This is a graduate project that I did on the topic of Lyme Disease. I hope that this project will help raise awareness for what I believe to be one of the fastest growing epidemics.
Contagion 1 Define Fomite.A fomite is an inanimate object.docxmaxinesmith73660
Contagion
1 Define Fomite.
A fomite is an inanimate object, substance or source of disease that can continue to transmit infectious organisms from one individual to another, thus leading to an outbreak of disease.
2 List the means of transmission.
An infectious disease can be transmitted by means of clothing, furniture, soap, a drinking glass and along with other tangible items. In the movie Contagion, the means of transmission was by various entities such as bedding sheets, a cough a martini glass.
3 Define contagious.
Contagious is a form of medical terminology associating with the likelihood of the transmission in terms of a specific disease or an adverse condition. The disease or illness becomes contagious when the infected individuals or organisms make contact or interacts with the non-affected individuals or organisms thus prolonging the continuation and spreading of the specified disease to another living being.
4 What human systems did the agent affect?
In the movie Contagion, the infectious virus was spread through the world’s population in less than a few weeks. This transferable virus latched onto the brain to destroyed the human’s immune system, unbalanced their thermoregulation and eventually kill the infected subjects. The virus spread so rapidly because it was attached onto the brain; the control center for the entire body. Due to the fact that the brain was so highly defeated, the virus continued to obliterate the rest of the human body’s functional systems.
5 Who was the index patient?
Beth Emhoff, the mother, wife and world traveler was determined to be the index patient of the specified infectious virus.
6 What was the mortality rate?
Through out the entire movie, the CDC (Centers of Disease Control and Prevention) officials were extremely hesitant in revealing the mortality rate caused by the infectious epidemic disease. The CDC stood to believe that if they were to inform the general public of the current death rate it would cause a detrimental outbreak of panic thus leading to uncontrollable chaos. The CDC did not want to inform the public that one out of every twelve individuals were susceptible to catching the deadly virus. When it finally came time to reveal the mortality rate to the entire world, 25-30% of the world’s population had already died. Approximately 2.5 million Americas contributed to the 25-30% mortality rate.
7 How did they “mitigate” the disease prior to the vaccine?
Prior to the discovery of the cure to the infectious disease and the availability of the vaccination, specific medical analysis and testing had to occur. When experimenting with this virus, the virus had to be alive in order for them to properly transfer it into another living creature. The scientists and epidemiologist working on this case had to implant the virus into over fifty monkeys to be able to see the potential outcome and cure rates.
In the mean time, forsythia a natural remedy was used by a fairly large po.
Prisoners of the Pandemic: Social and Forensic Conequences of the CoronavirusUniversité de Montréal
“Prisoners of the Pandemic:
Social and Forensic Consequences of the Coronavirus”
Abstract:
My title is a play on the word “prisoners” that forensic psychiatry deals with but, in fact, hearkens back to Plato's analogy of the cave with its prisoners in a situation of sensory deprivation. The confinement and social distancing strategies adopted almost universally across the planet to deal with the viral pandemic effectively imprisoned entire populations, leading to social isolation and sensory deprivation.
My talk will focus on the impacts of coronavirus syndemic on children and families and highlight the impacts of the isolating strategies of social distancing and confinement using the ACE (Adverse Childhood Experiences) Study as a model.
These strategies increase the risks for everyone but even more so for more dependent and vulnerable populations, especially children, creating what I call an "experimental child." The developmental impacts may be best understood through the new field of social neuroscience, an allied field of social psychiatry. The term for these wider consequences of the pandemic, triggering parallel social impacts beyond the viral disease, is syndemic which will be defined and described.
And among children, those who are already at risk are becoming even more vulnerable with consequences for normal development and social functioning and higher levels of anxiety, mental and relational disturbances with potential forensic consequences as well. The long-term consequences will require prospective longitudinal studies for decades to come, with a careful eye on all aspects of social and neurobiological functioning from school failure to higher delinquency and crime rates. This will require greater resources for following entire populations and targeting those at greater risk for prevention at every level - primary, secondary and tertiary.
Key words: Plato's cave, pandemic, syndemic, confinement, social distancing, sensory deprivation, social isolation, Social Determinant of Health (SDoH), Adverse Childhood Experiences (ACE) Study
References:
Di Nicola V. From Plato’s cave to the Covid-19 pandemic: Confinement, social distancing, and biopolitics. Global Mental Health & Psychiatry Review, 2021, 2(2): 8-9.
