Basal modification is a specialized cell structure found on the basal surface of epithelial cells. It is primarily composed of keratin, integrins, and cadherins. Basal modification functions to provide structural support to the epithelium and acts as a selective barrier between the epithelium and supporting tissue. It facilitates stable adhesion of basal cells to the basement membrane. This is achieved through desmosomes and hemidesmosomes, which connect adjacent epithelial cells and attach epithelial cells to the basement membrane, respectively.

1. BASAL
MODIFICATION

2. WHAT IS A
BASAL
MODIFICATION?
is a cell modification found on
the basal surface of the cell.
primarily composed of
keratin, integrins, and
cadherins.

3. FUNCTIONS OF
BASAL
MODIFICATION:
provides structural support for the
epithelium and serves as a selective
barrier for the movement of
materials to and from the supporting
tissue.
facilitate stable adhesion of basal
cells to basement membrane

4. HOW DOES
BASAL
MODIFICATION
WORKS?
Basal modification needs the
presence of desmosomes and
hemidesomosomes.

5. DESMOSOMES
Facilitates adhesion between
adjacent epithelial cells or cell-
cell contact at the plasma
membrane.

6. DESMOSOMES
Cell-cell adhesion.
Desmosomes pin adjacent
cells together.
Gives mechanical strength to
tissues.

7. WHAT IS
HEMIDESMOS
OMES?
Named for their resemblance to a half
desmosomes, mediate adhesion
between basal cells of epithelial tissues
and substratum.
Attach cells to extracellular materials
such as basement membrane.

8. HEMIDOSMOS
OMES
Connecting the basal epithelial
cells to the lamina lucida or
underlying basement membrane in
stratified and other complex
epithelia.

9. FUNCTION OF
DESMOSOMES
AND
HEMIDESMOSO
MES:
Adherens. Desmosomes
and Hemidesmosomes
junctions all act to connect
a cell to another cell or
structure.

10. SUMMARY:
1.basal modification is specialized
structure found on the basal
surface of the cell.
2.-composed of keratin, integrins,
and cadherins.
3.-functions:
●Provides structural support for the
epithelium and serves as a selective
barrier for the movement of
materials to and from the
supporting tissue.
●facilitate stable adhesion of basal
cells to basement membrane

11. SUMMARY:
hemidesmosomes in order to modificate.
5. Desmosomes-provide one of the
stronger cell-to-cell adhesion at the
plasma membrane.
 6. Hemidesmosomes-connect epithelial
cells to basement membrane or cell to
structure connection.
7. These are needed so that stable
adhesion of basal epithelial cells to the
underlying basement membrane can be
achieved. If these doesn't function well in
our body then, dysadhesion of the
epidermis and other skin disease will

12. THAT’SALL,THANKYOU!