1) The document discusses several cases of infants who experienced fractures, retinal hemorrhages, and brain injuries. In each case, the injuries were attributed to Shaken Baby Syndrome but the author argues they were actually due to an autoimmune response triggered by vaccination or infection.
2) The author's hypothesis is that vaccination or infection damages the beta cells in the pancreas, causing hypoinsulinemia. This inhibits cellular uptake of vitamin C, leading to "tissue scurvy" and failure of proteins involved in coagulation. This results in the bruising, bleeding, and fractures seen in the "triad".
3) Blood tests in the cases showed markers of coagulation disorders, vitamin deficiencies, and
Previous year question on osteoporosis based on neet pg, usmle, plab and fmge...Abhishek Gupta
Revision with a Master Quiz of 38 questions based on NEET PG Sample Questions on Osteoporosis from Previous Year NEET PG Online Exams.
http://medicoapps.org
Previous year question on osteoporosis based on neet pg, usmle, plab and fmge...Abhishek Gupta
Revision with a Master Quiz of 38 questions based on NEET PG Sample Questions on Osteoporosis from Previous Year NEET PG Online Exams.
http://medicoapps.org
Abstract—Hutchinson–Gilford Progeria Syndrome is a rare genetic disorder characterized by premature aging involving the skin, bones, heart, and blood vessels. We report a five year old female child with clinical manifestations characteristic of this syndrome. This child had a senile look with large cranium, frontal bossing, sparse light brown hair and dilated visible veins over the scalp. Other features were prominent eyes, beaked nose, micrognathia, sclerodermatous changes in both feet and legs, laxed and atrophic skin over dorsum of both hands and mottled pigmentation over trunk. Decreased high-density lipoprotein (HDL) levels was characteristic of the syndrome. This case is reported for its rarity and uncommon relationship with hypothyroidism.
Abstract—Hutchinson–Gilford Progeria Syndrome is a rare genetic disorder characterized by premature aging involving the skin, bones, heart, and blood vessels. We report a five year old female child with clinical manifestations characteristic of this syndrome. This child had a senile look with large cranium, frontal bossing, sparse light brown hair and dilated visible veins over the scalp. Other features were prominent eyes, beaked nose, micrognathia, sclerodermatous changes in both feet and legs, laxed and atrophic skin over dorsum of both hands and mottled pigmentation over trunk. Decreased high-density lipoprotein (HDL) levels was characteristic of the syndrome. This case is reported for its rarity and uncommon relationship with hypothyroidism.
Taming the ever-evolving Compliance Beast : Lessons learnt at LinkedIn [Strat...Shirshanka Das
Just when you think you have your Kafka and Hadoop clusters set up and humming and you’re well on your path to democratizing data, you realize that you now have a very different set of challenges to solve. You want to provide unfettered access to data to your data scientists, but at the same time, you need to preserve the privacy of your members, who have entrusted you with their data.
Shirshanka Das and Tushar Shanbhag outline the path LinkedIn has taken to protect member privacy in its scalable distributed data ecosystem built around Kafka and Hadoop.
They also discuss three foundational building blocks for scalable data management that can meet data compliance regulations: a centralized metadata system, a standardized data lifecycle management platform, and a unified data access layer. Some of these systems are open source and can be of use to companies that are in a similar situation. Along the way, they also look to the future—specifically, to the General Data Protection Regulation, which comes into effect in 2018—and outline LinkedIn’s plans for addressing those requirements.
But technology is just part of the solution. Shirshanka and Tushar also share the culture and process change they’ve seen happen at the company and the lessons they’ve learned about sustainable process and governance.
widespread epidemic of Zika virus (ZIKV) infection was reported in 2015 in South and Central America and the Caribbean. A major concern associated with this infection is the apparent increased incidence of microcephaly in fetuses born to mothers infected with ZIKV. In this report, we describe the case of an expectant mother who had a febrile illness with rash at the end of the first trimester of pregnancy while she was living in Brazil. Ultrasonography performed at 29 weeks of gestation revealed microcephaly with calcifications in the fetal brain and pla-centa. After the mother requested termination of the pregnancy, a fetal autopsy was performed. Micrencephaly (an abnormally small brain) was observed, with almost complete agyria, hydrocephalus, and multifocal dystrophic calcifications in the cortex and subcortical white matter, with associated cortical displacement and mild focal inf lammation. ZIKV was found in the fetal brain tissue on reverse-transcriptase–polymerase-chain-reaction (RT-PCR) assay, with consistent findings on electron microscopy. The complete genome of ZIKV was recovered from the fetal brain
A much-quoted aphorism in medicine is “Listen to your patient and they are telling you the diagnosis”. Most often, the history reveals the diagnosis and sometimes, it is all that is required to make the diagnosis. Unfortunately, in this age of modern technology-based medicine, many busy clinicians fail to get a proper history and miss important dots in the history that connect to the diagnosis. This is clinically relevant, as a specific diagnosis completely alters the nature of treatment and thereby improves prognosis.