Di Nicola V, Daly N. Growing up in a pandemic: Biomedical and psychosocial impacts of the COVID-19 crisis on children and families. Special Theme Issue: COVID-19 Pandemic and Social Psychiatry. World Social Psychiatry, 2020, 2(2): 148-151.
Felitti VJ, Anda RF. The relationship of adverse childhood experiences to adult medical disease, psychiatric disorders and sexual behavior: implications for health care. In: Lanius RA, Vermetten E, Pain C, eds. The Impact of Early Trauma on Health and Disease: The Hidden Epidemic. Cambridge, UK: Cambridge University Press; 2010:77-87.
263778731218 Abortion Clinic /Pills In Harare ,sisternakatoto
263778731218 Abortion Clinic /Pills In Harare ,ABORTION WOMEN’S CLINIC +27730423979 IN women clinic we believe that every woman should be able to make choices in her pregnancy. Our job is to provide compassionate care, safety,affordable and confidential services. That’s why we have won the trust from all generations of women all over the world. we use non surgical method(Abortion pills) to terminate…Dr.LISA +27730423979women Clinic is committed to providing the highest quality of obstetrical and gynecological care to women of all ages. Our dedicated staff aim to treat each patient and her health concerns with compassion and respect.Our dedicated group ABORTION WOMEN’S CLINIC +27730423979 IN women clinic we believe that every woman should be able to make choices in her pregnancy. Our job is to provide compassionate care, safety,affordable and confidential services. That’s why we have won the trust from all generations of women all over the world. we use non surgical method(Abortion pills) to terminate…Dr.LISA +27730423979women Clinic is committed to providing the highest quality of obstetrical and gynecological care to women of all ages. Our dedicated staff aim to treat each patient and her health concerns with compassion and respect.Our dedicated group of receptionists, nurses, and physicians have worked together as a teamof receptionists, nurses, and physicians have worked together as a team wwww.lisywomensclinic.co.za/
Flu Vaccine Alert in Bangalore Karnatakaaddon Scans
As flu season approaches, health officials in Bangalore, Karnataka, are urging residents to get their flu vaccinations. The seasonal flu, while common, can lead to severe health complications, particularly for vulnerable populations such as young children, the elderly, and those with underlying health conditions.
Dr. Vidisha Kumari, a leading epidemiologist in Bangalore, emphasizes the importance of getting vaccinated. "The flu vaccine is our best defense against the influenza virus. It not only protects individuals but also helps prevent the spread of the virus in our communities," he says.
This year, the flu season is expected to coincide with a potential increase in other respiratory illnesses. The Karnataka Health Department has launched an awareness campaign highlighting the significance of flu vaccinations. They have set up multiple vaccination centers across Bangalore, making it convenient for residents to receive their shots.
To encourage widespread vaccination, the government is also collaborating with local schools, workplaces, and community centers to facilitate vaccination drives. Special attention is being given to ensuring that the vaccine is accessible to all, including marginalized communities who may have limited access to healthcare.
Residents are reminded that the flu vaccine is safe and effective. Common side effects are mild and may include soreness at the injection site, mild fever, or muscle aches. These side effects are generally short-lived and far less severe than the flu itself.
Healthcare providers are also stressing the importance of continuing COVID-19 precautions. Wearing masks, practicing good hand hygiene, and maintaining social distancing are still crucial, especially in crowded places.
Protect yourself and your loved ones by getting vaccinated. Together, we can help keep Bangalore healthy and safe this flu season. For more information on vaccination centers and schedules, residents can visit the Karnataka Health Department’s official website or follow their social media pages.
Stay informed, stay safe, and get your flu shot today!
