Gifford Lecture One: Cosmos, Time, MemorySean Carroll
Based on my book The Big Picture, this is the first of five lectures exploring how different ways of talking about the world fit together. The other four lectures are on YouTube.
Einstein M Theory , String Theory and The Future Avinash Singh
The unification of fundamental forces of nature into a single force occupied Einstein attention for much of his later life. Today thousand of physicist, on the cutting edge of physics is still trying to solve it. Albert Einstein spent his last two decades and during his last hr. he was trying to unify all the theories and laws of universe into a single theory so powerful that can describe all the laws and theories of the universe but Einstein ran out of time unfulfilling his dream, now almost a half century later his dream has become the holy grail of the modern physics we may achieve Einstein dream with a new and radical set of ideas called string theory but if this revolutionary theory is right we are in real quite a shock, String Theory says we may be living in a world where reality meets science fiction, a universe of eleven dimension with parallel universes right next to us i.e.an elegant universe composed entirely of the music of strings, but what would be if we combine Einstein general theory of relatively,Newtonian Mechanics Maxwellian Electromagnetism and quantum mechanics to produce a theory that can explain the cosmic background radiation then it would be really a blockbuster in the history of science.
. I have seen that the weak force has ben successfully combined with electromagnetism so that they may be jointly viewed as aspects of a single electroweak force . theories that attempts to add the strong force to this combination-called grand unification theories (GUT) – are being persuade actively . This could be a theory that would seeks to complete the job by adding gravity – sometimes called theories of everything (TOE) .
A quick introduction to Mach's principleAdemir Xavier
The riddle of inertia quickly explained as a more fundamental interaction energy of all particles in the universe. Mach' principle in the pre-relativistic era.
Read in 2011, a very foundational book on physics, narrated in a very easy lay-man terms.. This book talks about constants, in nature and how we need to interpret and listen to these constants..
These are my book notes, great book one can buy this book on Amazon... worth a read for science buffs
Gifford Lecture One: Cosmos, Time, MemorySean Carroll
Based on my book The Big Picture, this is the first of five lectures exploring how different ways of talking about the world fit together. The other four lectures are on YouTube.
Einstein M Theory , String Theory and The Future Avinash Singh
The unification of fundamental forces of nature into a single force occupied Einstein attention for much of his later life. Today thousand of physicist, on the cutting edge of physics is still trying to solve it. Albert Einstein spent his last two decades and during his last hr. he was trying to unify all the theories and laws of universe into a single theory so powerful that can describe all the laws and theories of the universe but Einstein ran out of time unfulfilling his dream, now almost a half century later his dream has become the holy grail of the modern physics we may achieve Einstein dream with a new and radical set of ideas called string theory but if this revolutionary theory is right we are in real quite a shock, String Theory says we may be living in a world where reality meets science fiction, a universe of eleven dimension with parallel universes right next to us i.e.an elegant universe composed entirely of the music of strings, but what would be if we combine Einstein general theory of relatively,Newtonian Mechanics Maxwellian Electromagnetism and quantum mechanics to produce a theory that can explain the cosmic background radiation then it would be really a blockbuster in the history of science.
. I have seen that the weak force has ben successfully combined with electromagnetism so that they may be jointly viewed as aspects of a single electroweak force . theories that attempts to add the strong force to this combination-called grand unification theories (GUT) – are being persuade actively . This could be a theory that would seeks to complete the job by adding gravity – sometimes called theories of everything (TOE) .
A quick introduction to Mach's principleAdemir Xavier
The riddle of inertia quickly explained as a more fundamental interaction energy of all particles in the universe. Mach' principle in the pre-relativistic era.
Read in 2011, a very foundational book on physics, narrated in a very easy lay-man terms.. This book talks about constants, in nature and how we need to interpret and listen to these constants..
These are my book notes, great book one can buy this book on Amazon... worth a read for science buffs
Slides elaborated to illustrate the intervention of Mariano Artigas in the Summer School, June 10-15 2004: "The Impact of the Humanities on the Development of European Science", Venice (Italy). Organized by the Istituto Veneto di Scienze, Lettere ed Arti and the Galileo Chair of History of Science of the University of Padua.
