Background Phenylketonuria is an inherited disease which re.pdf
•
0 likes•2 views
Background: Phenylketonuria is an inherited disease which results from the lack of the enzyme phenylalanine hydroxylase (PAH). The PAH enzyme catalyzes the first step in the degradation of phenylalanine, as shown in Figure 30.1. In the phenylketonuric patient, phenylalanine accumulates which is eventually transaminated to phenylpyruvate, a phenylketone compound. Excess phenylpyruvate accumulates in the blood and urine and has the effect of causing mental retardation if untreated. Screening programs identify PKU babies at birth, and treatment consists of a low phenylalanine diet until maturation of the brain is completed. The structure and biochemical properties of the PAH enzyme have been well-studied.The gene for PAH has been isolated and has been localized to chromosome 12. The PAH enzyme is a protein 451 amino acids in length with a molecular weight of 51,900 daltons. More than 60 different mutant genes giving rise to nonfunctional PAH proteins have been identified in PKU patients. Question:Kinetic data in which PAH activity is compared with and without preincubation with phenylalanine is shown in Figure 30.3. Give a structural basis for the interpretation of these data. Figure 30.1. Phenylalanine and tyrosine meravurior. an essential cofactor for phenylalanine hydroxylase. 95Figure 30.1. Phenylalanine and tyrosmio ..... an essential cofactor for phenylalanine hydroxylase. 95.
Report
Share
Report
Share
Download to read offline
Recommended
phenylketonuria
PKU is an autosomal recessive genetic disorder caused by a deficiency in the enzyme phenylalanine hydroxylase. This enzyme is necessary to break down the amino acid phenylalanine. Without it, phenylalanine builds up to toxic levels in the blood and brain, which can lead to intellectual disabilities if left untreated. PKU is typically detected via newborn screening and treated through a lifelong low-phenylalanine diet. Some cases may also be managed through medication. Strict dietary control is necessary before and during pregnancy for women with PKU to prevent complications in their babies.
Phenylketonuria Ppt
Phenylketonuria (PKU) is a genetic disorder caused by a mutation that prevents the breakdown of phenylalanine. This allows phenylalanine levels to accumulate in the blood and brain, which can cause intellectual disabilities if left untreated. The condition is usually diagnosed via newborn screening, which tests for high phenylalanine levels. Treatment requires a lifelong low-phenylalanine diet to prevent cognitive issues and other health problems associated with elevated phenylalanine. Strict dietary control is necessary to manage PKU and avoid complications.
phenylketonuria
Phenylketonuria (PKU) is a genetic disorder that causes the buildup of phenylalanine in the body due to the lack of the enzyme phenylalanine hydroxylase. This enzyme is needed to break down phenylalanine from the diet. The buildup of phenylalanine can lead to intellectual disability if not treated through a low-protein diet. PKU results from mutations in the PAH gene which provides instructions for making the phenylalanine hydroxylase enzyme. The disorder was first discovered in 1934 and can now be diagnosed through newborn screening to help prevent complications through early treatment.
Pku concept map dr-kumar-ponnusamy-biochemistry-genetics-usmle-preparatory-co...
Dr. Kumar Ponnusamy and colleagues aim to delineate the molecular and biochemical basis of phenylketonuria (PKU), its diagnosis and management, and facilitate online teaching about it. PKU is an autosomal recessive genetic disorder caused by a mutation that renders the enzyme phenylalanine hydroxylase nonfunctional. This prevents the conversion of phenylalanine to tyrosine, leading to accumulation of phenylalanine and its toxic byproducts in the central nervous system, which can cause severe mental retardation if left untreated. Management of PKU involves a low-phenylalanine diet, avoiding aspartame, and careful control of phenylalanine levels during pregnancy to prevent adverse effects on fetal development.
Phenylketonuria #
A six-year-old boy was referred to the hospital for aggressive behavior and developmental delays. He was found to have phenylketonuria (PKU), an autosomal recessive disorder caused by a mutation in the PAH gene which results in high phenylalanine levels and intellectual disability if left untreated. Testing found elevated phenylalanine levels in his blood and urine. PKU must be treated through life with a low-phenylalanine diet to prevent neurological damage, as there is currently no cure. Gene therapy research aims to introduce a functional PAH gene to allow breakdown of phenylalanine in the liver.
Therapeutic applications of Phenylalanine ammonia lyase and Phenylalanine Hyd...
Therapeutic applications of Phenylalanine ammonia lyase and Phenylalanine Hydroxylse in phenylketonuria
Phenylketonuria(pku) new
This presentation is about the a disease , causes and cure.
Also it contains the experiments done on mouse models.I tried to explain it with the help of cathy diagrams.
PKU presentation
Phenylketonuria (PKU) is an inherited disorder caused by a deficiency of the enzyme phenylalanine hydroxylase, resulting in an inability to metabolize the essential amino acid phenylalanine. Left untreated, it can cause severe intellectual disability. It is diagnosed through newborn screening and treated with a phenylalanine-restricted diet. For pregnant women with PKU, careful control of phenylalanine levels through diet is needed to prevent complications in the fetus like intellectual disability and birth defects. The case study describes a woman with mild PKU who was able to deliver a healthy infant by maintaining her phenylalanine-restricted diet during pregnancy.
Recommended
phenylketonuria
PKU is an autosomal recessive genetic disorder caused by a deficiency in the enzyme phenylalanine hydroxylase. This enzyme is necessary to break down the amino acid phenylalanine. Without it, phenylalanine builds up to toxic levels in the blood and brain, which can lead to intellectual disabilities if left untreated. PKU is typically detected via newborn screening and treated through a lifelong low-phenylalanine diet. Some cases may also be managed through medication. Strict dietary control is necessary before and during pregnancy for women with PKU to prevent complications in their babies.
Phenylketonuria Ppt
Phenylketonuria (PKU) is a genetic disorder caused by a mutation that prevents the breakdown of phenylalanine. This allows phenylalanine levels to accumulate in the blood and brain, which can cause intellectual disabilities if left untreated. The condition is usually diagnosed via newborn screening, which tests for high phenylalanine levels. Treatment requires a lifelong low-phenylalanine diet to prevent cognitive issues and other health problems associated with elevated phenylalanine. Strict dietary control is necessary to manage PKU and avoid complications.
phenylketonuria
Phenylketonuria (PKU) is a genetic disorder that causes the buildup of phenylalanine in the body due to the lack of the enzyme phenylalanine hydroxylase. This enzyme is needed to break down phenylalanine from the diet. The buildup of phenylalanine can lead to intellectual disability if not treated through a low-protein diet. PKU results from mutations in the PAH gene which provides instructions for making the phenylalanine hydroxylase enzyme. The disorder was first discovered in 1934 and can now be diagnosed through newborn screening to help prevent complications through early treatment.
Pku concept map dr-kumar-ponnusamy-biochemistry-genetics-usmle-preparatory-co...
Dr. Kumar Ponnusamy and colleagues aim to delineate the molecular and biochemical basis of phenylketonuria (PKU), its diagnosis and management, and facilitate online teaching about it. PKU is an autosomal recessive genetic disorder caused by a mutation that renders the enzyme phenylalanine hydroxylase nonfunctional. This prevents the conversion of phenylalanine to tyrosine, leading to accumulation of phenylalanine and its toxic byproducts in the central nervous system, which can cause severe mental retardation if left untreated. Management of PKU involves a low-phenylalanine diet, avoiding aspartame, and careful control of phenylalanine levels during pregnancy to prevent adverse effects on fetal development.
Phenylketonuria #
A six-year-old boy was referred to the hospital for aggressive behavior and developmental delays. He was found to have phenylketonuria (PKU), an autosomal recessive disorder caused by a mutation in the PAH gene which results in high phenylalanine levels and intellectual disability if left untreated. Testing found elevated phenylalanine levels in his blood and urine. PKU must be treated through life with a low-phenylalanine diet to prevent neurological damage, as there is currently no cure. Gene therapy research aims to introduce a functional PAH gene to allow breakdown of phenylalanine in the liver.
Therapeutic applications of Phenylalanine ammonia lyase and Phenylalanine Hyd...
