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ACUTE RESPIRATORY TRACT INFECTIONS
(ARI)
Dr. Yordanos G(MD)
For Anesthesia 2nd yr students
4/28/2018
1
GENERAL CONSIDERATIONS
 Acute respiratory infection (ARI) is the leading cause
of morbidity and mortality in children under 5years of
age.
 ARI accounts for about 28% of under 5 mortality in
Ethiopia.
 ARI involves both upper and lower respiratory tract
infections
 Nearly 20% of ARI develop acute lower respiratory
tract infections, mainly pneumonia.
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RISK FACTORS FOR ARI
 Pollution
 lack of breast feeding
 Congenital abnormalities heart or Lung
 Immuno deficiency
 Malnutrition
 Young infants
 Poor socio-economic status
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ANATOMIC CLASSIFICATION
OF AIRWAY
 Upper Airway
all structures/ the part of air way above thoracic inlet,
 Supraglottic area(nasopharynx, epiglottis, larynx,
aryepiglottic folds, and false vocal cords)
 Glottic and subglottic area (extends from the vocal cords
to the extra thoracic segment of the trachea)
 Lower Airway –
 Intrathoracic trachea and into the lungs
 intrathoracic-extrapulmonary airway extends from the
thoracic inlet to the main stem bronchi
 the intrapulmonary airway is within the lung parenchyma
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Upper
Airway
Lower
Airways
UPPER RESPIRATORY TRACT INFECTIONS
1. Acute Pharyngitis
- refers to inflammation of the pharynx,
including erythema,edema, exudates, or
enanthem (ulcers, vesicles)
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COMMON ETIOLOGIES
Viruses Bacterial
Adenovirus
Coronavirus
Cytomegalovirus
Epstein-Barr
Enteroviruses
Herpes simplex virus
Human immunodeficiency virus
Human metapneumovirus
Influenza viruses
Measles virus
Parainfluenza viruses
Respiratory syncytial virus
Rhinoviruses
Streptococcus pyogenes
(Group A streptococcus)
Arcanobacterium haemolyticum
Fusobacterium necrophorum
Corynebacterium diphtheriae
Neisseria gonorrhoeae
Group C streptococci
Group G streptococci
Francisella tularensis
Chlamydophila pneumoniae
Chlamydia trachomatis
Mycoplasma pneumoniae
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GROUP A STREPTOCOCCUS
EPIDEMIOLOGY
 Strept. Pharyngitis uncommon before 2-3yrs,
has a peak incidence in the early school
years, and declines in late adolescence and
adulthood
 Peaks during winter and spring
 Group C strept. and Arcanobacterium-
haemolyticum are causes in adults.
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PATHOGENESIS OF ACUTE
PHARYNGITIS
 Major virulent factor of GABHS is the M-protein
 Type specific immunity develops and provides protection
from subsequent infection by the same M-type.
 Scarlet fever is caused by GABHS that produce one of the
three streptococcal pyrogenic exotoxins(SPE)-A,B,C.
 SPE-A is mostly(strongly) associated.
 Infection with one clade confers immunity to the same clade
& hence infection can occur up to three times.
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CLINICAL MANIFESTATIONS OF ACUTE
PHARYNGITIS
 Rapid onset with prominent sore throat & fever
 Headache and GI symptoms are common
 Pharynx is red &tonsils are enlarged & classically covered
with yellow blood tinged exudates
 Doughnut lesions or petechae on the soft palate and
posterior pharynx
 Uvula is red and swollen
 Tender and swollen ant. Cervical nodes
 Some may manifest with Scarlet fever-circumoral pallor,
strawberry tongue &red and finely papular rash that feels
like sandpaper & with goose pimples
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CONT……
 Onset of viral pharyngitis has more insidious onset
 Adeno virus(pharyngoconjuctival fever)
 Coxakie virus-herpangina1-2mm grayish vesicles
and punched out ulcers in the posterior pharynx
/acute lymphonodular pharyngitis3-6mm yellowish
white nodules on post. Pharynx.
 EBV has systemic manifestations as part of
infectious mononucleosis syndrome
 HSV- high grade fever and gingivostomatitis
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DIAGNOSIS
 Throat culture and rapid antigen-detection
tests (RADTs) are the diagnostic tests for
GAS available in routine clinical care.
 Throat culture is un imperfect gold standard for Dx of
GABHS pharyngitis (high false –ve and false +ve)
 Rapid test(less sensitive and highly specific) ,If +ve –
treat and - ve(strong clinical ground)- throat culture
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MANAGEMENT
 nonspecific, symptomatic therapy can be an important part of the
overall treatment plan( with anti-pyretics,analgesics,local anesthetics)
• Antibiotic therapy should be started immediately without culture for
children with symptomatic pharyngitis and a positive rapid
streptococcal antigen test, a clinical diagnosis of scarlet fever, a
household contact with documented streptococcal pharyngitis, a past
history of acute rheumatic fever, or a recent history of acute rheumatic
fever in a family member
 Penicillin v or amoxicillin for 10 days
 Erythromycin (if allergic to the above drugs)
 Clindamycin and Azithromycin clear carriers
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RECURRENT PHARYNGITIS
 Recurrent streptococcal pharyngitis can represent :
- relapse with an identical strain if type-specific antibody
has not yet developed.
- Poor compliance
 If GABHS is detected by repeat culture a few days after
completing treatment, therapy to eliminate carriage is
recommended.
 Prolonged pharyngitis (>1-2 wk) suggests another disorder
such as neutropenia or recurrent fever
syndromes,autoimmune diseases.
 Tonsillectomy lowers the incidence of pharyngitis for 1-2 yr
among children with recurrent episodes
 culture-positive GABHS pharyngitis that has been severe and frequent
(>7 episodes in the previous year, or >5 in each of the preceding 2 yror
≥3 in each of the previous 3 yr)
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COMPLICATION OF PHARYNGITIS:
 Otitis media
 Local suppurative complications like parapharyngial
abscess
 ARF and AGN
 Poststreptococcal reactive arthritis
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2. RETROPHARYNGEAL AND PARA
PHARYNGEAL ABSCESS
 Neck contains deeply located LNs including retro
&lateral pharyngeal nodes w/c drain the upper air way
&digestive tract
 Retropharyngeal space is located between the pharynx
& the cervical vertebrae extending down to superior
mediastinum.
 Lateral pharyngeal space is bounded by pharynx
medially carotid sheath posteriorly & muscles of styloid
process laterally.
 The two spaces communicate with each other.