Adv. biopharm. APPLICATION OF PHARMACOKINETICS : TARGETED DRUG DELIVERY SYSTEMSAkankshaAshtankar
MIP 201T & MPH 202T
ADVANCED BIOPHARMACEUTICS & PHARMACOKINETICS : UNIT 5
APPLICATION OF PHARMACOKINETICS : TARGETED DRUG DELIVERY SYSTEMS By - AKANKSHA ASHTANKAR
Lung Cancer: Artificial Intelligence, Synergetics, Complex System Analysis, S...Oleg Kshivets
RESULTS: Overall life span (LS) was 2252.1±1742.5 days and cumulative 5-year survival (5YS) reached 73.2%, 10 years – 64.8%, 20 years – 42.5%. 513 LCP lived more than 5 years (LS=3124.6±1525.6 days), 148 LCP – more than 10 years (LS=5054.4±1504.1 days).199 LCP died because of LC (LS=562.7±374.5 days). 5YS of LCP after bi/lobectomies was significantly superior in comparison with LCP after pneumonectomies (78.1% vs.63.7%, P=0.00001 by log-rank test). AT significantly improved 5YS (66.3% vs. 34.8%) (P=0.00000 by log-rank test) only for LCP with N1-2. Cox modeling displayed that 5YS of LCP significantly depended on: phase transition (PT) early-invasive LC in terms of synergetics, PT N0—N12, cell ratio factors (ratio between cancer cells- CC and blood cells subpopulations), G1-3, histology, glucose, AT, blood cell circuit, prothrombin index, heparin tolerance, recalcification time (P=0.000-0.038). Neural networks, genetic algorithm selection and bootstrap simulation revealed relationships between 5YS and PT early-invasive LC (rank=1), PT N0—N12 (rank=2), thrombocytes/CC (3), erythrocytes/CC (4), eosinophils/CC (5), healthy cells/CC (6), lymphocytes/CC (7), segmented neutrophils/CC (8), stick neutrophils/CC (9), monocytes/CC (10); leucocytes/CC (11). Correct prediction of 5YS was 100% by neural networks computing (area under ROC curve=1.0; error=0.0).
CONCLUSIONS: 5YS of LCP after radical procedures significantly depended on: 1) PT early-invasive cancer; 2) PT N0--N12; 3) cell ratio factors; 4) blood cell circuit; 5) biochemical factors; 6) hemostasis system; 7) AT; 8) LC characteristics; 9) LC cell dynamics; 10) surgery type: lobectomy/pneumonectomy; 11) anthropometric data. Optimal diagnosis and treatment strategies for LC are: 1) screening and early detection of LC; 2) availability of experienced thoracic surgeons because of complexity of radical procedures; 3) aggressive en block surgery and adequate lymph node dissection for completeness; 4) precise prediction; 5) adjuvant chemoimmunoradiotherapy for LCP with unfavorable prognosis.
Title: Sense of Taste
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the structure and function of taste buds.
Describe the relationship between the taste threshold and taste index of common substances.
Explain the chemical basis and signal transduction of taste perception for each type of primary taste sensation.
Recognize different abnormalities of taste perception and their causes.
Key Topics:
Significance of Taste Sensation:
Differentiation between pleasant and harmful food
Influence on behavior
Selection of food based on metabolic needs
Receptors of Taste:
Taste buds on the tongue
Influence of sense of smell, texture of food, and pain stimulation (e.g., by pepper)
Primary and Secondary Taste Sensations:
Primary taste sensations: Sweet, Sour, Salty, Bitter, Umami
Chemical basis and signal transduction mechanisms for each taste
Taste Threshold and Index:
Taste threshold values for Sweet (sucrose), Salty (NaCl), Sour (HCl), and Bitter (Quinine)
Taste index relationship: Inversely proportional to taste threshold
Taste Blindness:
Inability to taste certain substances, particularly thiourea compounds
Example: Phenylthiocarbamide
Structure and Function of Taste Buds:
Composition: Epithelial cells, Sustentacular/Supporting cells, Taste cells, Basal cells
Features: Taste pores, Taste hairs/microvilli, and Taste nerve fibers
Location of Taste Buds:
Found in papillae of the tongue (Fungiform, Circumvallate, Foliate)
Also present on the palate, tonsillar pillars, epiglottis, and proximal esophagus
Mechanism of Taste Stimulation:
Interaction of taste substances with receptors on microvilli
Signal transduction pathways for Umami, Sweet, Bitter, Sour, and Salty tastes
Taste Sensitivity and Adaptation:
Decrease in sensitivity with age
Rapid adaptation of taste sensation
Role of Saliva in Taste:
Dissolution of tastants to reach receptors
Washing away the stimulus
Taste Preferences and Aversions:
Mechanisms behind taste preference and aversion
Influence of receptors and neural pathways
Impact of Sensory Nerve Damage:
Degeneration of taste buds if the sensory nerve fiber is cut
Abnormalities of Taste Detection:
Conditions: Ageusia, Hypogeusia, Dysgeusia (parageusia)
Causes: Nerve damage, neurological disorders, infections, poor oral hygiene, adverse drug effects, deficiencies, aging, tobacco use, altered neurotransmitter levels
Neurotransmitters and Taste Threshold:
Effects of serotonin (5-HT) and norepinephrine (NE) on taste sensitivity
Supertasters:
25% of the population with heightened sensitivity to taste, especially bitterness
