1. Android N introduces multi-window mode which allows users to use multiple apps simultaneously by displaying them in split-screen or picture-in-picture modes.
2. Developers can configure their apps to support multi-window mode through settings like android:resizeableActivity and by handling configuration changes and lifecycle methods appropriately when an app is in a paused state but still visible.
3. Best practices for multi-window include designing first for the smallest screen size, handling all orientations, and ensuring activities work properly when launched by other apps in multi-window mode.