The document discusses generalized increased attenuation of the liver seen on clinical imaging. It provides 4 examples that can cause this appearance: hemochromatosis which causes diffuse homogeneous increased liver attenuation; glycogen storage disease where the liver is enlarged with high attenuation and prominent veins; thorotrast deposition leading to increased liver and spleen attenuation; and amiodarone use resulting in increased liver attenuation. The document examines imaging findings for differential diagnosis.

1. 77Generalized Increased
Attenuation of the Liver

2. CLINICAL IMAGAGING
AN ATLAS OF DIFFERENTIAL DAIGNOSIS
EISENBERG
DR. Muhammad Bin Zulfiqar
PGR-FCPS III SIMS/SHL

3. • Fig GI 77-1 Hemochromatosis. Diffuse
homogeneous increase in liver (and spleen)
attenuation when compared with that of other
soft-tissue organs. Note the hepatic and portal
veins, which stand out in bold relief as low-
attenuation structures against the abnormally
high attenuation of the liver parenchyma.129

4. • Fig GI 77-2 Glycogen storage disease. Diffuse
increase in attenuation of the enlarged liver with
prominent hepatic and portal venous structures
(arrows).122

5. • Fig GI 77-3 Thorotrast deposition. Generalized
increase in the attenuation of the liver (and
spleen).

6. • Fig GI 77-4 Amiodarone liver.138