Increased number of fungiform papillae
Contagion 1 Define Fomite.A fomite is an inanimate object.docxmaxinesmith73660
Contagion
1 Define Fomite.
A fomite is an inanimate object, substance or source of disease that can continue to transmit infectious organisms from one individual to another, thus leading to an outbreak of disease.
2 List the means of transmission.
An infectious disease can be transmitted by means of clothing, furniture, soap, a drinking glass and along with other tangible items. In the movie Contagion, the means of transmission was by various entities such as bedding sheets, a cough a martini glass.
3 Define contagious.
Contagious is a form of medical terminology associating with the likelihood of the transmission in terms of a specific disease or an adverse condition. The disease or illness becomes contagious when the infected individuals or organisms make contact or interacts with the non-affected individuals or organisms thus prolonging the continuation and spreading of the specified disease to another living being.
4 What human systems did the agent affect?
In the movie Contagion, the infectious virus was spread through the world’s population in less than a few weeks. This transferable virus latched onto the brain to destroyed the human’s immune system, unbalanced their thermoregulation and eventually kill the infected subjects. The virus spread so rapidly because it was attached onto the brain; the control center for the entire body. Due to the fact that the brain was so highly defeated, the virus continued to obliterate the rest of the human body’s functional systems.
5 Who was the index patient?
Beth Emhoff, the mother, wife and world traveler was determined to be the index patient of the specified infectious virus.
6 What was the mortality rate?
Through out the entire movie, the CDC (Centers of Disease Control and Prevention) officials were extremely hesitant in revealing the mortality rate caused by the infectious epidemic disease. The CDC stood to believe that if they were to inform the general public of the current death rate it would cause a detrimental outbreak of panic thus leading to uncontrollable chaos. The CDC did not want to inform the public that one out of every twelve individuals were susceptible to catching the deadly virus. When it finally came time to reveal the mortality rate to the entire world, 25-30% of the world’s population had already died. Approximately 2.5 million Americas contributed to the 25-30% mortality rate.
7 How did they “mitigate” the disease prior to the vaccine?
Prior to the discovery of the cure to the infectious disease and the availability of the vaccination, specific medical analysis and testing had to occur. When experimenting with this virus, the virus had to be alive in order for them to properly transfer it into another living creature. The scientists and epidemiologist working on this case had to implant the virus into over fifty monkeys to be able to see the potential outcome and cure rates.
In the mean time, forsythia a natural remedy was used by a fairly large po.
Prisoners of the Pandemic: Social and Forensic Conequences of the CoronavirusUniversité de Montréal
“Prisoners of the Pandemic:
Social and Forensic Consequences of the Coronavirus”
Abstract:
My title is a play on the word “prisoners” that forensic psychiatry deals with but, in fact, hearkens back to Plato's analogy of the cave with its prisoners in a situation of sensory deprivation. The confinement and social distancing strategies adopted almost universally across the planet to deal with the viral pandemic effectively imprisoned entire populations, leading to social isolation and sensory deprivation.
My talk will focus on the impacts of coronavirus syndemic on children and families and highlight the impacts of the isolating strategies of social distancing and confinement using the ACE (Adverse Childhood Experiences) Study as a model.
These strategies increase the risks for everyone but even more so for more dependent and vulnerable populations, especially children, creating what I call an "experimental child." The developmental impacts may be best understood through the new field of social neuroscience, an allied field of social psychiatry. The term for these wider consequences of the pandemic, triggering parallel social impacts beyond the viral disease, is syndemic which will be defined and described.
