How to evaluate a patient with Diarrhea.
Outline of the presentation:
1. Questions to ask the patient presenting with Diarrhea
2. Diarrhea, pathophysiology, classification
3. Walk-through UpToDate Algorithm for Acute and Chronic Diarrhea
This document provides guidance on evaluating and managing a patient presenting with diarrhea. It defines diarrhea and outlines the main pathophysiological causes. It emphasizes taking a thorough history, examining the patient, considering differential diagnoses, and appropriate use of laboratory tests and imaging. Mild to moderate dehydration is typically managed with oral rehydration, while more severe cases may require IV fluids. Antibiotics are only recommended for specific invasive bacterial infections. Overall treatment focuses on rehydration with oral or IV fluids as the mainstay.
metabolic acidosis develops because of defects in the ability of the renal tubules to perform the normal functions required to maintain acid-base balance.
This document discusses acute kidney injury (AKI), including its definition, epidemiology, causes, diagnosis, and treatment approaches. It provides details on:
- AKI definitions including RIFLE and KDIGO criteria.
- Common causes of AKI including pre-renal, intrinsic renal, and post-renal etiologies.
- Diagnostic evaluation including blood and urine tests, imaging, and biomarkers.
- General treatment principles including fluid resuscitation, eliminating nephrotoxins, and initiating renal replacement therapy.
- Specific approaches for pre-renal, intrinsic renal, and post-renal AKI as well as infections, nephrotoxins, and complications.
Calcium homeostasis & its related disordersenamifat
Calcium homeostasis is tightly regulated by three hormones - calcitriol, parathyroid hormone, and calcitonin. Calcium is important for bone formation, blood clotting, hormone release, and muscle contraction. Hypocalcemia can cause tetany and muscle spasms while hypercalcemia increases risk of kidney stones and cardiac arrhythmias. The kidneys play a key role in calcium balance by reabsorbing over 95% of the filtered calcium and regulating excretion.
This document summarizes renal tubular acidosis (RTA), a condition caused by defects in the kidney's ability to reabsorb bicarbonate or excrete hydrogen ions. It describes the different types of RTA - proximal RTA caused by impaired bicarbonate reabsorption in the proximal tubule, distal RTA caused by impaired acidification in the distal tubule, and rare combined proximal and distal RTA. The clinical features and causes of each type are discussed. Inherited forms are linked to mutations in genes encoding acid-base transporters. Acquired forms can result from conditions like autoimmune diseases.
This document discusses cirrhosis and its complications over two parts. Part I covers what cirrhosis is, its etiologies, clinical presentations, physical exam findings, laboratory tests, liver biopsy, and prognosis for different etiologies. Part II covers complications of cirrhosis including portal hypertension, variceal bleeding, hepatic encephalopathy, spontaneous bacterial peritonitis, hepatorenal syndrome, hepatopulmonary syndrome, and hepatocellular carcinoma screening and treatment. Liver transplantation is also discussed as a treatment option.
This document provides guidance on evaluating and managing a patient presenting with diarrhea. It defines diarrhea and outlines the main pathophysiological causes. It emphasizes taking a thorough history, examining the patient, considering differential diagnoses, and appropriate use of laboratory tests and imaging. Mild to moderate dehydration is typically managed with oral rehydration, while more severe cases may require IV fluids. Antibiotics are only recommended for specific invasive bacterial infections. Overall treatment focuses on rehydration with oral or IV fluids as the mainstay.
metabolic acidosis develops because of defects in the ability of the renal tubules to perform the normal functions required to maintain acid-base balance.
This document discusses acute kidney injury (AKI), including its definition, epidemiology, causes, diagnosis, and treatment approaches. It provides details on:
- AKI definitions including RIFLE and KDIGO criteria.
- Common causes of AKI including pre-renal, intrinsic renal, and post-renal etiologies.
- Diagnostic evaluation including blood and urine tests, imaging, and biomarkers.
- General treatment principles including fluid resuscitation, eliminating nephrotoxins, and initiating renal replacement therapy.
- Specific approaches for pre-renal, intrinsic renal, and post-renal AKI as well as infections, nephrotoxins, and complications.
Calcium homeostasis & its related disordersenamifat
Calcium homeostasis is tightly regulated by three hormones - calcitriol, parathyroid hormone, and calcitonin. Calcium is important for bone formation, blood clotting, hormone release, and muscle contraction. Hypocalcemia can cause tetany and muscle spasms while hypercalcemia increases risk of kidney stones and cardiac arrhythmias. The kidneys play a key role in calcium balance by reabsorbing over 95% of the filtered calcium and regulating excretion.
This document summarizes renal tubular acidosis (RTA), a condition caused by defects in the kidney's ability to reabsorb bicarbonate or excrete hydrogen ions. It describes the different types of RTA - proximal RTA caused by impaired bicarbonate reabsorption in the proximal tubule, distal RTA caused by impaired acidification in the distal tubule, and rare combined proximal and distal RTA. The clinical features and causes of each type are discussed. Inherited forms are linked to mutations in genes encoding acid-base transporters. Acquired forms can result from conditions like autoimmune diseases.
This document discusses cirrhosis and its complications over two parts. Part I covers what cirrhosis is, its etiologies, clinical presentations, physical exam findings, laboratory tests, liver biopsy, and prognosis for different etiologies. Part II covers complications of cirrhosis including portal hypertension, variceal bleeding, hepatic encephalopathy, spontaneous bacterial peritonitis, hepatorenal syndrome, hepatopulmonary syndrome, and hepatocellular carcinoma screening and treatment. Liver transplantation is also discussed as a treatment option.
