The basal ganglia consists of the caudate nucleus, lentiform nucleus, subthalamic nucleus, and substantia nigra. It receives input from the cerebral cortex and thalamus and sends output to the thalamus to influence motor control and cognition. Damage to specific parts of the basal ganglia results in movement disorders like Parkinson's disease, Huntington's disease, and others. The basal ganglia plays a key role in motor learning, planning movements, and controlling muscle tone through complex interactions between neurotransmitters like dopamine, GABA, and glutamate.
Large motor neurons originates from the anterior horn cells of spinal cord
They are myelinated nerve fibers
They innervates skeletal muscles
Each nerve fiber after entering the muscle belly, branches and stimulates 3- several hundreds of skeletal muscle fibers
Each nerve ending makes a junction – Neuromuscular Junction
NMJ is present at midpoint of the muscle
AP initiated in the muscle fiber by the nerve impulse, travels in both directions towards the muscle fiber ends
A 25-year-old lady comes to OPD with chief complaints of weakness and fatigability. Generally, during the morning she does not feel any significant weakness but, as day passes and she get involved in routine household works, weakness gradually starts to increase. The condition improves by some rest or sleep. She also reports double vision and difficulty in swallowing.
Physical examination – Ptosis, diplopia, proximal muscle weakness, normal deep tendon reflex, no sensory impairment.
What is the diagnosis?
Why does rest improve the symptoms?
How to manage the condition?
What is the physiological basis of the management?
Report Back from SGO 2024: What’s the Latest in Cervical Cancer?bkling
Are you curious about what’s new in cervical cancer research or unsure what the findings mean? Join Dr. Emily Ko, a gynecologic oncologist at Penn Medicine, to learn about the latest updates from the Society of Gynecologic Oncology (SGO) 2024 Annual Meeting on Women’s Cancer. Dr. Ko will discuss what the research presented at the conference means for you and answer your questions about the new developments.
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TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
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ARTIFICIAL INTELLIGENCE IN HEALTHCARE.pdfAnujkumaranit
Artificial intelligence (AI) refers to the simulation of human intelligence processes by machines, especially computer systems. It encompasses tasks such as learning, reasoning, problem-solving, perception, and language understanding. AI technologies are revolutionizing various fields, from healthcare to finance, by enabling machines to perform tasks that typically require human intelligence.
Title: Sense of Taste
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the structure and function of taste buds.
Describe the relationship between the taste threshold and taste index of common substances.
Explain the chemical basis and signal transduction of taste perception for each type of primary taste sensation.
Recognize different abnormalities of taste perception and their causes.
Key Topics:
Significance of Taste Sensation:
Differentiation between pleasant and harmful food
Influence on behavior
Selection of food based on metabolic needs
Receptors of Taste:
Taste buds on the tongue
Influence of sense of smell, texture of food, and pain stimulation (e.g., by pepper)
Primary and Secondary Taste Sensations:
Primary taste sensations: Sweet, Sour, Salty, Bitter, Umami
Chemical basis and signal transduction mechanisms for each taste
Taste Threshold and Index:
Taste threshold values for Sweet (sucrose), Salty (NaCl), Sour (HCl), and Bitter (Quinine)
Taste index relationship: Inversely proportional to taste threshold
Taste Blindness:
Inability to taste certain substances, particularly thiourea compounds
Example: Phenylthiocarbamide
Structure and Function of Taste Buds:
Composition: Epithelial cells, Sustentacular/Supporting cells, Taste cells, Basal cells
Features: Taste pores, Taste hairs/microvilli, and Taste nerve fibers
Location of Taste Buds:
Found in papillae of the tongue (Fungiform, Circumvallate, Foliate)
Also present on the palate, tonsillar pillars, epiglottis, and proximal esophagus
Mechanism of Taste Stimulation:
Interaction of taste substances with receptors on microvilli
Signal transduction pathways for Umami, Sweet, Bitter, Sour, and Salty tastes
Taste Sensitivity and Adaptation:
Decrease in sensitivity with age
Rapid adaptation of taste sensation
Role of Saliva in Taste:
Dissolution of tastants to reach receptors
Washing away the stimulus
Taste Preferences and Aversions:
Mechanisms behind taste preference and aversion
Influence of receptors and neural pathways
Impact of Sensory Nerve Damage:
Degeneration of taste buds if the sensory nerve fiber is cut
Abnormalities of Taste Detection:
Conditions: Ageusia, Hypogeusia, Dysgeusia (parageusia)
Causes: Nerve damage, neurological disorders, infections, poor oral hygiene, adverse drug effects, deficiencies, aging, tobacco use, altered neurotransmitter levels
Neurotransmitters and Taste Threshold:
Effects of serotonin (5-HT) and norepinephrine (NE) on taste sensitivity
Supertasters:
25% of the population with heightened sensitivity to taste, especially bitterness
Increased number of fungiform papillae
These lecture slides, by Dr Sidra Arshad, offer a quick overview of physiological basis of a normal electrocardiogram.