Therapeutic applications of Phenylalanine ammonia lyase and Phenylalanine Hydroxylse in phenylketonuria
Phenylketonuria(pku) new
This presentation is about the a disease , causes and cure.
Also it contains the experiments done on mouse models.I tried to explain it with the help of cathy diagrams.
PKU presentation
Phenylketonuria (PKU) is an inherited disorder caused by a deficiency of the enzyme phenylalanine hydroxylase, resulting in an inability to metabolize the essential amino acid phenylalanine. Left untreated, it can cause severe intellectual disability. It is diagnosed through newborn screening and treated with a phenylalanine-restricted diet. For pregnant women with PKU, careful control of phenylalanine levels through diet is needed to prevent complications in the fetus like intellectual disability and birth defects. The case study describes a woman with mild PKU who was able to deliver a healthy infant by maintaining her phenylalanine-restricted diet during pregnancy.
Phenyl ketonuria @@@@@
Classical phenylketonuria (PKU) is an inherited disorder where the enzyme phenylalanine hydroxylase is absent, preventing the conversion of phenylalanine to tyrosine. This causes phenylalanine to accumulate in the blood and be metabolized into alternative catabolites, including phenylpyruvic acid and phenylacetic acid conjugated with glutamine and excreted in urine, giving it a "mousy odor". Accumulation of phenylalanine can also impair serotonin and melanin formation. Clinical features include mental retardation, seizures, and eczema. Diagnosis involves measuring elevated plasma phenylalanine levels and testing urine for phenylpyruvate. Treatment
Phenylketonuria ( PKU) - Dr Padmesh
This document discusses phenylketonuria (PKU), a genetic disorder caused by a deficiency in the enzyme phenylalanine hydroxylase. This enzyme is needed to break down the amino acid phenylalanine. Without it, phenylalanine builds up to high levels in the blood and brain, which can cause intellectual disability if not treated early. The document outlines the causes, symptoms, diagnosis through newborn screening, and lifelong treatment through a phenylalanine-restricted diet for PKU patients. It also discusses milder forms that do not require dietary treatment and the rare cases caused by a deficiency in the cofactor tetrahydrobiopterin.
Aminoaciduria phenylketonuria
Phenylketonuria is one of fthe inborn error of metabolism. Its characteristically error in amino acid metabolism. This causes aminoaciduria. Phenylalanine is an amino acid requied for protein synthesis as well as synthesis of tyrosine. Deficiency of the enzyme phenylalanine hyydroxylase triggers the accumulation of phenylalanine in the blood and subsequent conversion and transamination to ohenylpyruvate which is a phenylketone. This causes accumulation of phenylketones in urine with characteristicc mousy smell.
This slide discussess the causes and biochemistry of this error.
PKU-biochemical genetic disorder- 19.1.2023.ppt
Phenylketonuria (PKU) is an autosomal recessive genetic disorder caused by a deficiency of the enzyme phenylalanine hydroxylase, resulting in an inability to metabolize the essential amino acid phenylalanine. If left untreated, PKU can cause intellectual disabilities, seizures, and other neurological problems in affected individuals. Treatment involves restricting dietary phenylalanine through a specialized low-protein diet to control phenylalanine levels. Females with PKU must adhere to the diet prior to and during pregnancy to prevent complications in offspring from high phenylalanine passing through the placenta.
Aminoaciduria and organic aciduria in neurology
aminoaciduria and organic aciduria are considered as important disorder in the group of inborn error of metabolism.
Phenylketonuria (PKU)
Phenylketonuria (PKU) : is a genetic disorder that is characterized by an inability of the body to utilize the essential amino acid, phenylalanine.
Phenylketonuria
Phenylketonuria (PKU) is a genetic disorder caused by mutations in the PAH gene that result in deficient phenylalanine hydroxylase enzyme activity. This prevents the breakdown of the essential amino acid phenylalanine, causing it to accumulate to toxic levels and cause neurological damage if left untreated. Symptoms of PKU include intellectual disability, seizures, and behavioral issues. Treatment involves a lifelong low-phenylalanine diet to control blood phenylalanine levels, as well as enzyme replacement or gene therapies currently under investigation.
Phenylketonuria (pku)
PHENYLKETONURIA is due to hyperphenylalaninemia
Classic variant of PKU is due to the absence of phenylalanine hydroxylase.
keto.pptx
Phenylketonuria (PKU) is an inherited disorder that causes the body to be unable to break down an amino acid called phenylalanine. If left untreated, it can cause intellectual disabilities and other neurological problems. There are different types of PKU depending on severity. It is caused by mutations that impact the phenylalanine hydroxylase enzyme needed to metabolize phenylalanine. Symptoms usually appear between 3-6 months of age if untreated. Diagnosis involves newborn blood tests and managing PKU involves a lifelong low-phenylalanine diet to control symptoms and prevent complications.
Genetic mutations project
PKU is a genetic mutation where the body lacks the enzyme phenylalanine hydroxylase needed to break down the amino acid phenylalanine. When phenylalanine builds up in the blood, it damages the brain and nervous system, potentially causing intellectual disabilities, behavioral issues, and other health problems. It is treated through a lifelong low-phenylalanine diet to prevent toxic buildup. PKU affects approximately 1 in 10,000-15,000 newborns. It is diagnosed through newborn screening and managed through dietary control.
Phenyl ketonuria
INBORN ERRORS OF METABOLISM, PKU, PHENYLKETONURIA, BY: MR. DINABANDHU BARAD, MSC TUTOR, SUM NURSING COLLEGE, SIKSHA O ANUSANDHAN DEEMED TO BE UNIVERSITY, BHUBANESWAR, ODISHA
Phenylketonuria
Phenylketonuria (PKU) is an inborn error of metabolism that results in decreased metabolism of the amino acid phenylalanine. A birth defect that causes an amino acid called phenylalanine to build up in the body.
Newborns should be screened for PKU.
Untreated phenylketonuria can lead to brain damage, intellectual disabilities, behavioural symptoms or seizures.
Treatment includes a strict diet with limited protein.
Phenylketonuria
This fill is represented has the WHAT IS PHENYLKETONURIA,DISCOVERY,NORMAL LEVEL IN BLOOD, HEREDITY,DEFECTS OF CHROMOSOME,CLASSESS OF PHENYLKETONURIA, SYMPTOMS, DIAGNOSIS, TREATMENT &etc...
Catabolism of phenylalanine and tyrosine and their metabolic disorders by BNP...
Catabolism of phenylalanine and tyrosine and their metabolic disorders by BNP...College of pharmaceutical sciences
Decarboxylation is the reaction by which CO2 is removed from the COOH group of an amino acid as a result an amine is formed. The reaction is catalyzed by the enzyme decarboxylase, which requires pyridoxal-P (B6-PO4) as coenzyme. Tissues like liver, kidney, brain possess the enzyme decarboxylase and also by microorganisms of intestinal tract. The enzyme removes CO2 from COOH and converts the amino acid to corresponding amine.
Phenylalanine is an essential, aromatic amino acid. The need for phenylalanine becomes minimal, if adequate tyrosine is supplied in the food. This is called the sparing action of tyrosine on phenylalanine.
Tyrosine is an aromatic amino acid. It is synthesized from phenylalanine, and so is a non-essential amino acid. The need for phenylalanine becomes minimal, if adequate tyrosine is supplied in the food. This is called the sparing action of tyrosine on the phenylalanine.
Seven amino acids produce acetyl CoA or acetoacetate and therefore are categorized as ketogenic. Of these, isoleucine, threonine, and the aromatic amino acids (phenylalanine, tyrosine, and tryptophan) are converted to compounds that produce both glucose and acetyl CoA or acetoacetate. Leucine and lysine do not produce glucose; they produce acetyl CoA and acetoacetate.
The name phenylketonuria is coined due to the fact that the metabolite phenylpyruvate is a keto acid (C6H5CH2−CO−COO−) excreted in urine in high amounts.