 Infection usually extends from infection of oropharnyx
 Once infected, the nodes progress through 3 stages
cellulitis,phlegmon and abscess
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ETIOLOGIES
 Usually polymicrobial
 Usual pathogens include group A strept.,
oropharyngeal anaerobes and S.aures
 Hib, klebsiella andMycobacterium avium-
intracellulare( MAI) are other causes
EPIDIMIOLOGY
 Common b/n 3-4yrs of age
 Males are affected more than females
 Rare after 5yrs b/c retropharyngeal nodes
involute at this age
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Retropharyngeal cellulites or abscess results from:-
 oropharygeal infection
 dental infection
 vertebral osteomyelitis
 Trauma to the oropharynx
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CLINICAL MANIFESTATIONS
Retropharyngeal abscess
 Fever,irritability,decreased oral intake and drooling of saliva
 Neck stiffness,tortocolis &refusal to move the neck
 Muffled voice,stridor and respiratory distress
 Bulging of posterior pharyngeal wall
 Cervical adenopathy may be present
Lateral pharyngeal abscess
 Fever,dysphagia &prominent bulge on the lateral pharyngeal
wall
 Sometimes there is medial displacement of tonsils
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INVESTIGATIONS
 Culture from the pus
 CT
 X-ray(wide retropharyngeal space >1/2 the thickness of
adjoining vertebrae
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Differential Dx
 epiglottis
 Foreign body aspiration
 Meningitis
 Lymphoma
 Hematoma
 Vertebral osteomyelitis
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MANAGEMENT
IV Abcs with or without drainage
 Cephalosporine plus Ampicillin-Sulbactam or
Chloramphenicol
 Clindamycin/cloxacillin
 50% of Pts do not need drainage
Indications for drainage
 obstruction
 failure to respond to IV Abcs
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CONT…..
COMPLICATIONS
 Upper air way obstruction
 Rupture leading to aspiration pneumonia
 Mediastinitis
 Thrombophlebitis of internal jugular vein(Lemierre Ds)
 Lemierre syndrome is a serious complication of F.
necrophorum pharyngitis and is characterized by
 septic thrombophlebitis of the internal jugular veins with
 septic pulmonary emboli,
 producing hypoxia and pulmonary infiltrates
 Erosion of carotid artery sheath
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3. PERITONSILLAR ABSCESS
 More common than deep neck infections
 Caused by invasion through the capsule of the tonsils
ETIOLOGY
 Group A strept,mixed oropharyngeal anaerobes
Clinical manifestation
 An adolescent with a recent history of acute pharyngotonsillitis
 Sore,fever,trismus &dysphagia
 Asymmetric tonsillar bulge with displacement of uvula (this is
diagnostic)
INVESTIGATION
 CT is helpful for revealing the abscess
 Culture from the pus
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MANAGEMENT
 Surgical drainage & Abcs
 Surgical drainage could be accomplished via
Needle aspiration(resolution in 95%)
 5% who fail after aspiration require incision and drainage
 Indications for tonsillectomy
 Failure to improve after 24hrs
 Recurrent abscess or tonsillitis
 Complications
COMPLICATIONS
 Feared complication is rupture and aspiration pneumonia
 There is 10% risk of recurrence
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4.CROUP(LARYNGEOTRACHEOBRONCH
ITIS)
 An acute respiratory illness characterized by
- distinctive barking cough, hoarseness, and inspiratory
stridor in a young child, usually between 6 months and 3
years old.
 This syndrome results from inflammation of varying
levels of the upper respiratory tract, which sometimes
spreads to the lower respiratory tract, producing
concomitant lower respiratory tract findings.
 Croup is primarily laryngotracheitis, and encompasses a
spectrum of infections from laryngitis to
laryngotracheobronchitis and sometimes
laryngotracheobronchopneumonitis.
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CROUP(LARYNGEOTRACHEOBRON
CHITIS)
 Minor reduction in cross
sectional area due to mucosal
edema or other inflammatory
processes cause an
exponential increase in air way
resistance
 The cricoid cartilage defines
the narrowest portion of the
upper air way in a child<10yrs
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ADULT
INFANT
ETIOLOGY
 Para influenza virus(types 1,2,3)-75% of cases
 Influenza(A &B),adenovirus,RSV&measles
 Rarely mycoplasma pneumonae
EPIDEMIOLOGY
 Age -3 months – 5years
 Peak is in the second year of life
 Males are more frequently affected
 Common in winter
 Recurrence common till 3-6yrs and decreases with age
 15 %have strong family history of croup
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Clinical manifestation
 Most common cause of upper resp. tract obstruction
 Pts usually have rhinorrhea,pharyngitis,mild cough &low grade fever
 Symptoms are worse at night
 Sms resolve with in a week
 Other Fx members may have mild resp. illness
INVESTIGATIONS
 PA chest X-ray steeple sign or inverted pencil sign
 Laryngoscope-erythematous edema with destruction of mucosal
epithelium
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RADIOGRAPH OF AN AIRWAY OF A PATIENT WITH
CROUP, SHOWING TYPICAL SUBGLOTTIC NARROWING
(STEEPLE SIGN).
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CROUP SCORING
SYSTEM:WESTLEY
 Level of consciousness: Normal, including
sleep = 0; disoriented = 5
 Cyanosis: None = 0; with agitation = 4; at
rest = 5
 Stridor: None = 0; with agitation = 1; at rest =
2
 Air entry: Normal = 0; decreased = 1;
markedly decreased = 2
 Retractions: None = 0; mild = 1; moderate = 2; severe =
3
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CONT……
 Mild croup is defined by a Westley croup
score of ≤2
 Moderate croup is defined by a Westley
croup score of 3 to 7
 Severe croup is defined by a Westley croup
score of ≥8
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MANAGEMENT
Mild croup _ home management
 Moderate to sever croup needs admission for Mx
 Steam therapy
 Dexamethasone
 Nebulized epinephrine
 Humidified Oxygen
 Fluid
 Artificial air way -Tracheostomy
Complications:
 Otitis media
 Bacterial trachitis
 Pneumonia
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6. EPIGLOTITIS
 Life threatening infection
 HIB is the most common cause
Clinical manifestation
 Sudden on set
 Rapidly progressing respiratory obstruction
 Fever, Toxicity, sore throat
 Voice/cry - muffled
 Soft stridor
 Drooling of saliva
 Hyper extended neck
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CONT…
Diagnosis:
 Clinical with out throat examination
 Blood culture
 Lateral cervical X-ray “thumb sign’’→→
 Never use spatula to examine"epiglottis
 Large *cherry red* epiglottis (laryngoscope)
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MANAGEMENT
Precaution
 Do not manipulate the throat
 Do not put patient in supine positions
 Do not send for X-ray
 Do not put on steam in halation, steroid or
epinephrine
 Maintenance IV fluid
 IV CAF/ Ampicilin/cephalosporins
 Endotracheal intubation
 Tracheostomy
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7. BACTERIAL TRACHEITIS
 Bacterial tracheitis is an acute bacterial infection of the
upper airway that is potentially life threatening.
 Staphylococcus aureus is the most commonly isolated
pathogen. Moraxella catarrhalis, nontypable H. influenzae,
and anaerobic organisms have also been implicated.
 The mean age is between 5 and 7 yr.
 Incidence and severity do not differ by sex.
 Bacterial tracheitis often follows a viral respiratory infection
(especially laryngotracheitis), so it may be considered a
bacterial complication of a viral disease, rather than a
primary bacterial illness.
 This life-threatening entity is more common than epiglottitis
in vaccinated populations
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CONT…
Clinical Manifestations
 Typically, brassy cough
 High fever and “toxicity” with respiratory distress can occur immediately
or after a few days of apparent improvement.
 The patient can lie flat, does not drool, and does not have the dysphagia
associated with epiglottitis.
 The usual treatment for croup (racemic epinephrine) is ineffective.