Learning objectives:
1. Define an electrocardiogram (ECG) and electrocardiography
2. Describe how dipoles generated by the heart produce the waveforms of the ECG
3. Describe the components of a normal electrocardiogram of a typical bipolar leads (limb II)
4. Differentiate between intervals and segments
5. Enlist some common indications for obtaining an ECG
Study Resources:
1. Chapter 11, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 9, Human Physiology - From Cells to Systems, Lauralee Sherwood, 9th edition
3. Chapter 29, Ganong’s Review of Medical Physiology, 26th edition
4. Electrocardiogram, StatPearls - https://www.ncbi.nlm.nih.gov/books/NBK549803/
5. ECG in Medical Practice by ABM Abdullah, 4th edition
6. ECG Basics, http://www.nataliescasebook.com/tag/e-c-g-basics
Explore natural remedies for syphilis treatment in Singapore. Discover alternative therapies, herbal remedies, and lifestyle changes that may complement conventional treatments. Learn about holistic approaches to managing syphilis symptoms and supporting overall health.
1. Basal Ganglia
Dr. Sai Sailesh Kumar G
Associate Professor
Department of Physiology
R.D. Gardi Medical College, Ujjain, Madhya Pradesh.
Email: dr.goothy@gmail.com
4. Functional anatomy
Corpus striatum is further divided into
Caudate nucleus
Lentiform nucleus
Lentiform nucleus is further divided into outer part-putamen and
inner part-globus pallidus
Globus pallidus is further divided into inner and outer segments
5.
6. Functional anatomy
The structure, functions and connections of putamen and
caudate nucleus is same so they both collectively called as
striatum or neo striatum
Striatum = Caudate nucleus + Putamen
Globus pallidus send major efferents of basal ganglia so it is
called as pallidum or paleo striatum
7.
8. Functional anatomy
Claustrum is present between putamen and insular cortex
Its functions are not properly known
Amygdaloid body is connected with limbic system and discussed
along with limbic system
Subthalamic nucleus is present lateral to hypothalamus
Substansia nigra consists of pars reticularis and pars compacta
9.
10.
11. Functional anatomy
Basal ganglia consists of
Caudate nucleus
Lentiform nucleus ( GP and Putamen)
Subthalamic nucleus
Sunstantia Nigra ( Pars compacta and pars reticularis)
15. Strionigral and nigrostrial pathways
Strionigral pathway – Neuro transmitter is GABA- inhibitory
Neuro transmitter
Nigro strial pathway neuro transmitter is dopamine which is an
inhibitory neuro transmitter to striatum.
Strio nigral pathway indirectly stimulates the striatum by
inhibiting dopamine release
16. Strionigral and nigrostrial pathways
Cortico strial pathway- glutamate is N.T ( stimulatory)
Thalamo strial pathway – glutamate is N.T ( stimulatory)
Nigro strial pathway- dopamine is N.T ( inhibitory)
The interplay between these N.T helps to regulate the muscle
tone and also block involuntary movements during the execution
of a particular act.
17. Functions
The precise functions of basal ganglia is not properly known.
Basal ganglia is an accessory motor system that functions in
close association with cerebral cortex and cortico spinal motor
control systems
Helps to plan and control complex patterns of muscle
movements
Example writing alphabets
18. Functions
Example writing alphabets
When basal ganglia damaged, ones writing becomes crude as if
one were learning how to write for the first time
Other patterns that need basal ganglia are cutting paper with
scissors, hammering nails, shooting a basketball, passing a
football, throwing a baseball, vocalization, controlled movements
of eyes any other skilled movements.
19.
20. Putamen circuit
1. From premotor and supplementary motor areas of motor cortex and
somatosensory areas of sensory cortex to putamen
2. From putamen to the internal portion of GP
3. From GP to venteroanterior and venterolateral nucleus of thalamus
4. From thalamus to primary motor cortex and premotor and
supplementary motor areas of cortex
21. Putamen circuit
Helps to execute learned pattens of movements
How?
Little is known about this function
Damage of circuit, certain patterns of movements becomes abnormal
Lesion of GP, leads to spontaneous and continuous writing
movements of hand, arm, neck and face.
These movements are called athetosis
22.
23. Putamen circuit
Lesion to subthalamic nucleus, sudden flailing movements of
entire limb, called as hemiballismus
Multiple small lesions in putamen leads to flickering movements
in hands, face and other parts of body, called as chorea.
Lesion to substantia nigra leads to common and extremely
severe disease called Parkinson’s disease.
24.
25.
26. Caudate circuit
Signals pass from cerebral cortex to caudate nucleus
Next transmitted to the internal globus pallidus
Then to relay nucleus of venteroanterior and ventero lateral nucleus of
thalamus
Finally back to the prefrontal, premotor and supplementary motor
areas of cerebral cortex.
Almost none returning to primary motor cortex.
