This document provides an overview of the insulin and glucagon hormones, including their structure, synthesis, regulation of secretion, receptors, and metabolic effects. Insulin is produced in the pancreas and promotes storage and use of glucose, fatty acids, and amino acids in the liver, muscle and fat tissues. Glucagon is also produced in the pancreas and opposes insulin by increasing glucose production and release from the liver during periods of low blood sugar. Disorders of insulin and glucagon action can lead to diabetes mellitus.
Blood sugar homeostasis is maintained through a balance of hepatic glucose production and peripheral glucose uptake regulated by hormones like insulin and glucagon. In the fasting state, low insulin and high glucagon promote gluconeogenesis and glycogenolysis to increase glucose production. After eating, high insulin and low glucagon stimulate glucose uptake in tissues and inhibit production. Disruptions can cause hyperglycemia or hypoglycemia.
This document discusses glucose homeostasis and the tightly regulated process of maintaining blood glucose levels within a narrow range. It describes the various sources of blood glucose, including dietary carbohydrates and the body's ability to produce glucose through glycogenolysis and gluconeogenesis when needed. Key hormones involved in regulating glucose include insulin, released after meals to lower blood glucose levels, and glucagon, released during fasting to raise blood glucose levels and promote glycogen breakdown and glucose production. Precise control of these opposing hormones is critical for metabolic health.
Insulin is a polypeptide hormone produced by beta cells in the pancreas that regulates fuel metabolism. It has important anabolic effects, promoting the storage and synthesis of glycogen, triglycerides, and proteins. Insulin secretion is stimulated by increases in blood glucose, amino acids, and gastrointestinal hormones after eating. It works to promote glucose uptake and storage in liver, muscle and fat tissues, while inhibiting glucose production and release. Insulin also increases lipid synthesis and inhibits lipid breakdown to regulate lipid metabolism.
Insulin is a peptide hormone synthesized in the pancreatic beta cells. It facilitates glucose entry into cells, glycogen synthesis, and inhibits gluconeogenesis and lipolysis. Insulin analogues have been developed with altered pharmacokinetics to better mimic physiological insulin release. Oral hypoglycemic drugs include sulfonylureas which stimulate insulin secretion, biguanides like metformin which reduce hepatic glucose production and enhance glucose uptake, thiazolidinediones which reduce insulin resistance, and DPP-4 inhibitors which prolong the effects of incretins. Sulfonylureas block KATP channels, meglitinides have a quick onset and offset of action, while metformin reduces gluconeogenesis and stimulates
This document discusses glucose homeostasis and diabetes. It covers:
- The roles of insulin, glucagon, and other hormones in regulating blood glucose levels. Insulin lowers glucose while glucagon raises it.
- The differences between type 1 and type 2 diabetes, including causes and treatments. Type 1 is an autoimmune disease treated with insulin, while type 2 is due to insulin resistance and may be treated with diet, exercise, or oral medication.
- How insulin works by binding receptors on cells and increasing glucose uptake, utilization, and storage. This lowers blood glucose levels.
The blood glucose level is tightly regulated between 70-110 mg/dl. After eating, levels may rise to 120-140 mg/dl before returning to normal. The liver plays a key role in regulating glucose through metabolic processes and hormones like insulin and glucagon. Insulin promotes glucose uptake and storage after eating, while glucagon and other hormones like epinephrine release glucose into the blood during periods of low blood sugar. Together, these hormonal and organ responses help maintain blood glucose within a narrow range.
1. Insulin is a peptide hormone that regulates blood glucose levels. It is synthesized and secreted by beta cells in the pancreas.
2. Glucagon is a hormone that increases blood glucose levels by stimulating glycogenolysis and gluconeogenesis in the liver. It is synthesized and secreted by alpha cells in the pancreas.
3. Diabetes mellitus is characterized by hyperglycemia and is classified as type 1 caused by lack of insulin production, type 2 caused by insulin resistance and relative lack of insulin, and gestational diabetes during pregnancy.
Blood glucose levels are normally maintained within a narrow range through the regulation of glucose entry into and removal from the bloodstream. Hormones like insulin and glucagon act in opposition to maintain glucose homeostasis, with insulin lowering blood glucose through promoting glucose uptake in cells and glucagon raising it through stimulating glucose production and release from the liver. A variety of tissues, including muscle, adipose, liver, and brain, play roles in glucose regulation through uptake, storage, production, and utilization of glucose.