This document discusses renal tubular acidosis (RTA), which is caused by defects in the kidney's ability to absorb bicarbonate or excrete acid. There are four main types of RTA - distal (Type 1), proximal (Type 2), mixed (Type 3), and hypoaldosteronism (Type 4). Type 1 is caused by impaired distal acid secretion and presents with metabolic acidosis and high urine pH. Type 2 is caused by reduced proximal bicarbonate reabsorption and can present as isolated proximal RTA or Fanconi syndrome. Mixed Type 3 has features of both Types 1 and 2. Type 4 is caused by aldosterone deficiency or resistance and presents with hyperkalemia and mild acid
Approach to a patient with hyponatremia (2) (1)Mohit Aggarwal
The document discusses hyponatremia, which refers to a low serum sodium level. It begins by defining hyponatremia and providing normal sodium levels. It then covers the frequency, age and sex predispositions, physiology/pathophysiology, types and causes. The types include hypovolemic, euvolemic, hypervolemic, redistributive, and pseudohyponatremia. Common causes are discussed like SIADH, heart failure, cirrhosis. The clinical approach involves assessing volume status, labs like sodium, osmolality, urine sodium. Management depends on the type and involves restricting free water intake or using hypertonic saline in severe cases to slowly correct the
The document provides an overview of approach to evaluating abnormal liver function tests (LFTs). It defines relevant liver enzymes and tests. Epidemiology studies show most abnormal LFT cases can be diagnosed noninvasively, and the most common findings are non-alcoholic fatty liver disease and steatohepatitis. A thorough history and physical exam is important to identify potential causes like medications, viruses, autoimmune conditions, or metabolic disorders. Common patterns on lab testing can help indicate hepatocellular injury, cholestasis or other chronic processes. A methodical evaluation and testing approach is outlined.
This document discusses the evaluation and causes of chronic diarrhea. It begins by defining chronic diarrhea and outlining the normal stool production process. It then describes the main mechanisms that can cause diarrhea - osmotic, secretory, inflammatory, and dysmotility. Specific causes are discussed under each mechanism, including diseases, medications, toxins, and dietary factors. The document outlines the evaluation of a patient with chronic diarrhea, including history, physical exam, stool tests, imaging, and other lab tests. It provides guidance on testing for malabsorption and evaluating postsurgical causes of chronic diarrhea.
This document provides an overview of hemolytic anemia in children. It defines hemolytic anemia as anemia resulting from increased red blood cell destruction. The document describes the different types of hemolytic anemia including hereditary, immune, and non-immune causes. It outlines the pathophysiology, clinical features, diagnostic approach and management of common forms of hemolytic anemia in children such as hereditary spherocytosis, thalassemia, sickle cell anemia, and G6PD deficiency. Investigations for diagnosis include blood counts, peripheral smear, reticulocyte count, hemoglobin electrophoresis and enzyme or genetic testing depending on etiology.
This document discusses various causes of congenital and chronic diarrhea in children. It defines diarrhea and describes different types including osmotic, secretory, and chronic nonspecific diarrhea. Specific conditions covered include glucose-galactose malabsorption, celiac disease, cystic fibrosis, tufting enteropathy, microvillus inclusion disease, congenital chloride diarrhea, intestinal lymphangiectasia, abetalipoproteinemia, and immunodeficiency-related diarrhea. The diagnostic approach and management strategies for each condition are summarized.
This document discusses hypernatremia, defined as a serum sodium level greater than 150 mEq/L. It describes the normal extracellular and intracellular fluid compartments and how they are affected by hypernatremia. Clinical signs of hypernatremia range from restlessness to seizures and death depending on the serum osmolality level. Common causes include inadequate water intake, excessive sodium intake, renal or GI losses. Treatment involves volume repletion first with isotonic fluids followed by a gradual decrease in sodium levels with hypotonic fluids over 1-2 days. Free water deficits are calculated to determine fluid replacement volumes needed.
This document discusses hepatic encephalopathy, which is a reversible neuropsychiatric complication of severe liver disease. It can be caused by cirrhosis, portal-systemic bypass, or acute liver failure. The pathogenic mechanisms involve ammonia toxicity and false neurotransmitters. Clinical manifestations range from sleep disturbances and confusion to coma. Treatment focuses on identifying and removing precipitating factors, reducing ammonia production, correcting amino acid imbalances, and managing complications. Prognosis depends on the underlying liver disease.
clinical approach to jaundice in adultsReem Alyahya
A 66-year-old man presented with yellowish discoloration of his eyes and itching over the past 3 months. He also reported an unintentional 10 kg weight loss and physical examination found a palpable mass in his right upper abdomen. Evaluation for jaundice includes history, physical exam, liver enzymes, imaging and other tests based on suspected etiology. In this case, the patient's symptoms suggest biliary obstruction caused by pancreatic cancer given his age, weight loss, abdominal mass and minimal itching.
This document provides information on the approach to a patient presenting with jaundice. It discusses the definitions, biochemistry, pathophysiology, history taking, physical examination, and investigations.
For a case example, it describes a 24-year-old female who presents with 4 days of fever, nausea, vomiting and anorexia. Her lab results show elevated bilirubin, ALT, and AST, with HAV IgM being positive on viral screening. Her examination and ultrasound are not suggestive of biliary obstruction. She is diagnosed with viral hepatitis A.
This document provides information on the definition, presentation, evaluation, investigation and treatment of anemia. It defines anemia as a hemoglobin level below certain thresholds based on sex. Anemia is often identified through screening tests but can sometimes present with symptoms of advanced anemia. Evaluation involves taking a medical history and performing a physical exam and blood tests. Based on test results, anemias are classified and specific treatment is given depending on the underlying cause, such as iron supplementation for iron deficiency anemia or blood transfusions for acute blood loss.
