ENHANCING CULTURAL INTELLIGENCE AND DIGITAL LITERACY IN ACCOUNTING EDUCATION:...ijejournal
Recent literature has advocated for the use of project based learning to engage students in active learning. This study examines how students’ learning is enhanced through an overseas project-based learning (PBL) programme at a Singapore University (UNIS), called the UNIS-XO pedagogy. Specifically, this study provides a framework through which students, faculty members, and industry partner can collaborate through consulting programs with the aim to provide feasible recommendations to the clients. Our findings suggest that an experiential PBL with an overseas client is an important learning experience through which students can strengthen their digital literacy as well as cross-cultural competency to make them more futureready for their work.
INFORMATION AND COMMUNICATION TECHNOLOGY SKILLS ' SUFFICIENCY OF EGYPTIAN ...ijait
his study aims at evaluating the sufficiency of IC
T skills of fresh accounting graduates by soliciting the opinion of senior accounting professionals. A questionnaire used as the data collection method, and descriptive statistics used for analysis. The resul
t of this research was surprisingly, as the level of the accounting graduates rated to be above average and they are very competent for current accounting
profession in Egypt. The research revealed that any
fresh graduate should be literate with Internet,word
processing software, spreadsheet software, e-mail,
commercial accounting software, and database
management software. The research has several pract
ical implications as well as a genuine value, as it
provides current set of ICT skills tools needed by
accounting profession in Egypt.
How to Implement Digital Business Transformation in Higher EducationAlaa Mahjoub
This presentation covers the following main points:-
Digital Business Transformation
Steps for Implementing Digital Business Transformation in the Higher Education Industry
How to Develop Digital Business Transformation Strategy
Higher Education Institution Operating Model
Higher Education Institution Business Capability Model
Partnering with Ecosystem Players
Building the Digital Business Technology Platform
Implementing the Digital Business Transformation Program
Building Talent for the Next Production Revolution – Key Trends and Opportuni...OECD CFE
Presentation by Michael Haertel, Bundesinstitut für Berufsbildung, Germany, at the 9th OECD Southeast Asian Regional Policy Network on Education and Skills 11-12 October 2017, Ha Noi, Viet Nam.
More information: http://www.oecd.org/employment/leed/employmentesssa.htm
ENHANCING CULTURAL INTELLIGENCE AND DIGITAL LITERACY IN ACCOUNTING EDUCATION:...ijejournal
Recent literature has advocated for the use of project based learning to engage students in active learning. This study examines how students’ learning is enhanced through an overseas project-based learning (PBL) programme at a Singapore University (UNIS), called the UNIS-XO pedagogy. Specifically, this study provides a framework through which students, faculty members, and industry partner can collaborate through consulting programs with the aim to provide feasible recommendations to the clients. Our findings suggest that an experiential PBL with an overseas client is an important learning experience through which students can strengthen their digital literacy as well as cross-cultural competency to make them more futureready for their work.
INFORMATION AND COMMUNICATION TECHNOLOGY SKILLS ' SUFFICIENCY OF EGYPTIAN ...ijait
his study aims at evaluating the sufficiency of IC
T skills of fresh accounting graduates by soliciting the opinion of senior accounting professionals. A questionnaire used as the data collection method, and descriptive statistics used for analysis. The resul
t of this research was surprisingly, as the level of the accounting graduates rated to be above average and they are very competent for current accounting
profession in Egypt. The research revealed that any
fresh graduate should be literate with Internet,word
processing software, spreadsheet software, e-mail,
commercial accounting software, and database
management software. The research has several pract
ical implications as well as a genuine value, as it
provides current set of ICT skills tools needed by
accounting profession in Egypt.
How to Implement Digital Business Transformation in Higher EducationAlaa Mahjoub
This presentation covers the following main points:-
Digital Business Transformation
Steps for Implementing Digital Business Transformation in the Higher Education Industry
How to Develop Digital Business Transformation Strategy
Higher Education Institution Operating Model
Higher Education Institution Business Capability Model
Partnering with Ecosystem Players
Building the Digital Business Technology Platform
Implementing the Digital Business Transformation Program
Building Talent for the Next Production Revolution – Key Trends and Opportuni...OECD CFE
Presentation by Michael Haertel, Bundesinstitut für Berufsbildung, Germany, at the 9th OECD Southeast Asian Regional Policy Network on Education and Skills 11-12 October 2017, Ha Noi, Viet Nam.
More information: http://www.oecd.org/employment/leed/employmentesssa.htm
Integrating human relation skills into the curriculum of industrial technolog...IJITE
Technological devices are playing such a significant role in our lives that educators are incorporating
Ipads, smartphones, and even Skyping via these devices to educate our future generations. Managing the
utilization of this technology has become an important issue for businesses and proposes the question: how
is it possible to maintain good human relations with customers, clients and other businesses with all of the
technological advancements that often prevent face-to-face interaction? This paper addresses the value of
assimilating human relation skills into the curriculum of Industrial Technology related programs.
Additionally, this article provides an overview of Industrial Technology related programs and will also
address how to differentiate between Human Resource Development programs and Human Resource
Management programs.
Development of creative economy thinking with idea marathon system via cloud ...Panita Wannapiroon Kmutnb
Chalit Kangvaravoot and Panita Wannapiroon, " Development of Creative Economy Thinking with Idea Marathon System via Cloud Computing Technology," International Journal of e-Education, e-Business, e-Management and e-Learning vo. 3, no. 3, pp. 267-270, 2013.