Phenylalanine cannot be converted to tyrosine. So, phenylalanine accumulates. Phenylalanine level in blood is elevated.Phenylketonuria alex gandhi and athavan balendran
Phenylketonuria is a genetic disorder caused by a mutation in the PAH gene, which results in excessive levels of the amino acid phenylalanine. If left untreated, it can cause intellectual disabilities, stunted growth, eczema, small head size, and seizures. Treatment involves maintaining appropriate phenylalanine levels through diet control. It occurs in about 1 in 10,000 to 15,000 births and can be diagnosed via a blood test.
enfermedades innatas del metabolismo pku
enfermedades innata del metabolismo- fenilcetonuriaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaenfermedades innata del metabolismo- fenilcetonuriaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaenfermedades innata del metabolismo- fenilcetonuriaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaenfermedades innata del metabolismo- fenilcetonuriaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaenfermedades innata del metabolismo- fenilcetonuriaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaenfermedades innata del metabolismo- fenilcetonuriaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaenfermedades innata del metabolismo- fenilcetonuriaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaenfermedades innata del metabolismo- fenilcetonuriaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaenfermedades innata del metabolismo- fenilcetonuriaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaenfermedades innata del metabolismo- fenilcetonuriaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaenfermedades innata del metabolismo- fenilcetonuriaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaenfermedades innata del metabolismo- fenilcetonuriaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaenfermedades innata del metabolismo- fenilcetonuriaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaenfermedades innata del metabolismo- fenilcetonuriaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaenfermedades innata del metabolismo- fenilcetonuriaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaenfermedades innata del metabolismo- fenilcetonuriaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaenfermedades innata del metabolismo- fenilcetonuriaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaenfermedades innata del metabolismo- fenilcetonuriaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaenfermedades innata del metabolismo- fenilcetonuriaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaenfermedades innata del metabolismo- fenilcetonuriaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaenfermedades innata del metabolismo- fenilcetonuriaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaenfermedades innata del metabolismo- fe
Phenylketonuria
Phenylketonuria (PKU) is a rare genetic disorder caused by a mutation in the PAH gene that results in a deficiency of the enzyme phenylalanine hydroxylase. This enzyme is needed to break down the amino acid phenylalanine, which accumulates and causes neurological damage if left untreated. PKU is typically diagnosed via newborn screening and can be successfully managed through a lifelong low-phenylalanine diet and supplements to prevent intellectual disability and other serious issues. Untreated PKU leads to neurological problems, but early diagnosis and strict dietary control allows patients to live healthy lives.
Phenylketonuria ..
Phenylketonuria (PKU) is a rare genetic disorder caused by a mutation that prevents the body from breaking down phenylalanine, leading to its buildup in the blood and brain. PKU is treated through a low-protein diet and dietary supplements to control phenylalanine levels and prevent intellectual disabilities and other health issues. Left untreated, PKU can cause permanent brain damage and intellectual disabilities. Newborns are screened for PKU through a heel prick blood test to enable early treatment and management of the disorder.
The Evolving Role of Current and Novel Therapies in Improving Outcomes in Adu...
The Evolving Role of Current and Novel Therapies in Improving Outcomes in Adu...PVI, PeerView Institute for Medical Education
Barbara K. Burton, MD, and Nicola Longo, MD, PhD, prepared useful practice aids pertaining to phenylketonuria for this CME activity titled "The Evolving Role of Current and Novel Therapies in Improving Outcomes in Adults With PKU." For the full presentation, monograph, complete CME information, and to apply for credit, please visit us at http://bit.ly/2sBC77b. CME credit will be available until June 13, 2019.Phenylketonuria PKU - Inborn error metabolism
The slides gives you a complete information on the inborn error metabolic disease Phenylketonuria (PKU) its cause, symptoms, mechanism and dietary management.
Weston contra la Universidad de Cornell La Universidad de C.pdf
Weston contra la Universidad de Cornell
La Universidad de Cornell le ofreci a Leslie Weston una ctedra asociada por un perodo de cinco
aos. La oferta lleg "con la titularidad" sujeta a una revisin del desempeo de Weston. Ella acept. Ms
tarde, Cornell se neg a otorgarle el estatus permanente, pero extendi su nombramiento por dos
aos "sin permanencia" y le dio la oportunidad de volver a presentarse. Ella estuvo de acuerdo.
Cornell volvi a negar su estatus permanente y finalmente rescindi su puesto. Weston present una
demanda en un tribunal del estado de Nueva York contra Cornell, alegando incumplimiento de
contrato. La universidad present una mocin de juicio sumario. La corte deneg la mocin. El
demandado apel.
Un tribunal de apelaciones intermedio del estado revoc la denegacin de la mocin de juicio sumario
de Cornell. Los trminos de la oferta original y la aceptacin de las partes se modificaron
materialmente por la oferta de Cornell de extender el nombramiento de Weston sin permanencia y
la aceptacin del nuevo trmino por parte de Weston.
La correspondencia impresa y escrita entre las partes proporcion la mayor parte de la
evidencia para respaldar las conclusiones de los tribunales en este caso. Parece razonable
que un intercambio de correo electrnico pueda servir para el mismo propsito? Por qu o por
qu no?
Supongamos que Weston hubiera renunciado a un puesto permanente en otra universidad
para aceptar la oferta original de Cornell. Habra sido diferente el resultado en este caso?.
Which signal of value approach is not a cost driver The qua.pdf
Which signal of value approach is not a cost driver?
The quality of brochures and sales presentations
Higher price Ongoing ad campaigns (which impact a products image and make it more widely
known)
More appealing or fancier packaging
The luxuriousness and ambience of high-end retailers and sales sites frequented by customers
Making buyers aware that a company (or its products) has prestigious customers
Ad content that emphasizes a products standout attributes.
More Related Content
Similar to Background Phenylketonuria is an inherited disease which re.pdf
Phenyl ketonuria @@@@@
Classical phenylketonuria (PKU) is an inherited disorder where the enzyme phenylalanine hydroxylase is absent, preventing the conversion of phenylalanine to tyrosine. This causes phenylalanine to accumulate in the blood and be metabolized into alternative catabolites, including phenylpyruvic acid and phenylacetic acid conjugated with glutamine and excreted in urine, giving it a "mousy odor". Accumulation of phenylalanine can also impair serotonin and melanin formation. Clinical features include mental retardation, seizures, and eczema. Diagnosis involves measuring elevated plasma phenylalanine levels and testing urine for phenylpyruvate. Treatment
Phenylketonuria ( PKU) - Dr Padmesh
This document discusses phenylketonuria (PKU), a genetic disorder caused by a deficiency in the enzyme phenylalanine hydroxylase. This enzyme is needed to break down the amino acid phenylalanine. Without it, phenylalanine builds up to high levels in the blood and brain, which can cause intellectual disability if not treated early. The document outlines the causes, symptoms, diagnosis through newborn screening, and lifelong treatment through a phenylalanine-restricted diet for PKU patients. It also discusses milder forms that do not require dietary treatment and the rare cases caused by a deficiency in the cofactor tetrahydrobiopterin.
Aminoaciduria phenylketonuria
Phenylketonuria is one of fthe inborn error of metabolism. Its characteristically error in amino acid metabolism. This causes aminoaciduria. Phenylalanine is an amino acid requied for protein synthesis as well as synthesis of tyrosine. Deficiency of the enzyme phenylalanine hyydroxylase triggers the accumulation of phenylalanine in the blood and subsequent conversion and transamination to ohenylpyruvate which is a phenylketone. This causes accumulation of phenylketones in urine with characteristicc mousy smell.
This slide discussess the causes and biochemistry of this error.
PKU-biochemical genetic disorder- 19.1.2023.ppt
Phenylketonuria (PKU) is an autosomal recessive genetic disorder caused by a deficiency of the enzyme phenylalanine hydroxylase, resulting in an inability to metabolize the essential amino acid phenylalanine. If left untreated, PKU can cause intellectual disabilities, seizures, and other neurological problems in affected individuals. Treatment involves restricting dietary phenylalanine through a specialized low-protein diet to control phenylalanine levels. Females with PKU must adhere to the diet prior to and during pregnancy to prevent complications in offspring from high phenylalanine passing through the placenta.
Aminoaciduria and organic aciduria in neurology
aminoaciduria and organic aciduria are considered as important disorder in the group of inborn error of metabolism.
