Non-ionic surfactant vesicles, commonly referred to as niosomes, have garnered significant attention within the pharmaceutical industry due to their remarkable capacity to encapsulate both hydrophilic and hydrophobic drugs. Recent studies have demonstrated the potential of these vesicles to enhance the bioavailability of drugs, making them a promising strategy for delivering various therapeutic agents such as gene materials, protein therapeutics, and chemical pharmaceuticals. This approach offers minimal toxicity and desirable targeting effectiveness. Niosomes are substantially more stable during the preparation and storage procedure than liposomes. The desired pharmacokinetics property can be attained through the optimization of constituents or surface modifications. This novel method of distribution is also facile to establish and expand, while maintaining cost-effective manufacturing expenses. This review article elucidates the fundamentals of niosomes as non-ionic surfactant vesicles, including their structure and components, as well as various formulation methods. Additionally, the article explores the diverse applications of niosomal in the analgesics.

1. ORAL PRESENTATION IRTEC 2.0-2024
*Department of Pharmaceutics, Nims Institute of Pharmacy, Nims University Rajasthan, Jaipur, 303121, India
Paper Title (CNID: OP037): ADVANCEMENT AND CHARACTERSTICS OF NON-
IONIC SURFACTANT VESICLE (NIOSOME) AND THEIR APPLICATION
FOR AN ANALGESICS
Presented by: *Prachi Pandey, Rahul Pal
The Second International Conference on Multidisciplinary Research Trends in
European, Asian, and African Countries (IRTEC 2.0-2024)

2. NON IONIC SURFACTANT VESICELS
 Niosomes are microscopic, spherical structures formed by non-ionic surfactants, often in combination with
cholesterol, that self-assemble into bilayers in an aqueous environment.
https://www.sciencedirect.com/science/article/pii/S2590006423002971

3. OVERVIEW OF NIOSOMES
https://www.researchgate.net/publication/318113949_Niosomes_A_Novel_Trend_of_Drug_Delivery
https://www.researchgate.net/publication/330724093_Advances_of_NonIonic_Surfactant_Vesicles_Niosomes_and_Their_Application_in_Drug_Delivery
https://link.springer.com/chapter/10.1007/978-3-030-84262-8_16

4. ANALGESIC
 An analgesic, also known as a painkiller or pain reliever, is a medication that reduces or relieves pain. They work
through various mechanisms to interrupt or block pain signals (COX- 1 and 2 along with kappa, mu and delta
receptor) at different stages of the pain pathway, offering comfort from mild to severe aches.
Analgesi
c
https://www.frontiersin.org/articles/10.3389/fphar.2020.580289/full

5. ANALGESIC AS NIOSOMAL FORMULATION
https://sciencedirect.com/science/article/abs/pii/S1773224717309851#!
Tramadol HCl encapsulated niosomes for extended analgesic effect following oral
administration.

6. CONCLUSION
Abou-Taleb, H. A., Khallaf, R. A., & Abdel-Aleem, J. A. (2018). Intranasal niosomes of
nefopam with improved bioavailability: preparation, optimization, and in-vivo
evaluation. Drug design, development and therapy, 3501-3516.
https://www.sciencedirect.com/science/article/abs/pii/S1773224719320362