8. • Comparison With Malignant Tumours:
Invasive and thus capable of spreading directly or by
metastasis -
Relatively rapid growth -
Pressure on and destruction of adjacent tissue
Formation of secondary tumours (metastasi)
Blood loss from ulcerated surface -
Obstruction of flow -
other paraneoplastic effects causing weight loss & debility -
9. Cellular pathology
Increased mitotic activities
Cellular disorganisation
Nuclear hyper-chromasia
Irregularity and enlargement
the normal cervical squamous epithelium at the left merges into the dysplastic
squamous epithelium at the right
11. Warning signs of Breast cancer
• Lump or thickening (breast, underarm)
• Dimpling or puckering of the skin.
• Bloody or spontaneous discharge from nipple.
• A sore on the breast that does not heal.
• Unusual pain Itch or rash, especially in nipple area.
• Retracted nipple(s).
12. Self breast examination
• Stand in front of a mirror and look at each breast separately. Note the size,
shape, colour, contour and direction of your breasts and nipples. Has there
been any change in size? Has any nipple become turned in or is there any
discharge or any change in the texture of the skin?
• Raise your arms over your head and look at your breasts, as you turn slowly
from side to side. Any swellling or puckering of the skin?
•
• Lean forward and examine each breast for change in outline or dimpling of the
skin.
• Now, lying down, using the pads of your three middle fingertips feel for any
lumps or bumpy areas
• Extend the examination to the breast tissue in the underarm. Keep moving
your hand across the nipple till you feel you have felt all parts of the breast.
13.
14.
15. • Investigation
• Early diagnosis
Detection of low grade dysplasias
Expectant local Treatment
Detection of High grade dysplasias
Surgery
16. Mutation
Inactivates tumour suppressor genes
Proliferation of Cells
Mutation inactivates DNA repair genes
Mutation of proto-oncogene creates an oncogene
Mutation inactivates several more tumour suppressor
genes
17. Cellular pathology
Increased mitotic activities
Cellular disorganisation
Nuclear hyper-chromasia
Irregularity and enlargement
the normal cervical squamous epithelium at the left merges into the dysplastic
squamous epithelium at the right
18.
19. When the entire epithelium is dysplastic ,gone beyond dysplasia and is now
neoplasia. If the basement membrane is still intact, as shown here, then the
process is called "carcinoma in situ"
20. Microinvasive squamous cell carcinoma with irregularly-
shaped and sharp invasive
Microinvasive squamous cell carcinoma with irregularly-shaped
and sharp invasive
parts
Carcinoma in situ of the squamous epithelium
Microinvasive squamous cell carcinoma with irregularly-
shaped and sharp invasive
parts
22. Risk Factors
• HPV infection
• Smoking
• Early age of first intercourse
• Multiple sexual partners or a partner with many sexual
partners
• High risk males as sexual partners (e.g., males whose
former partner had cervical cancer)
• History of other sexually transmitted diseases
• Human immunodeficiency virus (HIV)
• Other causes of immuno-suppression
23. • Long-term oral contraceptive (OCP) use
• Low RBC folate levels (often present with OCP use; even
when serum levels of RBCs are normal
• Vitamin A, beta-carotene, selenium, vitamin E, and
vitamin C dietary deficiencies
28. Grading of Malignant Neoplasms
I Well differentiated
II Moderately differentiated
III Poorly differentiated
IV Nearly anaplastic
29.
30.
31. • Treatment:
• xÉÉqÉÉlrÉ ÍcÉÌMüixÉÉ:
• As like Granthi.
• As like mamsapradoshaja, medovrudhijanya vyadhi.
• Patanakarma of Arbuda, followed by lepa of
Saidhava / gruta. (Harita)
• After doing sudation with a packet of cloth
containing ajashakruta, shigrumoola laksha etc. in
kangi, followed by massage ,the Arbuda should be
covered with leaves of Upodika / Arka be bandaged
over it.
• Swedana with snuhi lavana etc..
32. ÌuÉvÉãwÉÍcÉÌMüixÉÉ
• Vatarbuda - external use of karkalu, narikela, etc
with dugdha ghruta siddha taila for upanaha.
internally vataghna dravya siddha kwatha, kalka, kshira.
• Pittarbuda – externally mrudu snehana, svedana, upanaha.
udvartana with udumbara, darvipatrika
followed by lepa.
internally pittahara dravya siddha ghruta pana.
• Kapharbuda – vamana, raktavasechana, followed by lepa
application.
- Faeces of kapota, paravata mixed with
kansyaneela, langalidone mardana with gomutra,
palashakshira – lepa application.