1) Seven days of ingesting ASEA caused extensive mobilization of free fatty acids from adipose tissue in cyclists. This led to increased fat oxidation and sparing of amino acids and muscle glycogen during a 75km cycling trial.
2) ASEA intake was associated with increased serum levels of ascorbic acid, likely from the adrenal cortex, as well as higher levels of Krebs cycle intermediates post-exercise indicating increased fat metabolism.
3) The shifts in metabolites suggest ASEA supplementation may impact inflammation, oxidative stress, and physiologic stress through effects on fatty acid and amino acid metabolism. Further investigation is needed to understand other metabolic changes observed.
http://www.RedoxSignalingMolecules.ca - Frequently Asked Questions (And Answers)
1. What is ASEA?
ASEA is an immune boosting molecular complex consisting of reactive molecules, all native to the human body and naturally balanced. These molecules include a perfect balance of antioxidant enhancers that are balanced to support the immune system, detoxify the body and protect and fortify healthy tissue.
2. What Are Reactive Molecules?
Reactive molecules are either active electron acceptors (prone to take on electrons) or electron donors (prone to give up electrons). When these two classes of molecules are chemically balanced in our body, our immune systems can function at its optimal level.
3. How Do These Reactive Molecules Work?
There are two major roles for these reactive molecules in the body. First, they pair up with the natural antioxidants already in our body to help detoxify and fortify healthy tissue. Secondly, they supply the raw materials that the immune system needs in order to perform its natural function to detect and destroy harmful invaders and damaged cells.
4. How Much ASEA Should I Take?
ASEA has been proven to be entirely non-toxic at any reasonable dose. It can be taken orally, applied topically or inhaled without causing irritation. The recommended maintenance amount is 4 oz. per day for adults. ASEA is not recommended for pregnant or breastfeeding women. Consult with a physician if you are sensitive to salt intake.
5. Can I Apply ASEA To My Skin, Scrapes, Cuts, Or Burns?
ASEA is a natural disinfectant and antimicrobial and yet is soothing to the touch. ASEA can be used in a spray bottle for use on scrapes, burns and abrasions and can be liberally sprayed on the skin and will not cause irritation. ASEA contains a very small amount of chlorine. If you are allergic to chlorine, it is not recommended for use on the face. As always, consult a physician if there are any concerns.
6. Is ASEA Safe?
Testing has shown ASEA to be entirely safe and non-toxic no matter how it is consumed or applied. It has shown literally zero endotoxicity, cytotoxicity, and genotoxicity (mutagenic properties) in all 16 years of studies that were performed. Consult with a physician if you are sensitive to salt intake.
To order or join ASEA, Visit:
http://www.RedoxSignalingMolecules.ca or Call 1-416-335-4716
METABOLISM & STAMINA: Double-blind, 3rd-party, placebo-controlled human trials at Appalachian State Human Performance Lab, North Carolina Research Campus saw remarkable changes in 43 metabolites ("fingerprints" of bio-chemical reactions), massive release of fat to be used as fuel, and an unheard-of 12% increase in endurance (measured by ventilatory threshold, VO2max, time to "hitting the wall.") In a follow-up study, mice ran 29% farther.
The document discusses nutrition and fitness solutions for travelers. It defines a calorie as a unit of energy comprised of proteins, fats, and carbohydrates. Body fat is gained when caloric intake exceeds expenditure over time, causing a surplus of 3,500 calories, and lost when intake is lower than expenditure, creating a deficit of 3,500 calories. The number of calories a person needs depends on their basic energy needs, activity level, additional calories burned, and digestion needs. Macronutrient intake should fall within certain ranges as a percentage of total calories. Proper hydration is also important for health.
This document summarizes research on the effects of beta-hydroxy-beta-methylbutyrate (HMB). HMB is a metabolite of the essential amino acid leucine that is found in small amounts naturally. Studies have found that HMB supplementation can increase muscle strength, lean body mass, and aerobic/anaerobic capacity. The mechanisms of these effects include increasing protein synthesis and decreasing protein breakdown through inhibition of the ubiquitin-proteasome system. HMB may also act on the mTOR pathway to increase protein synthesis and provide substrates to support cell membrane integrity. However, the effects of HMB appear to be greater in untrained individuals compared to highly trained athletes.
Mary Rodavich - WVU Master's Defense PresentationMary Rodavich
The study examined the effects of non-marine sources of EPA or DHA (algae oil and yeast oil) versus fish oil on body weight and serum lipids in mice. Mice fed fish oil had significantly lower serum total cholesterol, non-HDL cholesterol, and triglycerides compared to other diet groups. Fish oil also increased EPA and DHA levels in the liver to a greater extent than algae oil or yeast oil. The results suggest that fish oil may be more effective than some non-marine sources at reducing cardiovascular disease risk factors.
1) There are two main types of carbohydrates - simple sugars like glucose and fructose, and complex carbohydrates like starches and cellulose which are long chains of sugars.
2) Proteins are polymers of amino acids, with each protein made of a different combination and sequence of amino acids. When amino acids bond together through condensation reactions, they form peptide bonds and polypeptide chains.
3) Fats are triglycerides made of glycerol bonded to three fatty acid molecules. The type of fatty acid determines if the fat is saturated, mono-unsaturated, or poly-unsaturated, and its state at room temperature.