After watching this lecture, learners will be able to:
Describe the various etiologies of non-traumatic paralysis
Illustrate the neuro exam for the paralyzed patient
Recognize the signs and symptoms of acute peripheral neuropathies
Explain the treatment of acute peripheral neuropathies
A ten-year-old boy is brought to clinic by his mother who stat.docxmakdul
A ten-year-old boy is brought to clinic by his mother who states that the boy has been listless and not eating. She also notes that he has been easily bruising without trauma as he says he is too tired to go out and play. He says his bones hurt sometimes. Mother states the child has had intermittent fevers that respond to acetaminophen. Maternal history negative for pre, intra, or post-partum problems. Child’s past medical history negative and he easily reached developmental milestones. Physical exam reveals a thin, very pale child who has bruises on his arms and legs in no particular pattern. The APRN orders complete blood count (CBC), and complete metabolic profile (CMP). The CBC revealed Hemoglobin of 6.9/dl, hematocrit of 19%, and platelet count of 80,000/mm3. The CMP demonstrated a blood urea nitrogen (BUN) of 34m g/dl and creatinine of 2.9 mg/dl. The APRN recognizes that the patient appears to have acute leukemia and renal failure and immediately refers the patient to the Emergency Room where a pediatric hematologist has been consulted and is waiting for the boy and his mother. The diagnosis of acute lymphoblastic leukemia (ALL) was made after extensive testing.
Question 1 of 2:
What is ALL?
--
QUESTION 2
A ten-year-old boy is brought to clinic by his mother who states that the boy has been listless and not eating. She also notes that he has been easily bruising without trauma as he says he is too tired to go out and play. He says his bones hurt sometimes. Mother states the child has had intermittent fevers that respond to acetaminophen. Maternal history negative for pre, intra, or post-partum problems. Child’s past medical history negative and he easily reached developmental milestones. Physical exam reveals a thin, very pale child who has bruises on his arms and legs in no particular pattern. The APRN orders complete blood count (CBC), and complete metabolic profile (CMP). The CBC revealed Hemoglobin of 6.9/dl, hematocrit of 19%, and platelet count of 80,000/mm3. The CMP demonstrated a blood urea nitrogen (BUN) of 34m g/dl and creatinine of 2.9 mg/dl. The APRN recognizes that the patient appears to have acute leukemia and renal failure and immediately refers the patient to the Emergency Room where a pediatric hematologist has been consulted and is waiting for the boy and his mother. The diagnosis of acute lymphoblastic leukemia (ALL) was made after extensive testing.
Question 2 of 2:
How does renal failure occur in some patients with ALL?
QUESTION 3
A 12-year-old female with known sickle cell disease (SCD) present to the Emergency Room in sickle cell crisis. The patient is crying with pain and states this is the third acute episode she has had in the last nine months. Both parents are present and appear very anxious and teary eyed. A diagnosis of acute sickle cell crisis was made. Appropriate therapeutic interventions were initiated by the APRN and the patient’s pain level decreased, and she was transferre.
NURS 6501
Knowledge Check: Module 8
Student Response
This Knowledge Check reviews the topics in Module 8 and is formative in nature. It is worth 20 points where each question is worth 1 point. You are required to submit a sufficient response of at least 2-4 sentences in length for each question.
Scenario 1: Acute Lymphoblastic Leukemia (ALL)
A ten-year-old boy is brought to clinic by his mother who states that the boy has been listless and not eating. She also notes that he has been easily bruising without trauma as he says he is too tired to go out and play. He says his bones hurt sometimes. Mother states the child has had intermittent fevers that respond to acetaminophen. Maternal history negative for pre, intra, or post-partum problems. Child’s past medical history negative and he easily reached developmental milestones. Physical exam reveals a thin, very pale child who has bruises on his arms and legs in no particular pattern. The APRN orders complete blood count (CBC), and complete metabolic profile (CMP). The CBC revealed Hemoglobin of 6.9/dl, hematocrit of 19%, and platelet count of 80,000/mm3. The CMP demonstrated a blood urea nitrogen (BUN) of 34m g/dl and creatinine of 2.9 mg/dl. The APRN recognizes that the patient appears to have acute leukemia and renal failure and immediately refers the patient to the Emergency Room where a pediatric hematologist has been consulted and is waiting for the boy and his mother. The diagnosis of acute lymphoblastic leukemia (ALL) was made after extensive testing.
Question 1 of 2:
What is ALL?
<Type your response here> Acute lymphoblastic leukemia (ALL) is most common in children and adolescents, ALL represents about 75% of all childhood and 67% of all adolescent leukemia cases blood and bone marrow that affects white blood cells. It occurs when a bone marrow cell develops errors in its DNA and affects the white blood cells. A sibling with acute lymphocytic leukemia have an increased risk of ALL
Question 2 of 2:
How does renal failure occur in some patients with ALL?
<Type your response here> renal failure occurs in patients with acute leukemia because of the outcome of the chemotherapeutic regimen, including leukemic infiltration of the kidneys, therapy-related side effects such as tumor lysis syndrome, nephrotoxic drugs, and septicemias.
