The ketogenic diet is a dietary model in which the lipids (fats) provide most of the calories (70 to 80% or 90%) while the carbohydrates (sugars) are made in very small quantities (up to 10% of calories). When the body is deprived of carbohydrates in this way, fat becomes its main source of energy (whether it comes from meals or is taken from reserves) and part of it is transformed into ketone bodies, hence the term "ketogenic". Ketones can be used as fuel for different organs, but they are mainly directed to the brain.
The ketogenic diet (or keto diet, for short) is a low-carb, high-fat diet that offers many health benefits.
A keto diet recipes that will help to lose weight fast without giving up your food. It has
A ketogenic diet is a high-fat, moderate-protein, low-carbohydrate diet that produces ketosis, a metabolic state where the body uses ketones from stored fat for energy instead of glucose from carbohydrates. Originally used to treat epilepsy, a ketogenic diet may aid in weight loss, reduce appetite and improve mental clarity and blood markers. However, it requires restricting carbohydrates to 5-10% of calories to induce ketosis and is not suitable for everyone due to potential health risks. While research on its long-term effects is still emerging, some proponents report benefits from following a ketogenic lifestyle.
Ketosis is a metabolic state where the body produces ketones from stored fat to use as energy, instead of glucose from carbohydrates. To enter ketosis, one must follow a ketogenic diet very low in carbohydrates (under 20g per day) for 2-8 days. Common signs of ketosis include keto breath, weight loss, increased energy, and testing positive on urine or blood ketone tests. A ketogenic diet provides most calories from fat, adequate protein, and very few carbs to induce ketosis and its metabolic effects long-term. Women may need to adjust macros based on their menstrual cycle. Beginners should focus on limiting carbs, eating enough fat and protein, and supplement
The keto diet has become popular for its health benefits like weight loss and disease prevention. It works by limiting carbohydrate intake to 5% of daily calories which forces the body to burn fat instead of glucose for energy. This ketogenic state provides benefits such as rapid weight loss from burning fat, reduced blood sugar and insulin levels, lower triglycerides and improved cholesterol - all of which can help prevent diseases like diabetes and heart disease. The keto diet aims to get 75% of calories from fat, 20% from protein, and only 5% from carbohydrates.
What I've learned from 16 Health, Nutrition, and Fitness Books; 4 Personal Trainers; 3 Boot Camp Instructors; 2 Nutritionists; and my Sister, a Fitness Model- what works, what doesn't, and what you should know.
A keto or ketogenic diet is a low-carb, moderate protein, higher-fat diet that can help burn fat more effectively and has many benefits for weight loss, health, and performance as shown in over 50 studies. On a keto diet, the body enters a state of ketosis where it burns fat instead of carbohydrates for energy. To achieve ketosis, the diet must restrict carbohydrate intake to under 50g of net carbs per day, ideally below 20g. The diet focuses on foods low in net carbs like meat, fish, eggs, cheese, and non-starchy vegetables.
A ketogenic diet focuses on high fat and low carb intake to induce a metabolic state called ketosis. When in ketosis, the body burns fat for energy instead of carbs. Three main types of ketogenic diets are standard ketogenic, cyclical ketogenic and targeted ketogenic. A ketogenic diet can help with weight loss and improve health markers for diabetes by reducing insulin resistance. Potential side effects include keto flu but can be minimized by supplementing electrolytes.
The document discusses the benefits of a ketogenic lifestyle. It explains that a ketogenic lifestyle involves eating low-carb, high-fat foods 99% of the time to induce a state of ketosis. Some key benefits mentioned are improved energy levels, reduced brain fog, weight loss, better management of diabetes, potential reduction of cancer and Alzheimer's risk, and decreased inflammation. The lifestyle is described as easy to follow and more natural or ancestral than a standard diet, with many health advantages.
The ketogenic diet (or keto diet, for short) is a low-carb, high-fat diet that offers many health benefits.
A keto diet recipes that will help to lose weight fast without giving up your food. It has
A ketogenic diet is a high-fat, moderate-protein, low-carbohydrate diet that produces ketosis, a metabolic state where the body uses ketones from stored fat for energy instead of glucose from carbohydrates. Originally used to treat epilepsy, a ketogenic diet may aid in weight loss, reduce appetite and improve mental clarity and blood markers. However, it requires restricting carbohydrates to 5-10% of calories to induce ketosis and is not suitable for everyone due to potential health risks. While research on its long-term effects is still emerging, some proponents report benefits from following a ketogenic lifestyle.
Ketosis is a metabolic state where the body produces ketones from stored fat to use as energy, instead of glucose from carbohydrates. To enter ketosis, one must follow a ketogenic diet very low in carbohydrates (under 20g per day) for 2-8 days. Common signs of ketosis include keto breath, weight loss, increased energy, and testing positive on urine or blood ketone tests. A ketogenic diet provides most calories from fat, adequate protein, and very few carbs to induce ketosis and its metabolic effects long-term. Women may need to adjust macros based on their menstrual cycle. Beginners should focus on limiting carbs, eating enough fat and protein, and supplement
The keto diet has become popular for its health benefits like weight loss and disease prevention. It works by limiting carbohydrate intake to 5% of daily calories which forces the body to burn fat instead of glucose for energy. This ketogenic state provides benefits such as rapid weight loss from burning fat, reduced blood sugar and insulin levels, lower triglycerides and improved cholesterol - all of which can help prevent diseases like diabetes and heart disease. The keto diet aims to get 75% of calories from fat, 20% from protein, and only 5% from carbohydrates.