Phenylketonuria (PKU)
Phenylketonuria (PKU) : is a genetic disorder that is characterized by an inability of the body to utilize the essential amino acid, phenylalanine.
Phenylketonuria
Phenylketonuria (PKU) is a genetic disorder caused by mutations in the PAH gene that result in deficient phenylalanine hydroxylase enzyme activity. This prevents the breakdown of the essential amino acid phenylalanine, causing it to accumulate to toxic levels and cause neurological damage if left untreated. Symptoms of PKU include intellectual disability, seizures, and behavioral issues. Treatment involves a lifelong low-phenylalanine diet to control blood phenylalanine levels, as well as enzyme replacement or gene therapies currently under investigation.
Phenylketonuria (pku)
PHENYLKETONURIA is due to hyperphenylalaninemia
Classic variant of PKU is due to the absence of phenylalanine hydroxylase.
keto.pptx
Phenylketonuria (PKU) is an inherited disorder that causes the body to be unable to break down an amino acid called phenylalanine. If left untreated, it can cause intellectual disabilities and other neurological problems. There are different types of PKU depending on severity. It is caused by mutations that impact the phenylalanine hydroxylase enzyme needed to metabolize phenylalanine. Symptoms usually appear between 3-6 months of age if untreated. Diagnosis involves newborn blood tests and managing PKU involves a lifelong low-phenylalanine diet to control symptoms and prevent complications.
Genetic mutations project
PKU is a genetic mutation where the body lacks the enzyme phenylalanine hydroxylase needed to break down the amino acid phenylalanine. When phenylalanine builds up in the blood, it damages the brain and nervous system, potentially causing intellectual disabilities, behavioral issues, and other health problems. It is treated through a lifelong low-phenylalanine diet to prevent toxic buildup. PKU affects approximately 1 in 10,000-15,000 newborns. It is diagnosed through newborn screening and managed through dietary control.
Phenyl ketonuria
INBORN ERRORS OF METABOLISM, PKU, PHENYLKETONURIA, BY: MR. DINABANDHU BARAD, MSC TUTOR, SUM NURSING COLLEGE, SIKSHA O ANUSANDHAN DEEMED TO BE UNIVERSITY, BHUBANESWAR, ODISHA
Phenylketonuria
Phenylketonuria (PKU) is an inborn error of metabolism that results in decreased metabolism of the amino acid phenylalanine. A birth defect that causes an amino acid called phenylalanine to build up in the body.
Newborns should be screened for PKU.
Untreated phenylketonuria can lead to brain damage, intellectual disabilities, behavioural symptoms or seizures.
Treatment includes a strict diet with limited protein.
Phenylketonuria
This fill is represented has the WHAT IS PHENYLKETONURIA,DISCOVERY,NORMAL LEVEL IN BLOOD, HEREDITY,DEFECTS OF CHROMOSOME,CLASSESS OF PHENYLKETONURIA, SYMPTOMS, DIAGNOSIS, TREATMENT &etc...
Catabolism of phenylalanine and tyrosine and their metabolic disorders by BNP...
Catabolism of phenylalanine and tyrosine and their metabolic disorders by BNP...College of pharmaceutical sciences
Decarboxylation is the reaction by which CO2 is removed from the COOH group of an amino acid as a result an amine is formed. The reaction is catalyzed by the enzyme decarboxylase, which requires pyridoxal-P (B6-PO4) as coenzyme. Tissues like liver, kidney, brain possess the enzyme decarboxylase and also by microorganisms of intestinal tract. The enzyme removes CO2 from COOH and converts the amino acid to corresponding amine.
Phenylalanine is an essential, aromatic amino acid. The need for phenylalanine becomes minimal, if adequate tyrosine is supplied in the food. This is called the sparing action of tyrosine on phenylalanine.
Tyrosine is an aromatic amino acid. It is synthesized from phenylalanine, and so is a non-essential amino acid. The need for phenylalanine becomes minimal, if adequate tyrosine is supplied in the food. This is called the sparing action of tyrosine on the phenylalanine.
Seven amino acids produce acetyl CoA or acetoacetate and therefore are categorized as ketogenic. Of these, isoleucine, threonine, and the aromatic amino acids (phenylalanine, tyrosine, and tryptophan) are converted to compounds that produce both glucose and acetyl CoA or acetoacetate. Leucine and lysine do not produce glucose; they produce acetyl CoA and acetoacetate.
The name phenylketonuria is coined due to the fact that the metabolite phenylpyruvate is a keto acid (C6H5CH2−CO−COO−) excreted in urine in high amounts.
Phenylalanine cannot be converted to tyrosine. So, phenylalanine accumulates. Phenylalanine level in blood is elevated.Phenylketonuria alex gandhi and athavan balendran
Phenylketonuria is a genetic disorder caused by a mutation in the PAH gene, which results in excessive levels of the amino acid phenylalanine. If left untreated, it can cause intellectual disabilities, stunted growth, eczema, small head size, and seizures. Treatment involves maintaining appropriate phenylalanine levels through diet control. It occurs in about 1 in 10,000 to 15,000 births and can be diagnosed via a blood test.
enfermedades innatas del metabolismo pku
enfermedades innata del metabolismo- fenilcetonuriaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaenfermedades innata del metabolismo- fenilcetonuriaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaenfermedades innata del metabolismo- fenilcetonuriaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaenfermedades innata del metabolismo- fenilcetonuriaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaenfermedades innata del metabolismo- fenilcetonuriaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaenfermedades innata del metabolismo- fenilcetonuriaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaenfermedades innata del metabolismo- fenilcetonuriaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaenfermedades innata del metabolismo- fenilcetonuriaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaenfermedades innata del metabolismo- fenilcetonuriaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaenfermedades innata del metabolismo- fenilcetonuriaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaenfermedades innata del metabolismo- fenilcetonuriaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaenfermedades innata del metabolismo- fenilcetonuriaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaenfermedades innata del metabolismo- fenilcetonuriaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaenfermedades innata del metabolismo- fenilcetonuriaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaenfermedades innata del metabolismo- fenilcetonuriaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaenfermedades innata del metabolismo- fenilcetonuriaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaenfermedades innata del metabolismo- fenilcetonuriaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaenfermedades innata del metabolismo- fenilcetonuriaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaenfermedades innata del metabolismo- fenilcetonuriaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaenfermedades innata del metabolismo- fenilcetonuriaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaenfermedades innata del metabolismo- fenilcetonuriaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaenfermedades innata del metabolismo- fe
Phenylketonuria
Phenylketonuria (PKU) is a rare genetic disorder caused by a mutation in the PAH gene that results in a deficiency of the enzyme phenylalanine hydroxylase. This enzyme is needed to break down the amino acid phenylalanine, which accumulates and causes neurological damage if left untreated. PKU is typically diagnosed via newborn screening and can be successfully managed through a lifelong low-phenylalanine diet and supplements to prevent intellectual disability and other serious issues. Untreated PKU leads to neurological problems, but early diagnosis and strict dietary control allows patients to live healthy lives.
Phenylketonuria ..
Phenylketonuria (PKU) is a rare genetic disorder caused by a mutation that prevents the body from breaking down phenylalanine, leading to its buildup in the blood and brain. PKU is treated through a low-protein diet and dietary supplements to control phenylalanine levels and prevent intellectual disabilities and other health issues. Left untreated, PKU can cause permanent brain damage and intellectual disabilities. Newborns are screened for PKU through a heel prick blood test to enable early treatment and management of the disorder.
The Evolving Role of Current and Novel Therapies in Improving Outcomes in Adu...
The Evolving Role of Current and Novel Therapies in Improving Outcomes in Adu...PVI, PeerView Institute for Medical Education
Barbara K. Burton, MD, and Nicola Longo, MD, PhD, prepared useful practice aids pertaining to phenylketonuria for this CME activity titled "The Evolving Role of Current and Novel Therapies in Improving Outcomes in Adults With PKU." For the full presentation, monograph, complete CME information, and to apply for credit, please visit us at http://bit.ly/2sBC77b. CME credit will be available until June 13, 2019.Phenylketonuria PKU - Inborn error metabolism
The slides gives you a complete information on the inborn error metabolic disease Phenylketonuria (PKU) its cause, symptoms, mechanism and dietary management.