Scenario 2: Sickle Cell Disease (SCD)
A 12-year-old female with known sickle cell disease (SCD) present to the Emergency Room in sickle cell crisis. The patient is crying with pain and states this is the third acute episode she has had in the last nine months. Both parents are present and appear very anxious and teary eyed. A diagnosis of acute sickle cell crisis was made. Appropriate therapeutic interventions were initiated by the APRN and the patient’s pain level decreased, and she was transferred to the pediatric intensive care unit (PICU) for observation and further management.
Question 1 of 2:
What is the pathophysiology of acute SCD crisis and ...
Everyone agrees that all children react differently to shots, and some kids will have bad reactions. There cannot be compulsory vaccination in absence of controlled clinical trials of the childhood vaccine schedule.
Clinical Case of Post-Vaccination Measles Followed By Severe Neutropeniainventionjournals
We present a 13 - month old girl, who develop a post vaccination measles infection after a MMR vaccine , followed by a severe neutropenia. The hematological changes last more than one year and resolved spontaneously. We report the clinical case as an extremely rare and unknown side effect of the vaccine.
www.AreVaccinesSafe.com
Mary Tocco has been independently researching the topic of “ Are Vaccines Safe? “ and many other health care questions that face the American Family. Mary has a DVD " Are Vaccines Safe? " that covers the many questions parents have about vaccines, and many more issues related to vaccines.
If you have any questions or would like to purchase " Are Vaccines Safe? " visit www.AreVaccinesSafe.com or e-mail Mary@marytocco.com
micro teaching on communication m.sc nursing.pdfAnurag Sharma
Microteaching is a unique model of practice teaching. It is a viable instrument for the. desired change in the teaching behavior or the behavior potential which, in specified types of real. classroom situations, tends to facilitate the achievement of specified types of objectives.
Explore natural remedies for syphilis treatment in Singapore. Discover alternative therapies, herbal remedies, and lifestyle changes that may complement conventional treatments. Learn about holistic approaches to managing syphilis symptoms and supporting overall health.
New Directions in Targeted Therapeutic Approaches for Older Adults With Mantl...i3 Health
i3 Health is pleased to make the speaker slides from this activity available for use as a non-accredited self-study or teaching resource.
This slide deck presented by Dr. Kami Maddocks, Professor-Clinical in the Division of Hematology and
Associate Division Director for Ambulatory Operations
The Ohio State University Comprehensive Cancer Center, will provide insight into new directions in targeted therapeutic approaches for older adults with mantle cell lymphoma.
STATEMENT OF NEED
Mantle cell lymphoma (MCL) is a rare, aggressive B-cell non-Hodgkin lymphoma (NHL) accounting for 5% to 7% of all lymphomas. Its prognosis ranges from indolent disease that does not require treatment for years to very aggressive disease, which is associated with poor survival (Silkenstedt et al, 2021). Typically, MCL is diagnosed at advanced stage and in older patients who cannot tolerate intensive therapy (NCCN, 2022). Although recent advances have slightly increased remission rates, recurrence and relapse remain very common, leading to a median overall survival between 3 and 6 years (LLS, 2021). Though there are several effective options, progress is still needed towards establishing an accepted frontline approach for MCL (Castellino et al, 2022). Treatment selection and management of MCL are complicated by the heterogeneity of prognosis, advanced age and comorbidities of patients, and lack of an established standard approach for treatment, making it vital that clinicians be familiar with the latest research and advances in this area. In this activity chaired by Michael Wang, MD, Professor in the Department of Lymphoma & Myeloma at MD Anderson Cancer Center, expert faculty will discuss prognostic factors informing treatment, the promising results of recent trials in new therapeutic approaches, and the implications of treatment resistance in therapeutic selection for MCL.
Target Audience
Hematology/oncology fellows, attending faculty, and other health care professionals involved in the treatment of patients with mantle cell lymphoma (MCL).
Learning Objectives
1.) Identify clinical and biological prognostic factors that can guide treatment decision making for older adults with MCL
2.) Evaluate emerging data on targeted therapeutic approaches for treatment-naive and relapsed/refractory MCL and their applicability to older adults
3.) Assess mechanisms of resistance to targeted therapies for MCL and their implications for treatment selection
Recomendações da OMS sobre cuidados maternos e neonatais para uma experiência pós-natal positiva.
Em consonância com os ODS – Objetivos do Desenvolvimento Sustentável e a Estratégia Global para a Saúde das Mulheres, Crianças e Adolescentes, e aplicando uma abordagem baseada nos direitos humanos, os esforços de cuidados pós-natais devem expandir-se para além da cobertura e da simples sobrevivência, de modo a incluir cuidados de qualidade.
Estas diretrizes visam melhorar a qualidade dos cuidados pós-natais essenciais e de rotina prestados às mulheres e aos recém-nascidos, com o objetivo final de melhorar a saúde e o bem-estar materno e neonatal.
Uma “experiência pós-natal positiva” é um resultado importante para todas as mulheres que dão à luz e para os seus recém-nascidos, estabelecendo as bases para a melhoria da saúde e do bem-estar a curto e longo prazo. Uma experiência pós-natal positiva é definida como aquela em que as mulheres, pessoas que gestam, os recém-nascidos, os casais, os pais, os cuidadores e as famílias recebem informação consistente, garantia e apoio de profissionais de saúde motivados; e onde um sistema de saúde flexível e com recursos reconheça as necessidades das mulheres e dos bebês e respeite o seu contexto cultural.