This document provides information on Pure Performance Energy FoodTM, which includes three products: an electrolyte sports drink, energy gels, and energy chews. It summarizes the key ingredients and benefits of each product. The electrolyte sports drink contains carbohydrates from tapioca syrup and maltodextrin to deliver energy, along with electrolytes like sodium and potassium. The energy gels fuel working muscles with a blend of complex and simple carbohydrates and include electrolytes. The energy chews also use carbohydrates as an energy source and contain electrolytes while tasting like wild berries. All products aim to replenish electrolytes lost through sweat and have great tastes.
http://www.RedoxSignalingMolecules.ca - Frequently Asked Questions (And Answers)
1. What is ASEA?
ASEA is an immune boosting molecular complex consisting of reactive molecules, all native to the human body and naturally balanced. These molecules include a perfect balance of antioxidant enhancers that are balanced to support the immune system, detoxify the body and protect and fortify healthy tissue.
2. What Are Reactive Molecules?
Reactive molecules are either active electron acceptors (prone to take on electrons) or electron donors (prone to give up electrons). When these two classes of molecules are chemically balanced in our body, our immune systems can function at its optimal level.
3. How Do These Reactive Molecules Work?
There are two major roles for these reactive molecules in the body. First, they pair up with the natural antioxidants already in our body to help detoxify and fortify healthy tissue. Secondly, they supply the raw materials that the immune system needs in order to perform its natural function to detect and destroy harmful invaders and damaged cells.
4. How Much ASEA Should I Take?
ASEA has been proven to be entirely non-toxic at any reasonable dose. It can be taken orally, applied topically or inhaled without causing irritation. The recommended maintenance amount is 4 oz. per day for adults. ASEA is not recommended for pregnant or breastfeeding women. Consult with a physician if you are sensitive to salt intake.
5. Can I Apply ASEA To My Skin, Scrapes, Cuts, Or Burns?
ASEA is a natural disinfectant and antimicrobial and yet is soothing to the touch. ASEA can be used in a spray bottle for use on scrapes, burns and abrasions and can be liberally sprayed on the skin and will not cause irritation. ASEA contains a very small amount of chlorine. If you are allergic to chlorine, it is not recommended for use on the face. As always, consult a physician if there are any concerns.
6. Is ASEA Safe?
Testing has shown ASEA to be entirely safe and non-toxic no matter how it is consumed or applied. It has shown literally zero endotoxicity, cytotoxicity, and genotoxicity (mutagenic properties) in all 16 years of studies that were performed. Consult with a physician if you are sensitive to salt intake.
To order or join ASEA, Visit:
http://www.RedoxSignalingMolecules.ca or Call 1-416-335-4716
METABOLISM & STAMINA: Double-blind, 3rd-party, placebo-controlled human trials at Appalachian State Human Performance Lab, North Carolina Research Campus saw remarkable changes in 43 metabolites ("fingerprints" of bio-chemical reactions), massive release of fat to be used as fuel, and an unheard-of 12% increase in endurance (measured by ventilatory threshold, VO2max, time to "hitting the wall.") In a follow-up study, mice ran 29% farther.
The document discusses nutrition and fitness solutions for travelers. It defines a calorie as a unit of energy comprised of proteins, fats, and carbohydrates. Body fat is gained when caloric intake exceeds expenditure over time, causing a surplus of 3,500 calories, and lost when intake is lower than expenditure, creating a deficit of 3,500 calories. The number of calories a person needs depends on their basic energy needs, activity level, additional calories burned, and digestion needs. Macronutrient intake should fall within certain ranges as a percentage of total calories. Proper hydration is also important for health.
This document summarizes research on the effects of beta-hydroxy-beta-methylbutyrate (HMB). HMB is a metabolite of the essential amino acid leucine that is found in small amounts naturally. Studies have found that HMB supplementation can increase muscle strength, lean body mass, and aerobic/anaerobic capacity. The mechanisms of these effects include increasing protein synthesis and decreasing protein breakdown through inhibition of the ubiquitin-proteasome system. HMB may also act on the mTOR pathway to increase protein synthesis and provide substrates to support cell membrane integrity. However, the effects of HMB appear to be greater in untrained individuals compared to highly trained athletes.
Mary Rodavich - WVU Master's Defense PresentationMary Rodavich
The study examined the effects of non-marine sources of EPA or DHA (algae oil and yeast oil) versus fish oil on body weight and serum lipids in mice. Mice fed fish oil had significantly lower serum total cholesterol, non-HDL cholesterol, and triglycerides compared to other diet groups. Fish oil also increased EPA and DHA levels in the liver to a greater extent than algae oil or yeast oil. The results suggest that fish oil may be more effective than some non-marine sources at reducing cardiovascular disease risk factors.
1) There are two main types of carbohydrates - simple sugars like glucose and fructose, and complex carbohydrates like starches and cellulose which are long chains of sugars.
2) Proteins are polymers of amino acids, with each protein made of a different combination and sequence of amino acids. When amino acids bond together through condensation reactions, they form peptide bonds and polypeptide chains.
3) Fats are triglycerides made of glycerol bonded to three fatty acid molecules. The type of fatty acid determines if the fat is saturated, mono-unsaturated, or poly-unsaturated, and its state at room temperature.
