This document describes simulations of a large-scale Internet application (Facebook) on cloud computing environments using a tool called CloudAnalyst. Several scenarios are simulated with different configurations for data center location, service broker algorithm, and VM load balancing algorithm. Key results include overall response time, data center processing time, and cost. The best performance was found with multiple data centers located in each region using proximity-based routing and throttled load balancing, with an average response time of 205ms and total cost of $1,128.94.