The Phase Theory towards the Unification of the Forces of Nature the Heart Be...IOSR Journals
A new theory has been presented, for the first time, called the "Phase Theory", which is the natural evolution of the physical thought and is considered the one beyond the super string theory. This theory solves the unsolved problems of the mysterious of matter, antimatter and interactions and makes a wide step towards the unification of the forces of nature. In this theory, the vibrating string of different frequency modes which determines the different types of elementary particles is replaced by a three dimensional infinitesimal pulsating (black)holes with the same frequency. Different types of elementary particles are determined by different phase angles associated with the same frequency. This allows the force of interactions to take place among elementary particles, without the need to invoke the notion of the force carrier particles, as the (stable) force of interactions can never take place between elementary particles at different frequencies. Besides the strong mathematical proofs given in this paper to prove its truthfulness, an experimental prediction has been given to confirm the theory presented in the form of the relation between the electron radius and quarks radii. The paper shows that quarks are direct consequence of this theory, and solves "the flavor problem" in QCD, and gives the clue to answer the questions of "Why are there so many flavors? The paper also derives the equation of the big bang theory which describes the singularity of the moment of creation of the universe.
The majority of physicists take it for granted that the universe is made up of matter. In turn, matter is
composed of atoms; atoms are made up of particles such as electrons, protons, neutrons, etc. Also, protons
and neutrons are composed of quarks, etc. Furthermore, that everything in nature is governed by the
known laws of physics and chemistry. The author only partially shares this view. He argues that many
phenomena in the universe may depend on rules or factors as yet incorporated by the physical sciences.
The last few years have led him to reflect on the many unsolved physics problems, such as the quest for the
theory of everything (ToE), the arrow of time, the interpretation of quantum mechanics, the fine-tuned
universe, etc. to mention just a few. The author posits that a field carries information, performs various
mathematical and computational operations, and behaves as an intelligent entity embedded with
consciousness.
The majority of physicists take it for granted that the universe is made up of matter. In turn, matter is composed of atoms; atoms are made up of particles such as electrons, protons, neutrons, etc. Also, protons
and neutrons are composed of quarks, etc. Furthermore, that everything in nature is governed by the known laws of physics and chemistry. The author only partially shares this view. He argues that many phenomena in the universe may depend on rules or factors as yet incorporated by the physical sciences.
The last few years have led him to reflect on the many unsolved physics problems, such as the quest for the theory of everything (ToE), the arrow of time, the interpretation of quantum mechanics, the fine-tuned
universe, etc. to mention just a few. The author posits that a field carries information, performs various mathematical and computational operations, and behaves as an intelligent entity embedded with consciousness.
Heisgnberg principle, energy levels & atomic spectraNoor Fatima
Heisgnberg principle, energy levels & atomic spectra word document full discription on these topics avaivale can be used as presentations or assignments. hope so it may help
The new emerging technology which is under research but when will come into practice, it will change the era of computing.
Its is based on changing the concept of inputs received by the machine.
till now the machine works with 0 and 1,however it will implement an input b/w 0 and 1 i.e 1/2.
The speed of processing will raise up-to 8 times and things will be beyond our expectations.
Extra dimensions and the arrow of time.pdfEran Sinbar
“The increase of disorder or entropy is what distinguishes the past from the future, giving a direction to time “– Stephen Hawking, A brief history of time. This statement arises two questions: Time is a universal concept, but order and disorder are both a subjective concept of our human brain. How can a subjective concept like disorder distinguish a universal concept like time? Why was the past in a lower entropy compared to the future?
This paper suggests that by quantizing space time and by adding an extra non local three dimensional (3D) grid like dimensions (grid dimension) these two questions can be approached.
