Anthelmintic drugs.pptx

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Anthelmintic Drugs

Anthelmintic Drugs
By
Dr. Nidhi Gupta
MM College of Pharmacy,
MM (Deemed to be University), Mullana, Ambala

Mebendazole,
Albendazole,
Praziquantel
Praziquantel,
Albendazole.

MOA of Mebandazole & Aldendazole
1. It acts by inhibiting microtubules synthesis. It binds with
parasite b-tubulin and inhibits its polymerization.
2. It blocks the glucose uptake in parasite and depletes its
glycogen stores.
MOA of Praziquantel
1. It is taken up by the susceptible worm and causes leakage
of intracellular calcium, thereby leading to the paralysis and
loss off intestinal mucosal grip….. expelled.

Uses-
Mebandazole- (namatodes)-Ascariasis (round worm),
pinworm diseases, hookworm infection.
Albendazole- Ascariasis (round worm), pinworm diseases,
hookworm infection and pin worm.
Diethyl carbamazine- filariasis
Praziquantel- (trematodes)
Niclosamide- (cestodes)

Synthesis of Diethyl carbamazine

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Anthelmintic drugs.pptx

1. Anthelmintic Drugs By Dr. Nidhi Gupta MM College of Pharmacy, MM (Deemed to be University), Mullana, Ambala

2.

3.

4. Mebendazole, Albendazole, Praziquantel Praziquantel, Albendazole.

5.

6. MOA of Mebandazole & Aldendazole 1. It acts by inhibiting microtubules synthesis. It binds with parasite b-tubulin and inhibits its polymerization. 2. It blocks the glucose uptake in parasite and depletes its glycogen stores. MOA of Praziquantel 1. It is taken up by the susceptible worm and causes leakage of intracellular calcium, thereby leading to the paralysis and loss off intestinal mucosal grip….. expelled.

7. Uses- Mebandazole- (namatodes)-Ascariasis (round worm), pinworm diseases, hookworm infection. Albendazole- Ascariasis (round worm), pinworm diseases, hookworm infection and pin worm. Diethyl carbamazine- filariasis Praziquantel- (trematodes) Niclosamide- (cestodes)

8. Synthesis of Diethyl carbamazine