Blood sugar homeostasis is maintained through a balance of hepatic glucose production and peripheral glucose uptake regulated by hormones like insulin and glucagon. In the fasting state, low insulin and high glucagon promote gluconeogenesis and glycogenolysis to increase glucose production. After eating, high insulin and low glucagon stimulate glucose uptake in tissues and inhibit production. Disruptions can cause hyperglycemia or hypoglycemia.
This document discusses glucose homeostasis and the tightly regulated process of maintaining blood glucose levels within a narrow range. It describes the various sources of blood glucose, including dietary carbohydrates and the body's ability to produce glucose through glycogenolysis and gluconeogenesis when needed. Key hormones involved in regulating glucose include insulin, released after meals to lower blood glucose levels, and glucagon, released during fasting to raise blood glucose levels and promote glycogen breakdown and glucose production. Precise control of these opposing hormones is critical for metabolic health.
Insulin is a polypeptide hormone produced by beta cells in the pancreas that regulates fuel metabolism. It has important anabolic effects, promoting the storage and synthesis of glycogen, triglycerides, and proteins. Insulin secretion is stimulated by increases in blood glucose, amino acids, and gastrointestinal hormones after eating. It works to promote glucose uptake and storage in liver, muscle and fat tissues, while inhibiting glucose production and release. Insulin also increases lipid synthesis and inhibits lipid breakdown to regulate lipid metabolism.
Insulin is a peptide hormone synthesized in the pancreatic beta cells. It facilitates glucose entry into cells, glycogen synthesis, and inhibits gluconeogenesis and lipolysis. Insulin analogues have been developed with altered pharmacokinetics to better mimic physiological insulin release. Oral hypoglycemic drugs include sulfonylureas which stimulate insulin secretion, biguanides like metformin which reduce hepatic glucose production and enhance glucose uptake, thiazolidinediones which reduce insulin resistance, and DPP-4 inhibitors which prolong the effects of incretins. Sulfonylureas block KATP channels, meglitinides have a quick onset and offset of action, while metformin reduces gluconeogenesis and stimulates
This document discusses glucose homeostasis and diabetes. It covers:
- The roles of insulin, glucagon, and other hormones in regulating blood glucose levels. Insulin lowers glucose while glucagon raises it.
- The differences between type 1 and type 2 diabetes, including causes and treatments. Type 1 is an autoimmune disease treated with insulin, while type 2 is due to insulin resistance and may be treated with diet, exercise, or oral medication.
- How insulin works by binding receptors on cells and increasing glucose uptake, utilization, and storage. This lowers blood glucose levels.
The blood glucose level is tightly regulated between 70-110 mg/dl. After eating, levels may rise to 120-140 mg/dl before returning to normal. The liver plays a key role in regulating glucose through metabolic processes and hormones like insulin and glucagon. Insulin promotes glucose uptake and storage after eating, while glucagon and other hormones like epinephrine release glucose into the blood during periods of low blood sugar. Together, these hormonal and organ responses help maintain blood glucose within a narrow range.
1. Insulin is a peptide hormone that regulates blood glucose levels. It is synthesized and secreted by beta cells in the pancreas.
2. Glucagon is a hormone that increases blood glucose levels by stimulating glycogenolysis and gluconeogenesis in the liver. It is synthesized and secreted by alpha cells in the pancreas.
3. Diabetes mellitus is characterized by hyperglycemia and is classified as type 1 caused by lack of insulin production, type 2 caused by insulin resistance and relative lack of insulin, and gestational diabetes during pregnancy.
Blood glucose levels are normally maintained within a narrow range through the regulation of glucose entry into and removal from the bloodstream. Hormones like insulin and glucagon act in opposition to maintain glucose homeostasis, with insulin lowering blood glucose through promoting glucose uptake in cells and glucagon raising it through stimulating glucose production and release from the liver. A variety of tissues, including muscle, adipose, liver, and brain, play roles in glucose regulation through uptake, storage, production, and utilization of glucose.