Deep Behavioral Phenotyping in Systems Neuroscience for Functional Atlasing a...Ana Luísa Pinho
Functional Magnetic Resonance Imaging (fMRI) provides means to characterize brain activations in response to behavior. However, cognitive neuroscience has been limited to group-level effects referring to the performance of specific tasks. To obtain the functional profile of elementary cognitive mechanisms, the combination of brain responses to many tasks is required. Yet, to date, both structural atlases and parcellation-based activations do not fully account for cognitive function and still present several limitations. Further, they do not adapt overall to individual characteristics. In this talk, I will give an account of deep-behavioral phenotyping strategies, namely data-driven methods in large task-fMRI datasets, to optimize functional brain-data collection and improve inference of effects-of-interest related to mental processes. Key to this approach is the employment of fast multi-functional paradigms rich on features that can be well parametrized and, consequently, facilitate the creation of psycho-physiological constructs to be modelled with imaging data. Particular emphasis will be given to music stimuli when studying high-order cognitive mechanisms, due to their ecological nature and quality to enable complex behavior compounded by discrete entities. I will also discuss how deep-behavioral phenotyping and individualized models applied to neuroimaging data can better account for the subject-specific organization of domain-general cognitive systems in the human brain. Finally, the accumulation of functional brain signatures brings the possibility to clarify relationships among tasks and create a univocal link between brain systems and mental functions through: (1) the development of ontologies proposing an organization of cognitive processes; and (2) brain-network taxonomies describing functional specialization. To this end, tools to improve commensurability in cognitive science are necessary, such as public repositories, ontology-based platforms and automated meta-analysis tools. I will thus discuss some brain-atlasing resources currently under development, and their applicability in cognitive as well as clinical neuroscience.
This pdf is about the Schizophrenia.
For more details visit on YouTube; @SELF-EXPLANATORY;
https://www.youtube.com/channel/UCAiarMZDNhe1A3Rnpr_WkzA/videos
Thanks...!
Introduction:
RNA interference (RNAi) or Post-Transcriptional Gene Silencing (PTGS) is an important biological process for modulating eukaryotic gene expression.
It is highly conserved process of posttranscriptional gene silencing by which double stranded RNA (dsRNA) causes sequence-specific degradation of mRNA sequences.
dsRNA-induced gene silencing (RNAi) is reported in a wide range of eukaryotes ranging from worms, insects, mammals and plants.
This process mediates resistance to both endogenous parasitic and exogenous pathogenic nucleic acids, and regulates the expression of protein-coding genes.
What are small ncRNAs?
micro RNA (miRNA)
short interfering RNA (siRNA)
Properties of small non-coding RNA:
Involved in silencing mRNA transcripts.
Called “small” because they are usually only about 21-24 nucleotides long.
Synthesized by first cutting up longer precursor sequences (like the 61nt one that Lee discovered).
Silence an mRNA by base pairing with some sequence on the mRNA.
Discovery of siRNA?
The first small RNA:
In 1993 Rosalind Lee (Victor Ambros lab) was studying a non- coding gene in C. elegans, lin-4, that was involved in silencing of another gene, lin-14, at the appropriate time in the
development of the worm C. elegans.
Two small transcripts of lin-4 (22nt and 61nt) were found to be complementary to a sequence in the 3' UTR of lin-14.
Because lin-4 encoded no protein, she deduced that it must be these transcripts that are causing the silencing by RNA-RNA interactions.
Types of RNAi ( non coding RNA)
MiRNA
Length (23-25 nt)
Trans acting
Binds with target MRNA in mismatch
Translation inhibition
Si RNA
Length 21 nt.
Cis acting
Bind with target Mrna in perfect complementary sequence
Piwi-RNA
Length ; 25 to 36 nt.
Expressed in Germ Cells
Regulates trnasposomes activity
MECHANISM OF RNAI:
First the double-stranded RNA teams up with a protein complex named Dicer, which cuts the long RNA into short pieces.
Then another protein complex called RISC (RNA-induced silencing complex) discards one of the two RNA strands.
The RISC-docked, single-stranded RNA then pairs with the homologous mRNA and destroys it.