What I've learned from 16 Health, Nutrition, and Fitness Books; 4 Personal Trainers; 3 Boot Camp Instructors; 2 Nutritionists; and my Sister, a Fitness Model- what works, what doesn't, and what you should know.
A keto or ketogenic diet is a low-carb, moderate protein, higher-fat diet that can help burn fat more effectively and has many benefits for weight loss, health, and performance as shown in over 50 studies. On a keto diet, the body enters a state of ketosis where it burns fat instead of carbohydrates for energy. To achieve ketosis, the diet must restrict carbohydrate intake to under 50g of net carbs per day, ideally below 20g. The diet focuses on foods low in net carbs like meat, fish, eggs, cheese, and non-starchy vegetables.
A ketogenic diet focuses on high fat and low carb intake to induce a metabolic state called ketosis. When in ketosis, the body burns fat for energy instead of carbs. Three main types of ketogenic diets are standard ketogenic, cyclical ketogenic and targeted ketogenic. A ketogenic diet can help with weight loss and improve health markers for diabetes by reducing insulin resistance. Potential side effects include keto flu but can be minimized by supplementing electrolytes.
The document discusses the benefits of a ketogenic lifestyle. It explains that a ketogenic lifestyle involves eating low-carb, high-fat foods 99% of the time to induce a state of ketosis. Some key benefits mentioned are improved energy levels, reduced brain fog, weight loss, better management of diabetes, potential reduction of cancer and Alzheimer's risk, and decreased inflammation. The lifestyle is described as easy to follow and more natural or ancestral than a standard diet, with many health advantages.
This document outlines an alkaline diet and lifestyle program called Weight Perfect 2.0. It discusses balancing the body's pH levels and choosing alkaline over acidic foods. Specific foods that are alkaline and acidic are listed. Videos related to diet, health, obesity and weight loss are also provided. The goal is to treat health at the cellular level by following an alkaline-focused diet, lifestyle changes and addressing sugar, fats and other toxic ingredients.
A keto diet is a higher-fat, lower-carb diet that burns fat more effectively and helps with weight loss and reducing hunger. When carb intake is low, the body enters a state called ketosis where it burns fat for energy instead of carbs. Foods included in the keto diet are meat, fish, eggs, high-fat dairy, nuts, berries and some vegetables while limiting carb sources like grains and starchy veggies. Following this diet can help achieve ketosis and its weight loss benefits.
The ketogenic diet (or keto diet, for short) is a low-carb, high-fat diet that offers many health benefits.
In fact, many studies show that this type of diet can help you lose weight and improve your health
Ketogenic diets may even have benefits against diabetes, cancer, epilepsy, and Alzheimer’s disease
The keto diet can lead to short-term weight loss but is not sustainable long-term and weight is likely regained after stopping the diet. People typically lose 1-10 pounds within the first week on keto as water weight, with larger individuals losing more. The keto diet puts the body in a state of ketosis, burning fat for fuel instead of carbohydrates, when carb intake is restricted and causing ketones to be used from stored body fat.
Keto diet meal plan for women over 50 ketogenic cookbook for easy meal planni...FreeLife8
Keto Diet Meal Plan for Women Over 50: Ketogenic Cookbook for Easy Meal Planning. 28 Days of Low-Carb Recipes to Boost Your Metabolism and Lose Weight. Start a Healthy Lifestyle for a Happy Menopause
The document provides 20 tips for following the keto diet successfully. Some key tips include researching the diet thoroughly beforehand, keeping meals simple at first, removing temptations from the home, committing fully to the diet, expecting "keto flu" symptoms initially, drinking plenty of water, making the diet fun through recipes and challenges, getting support from groups, meal planning, exercising, testing ketone levels, eating vegetables for carbs, sleeping enough, avoiding yo-yoing on and off the diet, focusing on allowed foods, and being patient as results may not be immediate.
The document discusses the ketogenic diet, including what foods can and cannot be eaten on the diet. It explains that the keto diet aims to put the body into a state of ketosis by reducing carb intake and increasing fat intake. While the diet may aid weight loss, an expert warns it is not recommended for mood improvement and could disrupt gut microbiota. The diet restricts foods high in carbs like fruits, grains and sugars but allows fatty meats, seafood, oils, dairy and some low-carb veggies.
This document provides an overview of the ketogenic diet and how it can be used for sustainable weight loss. It discusses that the standard American diet high in carbohydrates is actually making people sick and contributing to weight gain due to spikes in insulin levels. It then explains how the ketogenic diet works by putting the body into a state of ketosis, where it burns fat for energy instead of carbohydrates. This leads to stable energy levels and reduced appetite. The document emphasizes that the ketogenic diet is not just another temporary diet, but a lifestyle change, and discusses the importance of having the right mindset to achieve long-term success.
