The Key Player in Angiogenesis: BCAS3 Antibody

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St John's Laboratory Ltd

Breast carcinoma-amplified sequence 3: Function, Role in Disease and Research.

Science

“The Key Player in the formation
of new blood vessels”
www.stjohnslabs.com
BCAS3 antibody

BCAS3’s Function:
BCAS3 is a key player in
angiogenesis as it is:
1. Involved in regulating the
cell polarity and directional
endothelial cell migration.
2. Activates and recruits
CDC42.
3. Reorganizes the actin
cytoskeleton at the cell
leading edge.
www.stjohnslabs.com

BCAS3’s Involvement in Disease:
A chromosomal aberration
involving BCAS3 has been found in
some breast carcinoma cell lines.
Translocation t(17;20)(q23;q13) with
BCAS4.
www.stjohnslabs.com

BCAS3 in Research:
“Estrogen induces expression of BCAS3, a novel estrogen
receptor-alpha coactivator, through proline-, glutamic acid-,
and leucine-rich protein-1 (PELP1)”.
http://www.ncbi.nlm.nih.gov/pubmed/17505058
"Cloning of BCAS3 (17q23) and BCAS4 (20q13) genes that
undergo amplification, overexpression, and fusion in breast
cancer.”
http://www.ncbi.nlm.nih.gov/pubmed/12378525
www.stjohnslabs.com
"Human BCAS3 expression in embryonic stem
cells and vascular precursors suggests a role in
human embryogenesis and tumor angiogenesis.“
http://www.ncbi.nlm.nih.gov/pubmed/18030336

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