The document summarizes Bartter's and Gitelman's syndromes, which are inherited tubular defects characterized by low potassium levels and metabolic alkalosis. Bartter's syndrome involves defects in sodium reabsorption in the thick ascending limb of the loop of Henle, while Gitelman's syndrome involves a primary defect in the thiazide-sensitive sodium-chloride cotransporter in the distal convoluted tubule. Both conditions result in activation of the renin-angiotensin-aldosterone system and loss of potassium and hydrogen ions in the urine. Gitelman's syndrome generally presents later in life and has a more mild phenotype. Treatment aims to block prostaglandin E2 and al
Case scenarios in wilson disease by Dr Aabha NagralSanjeev Kumar
This document presents 4 case scenarios of patients with possible Wilson's disease:
1) A 16-year-old boy with liver dysfunction, tremors, and other symptoms. Tests confirmed low ceruloplasmin and elevated urine copper, diagnosing Wilson's disease.
2) An 8-year-old boy with a family history of liver disease. Low ceruloplasmin and KF rings confirmed Wilson's disease.
3) A 38-year-old man with liver dysfunction and severe neurological symptoms. Tests confirmed Wilson's disease affecting both the liver and brain.
4) A 2-year-old asymptomatic girl with a family history. Testing revealed subclinical Wilson's disease,
Hepatic encephalopathy is a reversible neuropsychiatric impairment that ranges from subtle mental status changes to deep coma in patients with acute or chronic liver disease. There are several proposed mechanisms for hepatic encephalopathy, including the ammonia, inflammation, oxidative stress, and manganese theories. The pathogenesis involves toxic substances bypassing the liver and affecting astrocyte function in the brain, which can lead to cerebral edema. Clinical examination is needed to diagnose hepatic encephalopathy and exclude other potential causes of altered mental status in cirrhotic patients.
PPT on Neonatal cholestasis by Dr.ajay k chourasiaAjay Kumar
This document provides an overview of neonatal cholestasis, including its definition, classification, and causes. It discusses infectious, metabolic, genetic/chromosomal, and other potential etiologies. Specific conditions are described in more detail such as Alagille syndrome, progressive familial intrahepatic cholestasis types 1-3, and Zellweger syndrome. Evaluation and management goals are to diagnose and treat underlying conditions, identify those amenable to surgery, and avoid unnecessary procedures for intrahepatic diseases.
This document discusses hyponatremia, defining it as a serum sodium level below 135 mEq/L. It classifies hyponatremia based on severity and chronicity. The physiology of water balance and factors regulating vasopressin are described. Causes of hyponatremia include hypovolaemia, euvoleamia, and hypervoleamia. SIADH criteria and causes are provided. A case report of refractory hyponatremia due to SIADH from cortical vein thrombosis and antithrombin III deficiency is summarized.
The document discusses acute kidney injury (AKI), including its definition, causes, evaluation, management, and complications. AKI is defined as an abrupt loss of kidney function leading to accumulation of waste and dysregulation of fluid and electrolytes. It can be caused by prerenal issues like decreased blood flow, intrinsic renal issues like nephrotoxins or glomerular disease, or postrenal issues like urinary obstruction. Evaluation includes labs, imaging, and potentially biopsy. Management focuses on fluid management, electrolyte disturbances, acidosis, nutrition, and dialysis if needed. Complications can include issues like heart problems, infections, bleeding, and mental status changes.
This document provides an overview of approaches to evaluating and diagnosing anemia in children. It begins by discussing the importance of anemia screening and various mechanisms that can cause anemia. It then describes key components of the medical history, physical exam, and basic lab tests to consider. These include a complete blood count, reticulocyte count, and peripheral blood smear. The document outlines three main approaches: pathophysiological, scenario-based, and morphological classification based on red blood cell size. For each approach, it provides details on evaluating different types of anemias like iron deficiency, megaloblastic, hemolytic, and hypoproliferative anemias. Overall, the document serves as a guide
Describes the secretion and functions of Antidiuretic hormone, abnormalities associated with ADH secretion, reasons of SIADH etc in details with figures.
This document discusses the approach to hypokalemia, including its definition, prevalence, physiology, causes, symptoms, diagnosis, and treatment. Hypokalemia is defined as a plasma potassium level below 3.5 mEq/L and can range from mild to severe. It affects around 14% of outpatients and is more common in hospitalized patients. Potassium levels are tightly regulated and most potassium is found intracellularly. Causes of hypokalemia include low intake, redistribution into cells, and increased loss due to renal or extra-renal factors. Clinical symptoms depend on severity and may include fatigue, weakness, constipation or arrhythmias. Treatment involves replacing potassium stores orally or intravenously
This document discusses motility disorders, focusing on constipation and fecal incontinence. It provides details on evaluating and diagnosing constipation, including taking a thorough history and conducting a physical exam. For mild constipation, lifestyle and dietary changes may help, along with laxatives. More severe cases require tests to determine if slow transit or problems relaxing muscles are causes. Treatments depend on test results and may include biofeedback, surgery, or supportive management.
Diarrhea is defined as an increase in stool frequency or liquidity. For infants it is considered diarrhea if there are more than 3 watery stools per day, while for older children it is 3 or more loose stools per day. The causes of diarrhea include viral, bacterial, and parasitic infections. Rotavirus is the most common cause of acute diarrhea in children. Treatment involves oral rehydration with solutions like ORS as well as continued feeding. For some cases antibiotics or zinc may be used. Prevention strategies include vaccines, handwashing, safe water, and breastfeeding.