And among children, those who are already at risk are becoming even more vulnerable with consequences for normal development and social functioning and higher levels of anxiety, mental and relational disturbances with potential forensic consequences as well. The long-term consequences will require prospective longitudinal studies for decades to come, with a careful eye on all aspects of social and neurobiological functioning from school failure to higher delinquency and crime rates. This will require greater resources for following entire populations and targeting those at greater risk for prevention at every level - primary, secondary and tertiary.
Key words: Plato's cave, pandemic, syndemic, confinement, social distancing, sensory deprivation, social isolation, Social Determinant of Health (SDoH), Adverse Childhood Experiences (ACE) Study
References:
Di Nicola V. From Plato’s cave to the Covid-19 pandemic: Confinement, social distancing, and biopolitics. Global Mental Health & Psychiatry Review, 2021, 2(2): 8-9.
Di Nicola V, Daly N. Growing up in a pandemic: Biomedical and psychosocial impacts of the COVID-19 crisis on children and families. Special Theme Issue: COVID-19 Pandemic and Social Psychiatry. World Social Psychiatry, 2020, 2(2): 148-151.
Felitti VJ, Anda RF. The relationship of adverse childhood experiences to adult medical disease, psychiatric disorders and sexual behavior: implications for health care. In: Lanius RA, Vermetten E, Pain C, eds. The Impact of Early Trauma on Health and Disease: The Hidden Epidemic. Cambridge, UK: Cambridge University Press; 2010:77-87.
263778731218 Abortion Clinic /Pills In Harare ,sisternakatoto
263778731218 Abortion Clinic /Pills In Harare ,ABORTION WOMEN’S CLINIC +27730423979 IN women clinic we believe that every woman should be able to make choices in her pregnancy. Our job is to provide compassionate care, safety,affordable and confidential services. That’s why we have won the trust from all generations of women all over the world. we use non surgical method(Abortion pills) to terminate…Dr.LISA +27730423979women Clinic is committed to providing the highest quality of obstetrical and gynecological care to women of all ages. Our dedicated staff aim to treat each patient and her health concerns with compassion and respect.Our dedicated group ABORTION WOMEN’S CLINIC +27730423979 IN women clinic we believe that every woman should be able to make choices in her pregnancy. Our job is to provide compassionate care, safety,affordable and confidential services. That’s why we have won the trust from all generations of women all over the world. we use non surgical method(Abortion pills) to terminate…Dr.LISA +27730423979women Clinic is committed to providing the highest quality of obstetrical and gynecological care to women of all ages. Our dedicated staff aim to treat each patient and her health concerns with compassion and respect.Our dedicated group of receptionists, nurses, and physicians have worked together as a teamof receptionists, nurses, and physicians have worked together as a team wwww.lisywomensclinic.co.za/
Flu Vaccine Alert in Bangalore Karnatakaaddon Scans
As flu season approaches, health officials in Bangalore, Karnataka, are urging residents to get their flu vaccinations. The seasonal flu, while common, can lead to severe health complications, particularly for vulnerable populations such as young children, the elderly, and those with underlying health conditions.
Dr. Vidisha Kumari, a leading epidemiologist in Bangalore, emphasizes the importance of getting vaccinated. "The flu vaccine is our best defense against the influenza virus. It not only protects individuals but also helps prevent the spread of the virus in our communities," he says.
This year, the flu season is expected to coincide with a potential increase in other respiratory illnesses. The Karnataka Health Department has launched an awareness campaign highlighting the significance of flu vaccinations. They have set up multiple vaccination centers across Bangalore, making it convenient for residents to receive their shots.
To encourage widespread vaccination, the government is also collaborating with local schools, workplaces, and community centers to facilitate vaccination drives. Special attention is being given to ensuring that the vaccine is accessible to all, including marginalized communities who may have limited access to healthcare.
Residents are reminded that the flu vaccine is safe and effective. Common side effects are mild and may include soreness at the injection site, mild fever, or muscle aches. These side effects are generally short-lived and far less severe than the flu itself.
Healthcare providers are also stressing the importance of continuing COVID-19 precautions. Wearing masks, practicing good hand hygiene, and maintaining social distancing are still crucial, especially in crowded places.
Protect yourself and your loved ones by getting vaccinated. Together, we can help keep Bangalore healthy and safe this flu season. For more information on vaccination centers and schedules, residents can visit the Karnataka Health Department’s official website or follow their social media pages.
Stay informed, stay safe, and get your flu shot today!
