factors
Tertiary structure of EGF

54. t
CG-IGF-2/ sh-Polypeptide-31
Growth Factors
Tertiary structure of IGF-2

55. t
CG-TGF-β1
Growth Factors
Tertiary structure of TGF-β1

56. t
CG-Thymosin-β4/ sh-Oligopeptide-4
Growth Factors
Tertiary structure of Thymosin-β4

57. t
CG-TRX/ sh-Polypeptide-2
Growth Factors
Tertiary structure of TRX

58. t
CG-bFGF/ sh-Polypeptide-1
Growth Factors
Tertiary structure of bFGF

59. t
CG-IGF-1/ sh-Oligopeptide-2
Growth Factors
Tertiary structure of IGF-1

60. t
CG-KGF/ sh-Polypeptide-3
Growth Factors
Tertiary structure of KGF

61. t
CG-VEGF/ sh-Polypeptide-9
Growth Factors
Tertiary structure of VEGF

62. t
Mesotherapy Treatment Plan
• Exfoliation
• Mesotherapy
• Massage
• Pure Vitamin E Caps / Face-mask
• UVB Cream
www.dermagenica.co.uk

63. Mesoroller
Micro needling
Collagen Induction Therapy
Dermaroller

65. The reduction of local fat
deposits/Cellulite
www.dermagenica.co.uk

66. t
Chin

67. t
Back

68. t
Abdomen

69. t
Butterfly Wings Region

70. t
Love Handles / Hips

71. t
Knees

72. t
Dermaheal LL
Mesotherapy for cellulite

73. t
www.dermagenica.co.uk

74. t
www.dermagenica.co.uk

87. t
Before After

93. t
www.dermagenica.co.uk

95. t
Before After

98. t
Before After

99. t
Knees
Thank you
for your attention!
www.dermagenica.co.uk