This document provides information on Pure Performance Energy FoodTM, which includes three products: an electrolyte sports drink, energy gels, and energy chews. It summarizes the key ingredients and benefits of each product. The electrolyte sports drink contains carbohydrates from tapioca syrup and maltodextrin to deliver energy, along with electrolytes like sodium and potassium. The energy gels fuel working muscles with a blend of complex and simple carbohydrates and include electrolytes. The energy chews also use carbohydrates as an energy source and contain electrolytes while tasting like wild berries. All products aim to replenish electrolytes lost through sweat and have great tastes.
ASEA Research Summary Presentation - http://bit.ly/1j4wXnnEinar Bjarnason
Metabolomics: Goal is to measure the influence of ASEA on small molecules (metabolites) that shift in response to supplementation. The shift in metabolites, depending on the nutritional product, may represent effects on inflammation, oxidative stress, and physiologic stress.
1) Ingestion of ASEA for one week strongly increased serum fatty acid levels in male cyclists, mobilizing fatty acids from adipose tissue for energy during exercise via beta-oxidation. This spared amino acid catabolism and increased Krebs cycle intermediates after exercise.
2) ASEA intake was associated with higher levels of the antioxidant ascorbic acid and lower levels of its breakdown products, both acutely and over time.
3) Some other metabolite changes were observed with ASEA supplementation, such as increases in creatinine and urea, but kidney and liver function markers were within normal ranges.
1) Seven days of ingesting ASEA caused higher blood levels of free fatty acids in cyclists, leading to increased fat burning and sparing of amino acids during a 75km cycling trial compared to placebo.
2) ASEA intake was associated with increased serum levels of antioxidants like ascorbic acid and higher levels of Krebs cycle intermediates after exercise.
3) Some markers like creatinine and urea increased after exercise with ASEA but routine clinical measures were unchanged between groups.
Asea > April 2012 Human Performance Study: Questions and Answers ASEA
The research was conducted at North Carolina Research Institute by Appalachian State University's Human Performance Laboratory led by Dr. David Nieman. 20 cyclists were randomized into groups drinking ASEA or a salt water placebo for 7 days. Blood tests before and after a 75km cycling trial found ASEA caused a significant shift in 43 metabolites prior to exercise, compared to 10-20 shifts typically found for supplements. This indicated ASEA primes the body for exercise by mobilizing fatty acids from fat stores to be used as fuel, both at rest and during exercise, sparing muscle glycogen. The results surprised researchers as most supplements only cause shifts after combined with exercise.
A double blind placebo controlled study of the LifeWave techno.docxransayo
A double blind placebo controlled study of the LifeWave technology as it relates to the
improvement of strength endurance in high performance college athletics
By David Schmidt, Richard Shaughnessy July 27, 2003
Abstract
The LifeWave technology is a new supplement and method for the improvement of athletic performance. LifeWave
is a means by which an individual may substantially increase their net strength endurance within as quickly as the
first use of the product. To evaluate this statement in an unbiased manner, a double blind placebo controlled study
was implemented at Troy State University in Troy, Alabama. The principal investigator of this study was Coach
Richard Shaughnessy, strength and conditioning coach for the Troy State department of athletics. A standardized
test was selected to measure net gains in strength endurance, and in this case the exercise that was performed by all
athletes was a 225 lb. flat Bench Press. The baseline data for this test was collected on Thursday June 26, 2003.
The comparative data was collected on the following Wednesday July 2, 2003. Athletes were divided into three
groups: Control, Placebo and Test. The Control group was tested “as is” on both of these testing days. The Placebo
group was given a set of patches filled with water; this group was unaware as to whether or not the patches were real
or water filled. The Test group was given a set of patches with the LifeWave technology; again, this group was
unaware as to the contents of the patches. It will be emphasized that the athletes using the LifeWave technology
used the product only once; the test was performed within 10 minutes of first applying the patches to the athletes.
Metabolism and ATP production
It is well known that in humans in order for locomotion to occur ATP must be available to the muscle as well as all
other cells. The biochemistry of metabolism is centered in the synthesis of carbohydrates, fats, proteins and nucleic
acids. For the purpose of this discussion we shall concern ourselves primarily with the metabolism, utilization and
transport of fats as they pertain to the production of ATP.
In carbohydrate metabolism that involves the glycolysis of glucose molecules to pyruvic acid for the purpose of
feeding the Krebs Cycle with high-energy molecules, a process called chemiosmosis is used to pump protons across
a membrane and provide the energy for ATP synthesis. The electron carrying coenzyme molecules from the Krebs
Cycle enter the chemiosmosis process, the electrons are lost from the coenzymes, the energy is used to pump
protons across the mitochondrial membrane, and as the protons flow to the outer compartment of the mitochondrion
the energy from the electron flow is used to synthesize ATP molecules.
In contrast, in the metabolism of fats – precipitated by these molecules being first broken down into fatty acids and
glycerol molecules during digestion –.
- The study demonstrated that the saturated fatty acid palmitate is cytotoxic to pancreatic β-cells, but the cells can recover when palmitate is removed.
- Polyunsaturated fatty acids (PUFAs) like EPA may aid in this recovery process.