This document discusses renal tubular acidosis (RTA), which is caused by defects in the kidney's ability to absorb bicarbonate or excrete acid. There are four main types of RTA - distal (Type 1), proximal (Type 2), mixed (Type 3), and hypoaldosteronism (Type 4). Type 1 is caused by impaired distal acid secretion and presents with metabolic acidosis and high urine pH. Type 2 is caused by reduced proximal bicarbonate reabsorption and can present as isolated proximal RTA or Fanconi syndrome. Mixed Type 3 has features of both Types 1 and 2. Type 4 is caused by aldosterone deficiency or resistance and presents with hyperkalemia and mild acid
Approach to a patient with hyponatremia (2) (1)Mohit Aggarwal
The document discusses hyponatremia, which refers to a low serum sodium level. It begins by defining hyponatremia and providing normal sodium levels. It then covers the frequency, age and sex predispositions, physiology/pathophysiology, types and causes. The types include hypovolemic, euvolemic, hypervolemic, redistributive, and pseudohyponatremia. Common causes are discussed like SIADH, heart failure, cirrhosis. The clinical approach involves assessing volume status, labs like sodium, osmolality, urine sodium. Management depends on the type and involves restricting free water intake or using hypertonic saline in severe cases to slowly correct the
The document provides an overview of approach to evaluating abnormal liver function tests (LFTs). It defines relevant liver enzymes and tests. Epidemiology studies show most abnormal LFT cases can be diagnosed noninvasively, and the most common findings are non-alcoholic fatty liver disease and steatohepatitis. A thorough history and physical exam is important to identify potential causes like medications, viruses, autoimmune conditions, or metabolic disorders. Common patterns on lab testing can help indicate hepatocellular injury, cholestasis or other chronic processes. A methodical evaluation and testing approach is outlined.
This document discusses the evaluation and causes of chronic diarrhea. It begins by defining chronic diarrhea and outlining the normal stool production process. It then describes the main mechanisms that can cause diarrhea - osmotic, secretory, inflammatory, and dysmotility. Specific causes are discussed under each mechanism, including diseases, medications, toxins, and dietary factors. The document outlines the evaluation of a patient with chronic diarrhea, including history, physical exam, stool tests, imaging, and other lab tests. It provides guidance on testing for malabsorption and evaluating postsurgical causes of chronic diarrhea.
This document provides an overview of hemolytic anemia in children. It defines hemolytic anemia as anemia resulting from increased red blood cell destruction. The document describes the different types of hemolytic anemia including hereditary, immune, and non-immune causes. It outlines the pathophysiology, clinical features, diagnostic approach and management of common forms of hemolytic anemia in children such as hereditary spherocytosis, thalassemia, sickle cell anemia, and G6PD deficiency. Investigations for diagnosis include blood counts, peripheral smear, reticulocyte count, hemoglobin electrophoresis and enzyme or genetic testing depending on etiology.
This document discusses various causes of congenital and chronic diarrhea in children. It defines diarrhea and describes different types including osmotic, secretory, and chronic nonspecific diarrhea. Specific conditions covered include glucose-galactose malabsorption, celiac disease, cystic fibrosis, tufting enteropathy, microvillus inclusion disease, congenital chloride diarrhea, intestinal lymphangiectasia, abetalipoproteinemia, and immunodeficiency-related diarrhea. The diagnostic approach and management strategies for each condition are summarized.
This document discusses hypernatremia, defined as a serum sodium level greater than 150 mEq/L. It describes the normal extracellular and intracellular fluid compartments and how they are affected by hypernatremia. Clinical signs of hypernatremia range from restlessness to seizures and death depending on the serum osmolality level. Common causes include inadequate water intake, excessive sodium intake, renal or GI losses. Treatment involves volume repletion first with isotonic fluids followed by a gradual decrease in sodium levels with hypotonic fluids over 1-2 days. Free water deficits are calculated to determine fluid replacement volumes needed.
This document discusses hepatic encephalopathy, which is a reversible neuropsychiatric complication of severe liver disease. It can be caused by cirrhosis, portal-systemic bypass, or acute liver failure. The pathogenic mechanisms involve ammonia toxicity and false neurotransmitters. Clinical manifestations range from sleep disturbances and confusion to coma. Treatment focuses on identifying and removing precipitating factors, reducing ammonia production, correcting amino acid imbalances, and managing complications. Prognosis depends on the underlying liver disease.
clinical approach to jaundice in adultsReem Alyahya
A 66-year-old man presented with yellowish discoloration of his eyes and itching over the past 3 months. He also reported an unintentional 10 kg weight loss and physical examination found a palpable mass in his right upper abdomen. Evaluation for jaundice includes history, physical exam, liver enzymes, imaging and other tests based on suspected etiology. In this case, the patient's symptoms suggest biliary obstruction caused by pancreatic cancer given his age, weight loss, abdominal mass and minimal itching.
This document provides information on the approach to a patient presenting with jaundice. It discusses the definitions, biochemistry, pathophysiology, history taking, physical examination, and investigations.
For a case example, it describes a 24-year-old female who presents with 4 days of fever, nausea, vomiting and anorexia. Her lab results show elevated bilirubin, ALT, and AST, with HAV IgM being positive on viral screening. Her examination and ultrasound are not suggestive of biliary obstruction. She is diagnosed with viral hepatitis A.
This document provides information on the definition, presentation, evaluation, investigation and treatment of anemia. It defines anemia as a hemoglobin level below certain thresholds based on sex. Anemia is often identified through screening tests but can sometimes present with symptoms of advanced anemia. Evaluation involves taking a medical history and performing a physical exam and blood tests. Based on test results, anemias are classified and specific treatment is given depending on the underlying cause, such as iron supplementation for iron deficiency anemia or blood transfusions for acute blood loss.
The document summarizes Bartter's and Gitelman's syndromes, which are inherited tubular defects characterized by low potassium levels and metabolic alkalosis. Bartter's syndrome involves defects in sodium reabsorption in the thick ascending limb of the loop of Henle, while Gitelman's syndrome involves a primary defect in the thiazide-sensitive sodium-chloride cotransporter in the distal convoluted tubule. Both conditions result in activation of the renin-angiotensin-aldosterone system and loss of potassium and hydrogen ions in the urine. Gitelman's syndrome generally presents later in life and has a more mild phenotype. Treatment aims to block prostaglandin E2 and al
Case scenarios in wilson disease by Dr Aabha NagralSanjeev Kumar
This document presents 4 case scenarios of patients with possible Wilson's disease:
1) A 16-year-old boy with liver dysfunction, tremors, and other symptoms. Tests confirmed low ceruloplasmin and elevated urine copper, diagnosing Wilson's disease.