Estas diretrizes consolidadas apresentam algumas recomendações novas e já bem fundamentadas sobre cuidados pós-natais de rotina para mulheres e neonatos que recebem cuidados no pós-parto em unidades de saúde ou na comunidade, independentemente dos recursos disponíveis.
É fornecido um conjunto abrangente de recomendações para cuidados durante o período puerperal, com ênfase nos cuidados essenciais que todas as mulheres e recém-nascidos devem receber, e com a devida atenção à qualidade dos cuidados; isto é, a entrega e a experiência do cuidado recebido. Estas diretrizes atualizam e ampliam as recomendações da OMS de 2014 sobre cuidados pós-natais da mãe e do recém-nascido e complementam as atuais diretrizes da OMS sobre a gestão de complicações pós-natais.
O estabelecimento da amamentação e o manejo das principais intercorrências é contemplada.
Recomendamos muito.
Vamos discutir essas recomendações no nosso curso de pós-graduação em Aleitamento no Instituto Ciclos.
Esta publicação só está disponível em inglês até o momento.
Prof. Marcus Renato de Carvalho
www.agostodourado.com
These lecture slides, by Dr Sidra Arshad, offer a quick overview of physiological basis of a normal electrocardiogram.
Learning objectives:
1. Define an electrocardiogram (ECG) and electrocardiography
2. Describe how dipoles generated by the heart produce the waveforms of the ECG
3. Describe the components of a normal electrocardiogram of a typical bipolar leads (limb II)
4. Differentiate between intervals and segments
5. Enlist some common indications for obtaining an ECG
Study Resources:
1. Chapter 11, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 9, Human Physiology - From Cells to Systems, Lauralee Sherwood, 9th edition
3. Chapter 29, Ganong’s Review of Medical Physiology, 26th edition
4. Electrocardiogram, StatPearls - https://www.ncbi.nlm.nih.gov/books/NBK549803/
5. ECG in Medical Practice by ABM Abdullah, 4th edition
6. ECG Basics, http://www.nataliescasebook.com/tag/e-c-g-basics
Prix Galien International 2024 Forum ProgramLevi Shapiro
June 20, 2024, Prix Galien International and Jerusalem Ethics Forum in ROME. Detailed agenda including panels:
- ADVANCES IN CARDIOLOGY: A NEW PARADIGM IS COMING
- WOMEN’S HEALTH: FERTILITY PRESERVATION
- WHAT’S NEW IN THE TREATMENT OF INFECTIOUS,
ONCOLOGICAL AND INFLAMMATORY SKIN DISEASES?
- ARTIFICIAL INTELLIGENCE AND ETHICS
- GENE THERAPY
- BEYOND BORDERS: GLOBAL INITIATIVES FOR DEMOCRATIZING LIFE SCIENCE TECHNOLOGIES AND PROMOTING ACCESS TO HEALTHCARE
- ETHICAL CHALLENGES IN LIFE SCIENCES
- Prix Galien International Awards Ceremony
Title: Sense of Smell
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the primary categories of smells and the concept of odor blindness.
Explain the structure and location of the olfactory membrane and mucosa, including the types and roles of cells involved in olfaction.
Describe the pathway and mechanisms of olfactory signal transmission from the olfactory receptors to the brain.
Illustrate the biochemical cascade triggered by odorant binding to olfactory receptors, including the role of G-proteins and second messengers in generating an action potential.
Identify different types of olfactory disorders such as anosmia, hyposmia, hyperosmia, and dysosmia, including their potential causes.
Key Topics:
Olfactory Genes:
3% of the human genome accounts for olfactory genes.
400 genes for odorant receptors.
Olfactory Membrane:
Located in the superior part of the nasal cavity.
Medially: Folds downward along the superior septum.
Laterally: Folds over the superior turbinate and upper surface of the middle turbinate.
Total surface area: 5-10 square centimeters.
Olfactory Mucosa:
Olfactory Cells: Bipolar nerve cells derived from the CNS (100 million), with 4-25 olfactory cilia per cell.
Sustentacular Cells: Produce mucus and maintain ionic and molecular environment.
Basal Cells: Replace worn-out olfactory cells with an average lifespan of 1-2 months.
Bowman’s Gland: Secretes mucus.
Stimulation of Olfactory Cells:
Odorant dissolves in mucus and attaches to receptors on olfactory cilia.
Involves a cascade effect through G-proteins and second messengers, leading to depolarization and action potential generation in the olfactory nerve.
Quality of a Good Odorant:
Small (3-20 Carbon atoms), volatile, water-soluble, and lipid-soluble.
Facilitated by odorant-binding proteins in mucus.
Membrane Potential and Action Potential:
Resting membrane potential: -55mV.
Action potential frequency in the olfactory nerve increases with odorant strength.
Adaptation Towards the Sense of Smell:
Rapid adaptation within the first second, with further slow adaptation.