- The effects of palmitate and EPA on insulin content, glucose-stimulated insulin secretion, and histone acetyltransferase activity were examined using a lipotoxicity model.
- Preliminary results showed that liporecovered cells had higher insulin content than untreated cells and recovered insulin secretion function, while chronic exposure to palmitate and EPA disrupted secretion. Histone acetyltransferase activity also decreased under chronic conditions but recovered with liporecovery.
The document discusses the three energy systems - ATP-CP, anaerobic glycolysis, and aerobic system - that produce ATP to fuel muscle contraction during exercise. The ATP-CP system relies on creatine phosphate and can supply energy for up to 10 seconds. Anaerobic glycolysis breaks down glycogen without oxygen and can fuel exercise for up to 2 minutes, producing lactic acid as a byproduct. The aerobic system breaks down carbohydrates, fats, and proteins with oxygen to slowly produce ATP over longer periods of exercise.
Osteoporosis - Definition , Evaluation and Management .pdfJim Jacob Roy
Osteoporosis is an increasing cause of morbidity among the elderly.
In this document , a brief outline of osteoporosis is given , including the risk factors of osteoporosis fractures , the indications for testing bone mineral density and the management of osteoporosis
share - Lions, tigers, AI and health misinformation, oh my!.pptxTina Purnat
• Pitfalls and pivots needed to use AI effectively in public health
• Evidence-based strategies to address health misinformation effectively
• Building trust with communities online and offline
• Equipping health professionals to address questions, concerns and health misinformation
• Assessing risk and mitigating harm from adverse health narratives in communities, health workforce and health system
Mercurius is named after the roman god mercurius, the god of trade and science. The planet mercurius is named after the same god. Mercurius is sometimes called hydrargyrum, means ‘watery silver’. Its shine and colour are very similar to silver, but mercury is a fluid at room temperatures. The name quick silver is a translation of hydrargyrum, where the word quick describes its tendency to scatter away in all directions.
The droplets have a tendency to conglomerate to one big mass, but on being shaken they fall apart into countless little droplets again. It is used to ignite explosives, like mercury fulminate, the explosive character is one of its general themes.
10 Benefits an EPCR Software should Bring to EMS Organizations Traumasoft LLC
The benefits of an ePCR solution should extend to the whole EMS organization, not just certain groups of people or certain departments. It should provide more than just a form for entering and a database for storing information. It should also include a workflow of how information is communicated, used and stored across the entire organization.
8 Surprising Reasons To Meditate 40 Minutes A Day That Can Change Your Life.pptxHolistified Wellness
We’re talking about Vedic Meditation, a form of meditation that has been around for at least 5,000 years. Back then, the people who lived in the Indus Valley, now known as India and Pakistan, practised meditation as a fundamental part of daily life. This knowledge that has given us yoga and Ayurveda, was known as Veda, hence the name Vedic. And though there are some written records, the practice has been passed down verbally from generation to generation.
- Video recording of this lecture in English language: https://youtu.be/Pt1nA32sdHQ
- Video recording of this lecture in Arabic language: https://youtu.be/uFdc9F0rlP0
- Link to download the book free: https://nephrotube.blogspot.com/p/nephrotube-nephrology-books.html
- Link to NephroTube website: www.NephroTube.com
- Link to NephroTube social media accounts: https://nephrotube.blogspot.com/p/join-nephrotube-on-social-media.html
Travel vaccination in Manchester offers comprehensive immunization services for individuals planning international trips. Expert healthcare providers administer vaccines tailored to your destination, ensuring you stay protected against various diseases. Conveniently located clinics and flexible appointment options make it easy to get the necessary shots before your journey. Stay healthy and travel with confidence by getting vaccinated in Manchester. Visit us: www.nxhealthcare.co.uk
ASEA Research Summary Presentation - http://bit.ly/1j4wXnnEinar Bjarnason
Metabolomics: Goal is to measure the influence of ASEA on small molecules (metabolites) that shift in response to supplementation. The shift in metabolites, depending on the nutritional product, may represent effects on inflammation, oxidative stress, and physiologic stress.
1) Ingestion of ASEA for one week strongly increased serum fatty acid levels in male cyclists, mobilizing fatty acids from adipose tissue for energy during exercise via beta-oxidation. This spared amino acid catabolism and increased Krebs cycle intermediates after exercise.
2) ASEA intake was associated with higher levels of the antioxidant ascorbic acid and lower levels of its breakdown products, both acutely and over time.
3) Some other metabolite changes were observed with ASEA supplementation, such as increases in creatinine and urea, but kidney and liver function markers were within normal ranges.
1) Seven days of ingesting ASEA caused higher blood levels of free fatty acids in cyclists, leading to increased fat burning and sparing of amino acids during a 75km cycling trial compared to placebo.
2) ASEA intake was associated with increased serum levels of antioxidants like ascorbic acid and higher levels of Krebs cycle intermediates after exercise.
3) Some markers like creatinine and urea increased after exercise with ASEA but routine clinical measures were unchanged between groups.
