1) The church in Antioch was fasting and praying when the Holy Spirit called Barnabas and Saul to a special mission. 2) The church ordained Barnabas and Saul through fasting, prayer, and laying hands on them. 3) Barnabas and Saul were then sent out by the Holy Spirit to proclaim the word of God, first traveling to Cyprus and preaching in Jewish synagogues in Salamis with John Mark's assistance.