Psychological adaptation greater than receptor adaptation, involving feedback inhibition from the central nervous system.
Primary Sensations of Smell:
Camphoraceous, Musky, Floral, Pepperminty, Ethereal, Pungent, Putrid.
Odor Detection Threshold:
Examples: Hydrogen sulfide (0.0005 ppm), Methyl-mercaptan (0.002 ppm).
Some toxic substances are odorless at lethal concentrations.
Characteristics of Smell:
Odor blindness for single substances due to lack of appropriate receptor protein.
Behavioral and emotional influences of smell.
Transmission of Olfactory Signals:
From olfactory cells to glomeruli in the olfactory bulb, involving lateral inhibition.
Primitive, less old, and new olfactory systems with different path
NVBDCP.pptx Nation vector borne disease control programSapna Thakur
NVBDCP was launched in 2003-2004 . Vector-Borne Disease: Disease that results from an infection transmitted to humans and other animals by blood-feeding arthropods, such as mosquitoes, ticks, and fleas. Examples of vector-borne diseases include Dengue fever, West Nile Virus, Lyme disease, and malaria.
These simplified slides by Dr. Sidra Arshad present an overview of the non-respiratory functions of the respiratory tract.
Learning objectives:
1. Enlist the non-respiratory functions of the respiratory tract
2. Briefly explain how these functions are carried out
3. Discuss the significance of dead space
4. Differentiate between minute ventilation and alveolar ventilation
5. Describe the cough and sneeze reflexes
Study Resources:
1. Chapter 39, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 34, Ganong’s Review of Medical Physiology, 26th edition
3. Chapter 17, Human Physiology by Lauralee Sherwood, 9th edition
4. Non-respiratory functions of the lungs https://academic.oup.com/bjaed/article/13/3/98/278874
Ocular injury ppt Upendra pal optometrist upums saifai etawah
Autoimmunity and non
1. Michael D Innis
Retired Haematologist, Princess Alexandra Hospital, Brisbane,Australia
Email address:
micinnis@bigpond.comMichael D. Innis
To cite this article:
Michael D InnisAutoimmunity and non-Accidental Injury in ChildrenClinical Medicine Research.MM-DD-2013, pp. x-x.
doi:10.11648/j.xxx.xxxxxxxx.xx
Abstract:
Background: The Shaken Baby Syndrome conceived by Guthkeltch to explain bruises, fractures, retinal and cerebral
haemorrhage and encephalopathy in children, called the ―triad‖, can be explained by an autoimmune reaction to antigens in
a genetically susceptible child.
Method: Children diagnosed as suffering from Non-accidental injuries were investigated for evidence of immune response
reactions following mandated vaccination and childhood illnesses.
Results: It was found in all the cases reported here the response to antigenic stimulation damaged the Beta cells in the
Pancreas causing Hypoinsulinaemia which inhibited the cellular uptake of Vitamin C resulting in liver dysfunction, failure
of carboxylation of the Vitamin K dependent proteins resulting in haemorrhages and fractures associated with the ―triad‖.
Conclusion: Fractures, retinal and subdural haemorrhages and encephalopathy in children – is an autoimmune response to
antigenic stimulation in a genetically susceptible individual. Common antigens are the mandated vaccines, viral bacterial
and parasitic infections.
Keywords: Shaken Baby Non-accidental Injury Triad
1. Introduction
A Psychologist, Ms Lisa Blakemore Brown, was the first to
draw attention to the injustice caused by the medical
profession‘s reliance on the diagnosis ―Munchausen
Syndrome by Proxy (MSBP) [1] when evaluating a
mother‘s concerns for her child. This diagnosis served
especially useful when the doctor could not explain a
child‘s bruise or fracture and refused to accept the mother‘s
version of events that the injuries followed mandated
immunization [2].
A 15 year old boy was found dead in his bed a week before
Christmas in 1994, 10 days after receiving the MR vaccine
at school. An inquest held in 1995 concluded that he died
from an epileptic fit, even though there had been no
personal or family history of epilepsy. Northern Ireland
Attorney General John Larkin QC, ordered a second
inquest stating, ―I consider it to be of enormous public
importance that the possible role of the MR vaccine in the
death of an apparently healthy boy be fully explored.‖[3]
Regarding the MMR/MR vaccine Wakefield and his
colleagues were the first to report methylmalonic acid in
the urine of autistic children and those with ASD who had
been given the vaccine. Urinary mehylmalonic acid was
significantly raised in all eight children who were tested,
compared with age matched conrols (p=0.003) [4].
Methymalonic acid in the urine is a marker of Viamin B12
deficiency resulting from an autoimmune destruction of the
Parietal cells of the stomach which produce Intrinsic Factor
required for the absorption of Vitamin B12 in the food.
Vitamin B12 deficiency causes demyelination of the
Central Nervous System and this explains the sensory,
motor and psychological symptoms of autism and would
also explain the death of the 15 year old boy.
Dr Jane Orient stated that mandatory vaccination is the
leading edge of the new ethic. The policy to require annual
influenza vaccination as a condition of working in a
medical facility illustrates the dogmatism of the public
health model and how it trumps individual autonomy, the
Hippocratic ethic, and also evidence-based medicine [5] a
view further explored here.
