Abstract - SGI EPC 10-2012
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Circulating endothelial progenitor cells (EPCs), which help repair damaged blood vessels, were found to be significantly higher in both obese pregnant women and mice compared to their lean counterparts. EPCs levels were measured in the first trimester of pregnancy using flow cytometry and were elevated across multiple EPC subtypes in obese subjects. While pregnancy itself increases EPCs, obesity appears to further elevate EPC levels during pregnancy, though it remains unclear if these additional EPCs function properly.
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Address: 1Laboratorio de Inmunología de la Reproducción, Facultad de Química y Biología, Universidad de Santiago de Chile, Santiago, Chile, 2Centro para el Desarrollo en Nanociencia y Nanotecnología-CEDENNA, Santiago, Chile, 3Millennium Institute for Fundamental and Applied Biology, Santiago, Chile, 4Unidad de Reproducción y Desarrollo, Facultad de Ciencias Biológicas, Pontificia Universidad Católica de Chile, Santiago, Chile and 5Instituto de Nutrición y Tecnología de los Alimentos, Universidad de Chile, Santiago, Chile
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BioMed Central
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Mating changes the subcellular distribution and the functionality of estrogen receptors in the rat oviduct Pedro A Orihuela*1,2, Lidia M Zuñiga3, Mariana Rios4, Alexis Parada- Bustamante3, Walter D Sierralta5, Luis A Velásquez1,2 and
Horacio B Croxatto1,2,3
Address: 1Laboratorio de Inmunología de la Reproducción, Facultad de Química y Biología, Universidad de Santiago de Chile, Santiago, Chile, 2Centro para el Desarrollo en Nanociencia y Nanotecnología-CEDENNA, Santiago, Chile, 3Millennium Institute for Fundamental and Applied Biology, Santiago, Chile, 4Unidad de Reproducción y Desarrollo, Facultad de Ciencias Biológicas, Pontificia Universidad Católica de Chile, Santiago, Chile and 5Instituto de Nutrición y Tecnología de los Alimentos, Universidad de Chile, Santiago, Chile
Email: Pedro A Orihuela* - pedro.orihuela@usach.cl; Lidia M Zuñiga - lzunigac@bio.puc.cl; Mariana Rios - mrios@bio.puc.cl; Alexis Parada- Bustamante - aparada@uc.cl; Walter D Sierralta - wsierra@inta.cl; Luis A Velásquez - luis.velasquez.c@usach.cl; Horacio B Croxatto - horacio.croxatto@usach.cl
* Corresponding author
Published: 30 November 2009 Received: 23 September 2009
Reproductive Biology and Endocrinology 2009, 7:139 doi:10.1186/1477-7827-7-139 This article is available from: http://www.rbej.com/content/7/1/139
Accepted: 30 November 2009
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Uses of of N-acetyl Cysteine in Medicine, obstetrics, gynecology and inferti...
(Reproductive biology and endocrinology) Luis Alberto Velasquez Cumplido
(Reproductive biology and endocrinology) Luis Alberto Velasquez Cumplido
Role of antioxidants in female infertility Dr. Jyoti Agarwal
Role of antioxidants in female infertility Dr. Jyoti Agarwal
Dr Ayman Ewies - The Effect of Exogenous Leptin Administration on Folliculoge...
Dr Ayman Ewies - The Effect of Exogenous Leptin Administration on Folliculoge...
Findings of Developmental Toxicity Studies of HBOC-201 in Rodent and Canine M...
Findings of Developmental Toxicity Studies of HBOC-201 in Rodent and Canine M...
Similar to Abstract - SGI EPC 10-2012
journal.pone.0133500
This study investigated the effects of moderate perinatal choline deficiency in piglets. Sows were fed either a choline sufficient or deficient diet during gestation. After farrowing, piglets were fed one of two milk replacers, either choline sufficient or deficient, for 4 weeks. Piglets exposed to postnatal choline deficiency had lower plasma choline levels and higher liver enzymes. They also had higher liver lipid content and lower plasma cholesterol. Prenatal choline deficiency resulted in smaller brain size. The results suggest piglets are a useful model for studying effects of perinatal choline deficiency seen in humans and rodents.
