This document discusses the challenges facing men who have sex with men (MSM) in the Middle East and North Africa region, including high rates of HIV prevalence, limited access to prevention and care services, violence, rejection, and self-stigma. It proposes strengthening advocacy efforts and promoting networking between LGBT organizations to facilitate combined HIV prevention approaches for MSM in hostile environments. A practical manual was developed with input from several regional associations to provide guidance on advocating for improved access to HIV prevention services for MSM.