 Intubation or tracheostomy may be necessary, but only 50-60% of
patients require intubation for management; younger patients are more
likely to need intubation..
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CONT….
 The major pathologic feature appears to be mucosal
swelling at the level of the cricoid cartilage, complicated by
copious, thick, purulent secretions, sometimes causing
pseudomembranes.
 The diagnosis is based on evidence of bacterial upper
airway disease, which includes high fever, purulent airway
secretions, and an absence of the classic findings of
epiglottitis. X-rays are not needed but can show the classic
findings
 purulent material is noted below the cords during
endotracheal intubation
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LATERAL RADIOGRAPH OF THE NECK OF A
PATIENT WITH BACTERIAL TRACHEITIS,
SHOWING PSEUDOMEMBRANE
DETACHMENT IN THE TRACHEA.
(FROM STROUD RH, FRIEDMAN NR: AN
UPDATE ON INFLAMMATORY DISORDERS OF
THE PEDIATRIC AIRWAY: EPIGLOTTITIS,
CROUP, AND TRACHEITIS, AM J
OTOLARYNGOL 22:268–275, 2001. PHOTO
COURTESY OF THE DEPARTMENT OF
RADIOLOGY, UNIVERSITY OF TEXAS
MEDICAL BRANCH AT GALVESTON.)
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Thick tracheal membranes seen on rigid
bronchoscopy. The supraglottis was normal. A,
Thick adherent membranous secretions. B, The
distal tracheobronchial tree is unremarkable. In
contrast to croup, tenacious secretions are seen
throughout the trachea, and in contrast to
bronchitis, the bronchi are not affected
MANAGEMENT
 Current empiric therapy recommendations for life-
threatening infections such as bacterial tracheitis
include vancomycin and a β-lactamase–resistant β-
lactam antimicrobial agent (e.g., naficillin or
oxacillin).
 an artificial airway should be strongly considered.
 Supplemental oxygen is usually necessary
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LOWER RESPIRATORY TRACT INFECTIONS
• Community Acquired pneumonia
• Bronchiolitis
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1.BRONCHIOLITIS
 Infection can cause obstruction to flow by
internal narrowing of the airways
 Bronchiolitis is the most common acute viral lower
respiratory tract illness occurring during the first 2 years of
life
 More common in 1-3months age
 is predominantly a viral disease.
 RSV is responsible for more than 50% of
cases. Other agents include
parainfluenza,adenovirus, rhinovirus, and
Mycoplasma.
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RISK FACTORS
 boys,
 in those who have not been breastfed,
 crowded conditions.
 mothers who smoked during pregnancy
The following children are at risk to develop severe
brochiolitis
 Age <12 wk,
 preterm birth, or
 underlying comorbidity such as
cardiovascular,pulmonary, neurologic, or
immunologic disease.
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PATHOPHYSIOLOGY
 characterized by bronchiolar obstruction with
edema, mucus, and cellular debris.
 resistance is inversely proportional to the 4th
power of the radius of the bronchiolar passage.
 radius of an airway is smaller during expiration,
early air trapping and
overinflation. complete obstruction,
atelectasis.
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CLINICAL MANIFESTATIONS
 Symptoms of URTI
 fever(low grade)
 Cough, Poor feeding, tachypenia
 Wheezing, signs of distress, cyanosis
 Apnea may be more prominent early in the course
of the disease in young infants (<2 mo old) or
former premature infants.
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CONT……
Differential diagnosis
• Bronchial asthma
 Broncho pneumonia
 CHF
 Congenital malformations
 Foreign body aspiration
 Gastroesophageal reflux
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DIAGNOSIS
 clinical,
 CXR can reveal hyperinflated lungs with
patchy atelectasis
 The white blood cell and differential counts
are usually normal.
 PCR and radioimmunoassays
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MANAGEMNET
Mainly supportive
 humidified Oxygen
 Fluid
 Bronchodilators?????
Antibiotics- only if there is bacterial superinfection
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PROGNOSIS
 1st 48-72 hr after onset of cough and
dyspnea; air hunger, apnea, and
respiratory acidosis.
 Median duration of symptoms is around 14
days
 Recurrent wheezing among most children, the
episodes diminish or disappear before reaching
teenage years

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2.PNEUMONIA
 Pneumonia, defined as inflammation of the
lung parenchyma,
 is the leading cause of death globally among
children younger than age 5 yr, accounting
for an estimated 1.2 million (18% total)
deaths annually
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CLASSIFICATION
 Based on the anatomic or radiologic distribution
- Lobar pneumonia
- multilobar(bronchopneumonia)
- interstial pneumonia
• Based on the setting of acqusition of the infection
- community acquired pneumonia
- Hospital acquired pneumonia
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RISK FACTORS
 Lung diseases-asthma, cystic fibrosis
 Anatomic abnormalities-TEF, cleft palate
 GERD-recurrent aspiration
 Neurologic disorders- loss of consciousness,
neuromuscular disorders
 Immunodeficiency states- HIV, malnutrition, steroid
therapy…
 CHF-VSD, AV canal defect
 Viral respiratory tract infection
 Lack of immunization
 Trauma, anesthesia, and aspiration.
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ETIOLOGIC AGENTS
Neonates Age<5yrs Older childeren(>5yrs)
•GBS
• Gram negatives-E.coli,
klebsella, Pseudomonas
• S. aureous
•Listeria monocytogens
Viral(most common)
- RSV
-influenza,parainfluenza
- adenovirus
Bacterial
- S.pneumoniae
-HIB
-Chlamydia
-S.aures
S. pneumonia
Mycoplasma
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PHYSIOLOGIC DEFENSE MECHANISMS
 Mucociliary clearance
 Secretory immunoglobulin A (IgA)
 Coughing
 Alveolar and bronchioles macrophages
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PATHOGENESIS
 Viral pneumonia ,spread of infection along the airways,
accompanied by direct injury of the respiratory
epithelium, which results in airway obstruction from
swelling, abnormal secretions, and cellular debris
 Atelectasis, interstitial edema, and ventilation-perfusion
mismatch causing significant hypoxemia often
accompany airway obstruction.
 Viral infection of the respiratory tract can also predispose
to secondary bacterial infection by disturbing normal host
defense mechanisms, altering secretions, and modifying
the bacterial flora.
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CONT…..
 In bacterial pneumonia organisms colonize the
trachea and subsequently gain access to the
lungs
 pneumonia may also result from direct seeding
of lung tissue after bacteremia. When bacterial
infection is established in the lung parenchyma
 M. pneumoniae – direct injury of airway epithelium
 S. pneumoniae -characteristic focal lobar involvement.
 Group A streptococcus - interstitial pneumonia
 S. aureus -confluent bronchopneumonia
pneumatoceles, empyema
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CONT…..
