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Life Science Seminar Proinvestor 5. October 2011   Martin Welschof Managing Director, Affitech A/S Affitech A/S, October, 2011
Disclaimer Forward Looking Statements . Affitech A/S is a public company listed on NASDAQ OMX Copenhagen. Recipients of this presentation are advised that this written presentation and any verbal comments to it provided by Executive Management contain forward looking statements, including without limitation those regarding Affitech’s financial position, business strategy, news flow, plans and objectives for future operations, including development plans and objectives relating to our products. Such forward looking statements are based upon assumptions of future events which may not prove to be accurate and involve known and unknown risks, uncertainties and other factors which may cause the Company’s actual results, performance or achievements to be materially different from those expressed or implied by such forward looking statements.  In addition, the forward looking statements in this document speak only as of the date of this presentation
Company snapshot  Affitech A/S, October, 2011 ,[object Object]
AT001/r84:A human selective anti-VEGF antibody with a new mode of action
AT008/CCR4: The first CBASTM antibody targeting a GPCR - advancing to candidate selection
Broad and growing pipeline of GPCR drug candidates
Powerful antibody discovery engine:
Unique proprietary technology platform, placing  Affitech at the forefront of antibody innovation
Partnerships:
Strong strategic partnerships for research, co-development and marketing,[object Object]
Pending in USA, Australia, Canada, Israel, India, China, Brazil, Norway, Croatia, SerbiaAT001/r84 patent ,[object Object],CCR4andCXCR4 patents  ,[object Object],[object Object]
Powerfultechnology drives discoveryengine Platform withhighcapacity to isolate multiple fully human antibody  candidates to targetswithchallengingspecificities CBASTM – cellbased antibody selection
AT001/r84 – potential for greater safety AT001/r84 antibody is a proprietary  antibody with anovel  mechanism of action: ,[object Object]
Binds VEGF selectively, inhibiting binding to VEGFR2 only and not VEGFR1
Preclinical data shows efficacy at least equal to Avastin® (bevacizumab)
Shows limited induction of side effectsLarge market opportunity for AT001/r84 in emerging markets : ,[object Object]
Low penetration of Avastin® in Russia/CIS
An anti-VEGF antibody has top priority on Russian short list of innovative drugs to be marketed by 2015Affitech A/S, October, 2011 Scheduled to enter phase I clinical trial  in Russia in 2011
AT001/r84 – more specific inhibition (VEGF) AT001/r84 More selective for anti-angiogenesis Avastin® VEGFR2 VEGFR1 VEGFR2 VEGFR1 the dominant ‘angiogenic’ receptor Affitech A/S, October, 2011
AT001/r84 progressing well ,[object Object]

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Life Science Seminar Highlights Affitech's Antibody Pipeline

  • 1. Life Science Seminar Proinvestor 5. October 2011   Martin Welschof Managing Director, Affitech A/S Affitech A/S, October, 2011
  • 2. Disclaimer Forward Looking Statements . Affitech A/S is a public company listed on NASDAQ OMX Copenhagen. Recipients of this presentation are advised that this written presentation and any verbal comments to it provided by Executive Management contain forward looking statements, including without limitation those regarding Affitech’s financial position, business strategy, news flow, plans and objectives for future operations, including development plans and objectives relating to our products. Such forward looking statements are based upon assumptions of future events which may not prove to be accurate and involve known and unknown risks, uncertainties and other factors which may cause the Company’s actual results, performance or achievements to be materially different from those expressed or implied by such forward looking statements. In addition, the forward looking statements in this document speak only as of the date of this presentation
  • 3.
  • 4. AT001/r84:A human selective anti-VEGF antibody with a new mode of action
  • 5. AT008/CCR4: The first CBASTM antibody targeting a GPCR - advancing to candidate selection
  • 6. Broad and growing pipeline of GPCR drug candidates
  • 8. Unique proprietary technology platform, placing Affitech at the forefront of antibody innovation
  • 10.
  • 11.
  • 12. Powerfultechnology drives discoveryengine Platform withhighcapacity to isolate multiple fully human antibody candidates to targetswithchallengingspecificities CBASTM – cellbased antibody selection
  • 13.
  • 14. Binds VEGF selectively, inhibiting binding to VEGFR2 only and not VEGFR1
  • 15. Preclinical data shows efficacy at least equal to Avastin® (bevacizumab)
  • 16.
  • 17. Low penetration of Avastin® in Russia/CIS
  • 18. An anti-VEGF antibody has top priority on Russian short list of innovative drugs to be marketed by 2015Affitech A/S, October, 2011 Scheduled to enter phase I clinical trial in Russia in 2011
  • 19. AT001/r84 – more specific inhibition (VEGF) AT001/r84 More selective for anti-angiogenesis Avastin® VEGFR2 VEGFR1 VEGFR2 VEGFR1 the dominant ‘angiogenic’ receptor Affitech A/S, October, 2011
  • 20.
  • 21. Preparing Clinical Trial Application for submission
  • 22.
  • 23. Multi-ligandGPCRs can be targeted for antibody therapy
  • 24. GPCRs - the largest known protein family at >2% of the entire genome
  • 25. Involved in a wide range of disorders and biological functions
  • 26.
  • 27. NDA filed in Japan for anti-CCR4 antibodyKW-0761 to treat Adult T-cell Leukemia-Lymphoma (ATL) (Kyowa Hakko Kirin, partnered with Amgen)
  • 29. A xenograph model successfully completed
  • 30. Development of an AT008/CCR4 manufacturing cell line initiated
  • 31. Six other chemokine receptor programs are being profiled in in vitro and in vivo models
  • 32.
  • 34.
  • 35. Next generation dual specificity/functionality antibody-like molecules
  • 36.
  • 37.
  • 38.
  • 39.
  • 41. Norwegian PE and institutions: ~30%
  • 42.
  • 43. CFO Stig Jarle Pettersen, Norwegian state authorized public accountant
  • 44. CSO Alexander Duncan, British, a leading antibody research scientist and business leaderFacilities in Copenhagen Bio Science Park , Denmark and in the Research Park in Oslo, Norway
  • 45. Contactdetails Affitech A/S, October, 2011 Affitech A/S Copenhagen, Denmark c/o COBIS Ole Maaløes Vej 3 DK- 2200 Kbh. N Denmark Telephone: +45 39 17 82 59 Email: IR@affitech.comf Affitech Research, Oslo, Norway Gaustadalléen 21 N-0349 Oslo Norway Telephone: +47 22 95 87 58 Fax: +47 22 95 83 58 Email: INFO@affitech.com WWW.affitech.com
  • 46. Affitech A/S addresses unmet medical needs in cancer, including hematological and solid tumors, and in serious inflammatory conditions Thank you for your attention