2) An 8-year-old boy with a family history of liver disease. Low ceruloplasmin and KF rings confirmed Wilson's disease.
3) A 38-year-old man with liver dysfunction and severe neurological symptoms. Tests confirmed Wilson's disease affecting both the liver and brain.
4) A 2-year-old asymptomatic girl with a family history. Testing revealed subclinical Wilson's disease,
Hepatic encephalopathy is a reversible neuropsychiatric impairment that ranges from subtle mental status changes to deep coma in patients with acute or chronic liver disease. There are several proposed mechanisms for hepatic encephalopathy, including the ammonia, inflammation, oxidative stress, and manganese theories. The pathogenesis involves toxic substances bypassing the liver and affecting astrocyte function in the brain, which can lead to cerebral edema. Clinical examination is needed to diagnose hepatic encephalopathy and exclude other potential causes of altered mental status in cirrhotic patients.
PPT on Neonatal cholestasis by Dr.ajay k chourasiaAjay Kumar
This document provides an overview of neonatal cholestasis, including its definition, classification, and causes. It discusses infectious, metabolic, genetic/chromosomal, and other potential etiologies. Specific conditions are described in more detail such as Alagille syndrome, progressive familial intrahepatic cholestasis types 1-3, and Zellweger syndrome. Evaluation and management goals are to diagnose and treat underlying conditions, identify those amenable to surgery, and avoid unnecessary procedures for intrahepatic diseases.
This document discusses hyponatremia, defining it as a serum sodium level below 135 mEq/L. It classifies hyponatremia based on severity and chronicity. The physiology of water balance and factors regulating vasopressin are described. Causes of hyponatremia include hypovolaemia, euvoleamia, and hypervoleamia. SIADH criteria and causes are provided. A case report of refractory hyponatremia due to SIADH from cortical vein thrombosis and antithrombin III deficiency is summarized.
The document discusses acute kidney injury (AKI), including its definition, causes, evaluation, management, and complications. AKI is defined as an abrupt loss of kidney function leading to accumulation of waste and dysregulation of fluid and electrolytes. It can be caused by prerenal issues like decreased blood flow, intrinsic renal issues like nephrotoxins or glomerular disease, or postrenal issues like urinary obstruction. Evaluation includes labs, imaging, and potentially biopsy. Management focuses on fluid management, electrolyte disturbances, acidosis, nutrition, and dialysis if needed. Complications can include issues like heart problems, infections, bleeding, and mental status changes.
This document provides an overview of approaches to evaluating and diagnosing anemia in children. It begins by discussing the importance of anemia screening and various mechanisms that can cause anemia. It then describes key components of the medical history, physical exam, and basic lab tests to consider. These include a complete blood count, reticulocyte count, and peripheral blood smear. The document outlines three main approaches: pathophysiological, scenario-based, and morphological classification based on red blood cell size. For each approach, it provides details on evaluating different types of anemias like iron deficiency, megaloblastic, hemolytic, and hypoproliferative anemias. Overall, the document serves as a guide
Describes the secretion and functions of Antidiuretic hormone, abnormalities associated with ADH secretion, reasons of SIADH etc in details with figures.
This document discusses the approach to hypokalemia, including its definition, prevalence, physiology, causes, symptoms, diagnosis, and treatment. Hypokalemia is defined as a plasma potassium level below 3.5 mEq/L and can range from mild to severe. It affects around 14% of outpatients and is more common in hospitalized patients. Potassium levels are tightly regulated and most potassium is found intracellularly. Causes of hypokalemia include low intake, redistribution into cells, and increased loss due to renal or extra-renal factors. Clinical symptoms depend on severity and may include fatigue, weakness, constipation or arrhythmias. Treatment involves replacing potassium stores orally or intravenously
This document discusses motility disorders, focusing on constipation and fecal incontinence. It provides details on evaluating and diagnosing constipation, including taking a thorough history and conducting a physical exam. For mild constipation, lifestyle and dietary changes may help, along with laxatives. More severe cases require tests to determine if slow transit or problems relaxing muscles are causes. Treatments depend on test results and may include biofeedback, surgery, or supportive management.
Diarrhea is defined as an increase in stool frequency or liquidity. For infants it is considered diarrhea if there are more than 3 watery stools per day, while for older children it is 3 or more loose stools per day. The causes of diarrhea include viral, bacterial, and parasitic infections. Rotavirus is the most common cause of acute diarrhea in children. Treatment involves oral rehydration with solutions like ORS as well as continued feeding. For some cases antibiotics or zinc may be used. Prevention strategies include vaccines, handwashing, safe water, and breastfeeding.
Chronic diarrhea can be caused by secretory, osmotic, or inflammatory mechanisms. A thorough history and physical exam aim to characterize the diarrhea and identify potential causes. Key evaluation involves stool analysis to classify diarrhea and rule out infection, as well as imaging and endoscopy to identify structural diseases. Further testing may include small bowel biopsy and labs to investigate endocrine or malabsorptive disorders. Common causes include irritable bowel syndrome, celiac disease, inflammatory bowel disease, infection, laxative abuse, and maldigestion/malabsorption.
This document discusses chronic diarrhea, defining it as diarrhea lasting more than 4 weeks. It classifies chronic diarrhea based on factors such as duration, volume, pathophysiology, and stool characteristics. Common causes include infections, inflammatory bowel disease, irritable bowel syndrome, malabsorption issues, and medication side effects. A thorough history, physical exam, and laboratory testing can help identify the underlying cause and guide management, which may include dietary changes, medications, or further testing and procedures.