The document discusses the ketogenic diet, which involves eating a high-fat, moderate-protein, and low-carbohydrate diet. This forces the body to burn fat instead of carbohydrates for energy and results in weight loss and other health benefits. The key aspects of the diet are eating foods high in healthy fats and proteins while limiting carbohydrates, as this induces a metabolic state called ketosis. A variety of foods that can be eaten on this diet are then outlined.
The Complete Guide to Ketogenic Diet
with 21-Day Meal Plan to Lose Weight,
Boost Your Metabolism and Stay
Healthy, Including Simple and Delicious
Recipes
When something new comes along, it takes a playbook to understand and utilize it. Well, this really is a game changer. Ketosis has many amazing benefits, but it is misunderstood, and hard to get into. Keto//OS changes all that, making the benefits of ketosis more accessible, and also opens up one of those rare opportunities to get in at the right time before it really explodes.
Recently, the keto diet has become extremely popular for its health benefits such as weight loss and preventing disease. The keto diet can be hugely beneficial, but how does it work to provide these benefits? You can get free e book here for more details.
The reason we aim at such high protein values is to lower the chance of losing muscle during our keto expedition. This way, you will have adequate protein for exercising and gaining muscle (if you’re in a caloric surplus), or adequate protein for keeping current lean muscle (if you’re in a caloric deficit).
The keto diet is a diet that consists of extremely high amounts of fat, low amounts of carbs and moderate amounts of protein. It's pretty restrictive. The idea behind the keto diet, is that instead of relying on glucose to fuel your body, it breaks down fat into ketone bodies and uses that for energy instead.
This document provides information about starting a 14-day keto diet meal plan, including two weeks of meal plans and recipes. It notes that a keto diet limits carbohydrate intake to below 20 grams per day to induce ketosis and fat burning. The document also lists some situations where one may need extra support doing a keto diet, such as if taking certain medications. It provides tips for starting keto successfully and avoiding "keto flu" symptoms.
This document provides an overview of the keto diet, including what it is, how it works, benefits, side effects, and tips for starting it. The keto diet is a low-carb, high-fat diet that puts the body into a state of ketosis, where it burns fat for energy instead of carbs. Benefits include weight loss, improved blood sugar control, and feeling full for longer. Potential side effects are keto flu, diarrhea, and ketoacidosis in rare cases. The document offers meal plan ideas and recipes to make starting the keto diet easier.
Intermittent fasting for_weight_loss__a_beginners_guide toWeight Loss Secrets
Table of Contents
INTERMITTENT FASTING FOR WEIGHT LOSS:
Introduction
Intermittent Fasting (IF): What is it?
How Fat is Stored & Burnt
Why Low-Calorie Diets Don’t Work
Intermittent Fasting – The 16 8 Method
Starting IF – 3 Crucial Factors To Success
Factor 1: Diet & Nutrition
Factor 2: Exercise
Factor 3: Recovery, Rest & The Importance of Sleep
Starting IF Your First 30
The ketogenic diet has gained popularity in health circles because of its weight loss benefits, but many of the studies done on keto have been focused on males and lab rats. What about the keto diet for women? Do the same health benefits that apply to men apply to women who choose to adopt a high-fat, low-carbohydrate eating pattern?
Let’s go over the science behind the diet to decipher keto diet benefits and risks for women, plus cover some simple tips to make sure you start the keto diet off on the right foot.
Are you interested in losing weight? Are you tired of diets that advocate low or no fats and crave your high fat meats? You may well be considering going on the keto diet, the new kid on the block. Endorsed by many celebrities including Halle Berry, LeBron James and Kim Kardashian among others, the keto diet has been the subject of much debate among dietitians and doctors. Do you wonder if the keto diet is safe and right for you?
Are you interested in losing weight? Are you tired of diets that advocate low or no fats and crave your high fat meats? You may well be considering going on the keto diet, the new kid on the block. Endorsed by many celebrities including Halle Berry, LeBron James and Kim Kardashian among others, the keto diet has been the subject of much debate among dietitians and doctors. Do you wonder if the keto diet is safe and right for you?
This document outlines an alkaline diet and lifestyle program called Weight Perfect 2.0. It discusses balancing the body's pH levels and choosing alkaline over acidic foods. Specific foods that are alkaline and acidic are listed. Videos related to diet, health, obesity and weight loss are also provided. The goal is to treat health at the cellular level by following an alkaline-focused diet, lifestyle changes and addressing sugar, fats and other toxic ingredients.
A keto diet is a higher-fat, lower-carb diet that burns fat more effectively and helps with weight loss and reducing hunger. When carb intake is low, the body enters a state called ketosis where it burns fat for energy instead of carbs. Foods included in the keto diet are meat, fish, eggs, high-fat dairy, nuts, berries and some vegetables while limiting carb sources like grains and starchy veggies. Following this diet can help achieve ketosis and its weight loss benefits.