A UNIVERSITY-INDUSTRY COLLABORATION CASE STUDY:INTEL REAL-TIME MULTI-VIEW FAC...ijejournal
Since 2011, University of Michigan—Shanghai Jiao Tong University Joint Institute (JI) has established 122
corporate-sponsored Capstone Design Projects (CDPs) with world leading companies such as Covidien,
General Electric, Hewlett Packard, Intel, and Siemens. Of these corporations, Intel was the first sponsor,
having funded 21 projects and mentored 105 students over four consecutive years. This paper is a longitudinal case study following three Intel-sponsored multi-view real-time face detection CDP teams with 15 undergraduate students during 2013 and 2014. On the technical side, the system design of face detection is based on Intel High Definition (HD) 4000 graphics and OpenCL. With numerous techniques,including accelerated pipeline over CPU and GPU, image decomposition, two-dimensional (2D) task
allocation, and a combination of Viola-Jones algorithm and continuously adaptive mean-shift (Camshift)
algorithm, a speed of 32 fps was attained for real-time multi-view face detection. In addition, a frontal view
detection accuracy of 81% was achieved in Phase I and a multi-view detection accuracy of 95% in Phase
III. Furthermore, an innovative application called face-detection game controller (FDGC) was developed.
On the other side, this research also addresses benefitsof stakeholders. After graduation, a third(5) of these
students worked in multinational corporations (MNCs) and two thirds (10) of these students entered top
American graduate schools. At the time of this writing, five of them have finished their master’s degrees and are currently working for famous companies, such as Amazon, Facebook, and Google.
The developing countries have to evaluate the existing vocational education programs against the needs of Industry 4.0 and improve them to meet the job specification. There is a need for cooperation and collaboration with the industries in the industrial corridor and hubs.
Towards a semantic standard for enterprise crowdsourcinglarshetmank
To cut expenses and save time, enterprise crowdsourcing is more and more used to disseminate corporate tasks, which are traditionally performed by a small group of people, to an undefined large workforce within and beyond the boundaries of a company. However, harnessing the positive effects of crowdsourcing faces several challenges, such as the efficient and proper assignment of a crowdsourcing task to an available and competent group of workers, or the securing of the integration and reuse of crowdsourcing data across heterogeneous business applications. To overcome these challenges, a semantic standard for enterprise crowdsourcing is developed and its applicability is shown by evaluating it against three diverse scenarios that may occur in real business environments. The proposed standard finally includes fifteen semantic elements to describe a crowdsourcing task and eight elements to define a user.
DIGITAL COMPETENCES FOR TEACHERS – THE DIGI.KOMPP MODEL IN AN INTERNATIONAL C...ijejournal
The digital competences of teachers have not yet been given sufficient attention in Austria. In order to meet
this need, the digi.kompP model has been developed on behalf of the Federal Ministry of Education and
Women's Affairs, led by the University College of Virtual Teacher Education. Based on national and
international framework models, the competency model is to serve as an instrument for self-assessment and
continuous professional development as well as for (higher) school development. The following is a brief
overview of international models that were relevant for the development of the competence grid. After that
the competence grid itself and its categories are presented. The article concludes with a discussion of the
integration of the competence grid into the international framework and its benefits in the Austrian
education system. This article aims to make a theoretical contribution to the categorization of teachers'
competencies.
Technology of India (CEDTI), Mohali was setup in May 1989. Primarily with the mission to train manpower in electronic design & technology by offering a variety of training programmed in diverse aspects of electronics design, product development, production technology, maintenance engineering, information technology and quality control, etc.
Lessons learnt from nearly 200 cases of knowledge management journeys by hong...2016
The talk summarises the lessons learnt from nearly 200 cases of Knowledge Management journeys by Hong Kong and Asian enterprises. Much of the data is gained through the extensive number of student, consultancy and research projects carried out or supervised by KMIRC staff at private companies, non-profit social services organizations and government departments. The projects include KM readiness assessments, knowledge audit, strategy formulation, taxonomy design and maintenance, cultural assessment and organizational change, knowledge retention from near-retirees, requirements elicitation and selection of collaboration tools including portals, search engine assessments, configuration and continuous improvements, IC reporting and many more. The speaker will outline the challenges and their respective solutions, the theory-practice gap, as well as some easy “entry points” into KM.
This talk is an extended version of an award-winning presentation delivered at the recently held European Conference on Knowledge Management, Udine, Italy.