Similar to Background Phenylketonuria is an inherited disease which re.pdf (20)
Catabolism of phenylalanine and tyrosine and their metabolic disorders by BNP...
Catabolism of phenylalanine and tyrosine and their metabolic disorders by BNP...
The Evolving Role of Current and Novel Therapies in Improving Outcomes in Adu...
The Evolving Role of Current and Novel Therapies in Improving Outcomes in Adu...
More from saravanfncy
Weston contra la Universidad de Cornell La Universidad de C.pdf
Weston contra la Universidad de Cornell
La Universidad de Cornell le ofreci a Leslie Weston una ctedra asociada por un perodo de cinco
aos. La oferta lleg "con la titularidad" sujeta a una revisin del desempeo de Weston. Ella acept. Ms
tarde, Cornell se neg a otorgarle el estatus permanente, pero extendi su nombramiento por dos
aos "sin permanencia" y le dio la oportunidad de volver a presentarse. Ella estuvo de acuerdo.
Cornell volvi a negar su estatus permanente y finalmente rescindi su puesto. Weston present una
demanda en un tribunal del estado de Nueva York contra Cornell, alegando incumplimiento de
contrato. La universidad present una mocin de juicio sumario. La corte deneg la mocin. El
demandado apel.
Un tribunal de apelaciones intermedio del estado revoc la denegacin de la mocin de juicio sumario
de Cornell. Los trminos de la oferta original y la aceptacin de las partes se modificaron
materialmente por la oferta de Cornell de extender el nombramiento de Weston sin permanencia y
la aceptacin del nuevo trmino por parte de Weston.
La correspondencia impresa y escrita entre las partes proporcion la mayor parte de la
evidencia para respaldar las conclusiones de los tribunales en este caso. Parece razonable
que un intercambio de correo electrnico pueda servir para el mismo propsito? Por qu o por
qu no?
Supongamos que Weston hubiera renunciado a un puesto permanente en otra universidad
para aceptar la oferta original de Cornell. Habra sido diferente el resultado en este caso?.
Which signal of value approach is not a cost driver The qua.pdf
Which signal of value approach is not a cost driver?
The quality of brochures and sales presentations
Higher price Ongoing ad campaigns (which impact a products image and make it more widely
known)
More appealing or fancier packaging
The luxuriousness and ambience of high-end retailers and sales sites frequented by customers
Making buyers aware that a company (or its products) has prestigious customers
Ad content that emphasizes a products standout attributes.
which bacterial DNA structure is used in recombinant technol.pdf
which bacterial DNA structure is used in recombinant technology to make insulin and other desired
proteins?
Which bacterial DNA structure is used in recombinant technology to make insulin and other
desired proteins?
ribosome
endospore
nucleoid
plasma membrane
plasmid.
What is risk culture How are people related to risk Explai.pdf
What is risk culture? How are people related to risk? Explain the
3Ts of risk management and the ABC Model of risk culture.
yah just fill the table by the terms that were given Saliva.pdf
yah just fill the table by the terms that were given
Salivary amylase, HCl and pepsin, pancreatic amylase, pancreatic lipase, trypsin and
chymotrypsin, nucleases, bile salts, sucrase / maltase / lactase, peptidases begin{tabular}{|l|l|l|l|l|}
hline Macromolecule & Chemicalcnzyme & Siteofproduction & Rite of action catalyzed hline
Carbohydrates & Salivary amylase & Salivary glands & Oral cavity & Starch to maltose hline
end{tabular} Proteins Nucleic acids Lipids.
What topic in human growth and development needs to be resea.pdf
What topic in human growth and development needs to be research on? I.e (1)Research methods
in the study of human development. (2)Concept of human development. (3) theories of human
development. (4)childhood development. (5)Adult development. (6)Factors influencing growth and
development. Pick and discuss on only one of these topics.
Uthiarian Prificiple hishtsprinciple Farnesa poinciple Commo.pdf
Uthiarian Prificiple hishtsprinciple Farnesa poinciple Common gobd principle Virtep principle ZFor
every dollar mes eara women earn 77 centh. The Teaic Cornocatian is bound dumping hazardous
mace al into the neerbrniver. Intival aetoplar - thapter I Tack 1 i Select which of the princleles der
thenaling etharally beat mutobes earb.
The main disagreement between James Madison and Alexander Ha.pdf
The main disagreement between James Madison and Alexander Hamilton about the General
Welfare was?
Whether the "general welfare" includes states
Whether the balance of interests is correctly weighed between the general welfare and individual
liberty
Whether federal powers are only those specifically listed in the constitution
Whether the federal government and states should both be able to tax citizens in order to change
behavior.
The hypothesis HO 12 Ha 1lt2 is an example of upper.pdf
The hypothesis, HO: 1=2, Ha: 1<2, is an example of: upper (right) tailed test. lower (left) tailed
test. paired test. two tailed test..
Ten Hellos Write a program to print ten Hellos They s.pdf
Ten Hellos! Write a program to print ten "Hello!"s. They should look as follows (see next line) and
please use a for() loop for i=4; i<=10.
1st Hello! 2nd Hello! 3rd Hello! 4th Hello! 5th Hello! 6th Hello! 7th Hello! 8th Hello! 9th Hello 10th
Hello!.
The Capital Asset Pricing Model CAPM is a financial model .pdf
The Capital Asset Pricing Model (CAPM) is a financial model that assumes returns on a portfolio
are normally distributed. Suppose a portfolio has an average annual return of 12.8% (i.e., an
average gain of 12.8%) with a standard deviation of 35%. A return of 0% means the value of the
portfolio doesn't change, a negative return means that the portfolio loses money, and a positive
return means that the portfolio gains money. (Round your answers to two decimal places.).
q1 Finalaccepting states q2 Transitions function No.pdf
q1) Final/accepting states?
q2) Transitions function?
Note that 1=20 Example of how to enter the Turing machine: Final/accepting states: Transition
function: d(q,a)=(q1,a,R)d(q,#)=(q2,#,L)d(q1,a)=(q,a,R) Important notes: - the Turing machine
should not leave the bounds of the input word (in particular, blank symbols must be left
unchanged) - the Turing machine should be deterministic - the Turing machine can have at most
23 states - the starting state is always - the blank symbol is - the tape alphabet consists of single
characters (letters or digits).
Select all of the characteristics of SEXUAL Reproduction A .pdf
Select all of the characteristics of SEXUAL Reproduction.
A
Organisms have to search for a mate, which can take a long time.
B
Offspring inherit half of their DNA from each parent.
C
Organisms can reproduce a large number of offspring quickly.
D
Organisms can reproduce without a mate.
E
Organisms have to grow and develop until they are mature enough to produce sex cells.
F
Offspring are genetically identical to the single parent..
Sabah proje ekibi toplants ilgin olacana sz verdi Pazarla.pdf
Sabah proje ekibi toplants ilgin olacana sz verdi. Pazarlama departman temsilcileri Jane Pauley ile
finans departman Juan Castro arasndaki gerilim birka haftadr --- aslnda proje ekibi
oluturulduundan beri artyor. Mkemmel rnler iin zel Projeler Blm bakan Sammy Bonsu, Project
Excellence'n proje yneticisi olarak Jane ve Juan'n ayn fikirde olmadklarnn farkndayd, ancak
(Sammy) zamanla birbirlerinin bak asn takdir edeceklerini anlad. ve ibirlii yapmaya balayn. imdiye
kadar, ne yazk ki, bu olmad. Aslnda, Sammy Bonsu'nun dier ekip yesinin davranlar, ballk veya
ibirlii eksiklii veya genel kalitesiz performansla ilgili olarak birinden veya dierinden ikayet almad bir
gn bile gemiyor gibi grnyor.