Dr Archivides ―Archie‖ Kalokerinos, while a General
Practitioner in rural Australia, observed that Aboriginal
children when vaccinated with the mandated vaccines
frequently developed the signs of scurvy and many died.
He reduced the death rate by avoiding immunization of
unwell children and by administering Vitamin C prior to
vaccinating them. His book ―Every Second Child‖ [6]
records his experiences. He was the first to recognize the
part played by vaccines as a cause of infantile scurvy. He
said, ―during one trial the prosecution said scurvy was no
longer seen. I replied – Yes it is. But it is not called
‗scurvy‘ it is called Shaken Baby Syndrome‖.
Professor Alan Clemetson related the signs and symptoms
of the ―triad‖ consisting of retinal haemorrhages, subdural
haematoma and encephalopathy to histamineaemia
following vaccination [7] and similar views had been
expressed by Gardner [8]. These authors have provided
alternative explanations for the ―Shaken Baby Syndrome‖
theory postulated by Guthkelch[9] and their views are
explored further.
2. 2. Method
Here it is shown that vaccines, and other forms of antigenic
stress damage the Beta cells of the islets of Langerhans and
the resulting hypoinsulinaemia, manifested in these cases
by hyperglycaemia, inhibits the cellular uptake of Vitamin
C where it functions as an electron donor for important
enzymes [10].causing ―tissue scurvy‖[11] – deficient
Vitamin C in the cells. .
Normally insulin binds to its receptor on the cell surface
and initiates a chain of events that leads to the insertion in
the plasma membrane of a transmembrane glucose
transporter called GLUT 4 which facilitates the transport of
glucose and other nutrients into the cell [11]. It is the
failure of this process, because of the lack of Insulin, which
prevents the entry of Vitamin C into the cell and causes
―tissue scurvy.‖ Tissue scurvy, when it involves the cells of
the liver leads to under carboxylation of the coagulation
factors and osteocalcin resulting in bruises, haemorrhages
and fractures [12].
This report explores the pathogenesis of the ―triad‖ and
concludes infections and antigenic stimulation of the
immune system by vaccines do indeed play a major role in
the pathogenesis of the ―triad‖ by inducing autoimmune
diabetes and associated Tissue Scurvy misdiagnosed as
Shaken Baby Syndrome, Abusive Head Trauma, Inflicted
Brain Injury and Non-accidental Injury.
3. Results
3.1. Case 1
A five month old infant, vaccinated with the usual
mandated vaccines four weeks earlier, was fed by the father
and put to bed. He was asleep for about 10-15 minutes
before the father heard the infant gasping for breath. He
immediately called the Emergency Medical Service.
The Ambulance arrived in about 10 minutes after the call
and transported the child to the Hospital where a Clinical
Investigation and Radiological examination revealed the
child had suffered a subdural haematoma.
Blood Tests showed:
1. Prothrombin Time 17.3 seconds (control 11.9 – 14.2)
2. International Normalized Ratio (INR) 1.46 (control
0.89 – 1.12)
3. Glucose 102 mg/dL (control 65-95)
4. Creatinine 0.3 mg/dL (control 0.5 -1.3)
5. Lactate 2.3 mmol/L (control 0.5 -1.6)
6. BUN/Creatine 35 (control 10-20)
7. Total Haemoglobin 6.8 g/dL (control 10.0-14.0)
8. Phosphorus 5.4 mg/dL (control 2.5- 4.5mg/dL)
Retinal haemorrhages were observed in the infant‘s left
eye and the infant‘s injuries were diagnosed as evidence of
the Shaken Baby Syndrome and reported by the Surgeon to
the appropriate authority who instituted Legal Proceedings.
It is clear from the Blood Tests that this child needed
urgent treatment of the Coagulation Disorder, Vitamin K
Deficiency, from which he was suffering and Vitamin K
was administered by intramuscular injection. Surgery was
performed and the subdural haematoma removed. The child
slowly recovered.
3.2. Case 2.
The second child of a 34 year old mother was born by
normal vaginal delivery and weighed 6lbs 13oz she was
breast fed and appeared to be progressing satisfactorily and
was immunized with the mandated vaccines at the age of 3
weeks. Following this, at the age of 7 weeks the child
began crying incessantly. The father attempted to comfort
her but she suddenly became limp, stopped breathing and
was rushed to hospital where resuscitation efforts were
commenced.
Investigations included:
1. Skeletal survey which showed.
a. Right parietal skull fracture
b. Right 6th and 7th rib fractures
2. CT of brain
a.5mm right parietal temporal subdural
haematoma
b. Cerebral oedema.
3. Blood Tests
a. Albumin 2.2 gm/dL
control 2.8 – 5.0
b. BUN/Creatine 50
5 - 35
c. Glucose 347 mg/dL
70 -105
d. Amylase 7 U/L
39 -214
e. Lipase 13UL
22 - 51
f. Haemoglobin 7.9g/dL
9.0 – 12.3
g. Platelets 512 K/UL
295 – 465
h. Prothrombin Time 15.4 sec 11.5 – 14.0
i. Fibrinogen 148 mg/dL
180 – 490
4. Urine Tests
a. Specific gravity 1.023
control 1.005 -1.03
b. Glucose
>1000mg/dL
0.00
Resuscitation efforts included mechanical ventilation and
endotracheal intubation but the infant expired after a
period of 11days.