Applying Educational Technology to Higher Education in Vietnam Opportunities ...ijtsrd
Industry 4.0 is happening at a very fast pace, with many impacts on Vietnamese education, both advantages and disadvantages. Therefore, big programs such as investing in modern infrastructure, information technology and communication training people who are dynamic, independent, creative, capable of integrating well to start their businesses are becoming urgent requirements to develop countries. In particular, training labor force to meet the requirements of development and integration of the society is at the heart of development strategies that every country must pay attention to. Therefore, higher education is more and more focused and improved in Vietnam these days. This paper discusses educational technology that has been applied in Dong Nai Technology University DNTU , which is known as one of prestigious universities in the south of Vietnam. It is expected that innovations in educational technology would facilitate students to develop themselves and make a great contribution of human resources to the society although those innovations have brought opportunities and challenges to Vietnamese universities in general and to DNTU in particular. The authors also propose recommendations to Vietnamese policy makers in terms of higher education. Huynh Nhu Yen Nhi "Applying Educational Technology to Higher Education in Vietnam: Opportunities and Challenges" Published in International Journal of Trend in Scientific Research and Development (ijtsrd), ISSN: 2456-6470, Volume-5 | Issue-2 , February 2021, URL: https://www.ijtsrd.com/papers/ijtsrd38387.pdf Paper Url: https://www.ijtsrd.com/humanities-and-the-arts/education/38387/applying-educational-technology-to-higher-education-in-vietnam-opportunities-and-challenges/huynh-nhu-yen-nhi
Integrating human relation skills into the curriculum of industrial technolog...IJITE
Technological devices are playing such a significant role in our lives that educators are incorporating
Ipads, smartphones, and even Skyping via these devices to educate our future generations. Managing the
utilization of this technology has become an important issue for businesses and proposes the question: how
is it possible to maintain good human relations with customers, clients and other businesses with all of the
technological advancements that often prevent face-to-face interaction? This paper addresses the value of
assimilating human relation skills into the curriculum of Industrial Technology related programs.
Additionally, this article provides an overview of Industrial Technology related programs and will also
address how to differentiate between Human Resource Development programs and Human Resource
Management programs.
Development of creative economy thinking with idea marathon system via cloud ...Panita Wannapiroon Kmutnb
Chalit Kangvaravoot and Panita Wannapiroon, " Development of Creative Economy Thinking with Idea Marathon System via Cloud Computing Technology," International Journal of e-Education, e-Business, e-Management and e-Learning vo. 3, no. 3, pp. 267-270, 2013.
A UNIVERSITY-INDUSTRY COLLABORATION CASE STUDY:INTEL REAL-TIME MULTI-VIEW FAC...ijejournal
Since 2011, University of Michigan—Shanghai Jiao Tong University Joint Institute (JI) has established 122
corporate-sponsored Capstone Design Projects (CDPs) with world leading companies such as Covidien,
General Electric, Hewlett Packard, Intel, and Siemens. Of these corporations, Intel was the first sponsor,
having funded 21 projects and mentored 105 students over four consecutive years. This paper is a longitudinal case study following three Intel-sponsored multi-view real-time face detection CDP teams with 15 undergraduate students during 2013 and 2014. On the technical side, the system design of face detection is based on Intel High Definition (HD) 4000 graphics and OpenCL. With numerous techniques,including accelerated pipeline over CPU and GPU, image decomposition, two-dimensional (2D) task
allocation, and a combination of Viola-Jones algorithm and continuously adaptive mean-shift (Camshift)
algorithm, a speed of 32 fps was attained for real-time multi-view face detection. In addition, a frontal view
detection accuracy of 81% was achieved in Phase I and a multi-view detection accuracy of 95% in Phase
III. Furthermore, an innovative application called face-detection game controller (FDGC) was developed.
On the other side, this research also addresses benefitsof stakeholders. After graduation, a third(5) of these
students worked in multinational corporations (MNCs) and two thirds (10) of these students entered top
American graduate schools. At the time of this writing, five of them have finished their master’s degrees and are currently working for famous companies, such as Amazon, Facebook, and Google.
The developing countries have to evaluate the existing vocational education programs against the needs of Industry 4.0 and improve them to meet the job specification. There is a need for cooperation and collaboration with the industries in the industrial corridor and hubs.
Towards a semantic standard for enterprise crowdsourcinglarshetmank
To cut expenses and save time, enterprise crowdsourcing is more and more used to disseminate corporate tasks, which are traditionally performed by a small group of people, to an undefined large workforce within and beyond the boundaries of a company. However, harnessing the positive effects of crowdsourcing faces several challenges, such as the efficient and proper assignment of a crowdsourcing task to an available and competent group of workers, or the securing of the integration and reuse of crowdsourcing data across heterogeneous business applications. To overcome these challenges, a semantic standard for enterprise crowdsourcing is developed and its applicability is shown by evaluating it against three diverse scenarios that may occur in real business environments. The proposed standard finally includes fifteen semantic elements to describe a crowdsourcing task and eight elements to define a user.
DIGITAL COMPETENCES FOR TEACHERS – THE DIGI.KOMPP MODEL IN AN INTERNATIONAL C...ijejournal
The digital competences of teachers have not yet been given sufficient attention in Austria. In order to meet
this need, the digi.kompP model has been developed on behalf of the Federal Ministry of Education and
Women's Affairs, led by the University College of Virtual Teacher Education. Based on national and
international framework models, the competency model is to serve as an instrument for self-assessment and
continuous professional development as well as for (higher) school development. The following is a brief
overview of international models that were relevant for the development of the competence grid. After that
the competence grid itself and its categories are presented. The article concludes with a discussion of the
integration of the competence grid into the international framework and its benefits in the Austrian
education system. This article aims to make a theoretical contribution to the categorization of teachers'
competencies.
Technology of India (CEDTI), Mohali was setup in May 1989. Primarily with the mission to train manpower in electronic design & technology by offering a variety of training programmed in diverse aspects of electronics design, product development, production technology, maintenance engineering, information technology and quality control, etc.