A Case Report on Intrahepatic Cholestasis of Pregnancy
This case study is about a primigravida mother period of gestation 29 weeks and 5 days diagnosed with intrahepatic cholestasis of pregnancy IHCP . She had been married since 1 year and it is her first pregnancy. The patient is having gestational diabetes mellitus and hypothyroidism. The patients was admitted to antenatal ward of St. Stephen’s Hospital , New Delhi, with chief complaints of itching in palms, soles and over umbilical area since 2 weeks. During the physical examination the rashes were seen on abdomen, legs and breast. Per abdomen examination and ultrasound revealed that vertex presentation of the fetus and FHR as 136 min and fetal weight as 1923 gram and presence of low lying placenta. Routine blood examination revealed that patient was also a case of gestational diabetes mellitus and hypothyroidism. After all the required investigation she was diagnosed with IHCP with gestational diabetes mellitus and hypothyroidism. IHCP is a pregnancy related liver disorder characterized by pruritus, most often in the late second or early trimester of pregnancy and raised serum bile acids. The maternal outcome after treatment is fair but fetal outcomes becomes adverse in most of the conditions. Ms. Rana Kamar | Dr. Rajwant Randhawa | Dr. Priyanaka Choudhary "A Case Report on Intrahepatic Cholestasis of Pregnancy" Published in International Journal of Trend in Scientific Research and Development (ijtsrd), ISSN: 2456-6470, Volume-6 | Issue-1 , December 2021, URL: https://www.ijtsrd.com/papers/ijtsrd49087.pdf Paper URL: https://www.ijtsrd.com/medicine/nursing/49087/a-case-report-on-intrahepatic-cholestasis-of-pregnancy/ms-rana-kamar
2007 List SKIN PROTEOMICS
This study analyzed proteins in the skin of mice with diet-induced type 2 diabetes compared to non-diabetic controls. Mice were fed a high-fat diet for 16 weeks to induce obesity and diabetes. Skin samples were then analyzed using proteomics. Out of over 1000 protein spots, 28 were significantly altered between diabetic and control mice, with 6 decreased and 22 increased. 17 of the altered proteins were involved in energy metabolism. This study identified proteins altered in diabetic mouse skin and suggests that skin proteomics could provide a noninvasive method for early diabetes diagnosis.
oski 4.pdf
This case report describes the surgical repair and management of a peritoneopericardial diaphragmatic hernia (PPDH) in a pregnant dog. A 3-year-old pregnant Golden Retriever presented with vomiting, lethargy, and pale gums. Diagnostic testing revealed a PPDH, with liver and omentum herniated into the pericardial sac. The dog underwent surgery to repair the diaphragmatic tear. Post-operatively, the dog experienced hypotension, tachycardia, and ventricular arrhythmias requiring intensive care. Over nine days of supportive care and monitoring, the dog's condition stabilized. The puppies were later delivered via cesarean section
DIABETES AND PREGNANCY -7 .ppt
This document discusses gestational diabetes. It provides information on:
1. Gestational diabetes is a form of diabetes that develops during pregnancy in women who do not have diabetes otherwise. It is caused by pregnancy hormones and/or insulin deficiency.
2. While gestational diabetes usually resolves after delivery, it increases the mother's risk of developing type 2 diabetes later in life. It can also increase risks for the baby if not well controlled, such as being too large or jaundice.
3. Screening all pregnant women for gestational diabetes is recommended, as prior selective screening missed some cases. Screening and treatment can help reduce risks for both mother and baby.
Glucose, microenvironments and cancer connections
Micro-environments of cells control cell growth & organization.In 2012 Bissell & team showed excess glucose in micro-environment lead to cancer growth.
Lapkas gizi
This case report describes a 5 year old boy presenting with severe malnutrition (marasmus), HIV infection, and hemorrhagic varicella. He had a history of diarrhea, fever, seizures, and weight loss. On examination, he showed signs of marasmus including low weight and loss of subcutaneous fat. Laboratory results found low CD4 count and anemia. He was diagnosed with severe malnutrition (marasmus), HIV infection, and varicella hemorrhage. Over two weeks of treatment including antibiotics, antiretrovirals and nutritional support, his condition improved with reduced diarrhea and fever.
Monitoring of Neonatal Haemodynamics
The document discusses three case studies of neonates presenting with various medical conditions. For each case, clinical details are provided about the neonate's condition, vital signs, lab results, and treatments administered. The reader is then prompted to indicate the next appropriate action or intervention in each case. The document also reviews various methods for monitoring hemodynamics and end-organ perfusion in neonates.
Obesity
The document discusses obesity and whether it should be considered a disease. It examines the genetic basis of obesity, finding that 23 genes are responsible for single-gene mutations causing obesity and over 400 genes are still being researched. It analyzes mice studies where the SH2B gene was knocked out (KO) or knocked out only in neuronal tissue (TGKO). KO mice became obese with high fat and insulin levels and were leptin resistant. TGKO mice were similar to wild type, showing neuronal expression of SH2B is important for regulating metabolism, appetite, and leptin/insulin sensitivity. The findings suggest SH2B levels in neurons are important for protecting against diet-induced obesity.
