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LYMPHOID TISSUE
Lymphocyte
LYMPHOID TISSUE
A) Diffuse lymphoid tissue
B) Encapsulated lymphoid organs:
1- Lymph nodes.
2- Spleen.
3- Tonsils (are incompletely encapsulated)
4- Thymus.
N.B. Both red bone marrow & Thymus are
considered 1ry. Lymphoid organs.
LYMPH NODES (L.N.)
(A) Stroma:
1- Capsule
2- Trabeculae (septa)
3- Reticular C.T.
(B) Parenchyma: (lymphoid tissue + lymph sinuses)
1- Cortex
2- Paracortex
3- Medulla
1. CORTEX OF L.N.
1- Lymphatic nodules (follicles):
a- 1ry: without germinal center
b- 2ry: with germinal center: Lighter
2- Cortical lymph sinuses.
2. PARACORTEX Of L.N.
• It is the thymus-dependent zone of L.N.
• It is composed mostly of T-lymphocytes.
3. MEDULLA OF L.N.
(1) Medullary cords:
are formed mainly of lymphoid cells
( B & T lymphocytes, plasma cells,
macrophages).
(2) Medullary lymph sinuses.
FUNCTIONS OF L.N.
• 1- Production of immunocompetent cells.
• 2- Filtration of lymph.
SPLEEN
A. Stroma:
1- Capsule.
2- Trabeculae.
3- Reticular C.T.
B. PARENCHYMA:
• (A) White pulp.
• (B) RED PULP.
N.B. No cortex, no medulla.
FUNCTIONS OF SPLEEN
1- Filtration of blood.
2- Phagocytosis of old RBCs &
old blood platelets & invading
microorganisms.
3- Production & proliferation of
immunocompetent B & T lymphocytes.
4- Production of antibodies.
Tonsils
(1) Palatine Tonsils.
(2) Pharyngeal Tonsil.
(3) Lingual Tonsils.
PALATINE TONSILS
Structure:
1- Epithelium:
non-keratinized stratified squamous.
2- Tonsilar crypts.
3- Lymphatic nodules.
4- Capsule: partial.
FUNCTION OF TONSILS
Production of antibodies.
THYMUS
A) Stroma:
1-Capsule
2-Interlobular trabeculae: incomplete
B) Thymic lobule:
1-Cortex
2-Medulla
CORTEX OF THYMIC LOBULE
A) It contains developing (immature) T- lymphocytes
(thymocytes).
98% of thymocytes die?
B) Epithelial reticular cells
C) Macrophages.
N.B. No lymphatic nodules
No plasma cells
No B-lymphocytes
MEDULLA OF THYMIC LOBULE
1-Hassall’s (thymic) corpuscles:
-Concentrically arranged epithelial reticular cells in
the medulla.
2- Mature small T lymphocytes
3- Macrophages.
4- Epithelial reticular cells.
N.B. Medulla of adjacent thymic lobules are
interconnected- Why? Incomplete trabeculae
FUNCTION OF THYMUS
Maturation of T lymphocytes.
(Immunoincompetent T cells →→→
Immunocompetent T cells).
General notes about thymus
• No lymphoid nodules
• No reticular fibers
• No sinuses or sinusoids

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9255010.ppt

  • 2. LYMPHOID TISSUE A) Diffuse lymphoid tissue B) Encapsulated lymphoid organs: 1- Lymph nodes. 2- Spleen. 3- Tonsils (are incompletely encapsulated) 4- Thymus. N.B. Both red bone marrow & Thymus are considered 1ry. Lymphoid organs.
  • 3. LYMPH NODES (L.N.) (A) Stroma: 1- Capsule 2- Trabeculae (septa) 3- Reticular C.T. (B) Parenchyma: (lymphoid tissue + lymph sinuses) 1- Cortex 2- Paracortex 3- Medulla
  • 4. 1. CORTEX OF L.N. 1- Lymphatic nodules (follicles): a- 1ry: without germinal center b- 2ry: with germinal center: Lighter 2- Cortical lymph sinuses.
  • 5. 2. PARACORTEX Of L.N. • It is the thymus-dependent zone of L.N. • It is composed mostly of T-lymphocytes. 3. MEDULLA OF L.N. (1) Medullary cords: are formed mainly of lymphoid cells ( B & T lymphocytes, plasma cells, macrophages). (2) Medullary lymph sinuses. FUNCTIONS OF L.N. • 1- Production of immunocompetent cells. • 2- Filtration of lymph.
  • 6. SPLEEN A. Stroma: 1- Capsule. 2- Trabeculae. 3- Reticular C.T. B. PARENCHYMA: • (A) White pulp. • (B) RED PULP. N.B. No cortex, no medulla.
  • 7. FUNCTIONS OF SPLEEN 1- Filtration of blood. 2- Phagocytosis of old RBCs & old blood platelets & invading microorganisms. 3- Production & proliferation of immunocompetent B & T lymphocytes. 4- Production of antibodies.
  • 8. Tonsils (1) Palatine Tonsils. (2) Pharyngeal Tonsil. (3) Lingual Tonsils.
  • 9. PALATINE TONSILS Structure: 1- Epithelium: non-keratinized stratified squamous. 2- Tonsilar crypts. 3- Lymphatic nodules. 4- Capsule: partial. FUNCTION OF TONSILS Production of antibodies.
  • 10. THYMUS A) Stroma: 1-Capsule 2-Interlobular trabeculae: incomplete B) Thymic lobule: 1-Cortex 2-Medulla
  • 11. CORTEX OF THYMIC LOBULE A) It contains developing (immature) T- lymphocytes (thymocytes). 98% of thymocytes die? B) Epithelial reticular cells C) Macrophages. N.B. No lymphatic nodules No plasma cells No B-lymphocytes
  • 12. MEDULLA OF THYMIC LOBULE 1-Hassall’s (thymic) corpuscles: -Concentrically arranged epithelial reticular cells in the medulla. 2- Mature small T lymphocytes 3- Macrophages. 4- Epithelial reticular cells. N.B. Medulla of adjacent thymic lobules are interconnected- Why? Incomplete trabeculae
  • 13. FUNCTION OF THYMUS Maturation of T lymphocytes. (Immunoincompetent T cells →→→ Immunocompetent T cells).
  • 14. General notes about thymus • No lymphoid nodules • No reticular fibers • No sinuses or sinusoids