Lessons learnt from nearly 200 cases of knowledge management journeys by hong...2016
The talk summarises the lessons learnt from nearly 200 cases of Knowledge Management journeys by Hong Kong and Asian enterprises. Much of the data is gained through the extensive number of student, consultancy and research projects carried out or supervised by KMIRC staff at private companies, non-profit social services organizations and government departments. The projects include KM readiness assessments, knowledge audit, strategy formulation, taxonomy design and maintenance, cultural assessment and organizational change, knowledge retention from near-retirees, requirements elicitation and selection of collaboration tools including portals, search engine assessments, configuration and continuous improvements, IC reporting and many more. The speaker will outline the challenges and their respective solutions, the theory-practice gap, as well as some easy “entry points” into KM.
This talk is an extended version of an award-winning presentation delivered at the recently held European Conference on Knowledge Management, Udine, Italy.
Applying Educational Technology to Higher Education in Vietnam Opportunities ...ijtsrd
Industry 4.0 is happening at a very fast pace, with many impacts on Vietnamese education, both advantages and disadvantages. Therefore, big programs such as investing in modern infrastructure, information technology and communication training people who are dynamic, independent, creative, capable of integrating well to start their businesses are becoming urgent requirements to develop countries. In particular, training labor force to meet the requirements of development and integration of the society is at the heart of development strategies that every country must pay attention to. Therefore, higher education is more and more focused and improved in Vietnam these days. This paper discusses educational technology that has been applied in Dong Nai Technology University DNTU , which is known as one of prestigious universities in the south of Vietnam. It is expected that innovations in educational technology would facilitate students to develop themselves and make a great contribution of human resources to the society although those innovations have brought opportunities and challenges to Vietnamese universities in general and to DNTU in particular. The authors also propose recommendations to Vietnamese policy makers in terms of higher education. Huynh Nhu Yen Nhi "Applying Educational Technology to Higher Education in Vietnam: Opportunities and Challenges" Published in International Journal of Trend in Scientific Research and Development (ijtsrd), ISSN: 2456-6470, Volume-5 | Issue-2 , February 2021, URL: https://www.ijtsrd.com/papers/ijtsrd38387.pdf Paper Url: https://www.ijtsrd.com/humanities-and-the-arts/education/38387/applying-educational-technology-to-higher-education-in-vietnam-opportunities-and-challenges/huynh-nhu-yen-nhi
Sustaining the move to online teaching and learning during and after the Covi...Poh-Sun Goh
additional online resources and links to cited references on session blog for this topic segment for Virtual AMEE 2020 Best Practice Session
see link below https://medicaleducationelearning.blogspot.com/2020/06/transformational-change-in-scholarship.html
Cloud Search Based Applications for Big Data - Challenges and Methodologies f...Accelerate Project
Presentation of Suciu et al. at "Workshop on Adaptive Resource Management and Scheduling for Cloud Computing", ARMS-CC 2015 ,
Donostia-San Sebastián, Spain, July 20th, 2015
What is needed for successful Cloud Computing implementation in education?TheSoFGr
School on the Cloud (SoC),
ICT Key Action 3 European Project - With the support of the Lifelong Learning Programme of the European Union
Author: Karl Donert
Abstract: This deliverable is the publication based on research undertaken before the 3rd Summit Meeting of the School on the Cloud Project. It is based on literature research and surveys of project participants.
The publication considers the current needs for the development of Cloud Computing in European education. It examines some of the ongoing barriers to the implementation of Cloud Computing in education and explores leadership and policy issues.
The publication led to the development and launch of a Brussels Declaration for a Cloud Computing Strategy for European Education.
Impact Communication Tools - Coaching Material for Social Entrepreneursikosom GmbH
Description of Tools that can be used to communicate your impact activities. This slide is part of the project "CE-RESPONSIBLE " by Interreg Central Europe. Hear the presentation at www.net4socialimpact.eu
This is an article about educational app development. It discusses the growth of the ed-tech market and the importance of technology in education. The article also outlines key features of successful ed-tech platforms. Some of the important points from this article are that ed-tech platforms should be user-friendly and accessible, and they should use technology to personalize the learning experience.
Project Report Format for Final Year Engineering Studentscutericha10
Project report is a written evidence of tasks, processes and activities that are undertaken and accomplished by the students while pursuing their projects and implementing it.
This report is an official document that reflects precise and concrete information about the different aspects of the project ranging from the overview, requirements, practical aspects, theoretical considerations, tasks furnished, outcomes gained, objectives listed, reports attached, abstracts, experiments and results, conclusions and recommendations to the implementation and scope of the project.
This pdf is about the Schizophrenia.
For more details visit on YouTube; @SELF-EXPLANATORY;
https://www.youtube.com/channel/UCAiarMZDNhe1A3Rnpr_WkzA/videos
Thanks...!
Slide 1: Title Slide
Extrachromosomal Inheritance
Slide 2: Introduction to Extrachromosomal Inheritance
Definition: Extrachromosomal inheritance refers to the transmission of genetic material that is not found within the nucleus.
Key Components: Involves genes located in mitochondria, chloroplasts, and plasmids.
Slide 3: Mitochondrial Inheritance
Mitochondria: Organelles responsible for energy production.
Mitochondrial DNA (mtDNA): Circular DNA molecule found in mitochondria.
Inheritance Pattern: Maternally inherited, meaning it is passed from mothers to all their offspring.
Diseases: Examples include Leber’s hereditary optic neuropathy (LHON) and mitochondrial myopathy.
Slide 4: Chloroplast Inheritance
Chloroplasts: Organelles responsible for photosynthesis in plants.