27. Caudate circuit
Important for cognitive functions
Thinking process of brain
Thoughts generated in brain
Motor action occurs
When we saw a lion if basal ganglia is intact, immediately we will turn away
from lion, run and even climb a tree
If basal ganglia are damaged the individual will takes longer and longer time
to think what to do………Lion will do by that time
28. Timing and scale the intensity of movements
To control movements two important capabilities of brain are
1. Determine how rapidly the movement is performed
2. Control how large the movement will be
We can write letter “a” slowly and rapidly
We can also write small a on paper and large A on the blackboard
The proportional characteristics of the letter remains same
29. Timing and scale the intensity of movements
In patients with basal ganglia lesion, these timing and scaling of
movements is almost absent
Basal ganglia functions in close association with cerebral cortex.
One important area is posterior parietal cortex
Lesion of posterior parietal cortex causes agnosia
30. Timing and scale the intensity of movements
Patient with right parietal cortex lesion try to copy drawings
Ability to copy left side of drawing is severely impaired
Such a person also avoid using his left side arm, hand or other
portions of his left side body for performance of task or washing
this side of the body ( personal neglect syndrome)
He lost sense that side body exists
31.
32. Functions of specific neurotransmitters
Dopamine pathway from substantia nigra to striatum
GABA pathway from striatum to substantia nigra
Ach pathway from cortex to striatum
Multiple general pathways from brian stem secrete norepinephrine,
serotonin, enkephalins and other N.T
Multiple glutamate pathways that provides most of excitatory signals
balances inhibitory signals by dopamine, GABA, serotonin pathways
34. Parkinson’s disease
Rigidity of much of the musculature of the body
Involuntary tremors of involved areas even when the person is resting ( resting tremors)
Akinesia – serious difficulty in initiating a movement
Postural instability caused by impaired postural reflexes leading to poor balance and falls
Dysphagia – difficulty in swallowing
Speech disorders
Gait disturbances
Fatigue
35. Parkinson’s disease
The cause of these abnormal motor effects is unknown
Dopamine is an inhibitory N.T
Damage to the nigrostriatal pathway causes the striatum to be overly
active
Continuous output of excitatory signals to the corticospinal motor
system
Overly excite many muscles - rigidity
36. Parkinson’s disease - Treatment
Administration of L-Dopa ameliorates many symptoms
Especially rigidity and akinesia
L-Dopa is converted to dopamine in brain and restore normal
balance between the N.T
Administration of dopamine has not produce similar effect
because dopamine can not cross BBB
37. Parkinson’s disease - Treatment
Administration of L-deprenyl
Inhibits monoamino oxidase
Responsible for destruction of dopamine secreted
So dopamine remains longer time in basal ganglia
A combination of L-dopa and L-deprenyl is more helpful
treatment
38.
39. HOME ABOUT • ISSUES • JOURNAL POLICIES • USERFUL INFO • CONTACT US
HOME ARCHIVES VOL 10 NO 3 (2019 ):VOLUME 10 ISSUE 3 Original Articles
Effect of caloric vestibular stimulation in a paraquat-induced
parkinsonian mouse model
Sai Sailesh Kumar Coothy
Assistant Professor & HOD, Department of Physiology, Vishnu Dental
College, Bhimavaram, West Godavari District-AndhraPradesh, India
Srilatha Coothy
Assistant Professor, Department of Biochemistry, Vishnu Dental College,
Bhimavaram, West Godavari District-AndhraPradesh.India
DOI:h tt p s://d oi.org/10.26452/ijrp s.vl0 i3.1
430
it!PDF
@ LATEX
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HOME ARCHIVES VOL10 NO 1 (2019}:VOLUME 10 ISSUE1 Original Articles
Effect of caloric vestibular stimulation on brain
neurotransmitters in an MPTP-induced mouse model of
Parkinson's disease
Kumar Sai Sailesh
Department of Physiology, Vishnu Dental College, Bhimavaram, West
Godavari District, Andhra Pradesh, India
Archana R
Department of Physiology, Saveetha Medical College, Saveetha Institute of
Medical and Technical Sciences, Thandalam , Chennai, Tamil Nadu, India
PDF
41.
42.
43.
44.
45.
46.
47.
48.
49.
50. Huntington’s disease (Huntington’s chorea)
Autosomal dominant hereditary disorder
Symptoms start at 30- 40 years
Starts with flicking movements in individual muscles
Then progressive severe distortional movements in entire body
Severe dementia develops along with motor dysfunctions
51. Huntington’s disease (Huntington’s chorea)
Damage of strionigral pathway
Loss of cell bodies of GABA secreting neurons
GABA pathway inhibits substantia nigra and GP
Loss of inhibition leads to outburst of signals from SN and GP
Cause distortional movements
52. Huntington’s disease (Huntington’s chorea)
Dementia may not be due to loss of GABAergic neurons
It may be due to loss of Ach secreting neurons especially in the
thinking areas of coirtex
The abnormal gene that cause disease has been found
The abnormal protein cause the disease is Huntington
How this protein cause disease is not known