Adv. biopharm. APPLICATION OF PHARMACOKINETICS : TARGETED DRUG DELIVERY SYSTEMSAkankshaAshtankar
MIP 201T & MPH 202T
ADVANCED BIOPHARMACEUTICS & PHARMACOKINETICS : UNIT 5
APPLICATION OF PHARMACOKINETICS : TARGETED DRUG DELIVERY SYSTEMS By - AKANKSHA ASHTANKAR
Lung Cancer: Artificial Intelligence, Synergetics, Complex System Analysis, S...Oleg Kshivets
RESULTS: Overall life span (LS) was 2252.1±1742.5 days and cumulative 5-year survival (5YS) reached 73.2%, 10 years – 64.8%, 20 years – 42.5%. 513 LCP lived more than 5 years (LS=3124.6±1525.6 days), 148 LCP – more than 10 years (LS=5054.4±1504.1 days).199 LCP died because of LC (LS=562.7±374.5 days). 5YS of LCP after bi/lobectomies was significantly superior in comparison with LCP after pneumonectomies (78.1% vs.63.7%, P=0.00001 by log-rank test). AT significantly improved 5YS (66.3% vs. 34.8%) (P=0.00000 by log-rank test) only for LCP with N1-2. Cox modeling displayed that 5YS of LCP significantly depended on: phase transition (PT) early-invasive LC in terms of synergetics, PT N0—N12, cell ratio factors (ratio between cancer cells- CC and blood cells subpopulations), G1-3, histology, glucose, AT, blood cell circuit, prothrombin index, heparin tolerance, recalcification time (P=0.000-0.038). Neural networks, genetic algorithm selection and bootstrap simulation revealed relationships between 5YS and PT early-invasive LC (rank=1), PT N0—N12 (rank=2), thrombocytes/CC (3), erythrocytes/CC (4), eosinophils/CC (5), healthy cells/CC (6), lymphocytes/CC (7), segmented neutrophils/CC (8), stick neutrophils/CC (9), monocytes/CC (10); leucocytes/CC (11). Correct prediction of 5YS was 100% by neural networks computing (area under ROC curve=1.0; error=0.0).
CONCLUSIONS: 5YS of LCP after radical procedures significantly depended on: 1) PT early-invasive cancer; 2) PT N0--N12; 3) cell ratio factors; 4) blood cell circuit; 5) biochemical factors; 6) hemostasis system; 7) AT; 8) LC characteristics; 9) LC cell dynamics; 10) surgery type: lobectomy/pneumonectomy; 11) anthropometric data. Optimal diagnosis and treatment strategies for LC are: 1) screening and early detection of LC; 2) availability of experienced thoracic surgeons because of complexity of radical procedures; 3) aggressive en block surgery and adequate lymph node dissection for completeness; 4) precise prediction; 5) adjuvant chemoimmunoradiotherapy for LCP with unfavorable prognosis.
Title: Sense of Taste
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the structure and function of taste buds.
Describe the relationship between the taste threshold and taste index of common substances.
Explain the chemical basis and signal transduction of taste perception for each type of primary taste sensation.
Recognize different abnormalities of taste perception and their causes.