Constipation is the symptom and is associated with primary & Secondary causes. Constipation is defined as occurrence of >3 episodes of bowel movements. the Rome III criteria defines the objective classification and bristol stool chart helps in assessing the type of stools passed. Management of constipation deals with early assess, treating the cause, adjuvant management, Pharmacological Management (laxatives, suppositories & enemas) and following constipation prevention bundle.
1. Acute diarrhea is defined as increased stool frequency or loose stools lasting less than 2 weeks. Chronic diarrhea lasts more than 4 weeks.
2. Pathogenic mechanisms of diarrhea include increasing intestinal transit speed, bacterial/toxin adhesion and invasion of the intestinal mucosa, and toxin production which can cause secretory or inflammatory diarrhea.
3. Evaluation of diarrhea involves determining if the patient truly has diarrhea or another condition like incontinence or impaction. Potential causes like medications, duration (acute vs chronic), and characteristics of the stool (watery, inflammatory, fatty) should be investigated.
This document provides guidance on managing chronic diarrhea. It defines chronic diarrhea as loose or watery stools occurring at least 3 times per day for 4 or more weeks. Most cases of chronic diarrhea in developed countries are non-infectious. A key distinction is between functional causes like IBS and organic causes. Symptoms, stool characteristics, medical history and dietary factors can help focus the differential diagnosis. Testing is recommended if alarm features are present or initial workup is inconclusive. Empiric treatments like loperamide, bile acid sequestrants or dietary changes may help symptomatic management when a cause cannot be identified.
Diarrhea is an increased frequency and decreased consistency of fecal discharge as compared with an individual’s normal bowel pattern.
It is often a symptom of a systemic disease.
Acute diarrhea is commonly defined as shorter than 14 days’ duration.
Persistent diarrhea as longer than 14 days’ duration.
Chronic diarrhea as longer than 30 days’ duration.
Most cases of acute diarrhea are caused by infections with viruses, bacteria, or protozoa, and are generally self-limited.
The document discusses the gastrointestinal tract and common intestinal problems. It covers the structure and function of the lower GI tract. Common issues like constipation, intestinal gas, and diarrhea are explained in detail, including causes and treatment approaches. Specific conditions that can affect the small intestine, like celiac disease and inflammatory bowel disease, are outlined. Nutrition management for these diseases is also addressed.
This nursing care plan addresses diarrhea in a patient. It includes nursing diagnoses, subjective and objective data, short and long term goals, assessments, interventions, health teaching, and an evaluation plan. The care plan involves assessing the cause of diarrhea, monitoring for dehydration, providing skin care and fluid/nutrition support, and educating the patient on diet, medication use, and hygiene. The goal is for the patient to experience relief from diarrhea and related symptoms within 2 weeks.
Acute diarrhea is caused by infections spread through the fecal-oral route. It affects over 1.7 billion people globally each year and causes 760,000 deaths in children under 5. The key to management is fluid replacement to prevent dehydration through oral rehydration solutions. Antimicrobial treatment is usually not needed for acute infectious diarrhea but may be used for invasive bacteria like Shigella or Salmonella to prevent systemic complications. Proper hygiene and sanitation can help limit the spread of diarrhea-causing illnesses.
Acute diarrhea is caused by infections spread through the fecal-oral route. It affects over 1.7 billion people globally each year and causes 760,000 deaths in children under 5. The key aspects of management are fluid replacement to prevent dehydration, using oral rehydration solutions, and antimicrobial treatment only for invasive infections or immunocompromised patients to prevent antibiotic resistance. Proper sanitation and hygiene can help limit the transmission of infectious agents causing acute diarrhea.
Unit 4 presentation on diarrhea by Anjali yadav.pptxanchalyadav895389
Diarrhea is defined as having 3 or more loose stools per day. Globally, nearly 1.7 billion cases of childhood diarrhea occur annually, making it a leading cause of death among children under 5. Diarrhea can be acute or chronic based on duration, and causes include infections, drugs, diet, surgery, and other miscellaneous factors. Management involves oral rehydration therapy to replace lost fluids, administering prescribed medications, maintaining nutrition, and educating on prevention.
presentation.presentation slides by ptxyakemichael
This document discusses diarrhea and vomiting in pediatric patients. It begins by defining diarrhea and vomiting and listing learning objectives. It then covers etiology, risk factors, clinical manifestations, complications, medical management including rehydration therapy, nursing management, and preventative measures for diarrhea. For vomiting, it defines vomiting, discusses physiology and causes. It also covers differential diagnosis and clinical manifestations of vomiting and red flag symptoms. Diagnostic evaluation for acute vomiting is also mentioned.
IRRITABLE BOWEL SYNDROME
The term irritable bowel syndrome is used to describe a functional gastrointestinal disorder characterized by a variable combination of chronic and recurrent intestinal symptoms not explained by structural or biochemical abnormalities.
Obstructed defecation syndrome (ODS) is a functional disorder leading to the sensing of outlet obstruction in the absence of any pathological findings. In this article, we also provide the etiology of acquired constipation. Constipation is a very common presentation by the patients of a practicing surgeon. Any constipation that defies the existing understanding merits consideration for its evaluation for ODS. Constipation can be of primary or secondary variety. After clinically excluding the usual causes of constipation and ruling out colonic motility disorders, specialised investigations like dynamic defecography help in further management of ODS.
This document provides an overview of the approach to diarrhea and constipation. It begins with defining normal gastrointestinal physiology, focusing on fluid absorption and secretion in the small intestine and colon. It then defines diarrhea and discusses the classification of acute diarrhea by duration. Infectious causes are the most common, with viruses, bacteria, and protozoa being the main pathogens. The approach to a patient with acute diarrhea involves initial assessment, managing dehydration, expectant management, investigating for specific causes if severe or persistent, and reporting outbreaks to public health authorities.