The ketogenic diet (or keto diet, for short) is a low-carb, high-fat diet that offers many health benefits.
In fact, many studies show that this type of diet can help you lose weight and improve your health
Ketogenic diets may even have benefits against diabetes, cancer, epilepsy, and Alzheimer’s disease
The keto diet can lead to short-term weight loss but is not sustainable long-term and weight is likely regained after stopping the diet. People typically lose 1-10 pounds within the first week on keto as water weight, with larger individuals losing more. The keto diet puts the body in a state of ketosis, burning fat for fuel instead of carbohydrates, when carb intake is restricted and causing ketones to be used from stored body fat.
Keto diet meal plan for women over 50 ketogenic cookbook for easy meal planni...FreeLife8
Keto Diet Meal Plan for Women Over 50: Ketogenic Cookbook for Easy Meal Planning. 28 Days of Low-Carb Recipes to Boost Your Metabolism and Lose Weight. Start a Healthy Lifestyle for a Happy Menopause
The document provides 20 tips for following the keto diet successfully. Some key tips include researching the diet thoroughly beforehand, keeping meals simple at first, removing temptations from the home, committing fully to the diet, expecting "keto flu" symptoms initially, drinking plenty of water, making the diet fun through recipes and challenges, getting support from groups, meal planning, exercising, testing ketone levels, eating vegetables for carbs, sleeping enough, avoiding yo-yoing on and off the diet, focusing on allowed foods, and being patient as results may not be immediate.
The document discusses the ketogenic diet, including what foods can and cannot be eaten on the diet. It explains that the keto diet aims to put the body into a state of ketosis by reducing carb intake and increasing fat intake. While the diet may aid weight loss, an expert warns it is not recommended for mood improvement and could disrupt gut microbiota. The diet restricts foods high in carbs like fruits, grains and sugars but allows fatty meats, seafood, oils, dairy and some low-carb veggies.
This document provides an overview of the ketogenic diet and how it can be used for sustainable weight loss. It discusses that the standard American diet high in carbohydrates is actually making people sick and contributing to weight gain due to spikes in insulin levels. It then explains how the ketogenic diet works by putting the body into a state of ketosis, where it burns fat for energy instead of carbohydrates. This leads to stable energy levels and reduced appetite. The document emphasizes that the ketogenic diet is not just another temporary diet, but a lifestyle change, and discusses the importance of having the right mindset to achieve long-term success.
The document discusses the ketogenic diet, which involves eating a high-fat, moderate-protein, and low-carbohydrate diet. This forces the body to burn fat instead of carbohydrates for energy and results in weight loss and other health benefits. The key aspects of the diet are eating foods high in healthy fats and proteins while limiting carbohydrates, as this induces a metabolic state called ketosis. A variety of foods that can be eaten on this diet are then outlined.
The Complete Guide to Ketogenic Diet
with 21-Day Meal Plan to Lose Weight,
Boost Your Metabolism and Stay
Healthy, Including Simple and Delicious
Recipes
When something new comes along, it takes a playbook to understand and utilize it. Well, this really is a game changer. Ketosis has many amazing benefits, but it is misunderstood, and hard to get into. Keto//OS changes all that, making the benefits of ketosis more accessible, and also opens up one of those rare opportunities to get in at the right time before it really explodes.
Recently, the keto diet has become extremely popular for its health benefits such as weight loss and preventing disease. The keto diet can be hugely beneficial, but how does it work to provide these benefits? You can get free e book here for more details.
The reason we aim at such high protein values is to lower the chance of losing muscle during our keto expedition. This way, you will have adequate protein for exercising and gaining muscle (if you’re in a caloric surplus), or adequate protein for keeping current lean muscle (if you’re in a caloric deficit).
The keto diet is a diet that consists of extremely high amounts of fat, low amounts of carbs and moderate amounts of protein. It's pretty restrictive. The idea behind the keto diet, is that instead of relying on glucose to fuel your body, it breaks down fat into ketone bodies and uses that for energy instead.
This document provides information about starting a 14-day keto diet meal plan, including two weeks of meal plans and recipes. It notes that a keto diet limits carbohydrate intake to below 20 grams per day to induce ketosis and fat burning. The document also lists some situations where one may need extra support doing a keto diet, such as if taking certain medications. It provides tips for starting keto successfully and avoiding "keto flu" symptoms.
This document provides an overview of the keto diet, including what it is, how it works, benefits, side effects, and tips for starting it. The keto diet is a low-carb, high-fat diet that puts the body into a state of ketosis, where it burns fat for energy instead of carbs. Benefits include weight loss, improved blood sugar control, and feeling full for longer. Potential side effects are keto flu, diarrhea, and ketoacidosis in rare cases. The document offers meal plan ideas and recipes to make starting the keto diet easier.
Intermittent fasting for_weight_loss__a_beginners_guide toWeight Loss Secrets
Table of Contents
INTERMITTENT FASTING FOR WEIGHT LOSS:
Introduction
Intermittent Fasting (IF): What is it?