 Recurrent pneumonia is defined as 2 or more
episodes in a single year or 3 or more episodes
ever, with radiographic clearing between
occurrences. An underlying disorder should be
considered if a child experiences recurrent
pneumonia
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CLINICAL MANIFESTATIONS
Preceding URTI followed by Cough, fast breathing,
and Fever
-Grunting, lethargy
-Tachypnea
-Chest recession
-Crepitation/ Bronchial breath sounds,
-Dullness, signs of effusion
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CONT…
Severe pneumonia:
 fast breathing (Tacypnea) + chest indrowing and grunting
HOSPITALIZATION OF CHILDREN WITH PNEUMONIA
 Age <6 mo
 Sickle cell anemia with acute chest syndrome
 Multiple lobe involvement
 Immunocompromised state
 Toxic appearance
 Moderate to severe respiratory distress
 Complicated pneumonia*
 Dehydration
 Vomiting or inability to tolerate oral fluids or medications
 No response to appropriate oral antibiotic therapy
 Social factors (e.g., inability of caregivers to administer medications
 at home or follow-up appropriately)
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DIAGNOSIS
- Clinical
-CBC-leukocytosis
-CXR- infiltrations
-consolidation
-pneumatocele
-pleural effusion
-Sputum (gram stain, AFB)
- Pleural fluid analysis-
-Blood culture
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RADIOGRAPHIC FINDINGS CHARACTERISTIC OF PNEUMOCOCCAL
PNEUMONIA IN A 14 YR OLD BOY WITH COUGH AND FEVER.
POSTEROANTERIOR (A) AND LATERAL (B) CHEST RADIOGRAPHS
REVEAL CONSOLIDATION IN THE RIGHT LOWER LOBE, STRONGLY
SUGGESTING BACTERIAL PNEUMONIA
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TREATMENT
 Treatment of suspected bacterial pneumonia
is based on the presumptive cause and the
age and clinical appearance of the child
 Out patient Mx:
- high doses of amoxicillin (80-90 mg/kg/24 h
other alternatives are augementin for 5-7
days.
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INPATIENT MANAGEMENT
• Neonate – Ampicillin +Gentamycine
 Children _ Crystalin penicillin +/- chloramphenicol
antibiotic sensitivity pattern and causative agent
known:
 Streptococcus-penicillin, Ceftriaxone, vancomycin
 Staphylococcus- Cloxacillin ,vancomycin,
Cephalosporin (1st Gen.)
 H.influenza-Chloramphenicol, Cephalosporin
 Gram negative organisms
-Aminoglycosids, Cephalosporin
-If the patient is not improving after 24-48 hrs, shift to
second line
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Complications-
 parapneumonic effusion
 Empyema/pyopneumothorax
 Lung abscess
 pericarditis/myocarditis
 Septicemia
 Septic arthritis/Osteomylitis
 Meningitis
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TRANSUDATE EMPYEMA
Appearance Clear Cloudy or purulent
Cell count (per mm3) <1000
Often >50,000 (cell count has limited
predictive value)
Cell type
Lymphocytes,
monocytes
Polymorphonuclear leukocytes
(neutrophils)
Lactate
dehydrogenase
<200 U/L >1000 U/L
Pleural fluid/serum
LDH ratio
<0.6 >0.6
Protein >3g Unusual Common
Pleural fluid/serum
protein ratio
<0.5 >0.5
Glucose* Normal Low (<40 mg/dL)
pH* Normal (7.40-7.60) <7.10
Gram stain Negative
Occasionally positive (less than one-
third of cases)
66
TREATMENT OF
COMPLICATIONS
Empyema- depends on the stage(exudative, fibrinopurulent,
organizing).
 Antibiotics 4-6wks
 Chest tube drainage
 Chest physiotherapy
Lung abscess-
 Braod spectrum antibiotics anaerobic coverage,
4-6wks
 Postural drainage, chest physiotherapy
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PREVENTION
• Vaccination PCV10 vaccine.
 has reduced the incidence of pneumonia
hospitalizations.
 The expansion of influenza vaccine
recommendations to include all children >6
mo of age might be expected to affect
pneumonia hospitalization rates in a similar
fashion, and ongoing surveillance is
warranted
4/28/2018
68
FOREIGN BODY ASPIRATION
EPIDEMIOLOGY AND ETIOLOGY
 Choking is a leading cause of morbidity and mortality
among children,especially those younger than age 4
yr
 Children, younger than 3 yr of age, account for 73%
of cases.
 The most common objects that children choke on are
food, coins, balloons, and toys.
 One-third of aspirated objects are nuts, particularly
peanuts. Fragments of raw carrot, apple, dried beans,
popcorn, and sunflower or watermelon seeds are also
aspirated, as are small toys or toy parts.
4/28/2018
69
 The majority of aspirated foreign bodies in
children are located in the bronchi (right
bronchus in 58%of the cases ) . Laryngeal
and tracheal foreign bodies are less
common.
4/28/2018
70
CLINICAL MANIFESTATIONS
 Has 3 stages:
1.Initial event: Violent paroxysms of coughing, choking,
gagging, and possibly airway obstruction occur
immediately when the foreign body is aspirated.
2.Asymptomatic interval: foreign body dislodges and
the immediate irritating sympt subside. accounts for a
large percentageof delayed diagnoses and
overlooked foreign bodies.
 3. Complications: Obstruction, erosion, or infection
develops; fever, cough, hemoptysis, pneumonia, and
atelectasis.
4/28/2018
71
CONT…..
 Choking or coughing episodes accompanied by
new onset wheezing are highly suggestive of an
airway foreign body.
 Physician should specifically inquire about nuts
since it is the most common foreign body
 The signs and symptoms of FBA vary according
to the location of the FB
 laryngotracheal FBs typically present with acute
respiratory distress, stridor, hoarseness,
increased respiratory effort, or complete airway
obstruction, which must be addressed promptly
4/28/2018
72
CONT….
 Bronchial foreign bodies are the most
common. The usual symptoms are coughing
and wheezing; hemoptysis, dyspnea,
choking, shortness of breath, respiratory
distress, decreased breath sounds, fever,
and cyanosis may also occur
 Tracheal foreign bodies are rare. Symptoms
of a tracheal foreign body include stridor,
wheeze, and dyspnea.
4/28/2018
73
DIAGNOSIS
 A witnessed episode of choking: defined as
the sudden onset of
cough and/or dyspnea and/or cyanosis in a
previously healthy child, has a sensitivity of
76 to 92 percent for the diagnosis of FBA.