This document discusses rumination disorder in a 16-year-old female patient. Rumination disorder involves repeatedly regurgitating and rechewing or reswallowing food after eating. It is considered a learned behavior rather than a medical condition. Treatment involves behavioral therapy like relaxation techniques and diaphragmatic breathing. For severe cases with weight loss, enteral nutrition may be needed. Multidisciplinary teams including nutrition, psychology, and gastroenterology have been shown to help patients learn to stop the rumination behavior through programs that focus on eating skills.
Diarrhea and vomiting in children
Vomiting (throwing up) and diarrhea (frequent, watery bowel movements) can be caused by viruses, bacteria, parasites, foods that are hard to digest (such as too many sweets) and other things.
This document discusses enteral and parenteral feeding methods. Enteral feeding refers to delivering nutrients through the gastrointestinal tract, either orally or through tubes placed in the nose, mouth or abdomen. Tube feeding provides nutrition when oral intake is impaired. Parenteral feeding involves intravenous delivery of nutrients and is used when enteral feeding is not possible due to conditions like short bowel syndrome or bowel obstruction. Both methods aim to meet nutritional needs but parenteral feeding carries higher risks like infection and requires venous access.
Rasamanikya is a excellent preparation in the field of Rasashastra, it is used in various Kushtha Roga, Shwasa, Vicharchika, Bhagandara, Vatarakta, and Phiranga Roga. In this article Preparation& Comparative analytical profile for both Formulationon i.e Rasamanikya prepared by Kushmanda swarasa & Churnodhaka Shodita Haratala. The study aims to provide insights into the comparative efficacy and analytical aspects of these formulations for enhanced therapeutic outcomes.
Cell Therapy Expansion and Challenges in Autoimmune DiseaseHealth Advances
There is increasing confidence that cell therapies will soon play a role in the treatment of autoimmune disorders, but the extent of this impact remains to be seen. Early readouts on autologous CAR-Ts in lupus are encouraging, but manufacturing and cost limitations are likely to restrict access to highly refractory patients. Allogeneic CAR-Ts have the potential to broaden access to earlier lines of treatment due to their inherent cost benefits, however they will need to demonstrate comparable or improved efficacy to established modalities.
In addition to infrastructure and capacity constraints, CAR-Ts face a very different risk-benefit dynamic in autoimmune compared to oncology, highlighting the need for tolerable therapies with low adverse event risk. CAR-NK and Treg-based therapies are also being developed in certain autoimmune disorders and may demonstrate favorable safety profiles. Several novel non-cell therapies such as bispecific antibodies, nanobodies, and RNAi drugs, may also offer future alternative competitive solutions with variable value propositions.
Widespread adoption of cell therapies will not only require strong efficacy and safety data, but also adapted pricing and access strategies. At oncology-based price points, CAR-Ts are unlikely to achieve broad market access in autoimmune disorders, with eligible patient populations that are potentially orders of magnitude greater than the number of currently addressable cancer patients. Developers have made strides towards reducing cell therapy COGS while improving manufacturing efficiency, but payors will inevitably restrict access until more sustainable pricing is achieved.
Despite these headwinds, industry leaders and investors remain confident that cell therapies are poised to address significant unmet need in patients suffering from autoimmune disorders. However, the extent of this impact on the treatment landscape remains to be seen, as the industry rapidly approaches an inflection point.
Muktapishti is a traditional Ayurvedic preparation made from Shoditha Mukta (Purified Pearl), is believed to help regulate thyroid function and reduce symptoms of hyperthyroidism due to its cooling and balancing properties. Clinical evidence on its efficacy remains limited, necessitating further research to validate its therapeutic benefits.
share - Lions, tigers, AI and health misinformation, oh my!.pptxTina Purnat
• Pitfalls and pivots needed to use AI effectively in public health
• Evidence-based strategies to address health misinformation effectively
• Building trust with communities online and offline
• Equipping health professionals to address questions, concerns and health misinformation
• Assessing risk and mitigating harm from adverse health narratives in communities, health workforce and health system
Local Advanced Lung Cancer: Artificial Intelligence, Synergetics, Complex Sys...Oleg Kshivets
Overall life span (LS) was 1671.7±1721.6 days and cumulative 5YS reached 62.4%, 10 years – 50.4%, 20 years – 44.6%. 94 LCP lived more than 5 years without cancer (LS=2958.6±1723.6 days), 22 – more than 10 years (LS=5571±1841.8 days). 67 LCP died because of LC (LS=471.9±344 days). AT significantly improved 5YS (68% vs. 53.7%) (P=0.028 by log-rank test). Cox modeling displayed that 5YS of LCP significantly depended on: N0-N12, T3-4, blood cell circuit, cell ratio factors (ratio between cancer cells-CC and blood cells subpopulations), LC cell dynamics, recalcification time, heparin tolerance, prothrombin index, protein, AT, procedure type (P=0.000-0.031). Neural networks, genetic algorithm selection and bootstrap simulation revealed relationships between 5YS and N0-12 (rank=1), thrombocytes/CC (rank=2), segmented neutrophils/CC (3), eosinophils/CC (4), erythrocytes/CC (5), healthy cells/CC (6), lymphocytes/CC (7), stick neutrophils/CC (8), leucocytes/CC (9), monocytes/CC (10). Correct prediction of 5YS was 100% by neural networks computing (error=0.000; area under ROC curve=1.0).
ABDOMINAL TRAUMA in pediatrics part one.drhasanrajab
Abdominal trauma in pediatrics refers to injuries or damage to the abdominal organs in children. It can occur due to various causes such as falls, motor vehicle accidents, sports-related injuries, and physical abuse. Children are more vulnerable to abdominal trauma due to their unique anatomical and physiological characteristics. Signs and symptoms include abdominal pain, tenderness, distension, vomiting, and signs of shock. Diagnosis involves physical examination, imaging studies, and laboratory tests. Management depends on the severity and may involve conservative treatment or surgical intervention. Prevention is crucial in reducing the incidence of abdominal trauma in children.