An autopsy was performed and the result reads:
―OPINION: It is our opinion that ----- , a 71/2
week old white female infant, died as a result of
Craniocerebral Injuries. At autopsy injuries
included a skull fracture with an overlying scalp
contusion. There was evidence of subdural
haemorrhages, subarachnoid haemorrhages as well
as brain parenchymal injuries.
A complete autopsy to include NeoGen studies,
toxicology
studies,
microscopic
tissue
examination, and x-rays was performed.
The manner of death is to be determined by the
Justice of the Peace‖.
The document is signed by 5 doctors.
3.3. Case 3
3. The child was one of triplets born after a 32 week gestation
and weighed 1560 gm. He was kept in the Intensive Care
Unit, suffered from Respiratory Distress Syndrome and
was placed on a respirator for three weeks. He was given
an injection of Vitamin K shortly after birth.
He was Formula fed and his progress was satisfactory and
at the age of 4 months he was given the routine vaccines.
Eight days following his vaccination he became irritable
and began crying and by the tenth day he was inconsolable
and refused his feeds.
That evening the mother noticed him struggling for breath
and he became limp, No time was lost in taking him to the
nearest Hospital where a CT scan showed a right subdural
haematoma.
A Blood Report showed:
1.Prothrombin Time 14.4 seconds Normal Range 10.8
-13.7
2.PartialThromboplastinTime44.6seconds 26.1 – 35.0
3.Platelets491K/mm3
150 – 450
4.Glucose153mg/dL
70 – 110,
B. Ophthalmoscopic Examination
Bilateral Retinal Haemorrhages
C. Skeletal Survey
No definite fractures either acute or old. However slight
irregularity of the distal left ulnar metaphysis as well as a
small lucancy through the lateral aspect of the distal right
tibia.
According to the father the possibility of the child having a
Non-accidental Injury was discussed because of the
subdural haematoma, bilateral retinal haemorrhages and the
irregular left ulnar metaphysis but it was not pursued as the
child slowly recovered,
3.4. Case 4
Birth Record
This child was born via vaginal delivery after a gestation
period of 31 weeks. She was placed in the Neonatal
Intensive Care Unit and required Continuous Positive
Airway Pressure. Her birth weight was 1300 grams.
Progress
Progress was satisfactory until at the age of 3 months,
when 18 days following her routine immunizations, her
mother noticed her mouth was bleeding and on looking into
the infant‘s mouth saw a lesion under the tongue which she
thought was due to Thrush. The mother gave her a dose of
Tylenol but the child continued to be ―fussy‖, had difficulty
in breathing, and was taken to the hospital Emergency
Room.
On examination she had an Oxygen saturation of 100%
on room air, mild retractions, shallow breathing,
tachypnoea, 6mm tear distal to the frenulum without active
bleeding,andpetechiae on the left arm and right thigh.
Investigations
1. A pediagram showed multiple rib fractures, left tibial
and left femur fractures.
2. Blood Chemistry
a. Creatinine 0.1 mg/dL
Control 0.4 – 1.2
b. Glucose
113 mg/dL
70 – 99
c. Total Protein 5.7 g/dL
6.4 – 8.4
d. Albumin
e. ALT
f. AST
3.4 g/dL
140 unit/L
46 unit/L
3.8 – 5.4?
0 – 65
0 – 37
Case 5Case 5
Birth
Carol, not her real name, the second child of a 24
year old mother who smoked throughout her pregnancy
was born by spontaneous vaginal delivery at full term. Her
Apgar scores were 8 at 1 minute, 10 at 5 minutes and 10 at
10 minutes and she weighed 2.79 kg and was given an
intramuscular injection of Vitamin K
Carol was Formula fed and appeared to be
progressing satisfactorily when seen at her 6 week
assessment where she received her 1stimmunizations
ofDTaP and Meningitis vaccine
Progress
Three days after these immunizations she started
vomiting and refused her feeds. The parents were
concerned at the appearance of two small finger-tip bruises
on her arm and took her to her GP who assured the parents
there was no cause for alarm.
Carol continued to be sickly and was fed with
difficulty and a visiting nursing note says, ―feeding well
with firm handling‖. Small frequent feeds were advised.
At the age of 6 weeks she was being fed by her
father when she suddenly ―spluttered some droplets of
milk out of her mouth, made a strange wheezing noise as if
she was both blowing and sucking at the same time. Her
eyes started to shut and rolled back and she went limp and
stopped breathing.
The Emergency Service were alerted and arrived
within a few minutes and artificial respiration restored
normal breathing. She was taken to the local Hospital
where she was intubated and a series of investigations
commenced.
Raddiology.
1. X-ray upper abdomen, chest and both obliques of the
chest.
a. Displaced healing fracture of the right clavicle
b. Fractures of the 6th,7th, 8th and 9th ribs next
to the spine.