Chloroplast DNA (cpDNA): Circular DNA molecule found in chloroplasts.
Inheritance Pattern: Often maternally inherited in most plants, but can vary in some species.
Examples: Variegation in plants, where leaf color patterns are determined by chloroplast DNA.
Slide 5: Plasmid Inheritance
Plasmids: Small, circular DNA molecules found in bacteria and some eukaryotes.
Features: Can carry antibiotic resistance genes and can be transferred between cells through processes like conjugation.
Significance: Important in biotechnology for gene cloning and genetic engineering.
Slide 6: Mechanisms of Extrachromosomal Inheritance
Non-Mendelian Patterns: Do not follow Mendel’s laws of inheritance.
Cytoplasmic Segregation: During cell division, organelles like mitochondria and chloroplasts are randomly distributed to daughter cells.
Heteroplasmy: Presence of more than one type of organellar genome within a cell, leading to variation in expression.
Slide 7: Examples of Extrachromosomal Inheritance
Four O’clock Plant (Mirabilis jalapa): Shows variegated leaves due to different cpDNA in leaf cells.
Petite Mutants in Yeast: Result from mutations in mitochondrial DNA affecting respiration.
Slide 8: Importance of Extrachromosomal Inheritance
Evolution: Provides insight into the evolution of eukaryotic cells.
Medicine: Understanding mitochondrial inheritance helps in diagnosing and treating mitochondrial diseases.
Agriculture: Chloroplast inheritance can be used in plant breeding and genetic modification.
Slide 9: Recent Research and Advances
Gene Editing: Techniques like CRISPR-Cas9 are being used to edit mitochondrial and chloroplast DNA.
Therapies: Development of mitochondrial replacement therapy (MRT) for preventing mitochondrial diseases.
Slide 10: Conclusion
Summary: Extrachromosomal inheritance involves the transmission of genetic material outside the nucleus and plays a crucial role in genetics, medicine, and biotechnology.
Future Directions: Continued research and technological advancements hold promise for new treatments and applications.
Slide 11: Questions and Discussion
Invite Audience: Open the floor for any questions or further discussion on the topic.
Cancer cell metabolism: special Reference to Lactate PathwayAADYARAJPANDEY1
Normal Cell Metabolism:
Cellular respiration describes the series of steps that cells use to break down sugar and other chemicals to get the energy we need to function.
Energy is stored in the bonds of glucose and when glucose is broken down, much of that energy is released.
Cell utilize energy in the form of ATP.
The first step of respiration is called glycolysis. In a series of steps, glycolysis breaks glucose into two smaller molecules - a chemical called pyruvate. A small amount of ATP is formed during this process.
Most healthy cells continue the breakdown in a second process, called the Kreb's cycle. The Kreb's cycle allows cells to “burn” the pyruvates made in glycolysis to get more ATP.
The last step in the breakdown of glucose is called oxidative phosphorylation (Ox-Phos).
It takes place in specialized cell structures called mitochondria. This process produces a large amount of ATP. Importantly, cells need oxygen to complete oxidative phosphorylation.
If a cell completes only glycolysis, only 2 molecules of ATP are made per glucose. However, if the cell completes the entire respiration process (glycolysis - Kreb's - oxidative phosphorylation), about 36 molecules of ATP are created, giving it much more energy to use.
IN CANCER CELL:
Unlike healthy cells that "burn" the entire molecule of sugar to capture a large amount of energy as ATP, cancer cells are wasteful.
Cancer cells only partially break down sugar molecules. They overuse the first step of respiration, glycolysis. They frequently do not complete the second step, oxidative phosphorylation.
This results in only 2 molecules of ATP per each glucose molecule instead of the 36 or so ATPs healthy cells gain. As a result, cancer cells need to use a lot more sugar molecules to get enough energy to survive.
Unlike healthy cells that "burn" the entire molecule of sugar to capture a large amount of energy as ATP, cancer cells are wasteful.
Cancer cells only partially break down sugar molecules. They overuse the first step of respiration, glycolysis. They frequently do not complete the second step, oxidative phosphorylation.
This results in only 2 molecules of ATP per each glucose molecule instead of the 36 or so ATPs healthy cells gain. As a result, cancer cells need to use a lot more sugar molecules to get enough energy to survive.
introduction to WARBERG PHENOMENA:
WARBURG EFFECT Usually, cancer cells are highly glycolytic (glucose addiction) and take up more glucose than do normal cells from outside.
Otto Heinrich Warburg (; 8 October 1883 – 1 August 1970) In 1931 was awarded the Nobel Prize in Physiology for his "discovery of the nature and mode of action of the respiratory enzyme.
WARNBURG EFFECT : cancer cells under aerobic (well-oxygenated) conditions to metabolize glucose to lactate (aerobic glycolysis) is known as the Warburg effect. Warburg made the observation that tumor slices consume glucose and secrete lactate at a higher rate than normal tissues.