Asea > April 2012 Human Performance Study: Questions and Answers ASEA
The research was conducted at North Carolina Research Institute by Appalachian State University's Human Performance Laboratory led by Dr. David Nieman. 20 cyclists were randomized into groups drinking ASEA or a salt water placebo for 7 days. Blood tests before and after a 75km cycling trial found ASEA caused a significant shift in 43 metabolites prior to exercise, compared to 10-20 shifts typically found for supplements. This indicated ASEA primes the body for exercise by mobilizing fatty acids from fat stores to be used as fuel, both at rest and during exercise, sparing muscle glycogen. The results surprised researchers as most supplements only cause shifts after combined with exercise.
A double blind placebo controlled study of the LifeWave techno.docxransayo
A double blind placebo controlled study of the LifeWave technology as it relates to the
improvement of strength endurance in high performance college athletics
By David Schmidt, Richard Shaughnessy July 27, 2003
Abstract
The LifeWave technology is a new supplement and method for the improvement of athletic performance. LifeWave
is a means by which an individual may substantially increase their net strength endurance within as quickly as the
first use of the product. To evaluate this statement in an unbiased manner, a double blind placebo controlled study
was implemented at Troy State University in Troy, Alabama. The principal investigator of this study was Coach
Richard Shaughnessy, strength and conditioning coach for the Troy State department of athletics. A standardized
test was selected to measure net gains in strength endurance, and in this case the exercise that was performed by all
athletes was a 225 lb. flat Bench Press. The baseline data for this test was collected on Thursday June 26, 2003.
The comparative data was collected on the following Wednesday July 2, 2003. Athletes were divided into three
groups: Control, Placebo and Test. The Control group was tested “as is” on both of these testing days. The Placebo
group was given a set of patches filled with water; this group was unaware as to whether or not the patches were real
or water filled. The Test group was given a set of patches with the LifeWave technology; again, this group was
unaware as to the contents of the patches. It will be emphasized that the athletes using the LifeWave technology
used the product only once; the test was performed within 10 minutes of first applying the patches to the athletes.
Metabolism and ATP production
It is well known that in humans in order for locomotion to occur ATP must be available to the muscle as well as all
other cells. The biochemistry of metabolism is centered in the synthesis of carbohydrates, fats, proteins and nucleic
acids. For the purpose of this discussion we shall concern ourselves primarily with the metabolism, utilization and
transport of fats as they pertain to the production of ATP.
In carbohydrate metabolism that involves the glycolysis of glucose molecules to pyruvic acid for the purpose of
feeding the Krebs Cycle with high-energy molecules, a process called chemiosmosis is used to pump protons across
a membrane and provide the energy for ATP synthesis. The electron carrying coenzyme molecules from the Krebs
Cycle enter the chemiosmosis process, the electrons are lost from the coenzymes, the energy is used to pump
protons across the mitochondrial membrane, and as the protons flow to the outer compartment of the mitochondrion
the energy from the electron flow is used to synthesize ATP molecules.
In contrast, in the metabolism of fats – precipitated by these molecules being first broken down into fatty acids and
glycerol molecules during digestion –.
- The study demonstrated that the saturated fatty acid palmitate is cytotoxic to pancreatic β-cells, but the cells can recover when palmitate is removed.
- Polyunsaturated fatty acids (PUFAs) like EPA may aid in this recovery process.
- The effects of palmitate and EPA on insulin content, glucose-stimulated insulin secretion, and histone acetyltransferase activity were examined using a lipotoxicity model.
- Preliminary results showed that liporecovered cells had higher insulin content than untreated cells and recovered insulin secretion function, while chronic exposure to palmitate and EPA disrupted secretion. Histone acetyltransferase activity also decreased under chronic conditions but recovered with liporecovery.
The document discusses the three energy systems - ATP-CP, anaerobic glycolysis, and aerobic system - that produce ATP to fuel muscle contraction during exercise. The ATP-CP system relies on creatine phosphate and can supply energy for up to 10 seconds. Anaerobic glycolysis breaks down glycogen without oxygen and can fuel exercise for up to 2 minutes, producing lactic acid as a byproduct. The aerobic system breaks down carbohydrates, fats, and proteins with oxygen to slowly produce ATP over longer periods of exercise.
Similar to Asea research summary_presentation (1) (8)
Osteoporosis - Definition , Evaluation and Management .pdfJim Jacob Roy
Osteoporosis is an increasing cause of morbidity among the elderly.
In this document , a brief outline of osteoporosis is given , including the risk factors of osteoporosis fractures , the indications for testing bone mineral density and the management of osteoporosis
share - Lions, tigers, AI and health misinformation, oh my!.pptxTina Purnat
• Pitfalls and pivots needed to use AI effectively in public health
• Evidence-based strategies to address health misinformation effectively
• Building trust with communities online and offline
• Equipping health professionals to address questions, concerns and health misinformation
• Assessing risk and mitigating harm from adverse health narratives in communities, health workforce and health system
Mercurius is named after the roman god mercurius, the god of trade and science. The planet mercurius is named after the same god. Mercurius is sometimes called hydrargyrum, means ‘watery silver’. Its shine and colour are very similar to silver, but mercury is a fluid at room temperatures. The name quick silver is a translation of hydrargyrum, where the word quick describes its tendency to scatter away in all directions.
The droplets have a tendency to conglomerate to one big mass, but on being shaken they fall apart into countless little droplets again. It is used to ignite explosives, like mercury fulminate, the explosive character is one of its general themes.