Key Topics:
Significance of Taste Sensation:
Differentiation between pleasant and harmful food
Influence on behavior
Selection of food based on metabolic needs
Receptors of Taste:
Taste buds on the tongue
Influence of sense of smell, texture of food, and pain stimulation (e.g., by pepper)
Primary and Secondary Taste Sensations:
Primary taste sensations: Sweet, Sour, Salty, Bitter, Umami
Chemical basis and signal transduction mechanisms for each taste
Taste Threshold and Index:
Taste threshold values for Sweet (sucrose), Salty (NaCl), Sour (HCl), and Bitter (Quinine)
Taste index relationship: Inversely proportional to taste threshold
Taste Blindness:
Inability to taste certain substances, particularly thiourea compounds
Example: Phenylthiocarbamide
Structure and Function of Taste Buds:
Composition: Epithelial cells, Sustentacular/Supporting cells, Taste cells, Basal cells
Features: Taste pores, Taste hairs/microvilli, and Taste nerve fibers
Location of Taste Buds:
Found in papillae of the tongue (Fungiform, Circumvallate, Foliate)
Also present on the palate, tonsillar pillars, epiglottis, and proximal esophagus
Mechanism of Taste Stimulation:
Interaction of taste substances with receptors on microvilli
Signal transduction pathways for Umami, Sweet, Bitter, Sour, and Salty tastes
Taste Sensitivity and Adaptation:
Decrease in sensitivity with age
Rapid adaptation of taste sensation
Role of Saliva in Taste:
Dissolution of tastants to reach receptors
Washing away the stimulus
Taste Preferences and Aversions:
Mechanisms behind taste preference and aversion
Influence of receptors and neural pathways
Impact of Sensory Nerve Damage:
Degeneration of taste buds if the sensory nerve fiber is cut
Abnormalities of Taste Detection:
Conditions: Ageusia, Hypogeusia, Dysgeusia (parageusia)
Causes: Nerve damage, neurological disorders, infections, poor oral hygiene, adverse drug effects, deficiencies, aging, tobacco use, altered neurotransmitter levels
Neurotransmitters and Taste Threshold:
Effects of serotonin (5-HT) and norepinephrine (NE) on taste sensitivity
Supertasters:
25% of the population with heightened sensitivity to taste, especially bitterness
Increased number of fungiform papillae
Ozempic: Preoperative Management of Patients on GLP-1 Receptor Agonists Saeid Safari
Preoperative Management of Patients on GLP-1 Receptor Agonists like Ozempic and Semiglutide
ASA GUIDELINE
NYSORA Guideline
2 Case Reports of Gastric Ultrasound
The Gram stain is a fundamental technique in microbiology used to classify bacteria based on their cell wall structure. It provides a quick and simple method to distinguish between Gram-positive and Gram-negative bacteria, which have different susceptibilities to antibiotics
These simplified slides by Dr. Sidra Arshad present an overview of the non-respiratory functions of the respiratory tract.
Learning objectives:
1. Enlist the non-respiratory functions of the respiratory tract
2. Briefly explain how these functions are carried out
3. Discuss the significance of dead space
4. Differentiate between minute ventilation and alveolar ventilation
5. Describe the cough and sneeze reflexes
Study Resources:
1. Chapter 39, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 34, Ganong’s Review of Medical Physiology, 26th edition
3. Chapter 17, Human Physiology by Lauralee Sherwood, 9th edition
4. Non-respiratory functions of the lungs https://academic.oup.com/bjaed/article/13/3/98/278874
micro teaching on communication m.sc nursing.pdfAnurag Sharma
Microteaching is a unique model of practice teaching. It is a viable instrument for the. desired change in the teaching behavior or the behavior potential which, in specified types of real. classroom situations, tends to facilitate the achievement of specified types of objectives.
Basavarajeeyam is a Sreshta Sangraha grantha (Compiled book ), written by Neelkanta kotturu Basavaraja Virachita. It contains 25 Prakaranas, First 24 Chapters related to Rogas& 25th to Rasadravyas.
5. We took a road trip to Minnesota to an outdoor festival –
lots of music, friends and camping. 5
6. I came home sick
with flu-like symptoms
that would not go
6
7. Over a 3 month period,
I saw many doctors,
but received NO diagnosis.
They said I would
eventually feel better.
I did (or so I thought).
7
“My Everyday Tools” February 10, 2011 via Flickr, Creative Commons Attribution
10. Then I got very very sick.
We saw over 20 doctors
all over the country
including a visit
to one of the top hospitals
in the United States –
still NO answers.
10
Michael Hicks, “img_0496" February 10, 2011 via Flickr, Creative Commons Attribution
12. As life moved on without us,
I spent years researching
my debilitating symptoms.
12
13. During my research,
I came across…
13
Scott Bauer, “Adult Deer Tick" February 10, 2011 via Wikimedia Commons, Creative Commons Attribution
14. I read about the initial symptoms,
and realized I had most of them
after my trip to Minnesota.
14
15. I read about the long-term symptoms,
and realized I had ALL of them.
15
16. I discovered that this disease
is often misdiagnosed as….
Multiple Sclerosis
Fibromyalgia
Chronic Fatigue Syndrome
Peripheral Neuropathy
Anxiety Disorders
Rheumatoid Arthritis
Parkinson’s Disease
16
17. I sought out a doctor who specializes
in tick-borne & chronic diseases. 17
18. After seven long years,
I finally had a diagnosis…
Lyme Disease
18
20. Lyme Disease is caused
by a spiral-shaped bacteria
that is often found in a tick.