How Fat is Stored & Burnt
Why Low-Calorie Diets Don’t Work
Intermittent Fasting – The 16 8 Method
Starting IF – 3 Crucial Factors To Success
Factor 1: Diet & Nutrition
Factor 2: Exercise
Factor 3: Recovery, Rest & The Importance of Sleep
Starting IF Your First 30
The ketogenic diet has gained popularity in health circles because of its weight loss benefits, but many of the studies done on keto have been focused on males and lab rats. What about the keto diet for women? Do the same health benefits that apply to men apply to women who choose to adopt a high-fat, low-carbohydrate eating pattern?
Let’s go over the science behind the diet to decipher keto diet benefits and risks for women, plus cover some simple tips to make sure you start the keto diet off on the right foot.
Are you interested in losing weight? Are you tired of diets that advocate low or no fats and crave your high fat meats? You may well be considering going on the keto diet, the new kid on the block. Endorsed by many celebrities including Halle Berry, LeBron James and Kim Kardashian among others, the keto diet has been the subject of much debate among dietitians and doctors. Do you wonder if the keto diet is safe and right for you?
Are you interested in losing weight? Are you tired of diets that advocate low or no fats and crave your high fat meats? You may well be considering going on the keto diet, the new kid on the block. Endorsed by many celebrities including Halle Berry, LeBron James and Kim Kardashian among others, the keto diet has been the subject of much debate among dietitians and doctors. Do you wonder if the keto diet is safe and right for you?
Are you interested in losing weight? Are you tired of diets that advocate low or no fats and crave your high fat meats? You may well be considering going on the keto diet, the new kid on the block. Endorsed by many celebrities including Halle Berry, LeBron James and Kim Kardashian among others, the keto diet has been the subject of much debate among dietitians and doctors. Do you wonder if the keto diet is safe and right for you?
Are you interested in losing weight? Are you tired of diets that advocate low or no fats and crave your high
fat meats? You may well be considering going on the keto diet, the new kid on the block. Endorsed by many
celebrities including Halle Berry, LeBron James and Kim Kardashian among others, the keto diet has been
the subject of much debate among dietitians and doctors. Do you wonder if the keto diet is safe and right for
you?
Are you interested in losing weight? Are you tired of diets that advocate low or no fats and crave your high fat meats? You may well be considering going on the keto diet, the new kid on the block. Endorsed by many celebrities including Halle Berry, LeBron James and Kim Kardashian among others, the keto diet has been the subject of much debate among dietitians and doctors. Do you wonder if the keto diet is safe and right for you?
Are you interested in losing weight? Are you tired of diets that advocate low or no fats and crave your high fat meats? You may well be considering going on the keto diet, the new kid on the block. Endorsed by many celebrities including Halle Berry, LeBron James and Kim Kardashian among others, the keto diet has been the subject of much debate among dietitians and doctors. Do you wonder if the keto diet is safe and right for you?
The document discusses the ketogenic or "keto" diet. It explains that the keto diet is high in fat, moderate in protein, and very low in carbohydrates, forcing the body to burn fat rather than glucose for energy. It provides examples of foods allowed on the keto diet and potential benefits like weight loss and improved health markers. However, it also notes short-term side effects may include "keto flu" symptoms as the body adapts to burning fat.
although ketogenic diet has been around for almost a century, it
is rapidly gaining popularity today. There is a reason why keto is
so highly regarded. It’s not a fad diet. It actually works, and it has
tremendous health benefits in addition to weight loss. When on
the keto diet, you are feeding your body exactly what it needs,
while eliminating toxins that will slow it down.
The keto diet is a high-fat, low-carb diet that forces the body to burn fat rather than carbs for energy. It restricts carbs to 20-50g per day to induce ketosis. Potential benefits include weight loss, reduced sugar spikes, and improved blood pressure and diabetes control. Side effects may include keto flu symptoms in the first week as the body adjusts. Long term safety is still being studied, but it can cause nutritional deficiencies if not properly planned. The keto diet may be a viable short-term weight loss option for some, but consultation with a doctor is recommended.
The document discusses the ketogenic or keto diet, which is high in fat and low in carbohydrates. It aims to put the body into a state of ketosis, burning fat for energy instead of carbohydrates. Potential benefits include weight loss and reduced appetite. Side effects in the initial period can include nausea, headaches and fatigue as the body adjusts. Long term risks include nutritional deficiencies and increased cholesterol levels if unhealthy fats are consumed regularly. The diet may be an effective short-term weight loss option for some, but requires commitment and is not suitable for all individuals or health conditions without medical supervision.
10 Benefits an EPCR Software should Bring to EMS Organizations Traumasoft LLC
The benefits of an ePCR solution should extend to the whole EMS organization, not just certain groups of people or certain departments. It should provide more than just a form for entering and a database for storing information. It should also include a workflow of how information is communicated, used and stored across the entire organization.
low birth weight presentation. Low birth weight (LBW) infant is defined as the one whose birth weight is less than 2500g irrespective of their gestational age. Premature birth and low birth weight(LBW) is still a serious problem in newborn. Causing high morbidity and mortality rate worldwide. The nursing care provide to low birth weight babies is crucial in promoting their overall health and development. Through careful assessment, diagnosis,, planning, and evaluation plays a vital role in ensuring these vulnerable infants receive the specialize care they need. In India every third of the infant weight less than 2500g.