Project Excellence yaklak 4 aydr alyor. Proje Mkemmellii iin son tarih, Denise Robinson (Mkemmel
rnler Bakan) tarafndan 1 Ocak 2021 olarak belirlendi. Sammy Bonsu, ilevler aras ekiplerle birlikte
4 projeden daha sorumluydu. Yllar boyunca, Excellent Products, pazara hzla yeni rnler getirmesi
ve mterileri memnun etmesiyle tannyordu. Sammy, irketin 20 yllk varlnn ayrlmaz bir parasyd.
Aslnda, Denise ve Sammy niversitede snf arkadalaryd. Birbirlerine her zaman byk bir gven ve
sayg duyarlar. Ancak, Jane Pauley ve Juan Castro arasnda farkl bir hikaye vard. Jane ve Juan,
Excellent Products'a be yl nce katld. Her biri son derece rekabeti ve iinden byk gurur duyuyor.
(Jane ve Juan) farkl grlere sahip olsalar da her biri irkete sadktr.
Ekip, sabah 9:00'da dzenli bir aylk proje durum toplants iin toplanrken, Sammy Bonsu proje
grevleri, ekip yelerinin yaad sorunlar ve projenin bugne kadarki performansna ilikin
deerlendirmeleri hakknda bir gncelleme ile balar. Sammy toplantya fazla dalmadan nce Jane
araya girerek, Sammy, nmzdeki 10 gn boyunca mterileri ziyaret etmek iin ehir dnda olacam, bu
yzden nmzdeki iki Cuma gn de durum toplantlarna katlamayacam.
Juan herkesin duyabilecei kadar yksek sesle, "yle grnyor," diye mrldand.
Jane etrafnda dnyor. "Buralarda baka bir iim var, biliyorsun ve bu da sat yapmay ieriyor. Her eyi
brakp bu toplantlara gelmeniz uygun olabilir ama bazlarmzn baka sorumluluklar var.
Juan karlk veriyor, "imdiye kadar toplantlarn yarsn karmann bahanesi buydu. Sadece meraktan,
diye devam etti alayc bir ekilde, daha ka kii havuz kenarnda taklrken ehir dndan gelen kk
insanlarla umay dnyor?
Jane parlak krmzya dner. "Sana katlanmak zorunda deilim. Fasulye sayalarnn bu iin nasl altna
veya kimin deer saladna dair hibir fikriniz yok. Her kuruunu analiz etmekle o kadar megulsn ki kalc
gz yorgunluun var!
Juan, "Satta srekli olarak siz kovboylarn arkasnda durmak zorunda kalmasaydm belki biraz dikkat
edebilirdim," diye kar kyor Juan. "Yemin ederim ki, bu bizi mahvedecek olsa bile, aylk rakamlarnz
yapmanza izin verseydi rnlerimizi ele verirdiniz!"
Jane ve Juan arasndaki tartmalar tam lekli bir dmanla dntnde ve kontrolden kma tehdidinde
bulunurken Sammy Bonsu hayretle arkasna yaslanr. Dier ekip yeleri, tepkisi iin Sammy'ye bakar.
Mhendislikten Anil Patel'in yznde komik bir .
Read Knowledge attitude and practice in relation to cathet.pdf
Read: Knowledge, attitude and practice in relation to catheter-associated urinary tract infection
prevention: A cross sectional study
Cited: Mong, I., Ramoo, V., Ponnampalavanar, S., Chong, M. C., & Wan Nawawi, W. N. F. (2022).
Knowledge, attitude and practice in relation to catheter-associated urinary tract infection (CAUTI)
prevention: A cross-sectional study. Journal of clinical nursing, 31(1-2), 209219.
https://doi.org/10.1111/jocn.15899
Answer:
1. Is the framework presented with clarity?. Is the framework linked to the research purpose? If no
theoretical framework identified, should there be? What framework might have been or could have
been used?
2. Identify the specific design of the study. Is the design appropriate for the study? Does the
sample fit with the research design and is the size sufficient? Was a data collection instrument
needed/used? How were data collected? Were reliability and validity accounted for?
3. Did the method used to gain study subjects coordinate with the study methodology? Was it
accurately and completely described?.
8 Suppose X and Y are two independent random variables both.pdf
8. Suppose X and Y are two independent random variables both uniformly distributed on [0,2].
Find (i) P(X<Y3), (ii) P(X+Y<21) and (iii) P(min(X,Y)>21)..
A 77yearold man with adenocarcinoma of the colon and emphy.pdf
A 77-year-old man with adenocarcinoma of the colon and emphysema resulting from 50+ years of
smoking had an exacerbation of his health in the last 3 months, requiring home oxygen and high-
dose corticosteroid use. He presents to the family doctor with shortness of breath and congestion
and was prescribed a 10-day course of Bactrim and an increase in corticosteroid dosage which
results in improvement of his condition. Upon completion of antibiotics, the patient suffers from
another exacerbation of symptoms; resulting in nausea, vomiting, a productive, purulent cough
and decrease in PO2 requiring hospitalization. Upon admission the patient is given an oxygen
mask to increase PO2, and an expectorated sputum sample is collected for Gram stain, routine
bacterial culture and fungal culture. The sputum Gram stain is shown below; documenting on
400X magnification a of filariform larvae, no WBC are seen. Subsequent bacterial culture results in
growth of normal respiratory microbiota only and the fungal culture is no growth after 1-week.
question 1:
question 2:
question 3:
question 4:
question 5:
A Nematode that has a lung phase as a part of their life cycle will be: All of the answers are correct
Ascaris lumbricoides Ancylostoma duodenale/Necator americanus Strongyloides stercoralisGiven
additional patient history information that this individual is a retired school teacher that has lived in
Falmouth on Cape Cod his entire life only leaving when as a marine from 1968 to 1971 he was
deployed on active duty to Vietnam during the war. Given this additional information, what
nematode is the most likely causative agent of this infection? Strongyloides stercoralis Ascaris
lumbricoides Ancylostoma duodenale Necator americanusWhy is this nematode able to persist in
the host for a long period of time? Potential for autoinfection Loeffler's syndrome and difficult to
elminate from pulmonary tissue Resistance to anti-parasitic treatments This is recognized as a
self-antigen by the host therefore a protective immune response is not produced.Organ transplant
patients must be screened for this isolate to prevent hyperinfection syndrome and fatal outcomes.
True FalseWhich white blood cell is increased in number during infections with this parasite?
Eosinophils Macrophage Innate Lymphoid Cells T cells.
public class CustomerList private ListltCustomergt .pdf
public class CustomerList
{
private List<Customer> customers;
public delegate void ChangeHandler(CustomerList customers);
public event ChangeHandler ChangedList;
public CustomerList()
{
customers = new List<Customer>();
}
public void Add(Customer c)
{
customers.Add(c);
}
public static CustomerList operator + (CustomerList customers, Customer c)
{
customers.Add(c);
return customers;
}
}
(Refer to code example 13-2) Which of the following statements adds a Customer object named
newCustomer to a CustomerList object named customers?
customers = customers + newCustomer;
A and B
customers.Add(newCustomer);
All of the above
customers += newCustomer;.
Parte 2 Verifique su comprensin Para cada individuo su.pdf
Parte 2 - Verifique su comprensin - Para cada individuo, sugiera un activo financiero de la lista
provista que sea apropiado para su circunstancia y explique su razonamiento.
cuenta corriente/efectivo cuenta de ahorro bienes races bitcoin certificados de depsito bonos
acciones (acciones).
Opcin mltiple 1 _________ se refiere a la confiscacin de.pdf
Opcin mltiple 1. _________ se refiere a la confiscacin de propiedad extranjera por parte de los
gobiernos anfitriones.a. Expatriacinb. Expropiacin c. Extraterritorialidadd. Ninguna de las
anteriores
2. En qu etapa del ciclo de vida del producto las empresas comienzan a producir en el extranjero?
a. Primerob. segundoc. tercero Cuatro
3. En trminos de mentalidad ejecutiva, las empresas ___________ son las ms propensas a
otorgar una autonoma considerable a las subsidiarias locales.a. policntrico b. Etnocntrico.