Multi-source connectivity as the driver of solar wind variability in the heli...Sérgio Sacani
The ambient solar wind that flls the heliosphere originates from multiple
sources in the solar corona and is highly structured. It is often described
as high-speed, relatively homogeneous, plasma streams from coronal
holes and slow-speed, highly variable, streams whose source regions are
under debate. A key goal of ESA/NASA’s Solar Orbiter mission is to identify
solar wind sources and understand what drives the complexity seen in the
heliosphere. By combining magnetic feld modelling and spectroscopic
techniques with high-resolution observations and measurements, we show
that the solar wind variability detected in situ by Solar Orbiter in March
2022 is driven by spatio-temporal changes in the magnetic connectivity to
multiple sources in the solar atmosphere. The magnetic feld footpoints
connected to the spacecraft moved from the boundaries of a coronal hole
to one active region (12961) and then across to another region (12957). This
is refected in the in situ measurements, which show the transition from fast
to highly Alfvénic then to slow solar wind that is disrupted by the arrival of
a coronal mass ejection. Our results describe solar wind variability at 0.5 au
but are applicable to near-Earth observatories.
The increased availability of biomedical data, particularly in the public domain, offers the opportunity to better understand human health and to develop effective therapeutics for a wide range of unmet medical needs. However, data scientists remain stymied by the fact that data remain hard to find and to productively reuse because data and their metadata i) are wholly inaccessible, ii) are in non-standard or incompatible representations, iii) do not conform to community standards, and iv) have unclear or highly restricted terms and conditions that preclude legitimate reuse. These limitations require a rethink on data can be made machine and AI-ready - the key motivation behind the FAIR Guiding Principles. Concurrently, while recent efforts have explored the use of deep learning to fuse disparate data into predictive models for a wide range of biomedical applications, these models often fail even when the correct answer is already known, and fail to explain individual predictions in terms that data scientists can appreciate. These limitations suggest that new methods to produce practical artificial intelligence are still needed.
In this talk, I will discuss our work in (1) building an integrative knowledge infrastructure to prepare FAIR and "AI-ready" data and services along with (2) neurosymbolic AI methods to improve the quality of predictions and to generate plausible explanations. Attention is given to standards, platforms, and methods to wrangle knowledge into simple, but effective semantic and latent representations, and to make these available into standards-compliant and discoverable interfaces that can be used in model building, validation, and explanation. Our work, and those of others in the field, creates a baseline for building trustworthy and easy to deploy AI models in biomedicine.
Bio
Dr. Michel Dumontier is the Distinguished Professor of Data Science at Maastricht University, founder and executive director of the Institute of Data Science, and co-founder of the FAIR (Findable, Accessible, Interoperable and Reusable) data principles. His research explores socio-technological approaches for responsible discovery science, which includes collaborative multi-modal knowledge graphs, privacy-preserving distributed data mining, and AI methods for drug discovery and personalized medicine. His work is supported through the Dutch National Research Agenda, the Netherlands Organisation for Scientific Research, Horizon Europe, the European Open Science Cloud, the US National Institutes of Health, and a Marie-Curie Innovative Training Network. He is the editor-in-chief for the journal Data Science and is internationally recognized for his contributions in bioinformatics, biomedical informatics, and semantic technologies including ontologies and linked data.
Introduction:
RNA interference (RNAi) or Post-Transcriptional Gene Silencing (PTGS) is an important biological process for modulating eukaryotic gene expression.
It is highly conserved process of posttranscriptional gene silencing by which double stranded RNA (dsRNA) causes sequence-specific degradation of mRNA sequences.
dsRNA-induced gene silencing (RNAi) is reported in a wide range of eukaryotes ranging from worms, insects, mammals and plants.
This process mediates resistance to both endogenous parasitic and exogenous pathogenic nucleic acids, and regulates the expression of protein-coding genes.
What are small ncRNAs?
micro RNA (miRNA)
short interfering RNA (siRNA)
Properties of small non-coding RNA:
Involved in silencing mRNA transcripts.
Called “small” because they are usually only about 21-24 nucleotides long.
Synthesized by first cutting up longer precursor sequences (like the 61nt one that Lee discovered).
Silence an mRNA by base pairing with some sequence on the mRNA.
Discovery of siRNA?
The first small RNA:
In 1993 Rosalind Lee (Victor Ambros lab) was studying a non- coding gene in C. elegans, lin-4, that was involved in silencing of another gene, lin-14, at the appropriate time in the
development of the worm C. elegans.
Two small transcripts of lin-4 (22nt and 61nt) were found to be complementary to a sequence in the 3' UTR of lin-14.
Because lin-4 encoded no protein, she deduced that it must be these transcripts that are causing the silencing by RNA-RNA interactions.
Types of RNAi ( non coding RNA)
MiRNA
Length (23-25 nt)
Trans acting
Binds with target MRNA in mismatch
Translation inhibition
Si RNA
Length 21 nt.
Cis acting
Bind with target Mrna in perfect complementary sequence
Piwi-RNA
Length ; 25 to 36 nt.
Expressed in Germ Cells
Regulates trnasposomes activity
MECHANISM OF RNAI:
First the double-stranded RNA teams up with a protein complex named Dicer, which cuts the long RNA into short pieces.
Then another protein complex called RISC (RNA-induced silencing complex) discards one of the two RNA strands.
The RISC-docked, single-stranded RNA then pairs with the homologous mRNA and destroys it.
THE RISC COMPLEX:
RISC is large(>500kD) RNA multi- protein Binding complex which triggers MRNA degradation in response to MRNA
Unwinding of double stranded Si RNA by ATP independent Helicase
Active component of RISC is Ago proteins( ENDONUCLEASE) which cleave target MRNA.
