Abnormal cytology & histology of cervix _ Histopathology

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Abnormal cytology & histology of cervix _ Histopathology

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Abnormal cytology & histology of cervix _ Histopathology

  1. 1. Abnormal cytology & histology of cervix DR PRAMOD TAJANE DNB, DGO
  2. 2. MORPHOLOGICAL ABNORMALITIES OF NUCLEUS Disproportionate enlargement Irregular outline Abnormal no.,size or shape Hyperchromatsia Condesation of chromatin Multinucleation
  3. 3. ABNORMALITIES OF CELLS
  4. 4. NORMAL CELLS ABNORMALCELLS
  5. 5. MILD DYSKARYOSIS Superficial or intrmediate type sqamous cells Angular borders,transulent cytoplasm Nucleus occupies>half of toyal area of cytoplasm Binucleation This corelates with CIN 1
  6. 6. CIN1  CIN1 (flat condyloma): an abnormal mitotic figure (yellow circle), numerous binucleated cells (green circle), superficial parakeratosis (red arrow). Disturbed structural organization of the epithelium in the lower third
  7. 7. MODERATE DYSKARYOSIS Intermediate ,parabasal or superficial type sqaomous cells Disproportionate nuclear enlargement Hyperchromatasia Nucleus occupies ½ to 2/3 of cytoplasm Correlate with CIN 2
  8. 8. CIN2 CIN 2 with koilocytosis: disorganized architecture of the lower half of the epithelium with cellular criteria of malignancy and viral infection.
  9. 9. SEVERE DYSKARYOSIS Basal type cells, different shape & size Round,oval polygonal or elongated in shape (fiber cells ) Tadpole cell –severe dyskaryotic cell with tail of cytoplasm In clumps or singly Nucleus fills the cell or rim of cytolasm Coarse chromatin Correlate with CIN3
  10. 10. CIN 3  CIN 3 superficial parakeratosis. Contrast with the normal exocervical epithelium.
  11. 11. KOILOCTOSIS Nuclear abnormalities seen with HPV infection Central clearing( perinuclear hallo) Hyperchromatasia, multinucleation
  12. 12. CARCINOMA IN SITU Parabasal cells Increased N/C ratio Irregular or multiple nucleus Granular chromatin scanty cytoplasm
  13. 13. INVASIVE CARCINOMA Cells are single or grouped in clusters Irregular nucleic, clumping of chromatin Large tadpole cells
  14. 14. COMPARISON OF CLASSIFICTIONS PAP CLASSIFICTION WHO 1962 CLASS1 RICHART NORMAL INFLAMMATORY BETHESDA1991 REVISED 2001 ASCUS MILD DYSPLASIA CIN 1 LGSIL MODERATE DYSPLASIA CIN2 HGSIL CLASS3 SEVERE DYSPLASIA CIN3 HGSIL CLASS4 CARSINOMA IN SITU CIN3 HGSIL CLASS5 INVASIVE INVASIVE CANCER INVASIVE CANCER CLASS 2

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