CXR:
 most aspirated objects are radiolucent so
may nt be helpful
 common radiographic findings in lower
airway FBA are hyperinflated lung,
4/28/2018
74
MANAGEMENT
If there is complete airway obstruction:
-back blows ,chest compressions in
infants, and the Heimlich maneuver in older
children, should be attempted
• Bronchoscopy
• Antibiotic and corticosteroids if the foreign
body has been retained for longer period
4/28/2018
75
COMPLICATIONS
 Air trapping
 Atelectasis
 Postobstrucive pneumonia
 bronchiectasis
4/28/2018
76
PREVENTION
 Hard and/or round foods should not be
offered to children younger than four years of
age
 Children should be taught to chew their food
well;
 Coins and other small items should not be
given to young children as rewards……
4/28/2018
77
4/28/2018
78

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Acute respiratory tract infections

  • 1. ACUTE RESPIRATORY TRACT INFECTIONS (ARI) Dr. Yordanos G(MD) For Anesthesia 2nd yr students 4/28/2018 1
  • 2. GENERAL CONSIDERATIONS  Acute respiratory infection (ARI) is the leading cause of morbidity and mortality in children under 5years of age.  ARI accounts for about 28% of under 5 mortality in Ethiopia.  ARI involves both upper and lower respiratory tract infections  Nearly 20% of ARI develop acute lower respiratory tract infections, mainly pneumonia. 4/28/2018ARI 2
  • 3. RISK FACTORS FOR ARI  Pollution  lack of breast feeding  Congenital abnormalities heart or Lung  Immuno deficiency  Malnutrition  Young infants  Poor socio-economic status 4/28/2018ARI 3
  • 4. ANATOMIC CLASSIFICATION OF AIRWAY  Upper Airway all structures/ the part of air way above thoracic inlet,  Supraglottic area(nasopharynx, epiglottis, larynx, aryepiglottic folds, and false vocal cords)  Glottic and subglottic area (extends from the vocal cords to the extra thoracic segment of the trachea)  Lower Airway –  Intrathoracic trachea and into the lungs  intrathoracic-extrapulmonary airway extends from the thoracic inlet to the main stem bronchi  the intrapulmonary airway is within the lung parenchyma 4/28/2018ARI 4 Upper Airway Lower Airways
  • 5. UPPER RESPIRATORY TRACT INFECTIONS 1. Acute Pharyngitis - refers to inflammation of the pharynx, including erythema,edema, exudates, or enanthem (ulcers, vesicles) 4/28/2018 5
  • 6. COMMON ETIOLOGIES Viruses Bacterial Adenovirus Coronavirus Cytomegalovirus Epstein-Barr Enteroviruses Herpes simplex virus Human immunodeficiency virus Human metapneumovirus Influenza viruses Measles virus Parainfluenza viruses Respiratory syncytial virus Rhinoviruses Streptococcus pyogenes (Group A streptococcus) Arcanobacterium haemolyticum Fusobacterium necrophorum Corynebacterium diphtheriae Neisseria gonorrhoeae Group C streptococci Group G streptococci Francisella tularensis Chlamydophila pneumoniae Chlamydia trachomatis Mycoplasma pneumoniae 4/28/2018 6
  • 7. GROUP A STREPTOCOCCUS EPIDEMIOLOGY  Strept. Pharyngitis uncommon before 2-3yrs, has a peak incidence in the early school years, and declines in late adolescence and adulthood  Peaks during winter and spring  Group C strept. and Arcanobacterium- haemolyticum are causes in adults. 4/28/2018 7
  • 8. PATHOGENESIS OF ACUTE PHARYNGITIS  Major virulent factor of GABHS is the M-protein  Type specific immunity develops and provides protection from subsequent infection by the same M-type.  Scarlet fever is caused by GABHS that produce one of the three streptococcal pyrogenic exotoxins(SPE)-A,B,C.  SPE-A is mostly(strongly) associated.  Infection with one clade confers immunity to the same clade & hence infection can occur up to three times. 4/28/2018 8
  • 9. CLINICAL MANIFESTATIONS OF ACUTE PHARYNGITIS  Rapid onset with prominent sore throat & fever  Headache and GI symptoms are common  Pharynx is red &tonsils are enlarged & classically covered with yellow blood tinged exudates  Doughnut lesions or petechae on the soft palate and posterior pharynx  Uvula is red and swollen  Tender and swollen ant. Cervical nodes  Some may manifest with Scarlet fever-circumoral pallor, strawberry tongue &red and finely papular rash that feels like sandpaper & with goose pimples 4/28/2018 9
  • 10. CONT……  Onset of viral pharyngitis has more insidious onset  Adeno virus(pharyngoconjuctival fever)  Coxakie virus-herpangina1-2mm grayish vesicles and punched out ulcers in the posterior pharynx /acute lymphonodular pharyngitis3-6mm yellowish white nodules on post. Pharynx.  EBV has systemic manifestations as part of infectious mononucleosis syndrome  HSV- high grade fever and gingivostomatitis 4/28/2018 10
  • 11. DIAGNOSIS  Throat culture and rapid antigen-detection tests (RADTs) are the diagnostic tests for GAS available in routine clinical care.  Throat culture is un imperfect gold standard for Dx of GABHS pharyngitis (high false –ve and false +ve)  Rapid test(less sensitive and highly specific) ,If +ve – treat and - ve(strong clinical ground)- throat culture 4/28/2018 11
  • 12. MANAGEMENT  nonspecific, symptomatic therapy can be an important part of the overall treatment plan( with anti-pyretics,analgesics,local anesthetics) • Antibiotic therapy should be started immediately without culture for children with symptomatic pharyngitis and a positive rapid streptococcal antigen test, a clinical diagnosis of scarlet fever, a household contact with documented streptococcal pharyngitis, a past history of acute rheumatic fever, or a recent history of acute rheumatic fever in a family member  Penicillin v or amoxicillin for 10 days  Erythromycin (if allergic to the above drugs)  Clindamycin and Azithromycin clear carriers 4/28/2018 12
  • 13. RECURRENT PHARYNGITIS  Recurrent streptococcal pharyngitis can represent : - relapse with an identical strain if type-specific antibody has not yet developed. - Poor compliance  If GABHS is detected by repeat culture a few days after completing treatment, therapy to eliminate carriage is recommended.  Prolonged pharyngitis (>1-2 wk) suggests another disorder such as neutropenia or recurrent fever syndromes,autoimmune diseases.  Tonsillectomy lowers the incidence of pharyngitis for 1-2 yr among children with recurrent episodes  culture-positive GABHS pharyngitis that has been severe and frequent (>7 episodes in the previous year, or >5 in each of the preceding 2 yror ≥3 in each of the previous 3 yr) 4/28/2018 13
  • 14. COMPLICATION OF PHARYNGITIS:  Otitis media  Local suppurative complications like parapharyngial abscess  ARF and AGN  Poststreptococcal reactive arthritis 4/28/2018 14
  • 15. 2. RETROPHARYNGEAL AND PARA PHARYNGEAL ABSCESS  Neck contains deeply located LNs including retro &lateral pharyngeal nodes w/c drain the upper air way &digestive tract  Retropharyngeal space is located between the pharynx & the cervical vertebrae extending down to superior mediastinum.  Lateral pharyngeal space is bounded by pharynx medially carotid sheath posteriorly & muscles of styloid process laterally.  The two spaces communicate with each other.  Infection usually extends from infection of oropharnyx  Once infected, the nodes progress through 3 stages cellulitis,phlegmon and abscess 4/28/2018 15
