SlideShare a Scribd company logo
WHO
2014
/
Oxiplatin (FOLFOX)
(
) 45-50 Gy
63
(Hb=5.6g/dL )
2016 11
( )
(gastric body)
(great curvature)
(lesser curvature)
9.4
(serosa layer)
1.3 (
)
(preoperative neoadjuvant concurrent
chemoradiotherapy)
(down-sizing)
(down-staging)
3
,
( )
(serosa layer)
( )
(Total gastrectomy with lymph
node dissection) Roux-en-Y
1.Yeh YS, Tsai HL, Ma CJ, Wu DC, Lu CY, Wu
IC, Hou MF, Wang JY.A retrospective study of
the safety and efficacy of a first-line treatment
with modified FOLFOX-4 in unresectable
advanced or recurrent gastric cancer patients.
Chemotherapy.2012;58:411-8.
2. De Vita F, Orditura M, Matano E, Bianco
R, Carlomagno C, Infusino S, Damiano V,
Simeone E, Diadema MR, Lieto E, Castellano
P, Pepe S, De Placido S, Galizia G, Di
Martino N, Ciardiello F, Catalano G, Bianco
AR: A phase II study of biweekly oxaliplatin
plus infusional 5-fluorouracil and folinic
acid (FOLFOX-4) as first-line treatment of
advanced gastric cancer patients.Br J Cancer
2005; 9: 1644-1649.
3. Oh SY, Kwon HC, Seo BG, Kim SH, Kim JS,
Kim HJ: A phase II study of oxaliplatin with
low dose leucovorin and bolus and continuous
infusion 5-fluorouracil (modified FOLFOX-4)
as first line therapy for patients with advanced
gastric cancer.Acta Oncol 2007; 46: 336-341.
4. Al-Batran SE, Atmaca A, Hegewisch-Becker
S, Jaeger D, Hahnfeld S, Rummel MJ, Seipelt
G, Rost A, Orth J, Knuth A, Jaeger E: Phase II
trial of biweekly infusional fluorouracil, folinic
acid, and oxaliplatin in patients with advanced
gastric cancer.J Clin Oncol 2004; 22: 658–663.
5. Bittoni A, Maccaroni E, Scartozzi M, Berardi
R, Cascinu S: Chemotherapy for locally
advanced and metastatic gastric cancer: state
of the art and future perspectives.Eur Rev Med
Pharmacol Sci 2010; 14: 309-314.
6. Suh SH, Kwon HC, Jo JH, Cho YR, Seo
BG, Lee DM, Kim SH, Kim JS, Kim
HJ: Oxaliplatin with biweekly low dose
leucovorin and bolus and continuous infusion
of 5-fluorouracil (modified FOLFOX 4) as
a salvage therapy for patients with advanced
gastric cancer.Cancer Res Treat 2005; 37: 279-
283.

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高雄醫師會誌97期-病例討論~葉永松、王照元-術前化學放射線治療無法根治性切除之胃癌

  • 2. 63 (Hb=5.6g/dL ) 2016 11 ( ) (gastric body) (great curvature) (lesser curvature) 9.4 (serosa layer) 1.3 ( )
  • 3. (preoperative neoadjuvant concurrent chemoradiotherapy) (down-sizing) (down-staging) 3 , ( ) (serosa layer) ( ) (Total gastrectomy with lymph node dissection) Roux-en-Y
  • 4. 1.Yeh YS, Tsai HL, Ma CJ, Wu DC, Lu CY, Wu IC, Hou MF, Wang JY.A retrospective study of the safety and efficacy of a first-line treatment with modified FOLFOX-4 in unresectable advanced or recurrent gastric cancer patients. Chemotherapy.2012;58:411-8. 2. De Vita F, Orditura M, Matano E, Bianco R, Carlomagno C, Infusino S, Damiano V, Simeone E, Diadema MR, Lieto E, Castellano P, Pepe S, De Placido S, Galizia G, Di Martino N, Ciardiello F, Catalano G, Bianco AR: A phase II study of biweekly oxaliplatin plus infusional 5-fluorouracil and folinic acid (FOLFOX-4) as first-line treatment of advanced gastric cancer patients.Br J Cancer 2005; 9: 1644-1649. 3. Oh SY, Kwon HC, Seo BG, Kim SH, Kim JS, Kim HJ: A phase II study of oxaliplatin with low dose leucovorin and bolus and continuous infusion 5-fluorouracil (modified FOLFOX-4) as first line therapy for patients with advanced gastric cancer.Acta Oncol 2007; 46: 336-341. 4. Al-Batran SE, Atmaca A, Hegewisch-Becker S, Jaeger D, Hahnfeld S, Rummel MJ, Seipelt G, Rost A, Orth J, Knuth A, Jaeger E: Phase II trial of biweekly infusional fluorouracil, folinic acid, and oxaliplatin in patients with advanced gastric cancer.J Clin Oncol 2004; 22: 658–663. 5. Bittoni A, Maccaroni E, Scartozzi M, Berardi R, Cascinu S: Chemotherapy for locally advanced and metastatic gastric cancer: state of the art and future perspectives.Eur Rev Med Pharmacol Sci 2010; 14: 309-314. 6. Suh SH, Kwon HC, Jo JH, Cho YR, Seo BG, Lee DM, Kim SH, Kim JS, Kim HJ: Oxaliplatin with biweekly low dose leucovorin and bolus and continuous infusion of 5-fluorouracil (modified FOLFOX 4) as a salvage therapy for patients with advanced gastric cancer.Cancer Res Treat 2005; 37: 279- 283.