Birth period, socioeconomical status, nutritional and intrauterine environment are the factors influencing low birth weight
Breast cancer: Post menopausal endocrine therapyDr. Sumit KUMAR
Breast cancer in postmenopausal women with hormone receptor-positive (HR+) status is a common and complex condition that necessitates a multifaceted approach to management. HR+ breast cancer means that the cancer cells grow in response to hormones such as estrogen and progesterone. This subtype is prevalent among postmenopausal women and typically exhibits a more indolent course compared to other forms of breast cancer, which allows for a variety of treatment options.
Diagnosis and Staging
The diagnosis of HR+ breast cancer begins with clinical evaluation, imaging, and biopsy. Imaging modalities such as mammography, ultrasound, and MRI help in assessing the extent of the disease. Histopathological examination and immunohistochemical staining of the biopsy sample confirm the diagnosis and hormone receptor status by identifying the presence of estrogen receptors (ER) and progesterone receptors (PR) on the tumor cells.
Staging involves determining the size of the tumor (T), the involvement of regional lymph nodes (N), and the presence of distant metastasis (M). The American Joint Committee on Cancer (AJCC) staging system is commonly used. Accurate staging is critical as it guides treatment decisions.
Treatment Options
Endocrine Therapy
Endocrine therapy is the cornerstone of treatment for HR+ breast cancer in postmenopausal women. The primary goal is to reduce the levels of estrogen or block its effects on cancer cells. Commonly used agents include:
Selective Estrogen Receptor Modulators (SERMs): Tamoxifen is a SERM that binds to estrogen receptors, blocking estrogen from stimulating breast cancer cells. It is effective but may have side effects such as increased risk of endometrial cancer and thromboembolic events.
Aromatase Inhibitors (AIs): These drugs, including anastrozole, letrozole, and exemestane, lower estrogen levels by inhibiting the aromatase enzyme, which converts androgens to estrogen in peripheral tissues. AIs are generally preferred in postmenopausal women due to their efficacy and safety profile compared to tamoxifen.
Selective Estrogen Receptor Downregulators (SERDs): Fulvestrant is a SERD that degrades estrogen receptors and is used in cases where resistance to other endocrine therapies develops.
Combination Therapies
Combining endocrine therapy with other treatments enhances efficacy. Examples include:
Endocrine Therapy with CDK4/6 Inhibitors: Palbociclib, ribociclib, and abemaciclib are CDK4/6 inhibitors that, when combined with endocrine therapy, significantly improve progression-free survival in advanced HR+ breast cancer.
Endocrine Therapy with mTOR Inhibitors: Everolimus, an mTOR inhibitor, can be added to endocrine therapy for patients who have developed resistance to aromatase inhibitors.
Chemotherapy
Chemotherapy is generally reserved for patients with high-risk features, such as large tumor size, high-grade histology, or extensive lymph node involvement. Regimens often include anthracyclines and taxanes.
Promoting Wellbeing - Applied Social Psychology - Psychology SuperNotesPsychoTech Services
A proprietary approach developed by bringing together the best of learning theories from Psychology, design principles from the world of visualization, and pedagogical methods from over a decade of training experience, that enables you to: Learn better, faster!
Know the difference between Endodontics and Orthodontics.Gokuldas Hospital
Your smile is beautiful.
Let’s be honest. Maintaining that beautiful smile is not an easy task. It is more than brushing and flossing. Sometimes, you might encounter dental issues that need special dental care. These issues can range anywhere from misalignment of the jaw to pain in the root of teeth.
Co-Chairs, Val J. Lowe, MD, and Cyrus A. Raji, MD, PhD, prepared useful Practice Aids pertaining to Alzheimer’s disease for this CME/AAPA activity titled “Alzheimer’s Disease Case Conference: Gearing Up for the Expanding Role of Neuroradiology in Diagnosis and Treatment.” For the full presentation, downloadable Practice Aids, and complete CME/AAPA information, and to apply for credit, please visit us at https://bit.ly/3PvVY25. CME/AAPA credit will be available until June 28, 2025.
The skin is the largest organ and its health plays a vital role among the other sense organs. The skin concerns like acne breakout, psoriasis, or anything similar along the lines, finding a qualified and experienced dermatologist becomes paramount.
How to Control Your Asthma Tips by gokuldas hospital.Gokuldas Hospital
Respiratory issues like asthma are the most sensitive issue that is affecting millions worldwide. It hampers the daily activities leaving the body tired and breathless.
The key to a good grip on asthma is proper knowledge and management strategies. Understanding the patient-specific symptoms and carving out an effective treatment likewise is the best way to keep asthma under control.