DICER: endonuclease (RNase Family III)
Argonaute: Central Component of the RNA-Induced Silencing Complex (RISC)
One strand of the dsRNA produced by Dicer is retained in the RISC complex in association with Argonaute
ARGONAUTE PROTEIN :
1.PAZ(PIWI/Argonaute/ Zwille)- Recognition of target MRNA
2.PIWI (p-element induced wimpy Testis)- breaks Phosphodiester bond of mRNA.)RNAse H activity.
MiRNA:
The Double-stranded RNAs are naturally produced in eukaryotic cells during development, and they have a key role in regulating gene expression .
Richard's entangled aventures in wonderlandRichard Gill
Since the loophole-free Bell experiments of 2020 and the Nobel prizes in physics of 2022, critics of Bell's work have retreated to the fortress of super-determinism. Now, super-determinism is a derogatory word - it just means "determinism". Palmer, Hance and Hossenfelder argue that quantum mechanics and determinism are not incompatible, using a sophisticated mathematical construction based on a subtle thinning of allowed states and measurements in quantum mechanics, such that what is left appears to make Bell's argument fail, without altering the empirical predictions of quantum mechanics. I think however that it is a smoke screen, and the slogan "lost in math" comes to my mind. I will discuss some other recent disproofs of Bell's theorem using the language of causality based on causal graphs. Causal thinking is also central to law and justice. I will mention surprising connections to my work on serial killer nurse cases, in particular the Dutch case of Lucia de Berk and the current UK case of Lucy Letby.
Acceleration platform based on cloud computing and validated learning for innovation in industry
1. ACCELERATION PLATFORM BASED ON
CLOUD COMPUTING AND VALIDATED
LEARNING FOR INNOVATION IN INDUSTRY
• George Suciu and Gyorgy Todoran
Faculty of Electronics, Telecommunications and Information Technology,
University POLITEHNICA of Bucharest
• Cristina Butca and Victor Suciu
R&D Department, Beia Consult International
Bucharest, Romania, 2015
3. Short Biography (1)
Graduated from the Faculty of Electronics,
Telecommunications and Information Technology at
the University “Politehnica” of Bucharest (UPB),
Romania (www.upb.ro)
MBA in Informatics Project Management from the
Faculty of Cybernetics, Statistics and Economic
Informatics of the Academy of Economic Studies
Bucharest (www.ase.ro)
Currently, Ph.D. Eng. Post-doc Researcher focused
on the field of big data, cloud communications, open
source, IPR and IoT/M2M
Since 2008 IT&C Solutions Manager - R&D
Department, being employed starting 1998 at BEIA
Consult International, a research performing SME
(www.beiaro.eu)
G. Suciu, et.al. (2015)
4. Short Biography (2)
Projects – www.beiaro.eu / www.mobcomm.pub.ro
FP7 (2 on-going)
REDICT : Regional Economic Development by ICT
eWALL : Electronic Wall for Active Long Living
NMSDMON : Network Management System Development and Monitoring
FAIR : Friendly Application for Interactive Receiver
Cloud Consulting : Cloud-based Automation of ERP and CRM software for Small Businesses
ACCELERATE: A Platform for the Acceleration of go-to market in the ICT industry
H2020 (1 on-going)
SWITCH: Software Workbench for Interactive, Time Critical and Highly self-adaptive Cloud applications (ICT-9)
National (more than 10 past projects, 5 on-going)
MobiWay: Mobility Beyond Individualism: an Integrated Platform for Intelligent Transportation Systems of Tomorrow
EV-BAT: Redox battery with fast charging capacity as a main source of energy for electric autovehicles
CarbaDetect: Imuno-biosensors for fast detection of carbamic pesticide residues (carbaryl, carbendazim) in horticultural products
SARAT-IWSN : Scalable Radio Transceiver for Instrumental Wireless Sensor Networks
COMM-CENTER : Developing of a “cloud communication center" by integrating a call/contact center platform with unified
communication technology, CRM system, “text-to-speech” and “automatic speech recognition” solutions in different languages
(including Romanian)
G. Suciu, et.al. (2015)
5. Introduction (1)
To successfully accelerate, companies need a new type of product development, the so
called validated learning process.
We describe a cloud platform that will bring together several services and instruments
that the companies usually rely on in their go-to-market process.
The main contribution of this presentation consists in the integration of several services
in the platform, such as:
awareness creation services,
trainings, seminars,
online courses,
coaching and mentoring services,
software tools that support specific parts of the acceleration process,
services that provide access to data needed to speed up go-to-market,
services to look for partners,
project management tools.
G. Suciu, et.al. (2015)
6. Introduction (2)
Validated learning - the practice of effectively measuring the accuracy of assumptions and
using the results of the validation to understand whether the assumption was correct and
if so, continue onto the next test.
Standards identified:
DMAIC – the main tool of Six Sigma projects and refers to learning cycles that are
based on information for improvement and stabilizing the processes and business
designs.
KAIZEN - a continuous improvement activity of all functions and processes within an
organization, from the Japanese philosophy of continuous good change.
Lean Startup - a method of developing business and products proposed shortening the
product development cycle by adopting a combination of experiments based on
assumptions of business and iterative product start up.
G. Suciu, et.al. (2015)
7. VIRTUAL COLLABORATION SPACES (1)
1. Validated Learning
the systematically search for matches between technology and market by validating the
mechanics of a business model;
consists in iterating rapidly between experiments, data collection and informed
decision making;
is defined as a process that is learned by applying a initial ideas and measured to
validate the effect;
Typical steps in the validated learning process:
specifying a target,
specifying metrics that represent the objective,
analysis of metrics and improvement;
achievement of other tests.