THE RISC COMPLEX:
RISC is large(>500kD) RNA multi- protein Binding complex which triggers MRNA degradation in response to MRNA
Unwinding of double stranded Si RNA by ATP independent Helicase
Active component of RISC is Ago proteins( ENDONUCLEASE) which cleave target MRNA.
DICER: endonuclease (RNase Family III)
Argonaute: Central Component of the RNA-Induced Silencing Complex (RISC)
One strand of the dsRNA produced by Dicer is retained in the RISC complex in association with Argonaute
ARGONAUTE PROTEIN :
1.PAZ(PIWI/Argonaute/ Zwille)- Recognition of target MRNA
2.PIWI (p-element induced wimpy Testis)- breaks Phosphodiester bond of mRNA.)RNAse H activity.
MiRNA:
The Double-stranded RNAs are naturally produced in eukaryotic cells during development, and they have a key role in regulating gene expression .
Professional air quality monitoring systems provide immediate, on-site data for analysis, compliance, and decision-making.
Monitor common gases, weather parameters, particulates.
THE IMPORTANCE OF MARTIAN ATMOSPHERE SAMPLE RETURN.Sérgio Sacani
The return of a sample of near-surface atmosphere from Mars would facilitate answers to several first-order science questions surrounding the formation and evolution of the planet. One of the important aspects of terrestrial planet formation in general is the role that primary atmospheres played in influencing the chemistry and structure of the planets and their antecedents. Studies of the martian atmosphere can be used to investigate the role of a primary atmosphere in its history. Atmosphere samples would also inform our understanding of the near-surface chemistry of the planet, and ultimately the prospects for life. High-precision isotopic analyses of constituent gases are needed to address these questions, requiring that the analyses are made on returned samples rather than in situ.
2. What is an equation?
An expression that tells that two things are equal.
L
H
S
R
H
S
The form of the World that we
perceives today…
3. 2 2 2
a b c Pythagoras, 530 BC
What does it tell us?
Link between the lengths of the sides on a right angled triangle, linking geometry and algebra
What did it lead to?
Distances between places without actually having to measure them, current theories of space, time, and
gravity…
Basis of Trigonometry
4. log log logxy x y
John Napeir, 1610
What does it tell us?
Big to small numbers
What did it lead to?
“Shortening the proceedings”
Exponential, Radioactive decay, and rates of growth, Earthquakes(Scales), (a predecessor to the calculator!)
5. 0
( ) ( )
lim
h
df f t h f t
dt h
Rate of
change of
quantity
With
respect to
some
quantity
Change
Newton, 1688
What does it tell us?
It tells us how to find the way in which function changes at any given moment in time, such as the speed of a car
What did it lead to?
Formulae for the volume & area of solids, laws of motion
Base of Calculus
Almost all the math in physics roams around calculus…
6. 1 2
2
m m
F G
d
What does it tell us?
It allows us to work out the gravitational force between two objects
What did it lead to?
“The system of the world”
How gravity works
Explanation to planetary motion; Earth and outside,
Basis for the laws of motion
the building of satellites
Newton, 1687
7. 1 i
What does it tell us?
That the square of the number i is -1, even though this is impossible!
What did it lead to?
“First term of Quantum Mechanics”
Creation of imaginary and complex numbers, which are used to explain waves, heat, electricity, and magnetism
Fourier series and Fourier Transform
Rafael Bombelli, 1572
8. 1 H
E 0 E
c t
1 E
H 0 H
c t
Electric
Field
Magnetic Field
Divergence = 0
Curl
Speed of
light
What does it tell us?
That electricity and magnetism are linked
What did it lead to?
“Waves in ether”
Unification of two great forces.
It predicted the existence/generation of electromagnetic waves other than light,
leading to radio, radar, and wireless computing
J. C. Maxwell, 1865
9. 2
E mc
What does it tell us?
“One thing is absolute”
Matter contains energy equal to its mass multiplied by the speed of light squared (a tiny
amount of matter contains lots of energy!)
What did it lead to?
Einstein, 1905