  • 16. ETIOLOGIES  Usually polymicrobial  Usual pathogens include group A strept., oropharyngeal anaerobes and S.aures  Hib, klebsiella andMycobacterium avium- intracellulare( MAI) are other causes EPIDIMIOLOGY  Common b/n 3-4yrs of age  Males are affected more than females  Rare after 5yrs b/c retropharyngeal nodes involute at this age 4/28/2018 16
  • 17. Retropharyngeal cellulites or abscess results from:-  oropharygeal infection  dental infection  vertebral osteomyelitis  Trauma to the oropharynx 4/28/2018 17
  • 18. CLINICAL MANIFESTATIONS Retropharyngeal abscess  Fever,irritability,decreased oral intake and drooling of saliva  Neck stiffness,tortocolis &refusal to move the neck  Muffled voice,stridor and respiratory distress  Bulging of posterior pharyngeal wall  Cervical adenopathy may be present Lateral pharyngeal abscess  Fever,dysphagia &prominent bulge on the lateral pharyngeal wall  Sometimes there is medial displacement of tonsils 4/28/2018 18
  • 19. INVESTIGATIONS  Culture from the pus  CT  X-ray(wide retropharyngeal space >1/2 the thickness of adjoining vertebrae 4/28/2018 19
  • 20. Differential Dx  epiglottis  Foreign body aspiration  Meningitis  Lymphoma  Hematoma  Vertebral osteomyelitis 4/28/2018 20
  • 21. MANAGEMENT IV Abcs with or without drainage  Cephalosporine plus Ampicillin-Sulbactam or Chloramphenicol  Clindamycin/cloxacillin  50% of Pts do not need drainage Indications for drainage  obstruction  failure to respond to IV Abcs 4/28/2018 21
  • 22. CONT….. COMPLICATIONS  Upper air way obstruction  Rupture leading to aspiration pneumonia  Mediastinitis  Thrombophlebitis of internal jugular vein(Lemierre Ds)  Lemierre syndrome is a serious complication of F. necrophorum pharyngitis and is characterized by  septic thrombophlebitis of the internal jugular veins with  septic pulmonary emboli,  producing hypoxia and pulmonary infiltrates  Erosion of carotid artery sheath 4/28/2018 22
  • 23. 3. PERITONSILLAR ABSCESS  More common than deep neck infections  Caused by invasion through the capsule of the tonsils ETIOLOGY  Group A strept,mixed oropharyngeal anaerobes Clinical manifestation  An adolescent with a recent history of acute pharyngotonsillitis  Sore,fever,trismus &dysphagia  Asymmetric tonsillar bulge with displacement of uvula (this is diagnostic) INVESTIGATION  CT is helpful for revealing the abscess  Culture from the pus 4/28/2018 23
  • 24. MANAGEMENT  Surgical drainage & Abcs  Surgical drainage could be accomplished via Needle aspiration(resolution in 95%)  5% who fail after aspiration require incision and drainage  Indications for tonsillectomy  Failure to improve after 24hrs  Recurrent abscess or tonsillitis  Complications COMPLICATIONS  Feared complication is rupture and aspiration pneumonia  There is 10% risk of recurrence 4/28/2018 24
  • 25. 4.CROUP(LARYNGEOTRACHEOBRONCH ITIS)  An acute respiratory illness characterized by - distinctive barking cough, hoarseness, and inspiratory stridor in a young child, usually between 6 months and 3 years old.  This syndrome results from inflammation of varying levels of the upper respiratory tract, which sometimes spreads to the lower respiratory tract, producing concomitant lower respiratory tract findings.  Croup is primarily laryngotracheitis, and encompasses a spectrum of infections from laryngitis to laryngotracheobronchitis and sometimes laryngotracheobronchopneumonitis. 4/28/2018 25
  • 26. CROUP(LARYNGEOTRACHEOBRON CHITIS)  Minor reduction in cross sectional area due to mucosal edema or other inflammatory processes cause an exponential increase in air way resistance  The cricoid cartilage defines the narrowest portion of the upper air way in a child<10yrs 4/28/2018 26 ADULT INFANT
  • 27. ETIOLOGY  Para influenza virus(types 1,2,3)-75% of cases  Influenza(A &B),adenovirus,RSV&measles  Rarely mycoplasma pneumonae EPIDEMIOLOGY  Age -3 months – 5years  Peak is in the second year of life  Males are more frequently affected  Common in winter  Recurrence common till 3-6yrs and decreases with age  15 %have strong family history of croup 4/28/2018 27
  • 28. Clinical manifestation  Most common cause of upper resp. tract obstruction  Pts usually have rhinorrhea,pharyngitis,mild cough &low grade fever  Symptoms are worse at night  Sms resolve with in a week  Other Fx members may have mild resp. illness INVESTIGATIONS  PA chest X-ray steeple sign or inverted pencil sign  Laryngoscope-erythematous edema with destruction of mucosal epithelium 4/28/2018 28
  • 29. RADIOGRAPH OF AN AIRWAY OF A PATIENT WITH CROUP, SHOWING TYPICAL SUBGLOTTIC NARROWING (STEEPLE SIGN). 4/28/2018 29
  • 30. CROUP SCORING SYSTEM:WESTLEY  Level of consciousness: Normal, including sleep = 0; disoriented = 5  Cyanosis: None = 0; with agitation = 4; at rest = 5  Stridor: None = 0; with agitation = 1; at rest = 2  Air entry: Normal = 0; decreased = 1; markedly decreased = 2  Retractions: None = 0; mild = 1; moderate = 2; severe = 3 4/28/2018 30
  • 31. CONT……  Mild croup is defined by a Westley croup score of ≤2  Moderate croup is defined by a Westley croup score of 3 to 7  Severe croup is defined by a Westley croup score of ≥8 4/28/2018 31
  • 32. MANAGEMENT Mild croup _ home management  Moderate to sever croup needs admission for Mx  Steam therapy  Dexamethasone  Nebulized epinephrine  Humidified Oxygen  Fluid  Artificial air way -Tracheostomy Complications:  Otitis media  Bacterial trachitis  Pneumonia 4/28/2018 32
  • 33. 6. EPIGLOTITIS  Life threatening infection  HIB is the most common cause Clinical manifestation  Sudden on set  Rapidly progressing respiratory obstruction  Fever, Toxicity, sore throat  Voice/cry - muffled  Soft stridor  Drooling of saliva  Hyper extended neck 4/28/2018 33
  • 34. CONT… Diagnosis:  Clinical with out throat examination  Blood culture  Lateral cervical X-ray “thumb sign’’→→  Never use spatula to examine"epiglottis  Large *cherry red* epiglottis (laryngoscope) 4/28/2018 34
  • 35. MANAGEMENT Precaution  Do not manipulate the throat  Do not put patient in supine positions  Do not send for X-ray  Do not put on steam in halation, steroid or epinephrine  Maintenance IV fluid  IV CAF/ Ampicilin/cephalosporins  Endotracheal intubation  Tracheostomy 4/28/2018 35
  • 36. 7. BACTERIAL TRACHEITIS  Bacterial tracheitis is an acute bacterial infection of the upper airway that is potentially life threatening.  Staphylococcus aureus is the most commonly isolated pathogen. Moraxella catarrhalis, nontypable H. influenzae, and anaerobic organisms have also been implicated.  The mean age is between 5 and 7 yr.  Incidence and severity do not differ by sex.  Bacterial tracheitis often follows a viral respiratory infection (especially laryngotracheitis), so it may be considered a bacterial complication of a viral disease, rather than a primary bacterial illness.  This life-threatening entity is more common than epiglottitis in vaccinated populations 4/28/2018 36
