11. Cyclophosphamide
• Forms DNA cross-links, resulting in inhibition
of DNA synthesis and function
• Use : Breast cancer,
• ovarian cancer non-Hodgkin’s lymphoma
• chronic lymphocytic leukemia
• neuroblastoma
13. Anti- Metabolites
Methotrexate
Inhibits DHFR, resulting in inhibition of synthesis
of thymidylate, purine nucleotides, serine, and
methionine
USE : Breast cancer,
head and neck cancer, primary CNS lymphoma, non-Hodgkin’s
lymphoma, bladder cancer, choriocarcinoma
19. Etoposide
• Inhibits topoisomerase II, resulting in DNA damage
USE
• Lung cancer,
• non-Hodgkin’s lymphoma
• gastric cancer
S/E
• Nausea, vomiting
• Alopecia,
• myelosuppression
20. Paclitaxel
Interferes with microtubule disassembly,
resulting in impaired mitosis
USE
Breast, lung, ovarian, gastroesophageal, prostate, bladder, and head and neck
cancers
S /E
Nausea, vomiting, hypotension, arrhythmias, hypersensitivity
Myelosuppression, peripheral sensory neuropathy
21. ANTI TUMOR ANTIBIOTICS
• BLEOMYCIN
• DOXORUBICIN
• MITOMYCIN
USE : Lymphoma , Myelomas , Sarcomas , Breast , lung , ovarian and thyroid
cancers
S/E
Nausea
Arrhythmias
Alopecia
Cardiomyopathy
24. • Tamoxifen
Blocks the binding of estrogen to receptors of
estrogen sensitive cancer cells in breast tissue
Use : Breast Ca
S/E : Nausea
Vomitting
Hot flushes
Vaginal bleeding
Venous thrombosis