Name: Borrelia burgdorferi
20
Center for Disease Control, “Borrelia burgdorferi-cropped” PHIL ID#6631, February 10, 2011, Public Domain
21. The two main ticks that carry the bacteria
are deer ticks & western black legged ticks.
21
Center for Disease Control, “TickMaster4_12” February 11, 2011, Public Domain
22. Ticks also carry
many types of bacterium
that cause co-infections.
22
Nemodus, “SOS Tick-I ain’t Afraid of No Tick" February 10, 2011 via Flickr, Creative Commons Attribution
23. Transmission is through the bite of a tick;
however, some physicians & researchers think
it can be passed sexually & congenitally.
23
Trevor Bair, “Sarah-28 Weeks Pregnant" February 10, 2011 via Flickr, Creative Commons Attribution
24. “She started showing signs
her first day of life
…and as her mom,
I knew something was wrong.
As I begged God to take it away
and give it to me instead,
I could have never imagined
the nightmare that was about to unfold…”
-Brandi, Lyme Disease Survivor
24
25. Along with flu-like symptoms,
in the initial stages,
a red bull’s eye rash
might appear.
25
Hannah Garrison, “Bulls Eye Lyme Disease Rash”, February 10, 2011 via Wikimedia Commons, Creative Commons Attribution
26. However, less than 50% remember
a tick bite or a bull’s eye rash.
I fall into that category.
Deer ticks can be the size of a poppy seed.
No wonder people miss them! 26
David Van Der Mark, “Teek-Tick" February 10, 2011 via Flickr, Creative Commons Attribution
27. The common diagnostic
lab tests are….
ELISA - only 65% accurate
Western Blot - only 70 to
80% accurate
27
28. Did you know a diagnostic test
has to be 95% accurate
to be considered successful?
28
29. Only labs that specialize
in tick-borne diseases
obtain the best results:
Igenex
Stony Brook
30. Since the tests are NOT reliable,
it is important to seek out a doctor
that specializes in diagnosing
tick-borne diseases.
They are often referred to as…
Lyme Literate Medical Doctors
(LLMD)
30
32. Standard IDSA and CDC treatment protocol:
a 14 day course of oral antibiotics
for patients bitten less than 30 days ago.
IDSA = Infectious Disease Society of America
CDC = Center for Disease Control 32
Keith Ramsey, “Pills" February 10, 2011 via Flickr, Creative Commons Attribution
33. If bitten more than a month ago,
then a 30 day course
of oral or IV antibiotics
is recommended as treatment.
33
34. “Up to 30% of Lyme Disease cases do not get
resolved after following these CDC guidelines.”
Author Bryan Rosner
Sales
34
35. I did that protocol, but
I am still very sick…
35
36. …and so are they
Great job today! Thank you for being so willing
to learn! People who are hungry to learn are
the ones that are the most successful in life!
Here's "Today's Tip of the Day":
In reported speech go one step back into the
past and change the time signifier as well as
the pronoun.
Example Sentences:
"I'm going to the supermarket. => "He said he
was going to the supermarket."
"She's seeing him tomorrow." => "She said she
was seeing him the next day."
See you in class tomorrow!! :)
36
38. Lyme Disease physicians have realized that long-term
therapy (3 months to 3 years) is necessary for individuals
who have had the disease longer than 30 days.
38
39. This conflicts with the IDSA’s recommendations,
so insurance companies often refuse to pay,
causing patients to spend $25K to 150K per year.
39
Daniel Borman, “Money, Money, Money" February 10, 2011 via Flickr, Creative Commons Attribution
40. How can you protect yourself
and your loved ones?
40
41. Avoid tick infested areas
including tall grasses, forests,
logs and piles of leaves. 41
Melanie Holtsman, “24 - Jumping In" February 11, 2011 via Flickr, Creative Commons Attribution
42. If you will be in a tick infested area,
dress in light-colored clothing.
42
48. References
International Lyme and Associated Diseases: www.ilads.org
California Lyme Disease Association: www.lymedisease.org
Rosner, Bryan (2007). The Top Ten Lyme Disease Treatments: Defeat Lyme
Disease with the Best of Conventional and Alternative Medicine. South
Lake Tahoe, CA: Biomed Publishing Group.
48