Life2018 maria vranceanu
Nutrigenetics and nutrigenomics analyze how genes influence nutrition and can be used to develop personalized nutrition plans. As genetic testing becomes more widespread, it may be possible to use sensors to recommend optimal diets based on an individual's genotype. Several genes like FTO, CCK, and CYP1A2 influence factors like appetite, meal size, and metabolism of certain foods. Understanding these gene-diet interactions could help reduce risk of diseases like cardiovascular disease, obesity, and cancer by tailoring diets. While nutrigenetic testing shows promise for personalized healthcare, consumer attitudes toward genetic testing will influence its future applications.
White Lies
This document provides an introduction to a report on the health consequences of consuming cow's milk. It begins with definitions of a healthy diet, noting it should be high in fruits/veggies, whole grains, and contain antioxidants, fiber, vitamins/minerals while being low in saturated fat, animal protein, and cholesterol. The introduction questions why people in some cultures consume cow's milk into adulthood, unlike other mammals, and notes the dairy industry promotes milk as healthy while increasing evidence links cow's milk to health problems. The aim is to present research on the health effects of cow's milk in order to provide balance to emotionally charged views of milk as natural and healthy.
Insulin resistance and pcos
The document summarizes key findings from a review of literature on polycystic ovary syndrome (PCOS). It finds that the most consistent predictors of PCOS are hyperandrogenemia (high levels of "male" hormones) in 60-80% of cases, hirsutism (excess hair growth) in 60% of cases, and polycystic ovaries in 75% of cases. It also discusses debates around definitions of PCOS and relationships with insulin resistance.
Insulin resistance and pcos
The document summarizes key findings from a review of literature on polycystic ovary syndrome (PCOS). It finds that the most consistent predictors of PCOS are hyperandrogenemia (high levels of "male" hormones) in 60-80% of cases, hirsutism (excess hair growth) in 60% of cases, and polycystic ovaries in 75% of cases. It also discusses debates around definitions of PCOS and relationships with insulin resistance.
Obesity: A Pediatric Epidemic
This document discusses the growing pediatric obesity epidemic and its associated health risks and anesthetic implications. Some key points:
- Up to 30% of children in some countries are now obese, representing a pandemic. Girls and certain ethnic groups have higher rates.
- Obese children often become obese adults and are at risk for conditions like asthma, sleep apnea, diabetes, and cardiovascular disease.
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Pregnancy toxeinia in a sheep flock
This document summarizes a case study of pregnancy toxemia in a flock of 320 sheep. Several ewes died or showed clinical signs of metabolic diseases like pregnancy toxemia and hypocalcemia early in lambing season. Blood tests of affected ewes showed hypocalcemia, hypoglycemia, and other abnormalities. The flock's feed had been reformulated to cut costs by substituting lower-cost by-products, resulting in lower pellet intake. Nutritional analysis found the new feed lacked sufficient fermentable carbohydrates for ewes' late pregnancy needs, putting them in severe energy deficit. This negative energy balance led to clinical signs from excessive fat mobilization and liver issues. The changes to the cheaper feed formulation, based
Cmwh 8-2015-039
This study aimed to assess the accuracy of prenatal ultrasound measurements of the interventricular septum (IVS) thickness, right myocardial wall thickness (RMWT), and left myocardial wall thickness (LMWT) in predicting postnatal outcomes in infants of diabetic mothers. 120 diabetic pregnant women underwent ultrasounds late in pregnancy to measure IVS, RMWT, and LMWT. Postnatal echocardiograms on infants found thicker values in those with uncontrolled diabetes. A prenatal IVS thickness of ≥4.5mm or IVS/LMWT ratio of ≤1.18 predicted hypertrophic cardiomyopathy and higher risks of fetal death or neonatal mortality.
Care of late preterm infant sandip
This document discusses the care of late preterm infants between 34-36 weeks gestation. It notes that these infants are at higher risk for temperature instability, hypoglycemia, respiratory distress, jaundice, feeding difficulties, and suspected sepsis compared to full term infants. The document provides details on the increased risks for respiratory issues, hypoglycemia, hyperbilirubinemia, infections, and impaired neurodevelopment in late preterm infants. It also outlines recommendations for admission criteria, in-hospital management and monitoring, discharge criteria, and follow-up care for late preterm infants.
Neonatal hypoglycaemia
This presenntation gives an overview of the causes of low sugar levels in newborn babies and its effects on the brain
Impact of Maternal Exercise (Blaize et al.) [2015]
This document summarizes a research study that examined the impact of maternal exercise during pregnancy on arterial function and atherosclerosis in offspring fed a high fat diet. Pregnant sows were divided into exercise-trained and sedentary groups. Offspring were fed a high fat diet and assessed at 4 and 8 months. The study found no significant differences in vascular function, atherosclerotic lesions, behavior, or ultrasound measures between offspring from exercised and sedentary mothers. Maternal exercise during pregnancy did not significantly alter these outcomes in offspring fed a high fat diet.