10 Benefits an EPCR Software should Bring to EMS Organizations Traumasoft LLC
The benefits of an ePCR solution should extend to the whole EMS organization, not just certain groups of people or certain departments. It should provide more than just a form for entering and a database for storing information. It should also include a workflow of how information is communicated, used and stored across the entire organization.
8 Surprising Reasons To Meditate 40 Minutes A Day That Can Change Your Life.pptxHolistified Wellness
We’re talking about Vedic Meditation, a form of meditation that has been around for at least 5,000 years. Back then, the people who lived in the Indus Valley, now known as India and Pakistan, practised meditation as a fundamental part of daily life. This knowledge that has given us yoga and Ayurveda, was known as Veda, hence the name Vedic. And though there are some written records, the practice has been passed down verbally from generation to generation.
- Video recording of this lecture in English language: https://youtu.be/Pt1nA32sdHQ
- Video recording of this lecture in Arabic language: https://youtu.be/uFdc9F0rlP0
- Link to download the book free: https://nephrotube.blogspot.com/p/nephrotube-nephrology-books.html
- Link to NephroTube website: www.NephroTube.com
- Link to NephroTube social media accounts: https://nephrotube.blogspot.com/p/join-nephrotube-on-social-media.html
Travel vaccination in Manchester offers comprehensive immunization services for individuals planning international trips. Expert healthcare providers administer vaccines tailored to your destination, ensuring you stay protected against various diseases. Conveniently located clinics and flexible appointment options make it easy to get the necessary shots before your journey. Stay healthy and travel with confidence by getting vaccinated in Manchester. Visit us: www.nxhealthcare.co.uk
Histololgy of Female Reproductive System.pptxAyeshaZaid1
Dive into an in-depth exploration of the histological structure of female reproductive system with this comprehensive lecture. Presented by Dr. Ayesha Irfan, Assistant Professor of Anatomy, this presentation covers the Gross anatomy and functional histology of the female reproductive organs. Ideal for students, educators, and anyone interested in medical science, this lecture provides clear explanations, detailed diagrams, and valuable insights into female reproductive system. Enhance your knowledge and understanding of this essential aspect of human biology.
1. ASEA Metabolomics Results
Nieman DC. Human Performance Laboratory, North Carolina Research Campus and
Appalachian State University
2. Metabolomics Laboratory,
North Carolina Research Campus,
David H. Murdock Research Institute
Appalachian state
Slide 1 Human Performance Laboratory
3. Blood/urine : Pre-Ex Post- Ex 1-h Blood/urine : Pre-Ex Post- Ex 1-h
Crossover
1-week • 75-km 1-week • 75-km
3-week washout
BASELINE
TESTING for ASEA cycling cycling
ASEA
VO2max,
body
1 week • 75-km
composition
(N=20 1-week • 75-km
Placebo cycling Placebo cycling
subjects)
Metabolomics: Goal is to measure the
influence of ASEA on small molecules
(metabolites) that shift in response to
supplementation. The shift in
metabolites, depending on the
nutritional product, may represent
effects on inflammation, oxidative
stress, and physiologic stress.
Appalachian state
Slide 2 Human Performance Laboratory
4. Working Summary
• Seven days ingestion of ASEA (relative to
placebo) caused an extensive mobilization of free
fatty acids from adipose tissue in male cyclists.
• Athletes on ASEA for 7-days started the 75-km
cycling trial with high blood free fatty acids
leading to increased fat oxidation and a sparing
of amino acids (and potentially muscle glycogen).
• ASEA intake was associated with a large increase
in serum ascorbic acid levels (probably from the
adrenal cortex).
• Serum creatinine and urea also increased post-
exercise. Appalachian state
Slide 3 Human Performance Laboratory
5. Myristic acid
Finding 1: Ingestion of ASEA beverage for one 14C Saturated Fatty Acid
week strongly increased serum fatty acids FDR=6.49E-32
Least Square Mean Area
levels (most likely from adipose tissue). 2,000
1,500
1) Chronic Effect: Higher fatty acid levels pre- 1,000
exercise (several types of fatty acids --- see slides). 500
-
ASEA Placebo
2) Acute Effect: Increased fatty acid oxidation Myristic acid
14C Saturated Fatty Acid
and mobilization during exercise (placebo
Least Square Mean Area
FDR=2.61E-20
condition was linked to a late mobilization). 2,000
1,500
1,000
500
-
Triglyceride Mobilization: corresponding Pre Post 1H Post
with the increase in free fatty acids, glycerol ASEA Placebo
was higher at baseline (indicative of extensive
adipose triglyceride hydrolysis).