  • 37. CONT… Clinical Manifestations  Typically, brassy cough  High fever and “toxicity” with respiratory distress can occur immediately or after a few days of apparent improvement.  The patient can lie flat, does not drool, and does not have the dysphagia associated with epiglottitis.  The usual treatment for croup (racemic epinephrine) is ineffective.  Intubation or tracheostomy may be necessary, but only 50-60% of patients require intubation for management; younger patients are more likely to need intubation.. 4/28/2018 37
  • 38. CONT….  The major pathologic feature appears to be mucosal swelling at the level of the cricoid cartilage, complicated by copious, thick, purulent secretions, sometimes causing pseudomembranes.  The diagnosis is based on evidence of bacterial upper airway disease, which includes high fever, purulent airway secretions, and an absence of the classic findings of epiglottitis. X-rays are not needed but can show the classic findings  purulent material is noted below the cords during endotracheal intubation 4/28/2018 38
  • 39. LATERAL RADIOGRAPH OF THE NECK OF A PATIENT WITH BACTERIAL TRACHEITIS, SHOWING PSEUDOMEMBRANE DETACHMENT IN THE TRACHEA. (FROM STROUD RH, FRIEDMAN NR: AN UPDATE ON INFLAMMATORY DISORDERS OF THE PEDIATRIC AIRWAY: EPIGLOTTITIS, CROUP, AND TRACHEITIS, AM J OTOLARYNGOL 22:268–275, 2001. PHOTO COURTESY OF THE DEPARTMENT OF RADIOLOGY, UNIVERSITY OF TEXAS MEDICAL BRANCH AT GALVESTON.) 4/28/2018 39 Thick tracheal membranes seen on rigid bronchoscopy. The supraglottis was normal. A, Thick adherent membranous secretions. B, The distal tracheobronchial tree is unremarkable. In contrast to croup, tenacious secretions are seen throughout the trachea, and in contrast to bronchitis, the bronchi are not affected
  • 40. MANAGEMENT  Current empiric therapy recommendations for life- threatening infections such as bacterial tracheitis include vancomycin and a β-lactamase–resistant β- lactam antimicrobial agent (e.g., naficillin or oxacillin).  an artificial airway should be strongly considered.  Supplemental oxygen is usually necessary 4/28/2018 40
  • 42. LOWER RESPIRATORY TRACT INFECTIONS • Community Acquired pneumonia • Bronchiolitis 4/28/2018 42
  • 43. 1.BRONCHIOLITIS  Infection can cause obstruction to flow by internal narrowing of the airways  Bronchiolitis is the most common acute viral lower respiratory tract illness occurring during the first 2 years of life  More common in 1-3months age  is predominantly a viral disease.  RSV is responsible for more than 50% of cases. Other agents include parainfluenza,adenovirus, rhinovirus, and Mycoplasma. 4/28/2018 43
  • 44. RISK FACTORS  boys,  in those who have not been breastfed,  crowded conditions.  mothers who smoked during pregnancy The following children are at risk to develop severe brochiolitis  Age <12 wk,  preterm birth, or  underlying comorbidity such as cardiovascular,pulmonary, neurologic, or immunologic disease. 4/28/2018 44
  • 45. PATHOPHYSIOLOGY  characterized by bronchiolar obstruction with edema, mucus, and cellular debris.  resistance is inversely proportional to the 4th power of the radius of the bronchiolar passage.  radius of an airway is smaller during expiration, early air trapping and overinflation. complete obstruction, atelectasis. 4/28/2018 45
  • 46. CLINICAL MANIFESTATIONS  Symptoms of URTI  fever(low grade)  Cough, Poor feeding, tachypenia  Wheezing, signs of distress, cyanosis  Apnea may be more prominent early in the course of the disease in young infants (<2 mo old) or former premature infants. 4/28/2018 46
  • 47. CONT…… Differential diagnosis • Bronchial asthma  Broncho pneumonia  CHF  Congenital malformations  Foreign body aspiration  Gastroesophageal reflux 4/28/2018 47
  • 48. DIAGNOSIS  clinical,  CXR can reveal hyperinflated lungs with patchy atelectasis  The white blood cell and differential counts are usually normal.  PCR and radioimmunoassays 4/28/2018 48
  • 49. MANAGEMNET Mainly supportive  humidified Oxygen  Fluid  Bronchodilators????? Antibiotics- only if there is bacterial superinfection 4/28/2018 49
  • 50. PROGNOSIS  1st 48-72 hr after onset of cough and dyspnea; air hunger, apnea, and respiratory acidosis.  Median duration of symptoms is around 14 days  Recurrent wheezing among most children, the episodes diminish or disappear before reaching teenage years  4/28/2018 50
  • 51. 2.PNEUMONIA  Pneumonia, defined as inflammation of the lung parenchyma,  is the leading cause of death globally among children younger than age 5 yr, accounting for an estimated 1.2 million (18% total) deaths annually 4/28/2018 51
  • 52. CLASSIFICATION  Based on the anatomic or radiologic distribution - Lobar pneumonia - multilobar(bronchopneumonia) - interstial pneumonia • Based on the setting of acqusition of the infection - community acquired pneumonia - Hospital acquired pneumonia 4/28/2018 52
  • 53. RISK FACTORS  Lung diseases-asthma, cystic fibrosis  Anatomic abnormalities-TEF, cleft palate  GERD-recurrent aspiration  Neurologic disorders- loss of consciousness, neuromuscular disorders  Immunodeficiency states- HIV, malnutrition, steroid therapy…  CHF-VSD, AV canal defect  Viral respiratory tract infection  Lack of immunization  Trauma, anesthesia, and aspiration. 4/28/2018 53
  • 54. ETIOLOGIC AGENTS Neonates Age<5yrs Older childeren(>5yrs) •GBS • Gram negatives-E.coli, klebsella, Pseudomonas • S. aureous •Listeria monocytogens Viral(most common) - RSV -influenza,parainfluenza - adenovirus Bacterial - S.pneumoniae -HIB -Chlamydia -S.aures S. pneumonia Mycoplasma 4/28/2018 54
  • 55. PHYSIOLOGIC DEFENSE MECHANISMS  Mucociliary clearance  Secretory immunoglobulin A (IgA)  Coughing  Alveolar and bronchioles macrophages 4/28/2018 55
  • 56. PATHOGENESIS  Viral pneumonia ,spread of infection along the airways, accompanied by direct injury of the respiratory epithelium, which results in airway obstruction from swelling, abnormal secretions, and cellular debris  Atelectasis, interstitial edema, and ventilation-perfusion mismatch causing significant hypoxemia often accompany airway obstruction.  Viral infection of the respiratory tract can also predispose to secondary bacterial infection by disturbing normal host defense mechanisms, altering secretions, and modifying the bacterial flora. 4/28/2018 56
  • 57. CONT…..  In bacterial pneumonia organisms colonize the trachea and subsequently gain access to the lungs  pneumonia may also result from direct seeding of lung tissue after bacteremia. When bacterial infection is established in the lung parenchyma  M. pneumoniae – direct injury of airway epithelium  S. pneumoniae -characteristic focal lobar involvement.  Group A streptococcus - interstitial pneumonia  S. aureus -confluent bronchopneumonia pneumatoceles, empyema 4/28/2018 57