Cell Therapy Expansion and Challenges in Autoimmune DiseaseHealth Advances
There is increasing confidence that cell therapies will soon play a role in the treatment of autoimmune disorders, but the extent of this impact remains to be seen. Early readouts on autologous CAR-Ts in lupus are encouraging, but manufacturing and cost limitations are likely to restrict access to highly refractory patients. Allogeneic CAR-Ts have the potential to broaden access to earlier lines of treatment due to their inherent cost benefits, however they will need to demonstrate comparable or improved efficacy to established modalities.
In addition to infrastructure and capacity constraints, CAR-Ts face a very different risk-benefit dynamic in autoimmune compared to oncology, highlighting the need for tolerable therapies with low adverse event risk. CAR-NK and Treg-based therapies are also being developed in certain autoimmune disorders and may demonstrate favorable safety profiles. Several novel non-cell therapies such as bispecific antibodies, nanobodies, and RNAi drugs, may also offer future alternative competitive solutions with variable value propositions.
Widespread adoption of cell therapies will not only require strong efficacy and safety data, but also adapted pricing and access strategies. At oncology-based price points, CAR-Ts are unlikely to achieve broad market access in autoimmune disorders, with eligible patient populations that are potentially orders of magnitude greater than the number of currently addressable cancer patients. Developers have made strides towards reducing cell therapy COGS while improving manufacturing efficiency, but payors will inevitably restrict access until more sustainable pricing is achieved.
Despite these headwinds, industry leaders and investors remain confident that cell therapies are poised to address significant unmet need in patients suffering from autoimmune disorders. However, the extent of this impact on the treatment landscape remains to be seen, as the industry rapidly approaches an inflection point.
Histololgy of Female Reproductive System.pptxAyeshaZaid1
Dive into an in-depth exploration of the histological structure of female reproductive system with this comprehensive lecture. Presented by Dr. Ayesha Irfan, Assistant Professor of Anatomy, this presentation covers the Gross anatomy and functional histology of the female reproductive organs. Ideal for students, educators, and anyone interested in medical science, this lecture provides clear explanations, detailed diagrams, and valuable insights into female reproductive system. Enhance your knowledge and understanding of this essential aspect of human biology.
1. Benefits Of Keto Diet
What is ketosis?
What exactly do we mean by that? Normally, carbohydrates are the main source of energy. It's
not for nothing: glucose is just a fuel that is very easy to transport and use. However, if you are
(virtually) not eating carbohydrates anymore, your body needs to find a different solution.
You then enter a ketogenic state, or ketosis for short. It really is just an expensive way of saying
that (body) fat is the main source of energy. Of course, this doesn't happen automatically,
because fat isn't as easy a source as carbohydrates. They must therefore first be converted into
ketones.
What is the ketogenic diet?
As mentioned, the ketosis diet is sort of an extreme form of a low carb diet. Most “standard”
low-carb diets still allow around 100 grams of carbohydrate per day. With the ketosis diet, that's
really out of the question. The often mentioned limit is around 30 grams. Enough to be able to
eat vegetables, then, but really no more than that. Even fruit is out of the question.
Additionally, the ketosis diet is made up of protein and most importantly a lot of fat. These fill more
than half of your calories. Lots of fish, eggs, meat, nuts and dairy, in other words! All of this to get
your body into ketosis.
2. What are ketones?
One of the main disadvantages of fat as an energy source is that the fat particles cannot reach your
brain through the blood. This means that it is difficult to supply your brain with energy when you are
in ketosis. Fortunately, your liver can convert fat into ketones, which can reach your brain. Ketones
are also needed for additional energy supply.
Once your body "shifts" to a position where the fat in your diet is a major source of energy, it also
becomes easier to burn body fat. However, the same chemical conversion process is behind this.
This way, a keto diet will help you shed those extra pounds more easily.
Benefits of the keto diet
What exactly are the advantages of this configuration? There are two important benefits to the keto
diet, which we'll briefly mention and explain here:
Fat saturates more than you probably think. So the chance is very low that you will ever go hungry
on a ketosis diet. In addition, due to the lack of carbohydrates, you no longer have fluctuations in
your blood sugar.
If you now often eat a lot of fast sugars through binge eating, that will probably decrease too! Finally,
the meals you eat are often quite tasty, precisely because of their high fat content. Only the variety is
not particularly impressive.
One of the apparent drawbacks of fat as an energy source is that the fat particles cannot reach your
brain through the blood. This means that it is difficult to energize your brain when you are in ketosis.
Fortunately, your liver can convert fat into ketones, which can reach your brain. Ketones are also
needed for additional energy supply.
Once your body "shifts" to a position where the fat in your diet is a major source of energy, it also
becomes easier to burn body fat. The same process of chemical conversion is behind this. This way,
a keto diet will help you shed those extra pounds more easily
3. What can I eat?
Recommended foods
Recommended foods are foods that contain fat or protein.