TG Hydrolysis
FFAs + Glycerol with ASEA
Appalachian state
Slide 4 Human Performance Laboratory
6. Post 7-day Ingestion:
Fatty Acids Higher in ASEA vs. Placebo
Myristic acid Palmitic Acid
14C Saturated Fatty Acid 16C Saturated Fatty Acid
FDR=6.49E-32 FDR=1.86E-25
Least Square Mean Area
2,000 25,000
Least Square Mean Area
1,800
1,600 20,000
1,400
1,200 15,000
1,000
800 10,000
600
400 5,000
200
- -
ASEA Placebo ASEA Placebo
Oleic Acid Stearic Acid
18C Monounsaturated n9 Fatty Acid 18C Saturated Fatty Acid
FDR=5.21E-18 FDR=3.22E-12
8000
18000
7000
Least Square Mean Area
16000
6000
14000
12000 5000
10000 4000
8000 3000
6000
2000
4000
2000 1000
0 0
ASEA Placebo ASEA Placebo
Appalachian state
Slide 5 Human Performance Laboratory
7. 7-days Ingestion of ASEA
Fatty Acids and Glycerol Backbone: Higher in ASEA vs. Placebo
Palmitelaidic Acid Capric Acid
16C Trans Fatty Acid 10C Saturated Fatty Acid
FDR=1.13E-08 FDR=5.39E-07
1,200 160
Least Square Mean Area
1,000 140
120
800
100
600 80
400 60
40
200
20
- 0
ASEA Placebo ASEA Placebo
Glycerol
Backbone of Triglycerides
FDR=9.49E-07
25000
20000
15000
10000
5000
0
ASEA Placebo Appalachian state
Slide 6 Human Performance Laboratory
8. Serum Fatty Acids During Exercise
Myristic acid Palmitic Acid
14C Saturated Fatty Acid 16C Saturated Fatty Acid
Least Square Mean Area
FDR=2.61E-20 FDR=1.56E-20
Least Square Mean Area
2,000 25,000
1,500 20,000
15,000
1,000
10,000
500
5,000
- -
Pre Post 1H Post Pre Post 1H Post
ASEA Placebo ASEA Placebo
Palmitelaidic Acid Oleic Acid
16C Trans Fatty Acid 18C Monunsaturated n9 Fatty Acid
Least Square Mean Area
Least Square Mean Area
FDR=1.66E-16 FDR = 7.96E-10
1,200 20,000
1,000
15,000
800
600 10,000
400
5,000
200
- -
Pre Post 1H Post Pre Post 1H Post
ASEA Placebo ASEA Placebo
Appalachian state
Slide 7 Human Performance Laboratory
9. Serum Fatty Acids During Exercise
Stearic Acid Capric Acid
18C Saturated Fatty Acids 10C Saturated Fatty Acids
FDR=1.33E-06 FDR=0.0059
Least Square Mean Area
Least Square Mean Area
12,000 200
10,000
150
8,000
6,000 100
4,000
50
2,000
- -
Pre Post 1H Post Pre Post 1H Post
ASEA Placebo ASEA Placebo
Lauric Acid Glyercol Monosterate
12C Saturated Fatty Acids FDR = 0.0060
FDR=0.0281
Least Square Mean Area
900
Least Square Mean Area
1,200 800
1,000 700
600
800
500
600 400
400 300
200
200 100
- -
Pre Post 1H Post Pre Post 1H Post
ASEA Placebo ASEA Placebo
Appalachian state
Slide 8 Human Performance Laboratory
10. Serum Aspartate Serum Serine
Serum Glycine
FDR=0.0075 FDR=0.0273
FDR=0.0162
Pyruvate
Pre Post 1H Post Pre Post 1H Post
Pre Post 1H Post
In urea cycle
Acetyl Co-A Serum Citrate
Serum Fumarate FDR = 0.0037
FDR=1.06E-06
Oxaloacetate Citrate
Pre Post 1H Post
Pre Post 1H Post Serum Threonine
FDR=0.0108
Serum Malate Malate Isocitrate
FDR= 0.0004 Graph Key
Pre Post 1H Post
ASEA Placebo
Pre Post 1H Post Via Beta Oxidation
alpha-
Fumarate
Ketoglutarate
Serum Leucine
FDR=0.0004
Succinate Succinyl CoA
Pre Post 1H Post
Finding 2: High levels of
blood free fatty acids were Via Odd Chain Beta Oxidation Via Glutamate
linked to a sparing of amino Serum Valine Serum Proline
FDR=0.0089
acid catabolism, and FDR=0.0066
increased Krebs Cycle
intermediates, post-exercise
Pre Post 1H Post
Pre Post 1H Post
Appalachian state
Slide 9
Human Performance Laboratory
11. Serum Amino Acids at Pre, Post, and 1H Post-Exercise
“Sparing” of Amino Acids with ASEA
Leucine Proline
Krebs Entry: alpha Ketoglutarate Krebs Entry: alpha Ketoglutarate
FDR =0.0004 FDR = 0.0066
30,000 50,000
Least Square Mean Area
Lesat Square Mean Area
25,000 40,000
20,000
30,000
15,000
20,000
10,000
5,000 10,000
- -
Pre Post 1H Post Pre Post 1H Post
ASEA Placebo ASEA Placebo
Aspartate Valine
Krebs Entry: Oxaloacetate Krebs Entry: Succinyl CoA
FDR = 0.0074 FDR = 0.0089
500 50,000
Lesat Square Mean Area
Lesat Square Mean Area
400 40,000
300 30,000
200 20,000
100 10,000
- -
Pre Post 1H Post Pre Post 1H Post
ASEA Placebo ASEA Placebo
Appalachian state
Slide 10 Human Performance Laboratory
12. Serum Amino Acids at Pre, Post, and 1H Post-Exericse
“Sparing” of Amino Acids with ASEA
Threonine Serine
Krebs Entry: Pyruvate Krebs Entry: Pyruvate
FDR= 0.0108 FDR= 0.0273
7,000 12,000
Lesat Square Mean Area
Lesat Square Mean Area
6,000 10,000
5,000
8,000
4,000
6,000
3,000
4,000
2,000
1,000 2,000
- -
Pre Post 1H Post Pre Post 1H Post
Glycine
Krebs Entry: Pyruvate
FDR= 0.0162
5
Lesat Square Mean Area
5
4
4
3
3 Graph Key
2
2
1
ASEA Placebo
1
-
Pre Post 1H Post
Appalachian state
Slide 11 Human Performance Laboratory
13. Serum Krebs Intermediate at Pre, Post, and 1H Post-Exercise
Higher Levels with ASEA
Fumarate Malate
FDR = 1.06E-06 FDR= 0.0004
600 200
Lesat Square Mean Area
Lesat Square Mean Area
180
500
160
400 140
120
300 100
80
200
60
100 40
20
- -
Pre Post 1H Post Pre Post 1H Post
Citrate
FDR = 0.0037
60.00
Least Squre Mean Area
50.00
40.00
30.00
20.00 Graph Key
10.00
ASEA Placebo
-
Pre Post 1H Post
Appalachian state
Slide 12 Human Performance Laboratory
14. 3) Ascorbic Acid Metabolism:
ASEA supplementation appears to be affecting ascorbic acid both acutely and chronically.