Morphological Changes of Placenta Associated with Maternal Anaemia
Morphological Changes of Placenta Associated with Maternal AnaemiaSSR Institute of International Journal of Life Sciences
ABSTRACT- Placenta is the mirror of fetomaternal status. The effect of anemia in pregnancy can be diverse and detrimental to the mother and the fetus. This prompted us to carry out the present study, which aimed to observe and compare the morphological features of placenta at term in anemic and non-anemic mothers of North Bengal and to find out the clinical relevance of such structural changes. Total 30 placentas were collected from each group of selected patients after delivery at labor room. Examination of placenta was conducted according to proforma. A general survey of umbilical cord, membranes, fetal surface, and maternal surface was carried out. The diameters were measured, area was estimated, and shape was noted. Placenta and fetus was weighed in the same scale. The volume was estimated by water displacement method. In anemic mothers, mean baby birth weight was found to be significantly less than that of control group. The mean placental weight in test group was significantly increased in comparison to controls. The mean placental volume and mean placental area in case of test group were significantly increased. Occurrence of morphological features, like subchorionic fibrosis; retroplacental clot, gross calcification, or placental infarction etc were found to be significantly higher in anemic mothers in comparison to non-anemic group. In the present study, it was proved that placenta has considerable functional reserve capacity. It tends to limit the ill-effects of tissue injury and of unfavorable maternal milieu like anemia. Our findings were in accordance with the previous studies in this field. Key-words- Placenta, Maternal anaemia, Morphological changes, Placental weightSimilar to Abstract - SGI EPC 10-2012 (20)
A Case Report on Intrahepatic Cholestasis of Pregnancy
A Case Report on Intrahepatic Cholestasis of Pregnancy
Impact of Maternal Exercise (Blaize et al.) [2015]
Impact of Maternal Exercise (Blaize et al.) [2015]
Morphological Changes of Placenta Associated with Maternal Anaemia
Morphological Changes of Placenta Associated with Maternal Anaemia
Abstract - SGI EPC 10-2012
- 1. Obesity Increases Circulating Endothelial Progenitor Cells in Human and Mouse Pregnancy. Julia Gefter, PhD.* 1,2 , Marlise F. Snyder 1 , Robert W. Powers, PhD 1,2 , and Carl A. Hubel, PhD. 1,2 Department of Obstetrics, Gynecology, Reproductive Sciences 1 Magee-Womens Research Institute 2 University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA Context: Endothelial progenitor cells (EPCs) are bone marrow-derived cells that enter the systemic circulation to replace defective or injured mature endothelial cells. We have previously reported significantly elevated circulating EPCs in human and mouse pregnancy. Patients with reduced or undetectable EPCs are at increased risk of endothelial dysfunction and cardiovascular disease. Obesity is associated with an increased risk of cardiovascular disease. We hypothesized that EPCs would be significantly lower in obese pregnant women. Objective: The objective of this study was to quantify circulating EPCs in lean and obese pregnant women and mice. Study Design: EPCs were quantified from whole blood by flow cytometry from 8 lean (BMI= 23.1±1.9 kg/m2 ) and 8 obese (BMI= 34.7±5.7 kg/m2 ) pregnant women collected in the first trimester (average 11 weeks gestation). EPCs were also quantified in whole blood from 4 lean and 9 high fat diet-induced obese pregnant mice. EPCs in human samples were identified as circulating angiogenic cells (CACs) 1. CD117+/CD34+, 2. CD133+/CD34+, 3. CD45dim/CD34+/CD31+/CD133+, and 4. CD45dim/CD34+/CD133+. EPCs in mouse samples were identified CD45-/ sca1+/ Flk1+ and CD45-/CD34+/Flk1+, and were quantified per blood volume. Statistical analysis was by Wilcoxin rank sum. Results: Circulating EPCs were significantly elevated in obese pregnant women compared to lean pregnant women (Table), and obese pregnant mice compared to lean mice (p<0.01). Conclusion: Contrary to our hypothesis, circulating EPCs were significantly elevated in obese pregnant women and high fat diet-induced obese pregnant mice. While pregnancy increases circulating EPCs, obesity appears to further increase circulating EPCs, however it is unclear if these cells are functioning appropriately. (not the case to think that further stress from wt. calls for more EPCs?...) Circulating EPCs Lean (n=8) Obese (n=8) CD117+/CD34+ 460 (290,822) 667 (522,757) CD133+/CD34+ 1078 (700,1889) 2175 (1398,2908) CD45dim/CD34+/CD31+/CD133+ 1329 (729,1670) 1907 (1608,2748) CD45dim/CD34+/CD133+ 1323 (729,1670) 1907 (1590,2940) Data are median (interquartile range); *: p<0.05 compared to lean.(no difference?) This project supported by National Institutes of Health grants P01-HD30367 and R01- HL091094.