The meat , including more fat: lamb chops, loin or ribs, entrecote of beef, chunks of lamb, pork, beef
or veal stew (stews, blanquettes ...);
The birds , with their skin duck, turkey, chicken, chicken;
The meats : hams, sausages;
The fish , particularly fatty fish: herring, mackerel, sardines, salmon;
The eggs ;
The aged cheeses ;
The nuts : almonds, hazelnuts, walnuts, pistachios ... and other nuts , avocado and olives;
The seeds rich in lipids : from chia , flax , pumpkin , sesame , sunflower ...
Tofu and tempeh ( high protein soy products ).
The fats in generous proportions.
Butter, sour cream and coconut oil are recommended daily , since they are rich in " short or medium
chain fatty acids" , lipids that promote the process of ketosis.
The canola oils and nuts are recommended on them for their omega 3 essential.
It is advisable to drink at least 1.5 to 2 liters per day , in order to compensate for the low water intake
of food (in general, foods high in fat contain little water).
4. Prohibited foods
Prohibited foods are the main sources of carbohydrates.
Breads, rusks and breakfast cereals;
Starchy foods: pasta, rice, potatoes, semolina, corn, quinoa, sweet potato, pulses;
The savory preparations paste : quiches, pizzas, pastries;
Breaded fish or meat;
The meals, soups and sauces trade ;
The sweet products : cookies, cakes, pastries, chocolate bars, candies, jams, honey, table sugar;
The sweet drinks : soft drinks, fruit drinks, iced teas ... and fruit juices.
It is possible to use a synthetic sweetener (aspartame, sucralose, stevia, etc.) to "sweeten" coffee or
tea or make desserts in which the flour is replaced by ground hazelnuts or almonds 8 .
Foods to moderate
Foods to moderate are foods containing low proportion of carbohydrates :
The dark chocolate over 85% cocoa;
Milk and plain dairy products: yoghurts, fermented milk and fresh cheeses: maximum one per day
(they provide lactose, which is a sugar);
Vegetables: maximum 150 g per meal;
The fruits least rich in sugar : lemon, red fruits, papaya, watermelon: maximum 50 g (the equivalent
of barely half a tray of raspberries) per day. Other fruits are not allowed.
Cons of the keto diet
A diet where you don't go hungry and lose weight - it seems like the perfect combination! Yet there
are still some holds in the grass. The keto diet has several drawbacks as well, of which we list the
three most important ones below:
A diet where you don't go hungry and lose weight - it seems like the perfect combination! Yet there
are still some holds in the grass. There are several drawbacks to the keto diet as well, of which we
list the three most important below:
The first month that you are on a keto diet, you will often feel bad. The reason is that your body is
not accustomed to the primary use of fat for energy. This makes it particularly difficult at the start to
maintain sufficient energy.
So you will feel very weak for a few weeks to a month, and maybe even just have the flu.
Headaches, fatigue and drowsiness are well known complaints. Fortunately, this “ketogenic flu” will
resolve itself over time.
A more structural problem is the one-sided side of the diet. You eat mostly meat, fish, eggs, and
dairy, supplemented with oil, avocados, nuts, and veg here and there.
5. So what you are completely missing are whole grains, for example. Although they can also provide
important nutrients, such as fiber! As a result, with a keto diet, you often need to take the
supplements to make sure you don't accumulate major deficiencies.
One final issue that will be important to many of our readers: A ketogenic diet is not ideal if you are
exercising fanatically. As an athlete, you only need carbohydrates because you use a relatively large
amount of energy.
Are you on the ketosis diet?
Is it helpful for you to follow a keto diet, or shouldn't you be? In any case, we do not recommend
following the diet for a longer period of time. During this time, you are building up too many
deficiencies, and the lack of carbohydrates can affect your insulin sensitivity. Moreover, after a while
you will also be tired of the limited variety of foods.
But do you want to try another way to lose fat? And aren't you so fanatic that you really need your
carbs? Then, it is definitely worth trying the keto diet for a limited time!
How do you get into ketosis?
Do you choose to start with the ketosis diet? Then, as said, it's important to really leave out all the
carbs except the veg. It doesn't just mean more bread, oats, pasta, rice and potatoes. Fruits are also
prohibited. You cannot drink even the smallest amounts of carbonated drinks and alcohol.
Your diet should be about 70% fat, 25% protein, and 5% carbohydrate. What is left then? As said:
lots of vegetables, protein and fat. It sounds a bit one-sided (and admittedly it is), but you can still do
a bit with it. We give you some short examples below.
Keto Recipes
Certainly, because you can of course vary endlessly with vegetables and meat, it is still relatively
possible to do so.
Ketones in urine
Then one last point. Now suppose you have been on the ketosis diet for a week - how do you know
if you are actually doing the right thing? After all, the intention is for your body to truly enter ketosis.
Fortunately, this can be tested using the aforementioned ketones. These must also be excreted from
your body. Some of it comes out through your breath, which is why bad breath is a common
complaint among people on this diet. However, much of it is also excreted in your urine.
Ketosis test
The latter is useful for a ketosis test. There is something called ketostix: test sticks with which you
measure ketone levels in your urine. So you can easily perform a test at home. Simply dip the swab
in your urine and if it becomes discolored, you will know you are in ketosis. Congratulations: your
body burns fat!