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Basavarajeeyam is a Sreshta Sangraha grantha (Compiled book ), written by Neelkanta kotturu Basavaraja Virachita. It contains 25 Prakaranas, First 24 Chapters related to Rogas& 25th to Rasadravyas.
Recomendações da OMS sobre cuidados maternos e neonatais para uma experiência pós-natal positiva.
Em consonância com os ODS – Objetivos do Desenvolvimento Sustentável e a Estratégia Global para a Saúde das Mulheres, Crianças e Adolescentes, e aplicando uma abordagem baseada nos direitos humanos, os esforços de cuidados pós-natais devem expandir-se para além da cobertura e da simples sobrevivência, de modo a incluir cuidados de qualidade.
Estas diretrizes visam melhorar a qualidade dos cuidados pós-natais essenciais e de rotina prestados às mulheres e aos recém-nascidos, com o objetivo final de melhorar a saúde e o bem-estar materno e neonatal.
Uma “experiência pós-natal positiva” é um resultado importante para todas as mulheres que dão à luz e para os seus recém-nascidos, estabelecendo as bases para a melhoria da saúde e do bem-estar a curto e longo prazo. Uma experiência pós-natal positiva é definida como aquela em que as mulheres, pessoas que gestam, os recém-nascidos, os casais, os pais, os cuidadores e as famílias recebem informação consistente, garantia e apoio de profissionais de saúde motivados; e onde um sistema de saúde flexível e com recursos reconheça as necessidades das mulheres e dos bebês e respeite o seu contexto cultural.
Estas diretrizes consolidadas apresentam algumas recomendações novas e já bem fundamentadas sobre cuidados pós-natais de rotina para mulheres e neonatos que recebem cuidados no pós-parto em unidades de saúde ou na comunidade, independentemente dos recursos disponíveis.
É fornecido um conjunto abrangente de recomendações para cuidados durante o período puerperal, com ênfase nos cuidados essenciais que todas as mulheres e recém-nascidos devem receber, e com a devida atenção à qualidade dos cuidados; isto é, a entrega e a experiência do cuidado recebido. Estas diretrizes atualizam e ampliam as recomendações da OMS de 2014 sobre cuidados pós-natais da mãe e do recém-nascido e complementam as atuais diretrizes da OMS sobre a gestão de complicações pós-natais.
O estabelecimento da amamentação e o manejo das principais intercorrências é contemplada.
Recomendamos muito.
Vamos discutir essas recomendações no nosso curso de pós-graduação em Aleitamento no Instituto Ciclos.
Esta publicação só está disponível em inglês até o momento.
Prof. Marcus Renato de Carvalho
www.agostodourado.com
NVBDCP.pptx Nation vector borne disease control programSapna Thakur
NVBDCP was launched in 2003-2004 . Vector-Borne Disease: Disease that results from an infection transmitted to humans and other animals by blood-feeding arthropods, such as mosquitoes, ticks, and fleas. Examples of vector-borne diseases include Dengue fever, West Nile Virus, Lyme disease, and malaria.
Histololgy of Female Reproductive System.pptxAyeshaZaid1
Dive into an in-depth exploration of the histological structure of female reproductive system with this comprehensive lecture. Presented by Dr. Ayesha Irfan, Assistant Professor of Anatomy, this presentation covers the Gross anatomy and functional histology of the female reproductive organs. Ideal for students, educators, and anyone interested in medical science, this lecture provides clear explanations, detailed diagrams, and valuable insights into female reproductive system. Enhance your knowledge and understanding of this essential aspect of human biology.
1. Approach to Diarrhea
Benazir Bhutto Hospital
Dr. Khubaib Samdani
Medical Unit - 1
Evaluating the Patient With Diarrhea
2. Outline Of My Presentation
Benazir Bhutto Hospital
Medical Unit - 1
Questions to ask the patient presenting with Diarrhea
Diarrhea, pathophysiology, classification
Walk-through UpToDate Algorithm for Acute and Chronic Diarrhea
1.
2.
3.
3. What is Diarrhea
Benazir Bhutto Hospital Medical Unit - 1
Diarrhea is a symptom or sign, not a disease, and can be
caused by numerous conditions.
Diarrhea can be defined by increased stool frequency,
liquidity, or volume.
Diarrhea is objectively defined as passing a stool weight
or volume greater than 200 g or 200 mL per 24 hours.
4. Medical Unit - 1 Benazir Bhutto Hospital
Talley &
O'Connor's
Clinical
Examination
- 8th Edition
Source:
5. Osmotic Diarrhea: unabsorbed substance draws water from the
plasma into the intestinal lumen along osmotic gradients.
Secretory Diarrhea: disordered electrolyte transport and, despite the
term, is more commonly caused by decreased absorption rather than
net secretion.
Inflammatory Diseases: cause diarrhea with exudative, secretory, or
osmotic components.
Altered Motility: of the intestine or colon may alter fluid absorption
by increasing or decreasing the exposure of luminal content to
intestinal absorptive surface.
Benazir Bhutto Hospital
Medical Unit - 1
6. Medical Unit - 1 Benazir Bhutto Hospital
Classification and Pathophysiology of Diarrhea
18. Benazir Bhutto Hospital
Medical Unit - 1
Important Points
- Rule out fecal incontinence and fecal impaction.
- Rule out medications as a cause of diarrhea (drug-induced diarrhea)
- Consider factitious diarrhea.
21. References
Sweetser S. Evaluating the patient with diarrhea: a case-based approach.
Mayo Clin Proc. 2012;87(6):596-602. doi:10.1016/j.mayocp.2012.02.015
https://www.uptodate.com/contents/image?imageKey=ID%2F68348
Davidson's Principles and Practices of Medicine - 23rd Edition
Talley & O'Connor's Clinical Examination - 8th Edition