The 90/10 Rule states that 90% of life is determined by how you react to what happens to you, while only 10% of life is made up of actual events outside of your control. How you react to situations, both positive and negative, largely dictates your outcomes. The document provides an example of how having a negative reaction to a spilled cup of coffee can ruin an entire day, while choosing to react positively would lead to a much better outcome despite the same initial event. Your reactions are within your control, so focusing on responding constructively is important for your well-being and success.