G. Suciu, et.al. (2015)
8. VIRTUAL COLLABORATION SPACES (2)
2. Learning cycle
Are social learning platforms;
A learning cycle will take a number of steps or phases, the latter being followed by first;
There are several models of learning cycles, such as:
Kurt Lewin;
Kolb and Fry;
Honey and Mumford;
Alistair Smith.
include a number of theories that suggest systematic differences in natural or usual
pattern of individuals for the acquisition and processing of information in learning
situations.
G. Suciu, et.al. (2015)
9. PROPOSED CLOUD ACCELERATION PLATFORM FOR INNOVATION IN INDUSTRY (1)
To acquire knowledge and qualified persons, ITC system developers rely heavily on
consultants, advisors and other providers of domain specific knowledge and can provide
training and coaching programs.
The several services that will be integrated in the platform are:
G. Suciu, et.al. (2015)
10. Service to look for partners - a management service that lets the users to take a
hands-on approach to a wide range of activities related to getting support, building
projects and finding opportunities.
Project management tools - a service that offer support for task management,
resource allocation, tracking, Gantt charts, and much more.
Services that provide access to data needed to speed up go-to-market - search
based services.
Awareness creation services - the most effective and least expensive channels for
online advertising and building a positive reputation.
Software tools that support specific parts of the acceleration process provides a
scientific approach to creating and managing startups and get a desired product to
customers hands faster.
PROPOSED CLOUD ACCELERATION PLATFORM FOR INNOVATION IN INDUSTRY (2)
G. Suciu, et.al. (2015)
11. Mentoring service help the users to refine their business strategy, map out the
direction that their business should be taking and assist in setting goals for their
business to succeed.
Seminars - meetings in which people can learn about a topic and are usually
interactive sessions where the participants engage in discussions about the delineated
topic.
Online course - an electronic learning method.
Coaching service - distinct from other forms of training because he focuses on the
method of learning.
Trainings - organized activities aimed at imparting information and/or instructions to
improve the recipient's performance or to help him or her attain a required level of
knowledge or skill.
PROPOSED CLOUD ACCELERATION PLATFORM FOR INNOVATION IN INDUSTRY (3)
G. Suciu, et.al. (2015)
12. Conclusions
To successfully accelerate, companies need a new type of product development, the so
called validated learning process.
Validated learning process systematically searches the fit between technology and market,
by validating the mechanics of a business model.
In this presentation we describe the validated learning process and learning cycles.
Learning cycles are social learning platforms.
Diverse perspectives, ideas, interests and local knowledge are taken into account in order
to find alternative solutions that are optimal in comparison with established approaches.
G. Suciu, et.al. (2015)
13. University “POLITEHNICA“ of Bucharest
Faculty of Electronics, Telecommunications & Information Technology
Any questions ?
george@beia.ro
The work has been funded by the Sectoral Operational Programme Human Resources Development 2007-2013 of the Ministry of
European Funds through the Financial Agreement POSDRU/159/1.5/S/134398.
G. Suciu, et.al. (2015)
14. References
Munch, J., 2012. Evolving Process Simulators by Using Validated Learning. In ICSSP 2012, International Conference on
Software and System Process. IEEE. Page 226
Pyzdek, T., 2014. The Six Sigma handbook, McGraw-Hill Education. Page 25
Shabalina, O., Sadovnikova, N., Kravets, A., 2013. Methodology of teaching software engineering: game-based learning
cycle, In ECBS-EERC 2013, 3rd Eastern European Regional Conference on the Engineering of Computer Based Systems.
IEEE, Page 113
Militaru, T. L., Suciu, G., Todoran, G., 2012. The evaluation of the e-learning applications' quality, In IE 2012, 11th
International Conference on Informatics in Economy. Page 168
Glanz, J., 2014. Action research: An educational leader's guide to school improvement, Rowman & Littlefield. Page 15
Kolb D. A., Fry, R., 1975. Toward an applied theory of experiential learning, In C. Cooper (ed.), Theories of Group
Process, London: John Wiley. Page 9
Mumford, A., 1997. Putting Learning Styles to Work, In Action Learning at Work. Gower Publishing. Page 121
Bidin, B, Omar, A. R., Jaafar, R. 2012. Ergonomics Evaluation of Training Activities Postures in Engineering Workshop at
Vocational Training Center”, In CHUSER 2012, Colloquium on Humanities, Science and Engineering. IEEE. Page 669
Chang, C., Fang, Y., Zhan, Q., 2009. Design principles and methods of activities for teachers’ online training, In ICNDS
'09, International Conference on Networking and Digital Society. IEEE. Page 259
Jonassen, D.H., Rohrer-Murphy, L., 1999. Activity Theory as a Framework for Designing Constructivist Learning
Environments”, In Educational Technology Research and Development, vol. 47, no. 1. Page 62
Wan, L., Zhao, C., Luo, Q., 2006. Navigation and Sequencing Strategy of Learning Process in Distance Learning Context,
In 36th Annual Frontiers in Education Conference. IEEE. Page 26
Farmer, R.A., Hughes, B. 2005. A Situated Learning Perspective on Learning Object Design Advanced Learning, In ICALT
2005, Fifth IEEE International Conference on Technologies. IEEE. Page 7
G. Suciu, et.al. (2015)