2. Skull X-Ray Widening of the sutures. No
fracture seen.
3. Brain Scan. Moderate parafalcine
subdural haemorrhage
Blood Count
Haemoglobin 9.1 g/dL
Normal Range 10.0 –
13.5Platelets
741 x109 /L
150 --450
Coagulation Screen
ProthrombinTime 15.1secs
8.2—14.1
Fibrinogen
1.6 g/L
1.70----4.0
Blood Tests
Albumin
28 g/L
35 –55
Alkaline Phosphatase
321 U/L
65---265
4. Alanine Transaminase
59 U/L
5----45
Lactate
6.6 mmol/L
1.1---2.2
Urine
Ptorein
Trace by Multistix
Glucose
+ by Multistix
Blood
Trace by Multistix
Attempts at resuscitation failed. A Postmortem
examination was carried out and Death was attributed to
Non-accidental Injury and the father was arrested and
charged with the murder of the child.
Trial
Prosecution Witnesses
1st Consultant Radiologist (Expert witness for the
Posecution) Summary:
―This child has suffered multiple episodes of
physical injury includinsg
Rib fractures of three different ages in
multiple sites due to squeezing
Metaphyseal limb fractures in
mu;tiplesitesof at least two different ages
due to gripping andtwisting (or flailing)
injuries
An old clavicular fracture probably due
to direct trauma
A subdural haematoma due to
shaking(and/or impact if fracture is
proven) in the day prior to collapse at
home
A final event leading to cardiorespiratory
arrest at home, leading to death.‖
2nd Consultant Radiologist
―In my opinion, the total constellation of
the injuries is entirely typical of nonaccidental injury and that is taking into
account the mechanism of causation of
most of the injuries ‖
Consultant Haematologist.
Ther are no haematological disorders
which would explain the bony
abnormalities in this child.
Defence Witnesses
Reduced levels of Albumin and
Fibrinogen together with Increased
Alanine Transaminase were evidence
of Liver dysfunction and the Increase
in ProthrombinTime were supportive
evidence of a deficiency of Vitamin K
Verdict
The Judge recognized the father as a loving
caring honourable man who would never injury
anyone, least of all his own child and he dismissed the
charge and gave his verdict of Not Guilty.
However the Prosecution Radiologists and
Haematologist had convinced him the child’s injuries
had been inflicted and he instructed the search for the
killer should continue.
In cases such as this when the Judge is presented
opposing opinions of the Prosecution and Defence ,. it
would seem fairer to accept the evidence of the accused
as it is impossible for anyone untrained in the subtleties
of differential diagnosis to assess the relevance of either
the argument of the prosecution or that of the defence.
This is a classical example of the current “main stream”
view which ignores the possibility of a deficiency of
Vitamin C or K as the cause of both fractures and
haemorrhage in a child in spite of the clear evidence of
a nutritional defect.
4. Interpretation
In all four cases shown here there is evidence that
hyperglycaemia followed vaccination and hyperglycaemia
implies hypoinsulinism, an autoimmune disorder resulting
from the destruction of the Beta cells of the pancreas. Since
insulin is required for the transfer of vitamin C into the
cells the intracellular vitamin C is reduced [12]. The
resulting ―tissue scurvy‖ compromises the function of the
Liver by inhibiting carboxylation of the clotting and bone
forming factors and is manifested as the signs and
symptoms of the ―triad‖.
Both Dr Kalokerinos and Professor Clemetson
recommended giving the infant Vitamin C before
vaccination but it would seem more appropriate to do an
intradermal skin test to test for sensitivity in every case.
Both were firmly of the view that a metabolic abnormality
of Vitamin C was the essential cause of the signs and
symptoms of the alleged ―Non-accidental injuries‖.
Contrary views have recently been expressed by Sheets, L.
K. et al 2013.Sentinel Injuries in Infants Evaluated for
Child
Physical
Abuse,
Pediatrics,
11
March.http://pediatrics.aappublications.org/content/early/2
013/03/06/peds.2012-2780and by Dr Angelo P Giardino in
Medscape April 1 2013.
Both these reports repeat the arguments of their
predecessors without providing any scientific evidence for
their opinions.
While the only antigen examined in these findings is
limited to mandated vaccines it is clear that numerous viral,
bacterial, parasitic and chemical antigens could generate an
autoimmune response and affect other tissues such as the
nervous system and cause Autism.
I conclude the warnings of Ms Lisa Blakemore Brown to
ignore the Munchausan Syndrome By Proxy is sound
advice and the views of Dr Archie Kalokerinos and
Professor Alan Clemetson on the subject of ―unexplained
injuries‖ are valid and it is time the governments of the
UK, USA, Canada and Australia ban the diagnoses Shaken
Baby Syndrome and any of its ―morphs‖ and restore Justice
to the Legal Systems of the Country.
Acknowledgments
5. I wish to acknowledge the help I received from the late
Professor Alan Clemetson and the late Dr Archie
Kalokerinos both of whom sent me copies of their
publications. I also wish to thank the parents of the children
reported here who provided me with the information
recorded.
References
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