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ANTI-OBESITY ACTIVITY OF ANTHOCYANINS AND
CORRESPONDING INTRODUCTION IN DIETARY PLANS
AMAL DHIVAHAR S(UR16BT060)
DEPARTMENT OF BIOTECHNOLOGY, SCHOOL OF AGRICULTURE AND BIOSCIENCES,
KARUNYA INSTITUTE OF TECHNOLOGY AND SCIENCES, COIMBATORE – 641 114, INDIA.
Emerging Food
Technologies – Food
Biotechnology
ABSTRACT:
Obesity is considered to be a crucial health issue leading to some of the disturbing
physical, psychological and social consequences. Obesity refers to the state of being
grossly fat or overweight. Though proper medications have not been framed for it’s
cure, the amount of money and hard work invested for formulating a solution
regarding this affair is massive. Developing natural products from fruits and
vegetables with bioactivities into anti-disease agents has become a hot spot in
research. In a similar case, anthocyanins are found to be extra attractive, as they
have been proved to show anti-obesity effects. Not just considering this water-
soluble vacuolar pigment as a medicine, but making it as a part of one’s daily diet
would help reduce the complexity in attempting to lose weight, that has been
gained unnecessarily. Thus, understanding the medicinal avails of anthocyanin and
implementing it as a part of one’s diet would be a more effective strategy for
approaching obesity and related predicaments.
Keywords: Obesity, anthocyanin, medication, bioactivity, diet.
WHAT IS OBESITY?
• State of being grossly fat or overweight
• Excessive adipose tissue
• Body Mass Index (BMI) of 30 or above
• Negative effect on health
Consequences
Of being obese
Cardiovascular disease,
Type 2 diabetes,
Stroke, High blood
pressure, etc
Physical effects
Unemployment, Critics,
failure in marriage life,
etc
Social effects
Depression, anxiety,
low quality of life, low
self-esteem, etc
Psychological effects
Life
expectancy
is reduced
by more
than 9
years
ANTHOCYANINS: (ANTHOCYANIDINS WITH
SUGAR GROUPS)
 water-soluble vacuolar pigments
depending on their pH, may appear red, purple, or blue
 Food plants rich in anthocyanins include the blueberry,
raspberry, black rice, brinjal and black soybean, among
many others that are red, blue, purple, or black
 Some of the colours of autumn leaves are derived from
anthocyanins
ANTHOCYANINS MAY EXERT BENEFICIAL EFFECTS IN
OBESITY BY:
1.) inhibiting lipid absorption
2.) increasing energy expenditure
3.) regulating lipid metabolism
4.) suppressing food intake and
5.) regulating gut microbiota
(according to research studies)
L. Xie et al. Trends in Food Science & Technology 72 (2018) 13–24
DIET AND DIETARY PLANS:
• In nutrition, diet is the sum of food consumed by a
person or other organism.
• The word diet often implies the use of specific intake of
nutrition for health or weight-management reasons.
• Dietary plans are framed when a person is determined
to undergo the process of either weight gain or weight
loss in order to lead a healthy lifestyle.
CRITERIA:
• Start by replacing ordinary fruits & vegies with purple ones!
• Include the pigment as a part of your food by either eating
them as a whole or by preparing various recipes out of it
• Continue this programmed diet until you achieve desirable
results yet, continuing the same still is appreciable
• Such a kind of a diet coupled with physical exercises will
definitely yield greater results
EXTRACTION FOR FORMULATION:
Materials required:
substrate (biomass)
Cooler – freezer
Homogenizer grinder
dionex model ASE 200 equipped with a solvent controller
HPLC instrument
Required associated chemical agents (anthocyanin standards of the 3-
monoglucosides of delphinidin (Dpd), cyanidin(Cyd), petunidin (Ptd),
pelargonidin (Pgd), peonidin (Pnd), and malvidin (Mvd), etc)
ACCELERATED SOLVENT EXTRACTION (ASE):
• “extracts compounds from solid and semi-solid
samples quickly with small solvent volume”
• You will save
Time
solvent and
money
• generate results in a fraction of the time compared
to traditional techniques such as Soxhlet or
sonication.
BIOSYNTHESIS OF ANTHOCYANINS IN
MICROORGANISMS:
• production of anthocyanins from
genetically engineered microorganisms
• that express plant anthocyanins
biosynthetic pathways.
DRUG ADMINISTRATION:
• Oral (capsules / tonic)
• IV
• Subcutaneous
• Intramuscular injection
• Sublingual
• Intrathecal administration
• Nasal administration, etc
CONCLUSION:
• Anthocyanin is found to be an effective solution for problems
concerning obesity
• The pigment can be directly taken in as a part of one’s daily
meal
• Extraction and purification gives formulations for drug
designing and preparation
• Few or no side effects are identified during the experimental
trials of testing the anti-obesity characteristic ability of
anthocyanin pigments.