Geocntrico. centocntrico
4. Las empresas multinacionales tienen ms poder de negociacin, en relacin con los gobiernos
anfitriones, cuando pueden ofrecer lo siguiente al pas anfitrin: a. inversiones de capital b.
desarrollos de infraestructurac. trabajosd. Todas las anteriores e. Ninguna de las anteriores
5. Las empresas multinacionales encontrarn que un pas anfitrin es un destino menos atractivo
cuando . . .a. Las ganancias de la empresa no son fcilmente repatriadas b. El gobierno es
establec. Los tipos de cambio entre el pas de origen y el anfitrin no fluctan. Ninguna de las
anteriores
6. Es posible que los pases en desarrollo no puedan proteger su medio ambiente de los efectos
de la industrializacin, por dainos que sean, porque a. No les interesan las consecuencias
perjudiciales. b. Valorarn ms el aumento del empleo que la salud y la seguridad de los
ciudadanos. .c.No pueden permitirse las tecnologas necesarias para fabricar de una manera ms
ecolgica. re. Ninguna de las anteriores.
7. Las instituciones que promueven la conducta tica han incluido todas las siguientes excepto a.
La OIT (Organizacin Internacional del Trabajo) b. La OCDE (Organizacin para la Cooperacin y el
Desarrollo Econmicos) c. La CCI (Cmara de Comercio Internacional) d. El FMI (Organizacin
Internacional del Trabajo) Fondo Monetario)
8. Cul de las siguientes afirmaciones describe con mayor precisin la relacin que una empresa
debe tener con sus partes interesadas? a. Los clientes exigen bienes de calidad a un precio justo
y, a cambio, se espera que no demanden a la empresa si algo sale mal. b. capital de los
accionistas y, a cambio, proporcionar rendimientos saludables. c. Las partes interesadas brindan
incentivos a las empresas y, a cambio, las empresas contribuyen a todos los grupos de partes
interesadas. d. Las empresas valoran a todos los grupos de partes interesadas por igual en todo
momento.
9. Como uno de los grupos de partes interesadas de una CMN, los gobiernos anfitriones esperan
todo lo siguiente, excepto a. Mercanca gratis b. Mayor empleo para los locales c. Pago de
impuestos d. Respeto por las costumbres y la cultura locales
10. El debate sobre el libre comercio puede caracterizarse por la preocupacin por a.la creacin de
puestos de trabajo a largo plazo pero con bolsas de desempleo a corto plazo b.la creacin de
puestos de trabajo a corto plazo pero con bolsas de desempleo a largo plazo, se crea ms
comercio entre los bloques comerciales regionales que dentro d.
More from saravanfncy (20)
Weston contra la Universidad de Cornell La Universidad de C.pdf
Weston contra la Universidad de Cornell La Universidad de C.pdf
Which signal of value approach is not a cost driver The qua.pdf
Which signal of value approach is not a cost driver The qua.pdf
which bacterial DNA structure is used in recombinant technol.pdf
which bacterial DNA structure is used in recombinant technol.pdf
What is risk culture How are people related to risk Explai.pdf
What is risk culture How are people related to risk Explai.pdf
yah just fill the table by the terms that were given Saliva.pdf
yah just fill the table by the terms that were given Saliva.pdf
What topic in human growth and development needs to be resea.pdf
What topic in human growth and development needs to be resea.pdf
Uthiarian Prificiple hishtsprinciple Farnesa poinciple Commo.pdf
Uthiarian Prificiple hishtsprinciple Farnesa poinciple Commo.pdf
The main disagreement between James Madison and Alexander Ha.pdf
The main disagreement between James Madison and Alexander Ha.pdf
The hypothesis HO 12 Ha 1lt2 is an example of upper.pdf
The hypothesis HO 12 Ha 1lt2 is an example of upper.pdf
Ten Hellos Write a program to print ten Hellos They s.pdf
Ten Hellos Write a program to print ten Hellos They s.pdf
The Capital Asset Pricing Model CAPM is a financial model .pdf
The Capital Asset Pricing Model CAPM is a financial model .pdf
q1 Finalaccepting states q2 Transitions function No.pdf
q1 Finalaccepting states q2 Transitions function No.pdf
Select all of the characteristics of SEXUAL Reproduction A .pdf
Select all of the characteristics of SEXUAL Reproduction A .pdf
Sabah proje ekibi toplants ilgin olacana sz verdi Pazarla.pdf
Sabah proje ekibi toplants ilgin olacana sz verdi Pazarla.pdf
Read Knowledge attitude and practice in relation to cathet.pdf
Read Knowledge attitude and practice in relation to cathet.pdf
8 Suppose X and Y are two independent random variables both.pdf
8 Suppose X and Y are two independent random variables both.pdf
A 77yearold man with adenocarcinoma of the colon and emphy.pdf
A 77yearold man with adenocarcinoma of the colon and emphy.pdf
public class CustomerList private ListltCustomergt .pdf
public class CustomerList private ListltCustomergt .pdf
Parte 2 Verifique su comprensin Para cada individuo su.pdf
Parte 2 Verifique su comprensin Para cada individuo su.pdf
Opcin mltiple 1 _________ se refiere a la confiscacin de.pdf
Opcin mltiple 1 _________ se refiere a la confiscacin de.pdf
Recently uploaded
ISO/IEC 27001, ISO/IEC 42001, and GDPR: Best Practices for Implementation and...
Denis is a dynamic and results-driven Chief Information Officer (CIO) with a distinguished career spanning information systems analysis and technical project management. With a proven track record of spearheading the design and delivery of cutting-edge Information Management solutions, he has consistently elevated business operations, streamlined reporting functions, and maximized process efficiency.
Certified as an ISO/IEC 27001: Information Security Management Systems (ISMS) Lead Implementer, Data Protection Officer, and Cyber Risks Analyst, Denis brings a heightened focus on data security, privacy, and cyber resilience to every endeavor.
His expertise extends across a diverse spectrum of reporting, database, and web development applications, underpinned by an exceptional grasp of data storage and virtualization technologies. His proficiency in application testing, database administration, and data cleansing ensures seamless execution of complex projects.
What sets Denis apart is his comprehensive understanding of Business and Systems Analysis technologies, honed through involvement in all phases of the Software Development Lifecycle (SDLC). From meticulous requirements gathering to precise analysis, innovative design, rigorous development, thorough testing, and successful implementation, he has consistently delivered exceptional results.
Throughout his career, he has taken on multifaceted roles, from leading technical project management teams to owning solutions that drive operational excellence. His conscientious and proactive approach is unwavering, whether he is working independently or collaboratively within a team. His ability to connect with colleagues on a personal level underscores his commitment to fostering a harmonious and productive workplace environment.
Date: May 29, 2024
Tags: Information Security, ISO/IEC 27001, ISO/IEC 42001, Artificial Intelligence, GDPR
-------------------------------------------------------------------------------
Find out more about ISO training and certification services
Training: ISO/IEC 27001 Information Security Management System - EN | PECB
ISO/IEC 42001 Artificial Intelligence Management System - EN | PECB
General Data Protection Regulation (GDPR) - Training Courses - EN | PECB
Webinars: https://pecb.com/webinars
Article: https://pecb.com/article
-------------------------------------------------------------------------------
For more information about PECB:
Website: https://pecb.com/
LinkedIn: https://www.linkedin.com/company/pecb/
Facebook: https://www.facebook.com/PECBInternational/
Slideshare: http://www.slideshare.net/PECBCERTIFICATION
Advanced Java[Extra Concepts, Not Difficult].docx
This is part 2 of my Java Learning Journey. This contains Hashing, ArrayList, LinkedList, Date and Time Classes, Calendar Class and more.
Top five deadliest dog breeds in America
Thinking of getting a dog? Be aware that breeds like Pit Bulls, Rottweilers, and German Shepherds can be loyal and dangerous. Proper training and socialization are crucial to preventing aggressive behaviors. Ensure safety by understanding their needs and always supervising interactions. Stay safe, and enjoy your furry friends!
বাংলাদেশ অর্থনৈতিক সমীক্ষা (Economic Review) ২০২৪ UJS App.pdf
বাংলাদেশের অর্থনৈতিক সমীক্ষা ২০২৪ [Bangladesh Economic Review 2024 Bangla.pdf] কম্পিউটার , ট্যাব ও স্মার্ট ফোন ভার্সন সহ সম্পূর্ণ বাংলা ই-বুক বা pdf বই " সুচিপত্র ...বুকমার্ক মেনু 🔖 ও হাইপার লিংক মেনু 📝👆 যুক্ত ..