  • 58. CONT…..  Recurrent pneumonia is defined as 2 or more episodes in a single year or 3 or more episodes ever, with radiographic clearing between occurrences. An underlying disorder should be considered if a child experiences recurrent pneumonia 4/28/2018 58
  • 59. CLINICAL MANIFESTATIONS Preceding URTI followed by Cough, fast breathing, and Fever -Grunting, lethargy -Tachypnea -Chest recession -Crepitation/ Bronchial breath sounds, -Dullness, signs of effusion 4/28/2018 59
  • 60. CONT… Severe pneumonia:  fast breathing (Tacypnea) + chest indrowing and grunting HOSPITALIZATION OF CHILDREN WITH PNEUMONIA  Age <6 mo  Sickle cell anemia with acute chest syndrome  Multiple lobe involvement  Immunocompromised state  Toxic appearance  Moderate to severe respiratory distress  Complicated pneumonia*  Dehydration  Vomiting or inability to tolerate oral fluids or medications  No response to appropriate oral antibiotic therapy  Social factors (e.g., inability of caregivers to administer medications  at home or follow-up appropriately) 4/28/2018 60
  • 61. DIAGNOSIS - Clinical -CBC-leukocytosis -CXR- infiltrations -consolidation -pneumatocele -pleural effusion -Sputum (gram stain, AFB) - Pleural fluid analysis- -Blood culture 4/28/2018 61
  • 62. RADIOGRAPHIC FINDINGS CHARACTERISTIC OF PNEUMOCOCCAL PNEUMONIA IN A 14 YR OLD BOY WITH COUGH AND FEVER. POSTEROANTERIOR (A) AND LATERAL (B) CHEST RADIOGRAPHS REVEAL CONSOLIDATION IN THE RIGHT LOWER LOBE, STRONGLY SUGGESTING BACTERIAL PNEUMONIA 4/28/2018 62
  • 63. TREATMENT  Treatment of suspected bacterial pneumonia is based on the presumptive cause and the age and clinical appearance of the child  Out patient Mx: - high doses of amoxicillin (80-90 mg/kg/24 h other alternatives are augementin for 5-7 days. 4/28/2018 63
  • 64. INPATIENT MANAGEMENT • Neonate – Ampicillin +Gentamycine  Children _ Crystalin penicillin +/- chloramphenicol antibiotic sensitivity pattern and causative agent known:  Streptococcus-penicillin, Ceftriaxone, vancomycin  Staphylococcus- Cloxacillin ,vancomycin, Cephalosporin (1st Gen.)  H.influenza-Chloramphenicol, Cephalosporin  Gram negative organisms -Aminoglycosids, Cephalosporin -If the patient is not improving after 24-48 hrs, shift to second line 4/28/2018 64
  • 65. Complications-  parapneumonic effusion  Empyema/pyopneumothorax  Lung abscess  pericarditis/myocarditis  Septicemia  Septic arthritis/Osteomylitis  Meningitis 4/28/2018 65
  • 66. TRANSUDATE EMPYEMA Appearance Clear Cloudy or purulent Cell count (per mm3) <1000 Often >50,000 (cell count has limited predictive value) Cell type Lymphocytes, monocytes Polymorphonuclear leukocytes (neutrophils) Lactate dehydrogenase <200 U/L >1000 U/L Pleural fluid/serum LDH ratio <0.6 >0.6 Protein >3g Unusual Common Pleural fluid/serum protein ratio <0.5 >0.5 Glucose* Normal Low (<40 mg/dL) pH* Normal (7.40-7.60) <7.10 Gram stain Negative Occasionally positive (less than one- third of cases) 66
  • 67. TREATMENT OF COMPLICATIONS Empyema- depends on the stage(exudative, fibrinopurulent, organizing).  Antibiotics 4-6wks  Chest tube drainage  Chest physiotherapy Lung abscess-  Braod spectrum antibiotics anaerobic coverage, 4-6wks  Postural drainage, chest physiotherapy 4/28/2018 67
  • 68. PREVENTION • Vaccination PCV10 vaccine.  has reduced the incidence of pneumonia hospitalizations.  The expansion of influenza vaccine recommendations to include all children >6 mo of age might be expected to affect pneumonia hospitalization rates in a similar fashion, and ongoing surveillance is warranted 4/28/2018 68
  • 69. FOREIGN BODY ASPIRATION EPIDEMIOLOGY AND ETIOLOGY  Choking is a leading cause of morbidity and mortality among children,especially those younger than age 4 yr  Children, younger than 3 yr of age, account for 73% of cases.  The most common objects that children choke on are food, coins, balloons, and toys.  One-third of aspirated objects are nuts, particularly peanuts. Fragments of raw carrot, apple, dried beans, popcorn, and sunflower or watermelon seeds are also aspirated, as are small toys or toy parts. 4/28/2018 69
  • 70.  The majority of aspirated foreign bodies in children are located in the bronchi (right bronchus in 58%of the cases ) . Laryngeal and tracheal foreign bodies are less common. 4/28/2018 70
  • 71. CLINICAL MANIFESTATIONS  Has 3 stages: 1.Initial event: Violent paroxysms of coughing, choking, gagging, and possibly airway obstruction occur immediately when the foreign body is aspirated. 2.Asymptomatic interval: foreign body dislodges and the immediate irritating sympt subside. accounts for a large percentageof delayed diagnoses and overlooked foreign bodies.  3. Complications: Obstruction, erosion, or infection develops; fever, cough, hemoptysis, pneumonia, and atelectasis. 4/28/2018 71
  • 72. CONT…..  Choking or coughing episodes accompanied by new onset wheezing are highly suggestive of an airway foreign body.  Physician should specifically inquire about nuts since it is the most common foreign body  The signs and symptoms of FBA vary according to the location of the FB  laryngotracheal FBs typically present with acute respiratory distress, stridor, hoarseness, increased respiratory effort, or complete airway obstruction, which must be addressed promptly 4/28/2018 72
  • 73. CONT….  Bronchial foreign bodies are the most common. The usual symptoms are coughing and wheezing; hemoptysis, dyspnea, choking, shortness of breath, respiratory distress, decreased breath sounds, fever, and cyanosis may also occur  Tracheal foreign bodies are rare. Symptoms of a tracheal foreign body include stridor, wheeze, and dyspnea. 4/28/2018 73
  • 74. DIAGNOSIS  A witnessed episode of choking: defined as the sudden onset of cough and/or dyspnea and/or cyanosis in a previously healthy child, has a sensitivity of 76 to 92 percent for the diagnosis of FBA. CXR:  most aspirated objects are radiolucent so may nt be helpful  common radiographic findings in lower airway FBA are hyperinflated lung, 4/28/2018 74
  • 75. MANAGEMENT If there is complete airway obstruction: -back blows ,chest compressions in infants, and the Heimlich maneuver in older children, should be attempted • Bronchoscopy • Antibiotic and corticosteroids if the foreign body has been retained for longer period 4/28/2018 75
  • 76. COMPLICATIONS  Air trapping  Atelectasis  Postobstrucive pneumonia  bronchiectasis 4/28/2018 76
  • 77. PREVENTION  Hard and/or round foods should not be offered to children younger than four years of age  Children should be taught to chew their food well;  Coins and other small items should not be given to young children as rewards…… 4/28/2018 77