This document summarizes information about antiseizure drugs (ASDs), including their mechanisms of action, uses, and side effects. It discusses several commonly used ASDs like carbamazepine, phenytoin, valproic acid, phenobarbital, primidone, and benzodiazepines. It also covers newer drugs such as lamotrigine, topiramate, tiagabine, levetiracetam, and zonisamide. The document stresses the importance of therapeutic drug monitoring to ensure effective drug levels and avoid toxicity when using ASDs.

1. ANTISEIZURE DRUGS Zenaida N. Maglaya,MD,FPSECP Department of Pharmacology

8. II.ABSENCE SEIZURES Ethosuximide, valproic acid, clonazepam Recent: Lamotrigine III MYOCLONIC SEIZURES Valproic acid, clonazepam Recent: Lamotrigine /topiramate

10. PARTIAL W/ 2 0 GENERALIZED TONIC-CLONIC SEIZURES CARBAMAZEPINE, VALPROATE PHENOBARBITAL PHENYTOIN Recent : gabapentin, tiagabine lamotrigine,levetiracetam, topiramate, zonisamide

25. CARBAMAZEPINE Drug Interactions 4. Carbamazepine increases drug levels : cimetidine, isoniazid 5. Lithium induces carbamazepine toxicity.

45. EFFECTIVE PLASMA LEVELS > 100 50 - 100 Valproic Acid > 100 50 -100 Ethosuximide > 40 10 - 40 Phenobarbital >20 10 - 20 Phenytoin > 8 4 - 12 Carbamzepine TOXIC LEVEL (ug/mL) Effective Level(ug/m DRUG