আমাদের সবার জন্য খুব খুব গুরুত্বপূর্ণ একটি বই ..বিসিএস, ব্যাংক, ইউনিভার্সিটি ভর্তি ও যে কোন প্রতিযোগিতা মূলক পরীক্ষার জন্য এর খুব ইম্পরট্যান্ট একটি বিষয় ...তাছাড়া বাংলাদেশের সাম্প্রতিক যে কোন ডাটা বা তথ্য এই বইতে পাবেন ...
তাই একজন নাগরিক হিসাবে এই তথ্য গুলো আপনার জানা প্রয়োজন ...।
বিসিএস ও ব্যাংক এর লিখিত পরীক্ষা ...+এছাড়া মাধ্যমিক ও উচ্চমাধ্যমিকের স্টুডেন্টদের জন্য অনেক কাজে আসবে ...
A Strategic Approach: GenAI in Education
Artificial Intelligence (AI) technologies such as Generative AI, Image Generators and Large Language Models have had a dramatic impact on teaching, learning and assessment over the past 18 months. The most immediate threat AI posed was to Academic Integrity with Higher Education Institutes (HEIs) focusing their efforts on combating the use of GenAI in assessment. Guidelines were developed for staff and students, policies put in place too. Innovative educators have forged paths in the use of Generative AI for teaching, learning and assessments leading to pockets of transformation springing up across HEIs, often with little or no top-down guidance, support or direction.
This Gasta posits a strategic approach to integrating AI into HEIs to prepare staff, students and the curriculum for an evolving world and workplace. We will highlight the advantages of working with these technologies beyond the realm of teaching, learning and assessment by considering prompt engineering skills, industry impact, curriculum changes, and the need for staff upskilling. In contrast, not engaging strategically with Generative AI poses risks, including falling behind peers, missed opportunities and failing to ensure our graduates remain employable. The rapid evolution of AI technologies necessitates a proactive and strategic approach if we are to remain relevant.
Pollock and Snow "DEIA in the Scholarly Landscape, Session One: Setting Expec...
Pollock and Snow "DEIA in the Scholarly Landscape, Session One: Setting Expec...National Information Standards Organization (NISO)
This presentation was provided by Steph Pollock of The American Psychological Association’s Journals Program, and Damita Snow, of The American Society of Civil Engineers (ASCE), for the initial session of NISO's 2024 Training Series "DEIA in the Scholarly Landscape." Session One: 'Setting Expectations: a DEIA Primer,' was held June 6, 2024.Hindi varnamala | hindi alphabet PPT.pdf
हिंदी वर्णमाला पीपीटी, hindi alphabet PPT presentation, hindi varnamala PPT, Hindi Varnamala pdf, हिंदी स्वर, हिंदी व्यंजन, sikhiye hindi varnmala, dr. mulla adam ali, hindi language and literature, hindi alphabet with drawing, hindi alphabet pdf, hindi varnamala for childrens, hindi language, hindi varnamala practice for kids, https://www.drmullaadamali.com
Digital Artifact 1 - 10VCD Environments Unit
Digital Artifact 1 - 10VCD Environments Unit - NGV Pavilion Concept Design
Assessment and Planning in Educational technology.pptx
In an education system, it is understood that assessment is only for the students, but on the other hand, the Assessment of teachers is also an important aspect of the education system that ensures teachers are providing high-quality instruction to students. The assessment process can be used to provide feedback and support for professional development, to inform decisions about teacher retention or promotion, or to evaluate teacher effectiveness for accountability purposes.
Introduction to AI for Nonprofits with Tapp Network
Dive into the world of AI! Experts Jon Hill and Tareq Monaur will guide you through AI's role in enhancing nonprofit websites and basic marketing strategies, making it easy to understand and apply.
BÀI TẬP BỔ TRỢ TIẾNG ANH 8 CẢ NĂM - GLOBAL SUCCESS - NĂM HỌC 2023-2024 (CÓ FI...
BÀI TẬP BỔ TRỢ TIẾNG ANH 8 CẢ NĂM - GLOBAL SUCCESS - NĂM HỌC 2023-2024 (CÓ FI...Nguyen Thanh Tu Collection
https://app.box.com/s/y977uz6bpd3af4qsebv7r9b7s21935vdHow to Add Chatter in the odoo 17 ERP Module
In Odoo, the chatter is like a chat tool that helps you work together on records. You can leave notes and track things, making it easier to talk with your team and partners. Inside chatter, all communication history, activity, and changes will be displayed.
How to Manage Your Lost Opportunities in Odoo 17 CRM
Odoo 17 CRM allows us to track why we lose sales opportunities with "Lost Reasons." This helps analyze our sales process and identify areas for improvement. Here's how to configure lost reasons in Odoo 17 CRM
A Survey of Techniques for Maximizing LLM Performance.pptx
A Survey of Techniques for Maximizing LLM Performance
Recently uploaded (20)
ISO/IEC 27001, ISO/IEC 42001, and GDPR: Best Practices for Implementation and...
ISO/IEC 27001, ISO/IEC 42001, and GDPR: Best Practices for Implementation and...
বাংলাদেশ অর্থনৈতিক সমীক্ষা (Economic Review) ২০২৪ UJS App.pdf
বাংলাদেশ অর্থনৈতিক সমীক্ষা (Economic Review) ২০২৪ UJS App.pdf
Pride Month Slides 2024 David Douglas School District
Pride Month Slides 2024 David Douglas School District
Pollock and Snow "DEIA in the Scholarly Landscape, Session One: Setting Expec...
Pollock and Snow "DEIA in the Scholarly Landscape, Session One: Setting Expec...
Assessment and Planning in Educational technology.pptx
Assessment and Planning in Educational technology.pptx
Introduction to AI for Nonprofits with Tapp Network
Introduction to AI for Nonprofits with Tapp Network
Liberal Approach to the Study of Indian Politics.pdf
Liberal Approach to the Study of Indian Politics.pdf
BÀI TẬP BỔ TRỢ TIẾNG ANH 8 CẢ NĂM - GLOBAL SUCCESS - NĂM HỌC 2023-2024 (CÓ FI...
BÀI TẬP BỔ TRỢ TIẾNG ANH 8 CẢ NĂM - GLOBAL SUCCESS - NĂM HỌC 2023-2024 (CÓ FI...
How to Manage Your Lost Opportunities in Odoo 17 CRM
How to Manage Your Lost Opportunities in Odoo 17 CRM
A Survey of Techniques for Maximizing LLM Performance.pptx
A Survey of Techniques for Maximizing LLM Performance.pptx
Background Phenylketonuria is an inherited disease which re.pdf
- 1. Background: Phenylketonuria is an inherited disease which results from the lack of the enzyme phenylalanine hydroxylase (PAH). The PAH enzyme catalyzes the first step in the degradation of phenylalanine, as shown in Figure 30.1. In the phenylketonuric patient, phenylalanine accumulates which is eventually transaminated to phenylpyruvate, a phenylketone compound. Excess phenylpyruvate accumulates in the blood and urine and has the effect of causing mental retardation if untreated. Screening programs identify PKU babies at birth, and treatment consists of a low phenylalanine diet until maturation of the brain is completed. The structure and biochemical properties of the PAH enzyme have been well-studied.The gene for PAH has been isolated and has been localized to chromosome 12. The PAH enzyme is a protein 451 amino acids in length with a molecular weight of 51,900 daltons. More than 60 different mutant genes giving rise to nonfunctional PAH proteins have been identified in PKU patients. Question:Kinetic data in which PAH activity is compared with and without preincubation with phenylalanine is shown in Figure 30.3. Give a structural basis for the interpretation of these data. Figure 30.1. Phenylalanine and tyrosine meravurior. an essential cofactor for phenylalanine hydroxylase. 95Figure 30.1. Phenylalanine and tyrosmio ..... an essential cofactor for phenylalanine hydroxylase. 95