Chronic Differences: ASEA group has lower baseline levels of fructose and lower levels of threonic
acid. Fructose is broken down into ascorbic acid which is further metabolized into threonic acid. This
could be suggestive of higher ascorbic acid production but no differences in groups were detected at
baseline.
Fructose Threonic Acid
FDR=1.12E-05 FDR=1.46E-98
Least Square Mean
Least Square Mean
1500 8
6
1000
Area
Area
4
500
2
0 0
ASEA Placebo ASEA Placebo
Acute Differences: ASEA group has higher levels of ascorbic acid, an antioxidant, and lower levels of
both fructose and threonic acid.
Ascorbic Acid Fructose Threonic Acid
FDR = 5.6E-06 FDR = 0.0002 FDR=0.0031
Least Square Mean
Least Square Mean
1,500 1,500 10
Least Square Mean
8
1,000 1,000
Area
Area
6
Area
500 500 4
2
- -
Pre Post 1H Post Pre Post 1H Post -
Pre Post 1H Post
Graph Key
Appalachian state
Slide 13 ASEA Placebo Human Performance Laboratory
15. 4) Other Changes. Some other changes were found both acutely and
chronically that require further investigation into implications.
Aminomalonic Acid Serum Creatinine
FDR = 1.13E-05 FDR=2.55 E-06
Least Square Mean Area
400 900
Least Squre Mean Area
350 800
300 700
250 600
500
200
400
150
300
100 200
50 100
- -
Pre Post 1H Post Pre Post 1H Post
Plays role in binding calcium to protein Breakdown product of creatine
Urea
FDR = 0.0108
Least Square Mean Area 120
100
80
60
40
20
Graph Key
-
Pre Post 1H Post
ASEA Placebo Formed in liver; Removal of nitrogen and ammonia
Appalachian state
Slide 14 Human Performance Laboratory
16. Blood Urinary Nitrogen (BUN)
Normal Range: 8-20 mg/dl
25
20
15
mg/dl
Placebo
10 ASEA
5
0
Pre Post 1H
BUN levels did not differ between treatment
(treatment x time p-value=0.9743)
Appalachian state
Slide 15 Human Performance Laboratory
17. Creatinine
Normal Range: 0.7-1.2 mg/dl
1.4
1.2
1
0.8
mg/dl
Placebo
0.6
ASEA
0.4
0.2
0
Pre Post 1H
Creatinine levels did not differ between treatment (treatment
x time p-value=0.7717)
Appalachian state
Slide 16 Human Performance Laboratory
18. Bilirubin
Normal Range: 0.3-1.2 mg/dl
1
0.8
0.6
mg/dl
Placebo
0.4 ASEA
0.2
0
Pre Post 1H
Bilirubin levels did not differ between treatment
(treatment x time p-value=0.9971)
Appalachian state
Slide 17 Human Performance Laboratory
19. Alkaline Phosphatase
Normal Range: 39-117 IU/L
68
66
64
IU/L
62 Placebo
60 ASEA
58
56
Pre Post 1H
Alkaline Phosphatase levels did not differ between
treatment (treatment x time p-value=0.8819)
Appalachian state
Slide 18 Human Performance Laboratory
20. AST
Normal Range: 15-41 IU/L
40
35
30
25
IU/L
20 Placebo
15 ASEA
10
5
0
Pre Post 1H
AST levels did not differ between treatment
(treatment x time p-value=0.9546)
Appalachian state
Slide 19 Human Performance Laboratory
21. ALT
Normal Range: 17-63 IU/L
40
35
30
25
IU/L
20 Placebo
15 ASEA
10
5
0
Pre Post 1H
ALT levels did not differ between treatment
(treatment x time p-value=0.9739)
Appalachian state
Slide 20 Human Performance Laboratory