REFERENCES
• https://www.sciencedirect.com/science/article/pii/S092422441730626X?via%3Dihub
• https://pubs.acs.org/doi/abs/10.1021/jf904087n

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Anti-Obesity Activity of Anthocyanins and Corresponding Introduction in Dietary Plans

  • 1. ANTI-OBESITY ACTIVITY OF ANTHOCYANINS AND CORRESPONDING INTRODUCTION IN DIETARY PLANS AMAL DHIVAHAR S(UR16BT060) DEPARTMENT OF BIOTECHNOLOGY, SCHOOL OF AGRICULTURE AND BIOSCIENCES, KARUNYA INSTITUTE OF TECHNOLOGY AND SCIENCES, COIMBATORE – 641 114, INDIA. Emerging Food Technologies – Food Biotechnology
  • 2. ABSTRACT: Obesity is considered to be a crucial health issue leading to some of the disturbing physical, psychological and social consequences. Obesity refers to the state of being grossly fat or overweight. Though proper medications have not been framed for it’s cure, the amount of money and hard work invested for formulating a solution regarding this affair is massive. Developing natural products from fruits and vegetables with bioactivities into anti-disease agents has become a hot spot in research. In a similar case, anthocyanins are found to be extra attractive, as they have been proved to show anti-obesity effects. Not just considering this water- soluble vacuolar pigment as a medicine, but making it as a part of one’s daily diet would help reduce the complexity in attempting to lose weight, that has been gained unnecessarily. Thus, understanding the medicinal avails of anthocyanin and implementing it as a part of one’s diet would be a more effective strategy for approaching obesity and related predicaments. Keywords: Obesity, anthocyanin, medication, bioactivity, diet.
  • 3. WHAT IS OBESITY? • State of being grossly fat or overweight • Excessive adipose tissue • Body Mass Index (BMI) of 30 or above • Negative effect on health
  • 4. Consequences Of being obese Cardiovascular disease, Type 2 diabetes, Stroke, High blood pressure, etc Physical effects Unemployment, Critics, failure in marriage life, etc Social effects Depression, anxiety, low quality of life, low self-esteem, etc Psychological effects Life expectancy is reduced by more than 9 years
  • 5. ANTHOCYANINS: (ANTHOCYANIDINS WITH SUGAR GROUPS)  water-soluble vacuolar pigments depending on their pH, may appear red, purple, or blue  Food plants rich in anthocyanins include the blueberry, raspberry, black rice, brinjal and black soybean, among many others that are red, blue, purple, or black  Some of the colours of autumn leaves are derived from anthocyanins
  • 6. ANTHOCYANINS MAY EXERT BENEFICIAL EFFECTS IN OBESITY BY: 1.) inhibiting lipid absorption 2.) increasing energy expenditure 3.) regulating lipid metabolism 4.) suppressing food intake and 5.) regulating gut microbiota (according to research studies)
  • 7. L. Xie et al. Trends in Food Science & Technology 72 (2018) 13–24
  • 8. DIET AND DIETARY PLANS: • In nutrition, diet is the sum of food consumed by a person or other organism. • The word diet often implies the use of specific intake of nutrition for health or weight-management reasons. • Dietary plans are framed when a person is determined to undergo the process of either weight gain or weight loss in order to lead a healthy lifestyle.
  • 9. CRITERIA: • Start by replacing ordinary fruits & vegies with purple ones! • Include the pigment as a part of your food by either eating them as a whole or by preparing various recipes out of it • Continue this programmed diet until you achieve desirable results yet, continuing the same still is appreciable • Such a kind of a diet coupled with physical exercises will definitely yield greater results
  • 10. EXTRACTION FOR FORMULATION: Materials required: substrate (biomass) Cooler – freezer Homogenizer grinder dionex model ASE 200 equipped with a solvent controller HPLC instrument Required associated chemical agents (anthocyanin standards of the 3- monoglucosides of delphinidin (Dpd), cyanidin(Cyd), petunidin (Ptd), pelargonidin (Pgd), peonidin (Pnd), and malvidin (Mvd), etc)
  • 11. ACCELERATED SOLVENT EXTRACTION (ASE): • “extracts compounds from solid and semi-solid samples quickly with small solvent volume” • You will save Time solvent and money • generate results in a fraction of the time compared to traditional techniques such as Soxhlet or sonication.
  • 12. BIOSYNTHESIS OF ANTHOCYANINS IN MICROORGANISMS: • production of anthocyanins from genetically engineered microorganisms • that express plant anthocyanins biosynthetic pathways.
  • 13. DRUG ADMINISTRATION: • Oral (capsules / tonic) • IV • Subcutaneous • Intramuscular injection • Sublingual • Intrathecal administration • Nasal administration, etc
  • 14. CONCLUSION: • Anthocyanin is found to be an effective solution for problems concerning obesity • The pigment can be directly taken in as a part of one’s daily meal • Extraction and purification gives formulations for drug designing and preparation • Few or no side effects are identified during the experimental trials of testing the anti-obesity characteristic ability of anthocyanin pigments.
  • 15.