Definition of hormones
Pancreas
Intro of insulin
Chemistry
Biosynthesis
Action of insulin
Metabolic effect on insulin
Factors effect insulin secretion
Disorders related to insulin hormone
Treatment
Brand name of insulin in market
Diabetes mellitus is characterized by hyperglycemia due to insufficient insulin production or ineffective insulin. There are two main types - type 1 diabetes results from autoimmune destruction of insulin-producing pancreatic beta cells, while type 2 diabetes involves insulin resistance along with relative insulin deficiency. Insulin regulates carbohydrate, fat, and protein metabolism, maintaining blood glucose levels. Glucagon has opposing effects, promoting gluconeogenesis and glycolysis to increase glucose levels. Tight regulation of insulin and glucagon secretion is needed to keep glucose within its narrow physiological range.
The document discusses various aspects of antidiabetic drugs including:
- Insulin is produced in the pancreatic beta cells and helps regulate blood glucose levels. It exists as two chains and is processed from proinsulin. Insulin secretion is stimulated by glucose and other factors.
- Other pancreatic hormones that regulate blood glucose include glucagon, somatostatin, pancreatic peptide, and ghrelin.
- Diabetes mellitus occurs when there is not enough insulin or when cells ignore insulin signals. The main types are type 1 caused by beta cell destruction and type 2 caused by insulin resistance and relative deficiency.
- Common antidiabetic drug classes include insulin, sulfonylureas, me
Glucose is the main sugar found in the blood. The body get glucose from the food we eat.
This sugar is an important source of energy and provides nutrients to the body’s organs, muscles and nervous system.
Blood sugar concentration, or glucose level, refers to the amount of glucose present in the blood of a human.
Insulin is a hormone produced by the pancreas that regulates glucose metabolism and favors the storage and synthesis of carbohydrates, proteins, and fats in cells. It binds to insulin receptors on cells, triggering a signaling cascade that increases the translocation of GLUT-4 glucose transporters to cell membranes. This allows glucose uptake into cells, where it is used or stored as glycogen in the liver and muscle or converted to triglycerides for storage in adipose tissue. Insulin also inhibits the breakdown of glycogen, triglycerides, and proteins, favoring their synthesis and storage over degradation.
The document discusses the pancreas and its role in producing digestive enzymes and peptide hormones like insulin, glucagon, and somatostatin. It describes the four types of diabetes, focusing on type 1 diabetes which results from an absolute deficiency of insulin due to destruction of beta cells in the pancreas. Signs and symptoms of type 1 diabetes include polydipsia, polyphagia, polyuria, and weight loss. Treatment involves administering exogenous insulin through injections to control blood glucose levels.
The endocrine system consists of ductless glands that secrete hormones directly into the the blood stream and are carried to the target organs through blood
The document discusses hormonal regulation of blood glucose levels. It explains that insulin, glucagon, and epinephrine work to keep blood glucose within a narrow range. Insulin is released when glucose is high and signals cells to take up and store glucose. Glucagon is released when glucose is low and signals the liver to produce glucose through gluconeogenesis and glycogen breakdown. Epinephrine prepares the body for activity by stimulating glycogen and fat breakdown. Diabetes results from defects in insulin production or action, leading to high blood glucose and ketone production. Prolonged fasting relies on gluconeogenesis and ketone bodies for fuel. Alcohol excess can cause hypoglycemia by inhibiting gluconeogenesis in the liver.
The document discusses endocrine physiology, focusing on the pancreas and its role in regulating blood glucose levels. It describes:
1) The pancreas contains islets of Langerhans that produce hormones like insulin and glucagon which regulate fuel storage and use.
2) Insulin is produced by beta cells, lowers blood glucose, and promotes fuel storage in liver, muscle and fat tissues.
3) Glucagon is produced by alpha cells, raises blood glucose levels by promoting glycogenolysis and gluconeogenesis in the liver.
4) Diabetes mellitus results from low insulin levels and high blood glucose. The two primary types are type 1 caused by beta cell destruction and type 2
Insulin is a hormone produced by the pancreas that regulates blood sugar levels. It is composed of two chains of amino acids and functions by promoting the uptake and storage of glucose in the liver, muscle and fat cells. Diabetes occurs when the pancreas produces little or no insulin (Type 1) or the body does not respond properly to insulin (Type 2), resulting in high blood sugar levels. The main types of diabetes are juvenile onset (Type 1) and maturity onset (Type 2) diabetes.
1. Blood glucose levels are normally maintained within a narrow range through the rates of glucose entering and leaving the bloodstream.
2. When blood glucose levels drop, glucagon is secreted to stimulate glucose production and release from the liver through glycogenolysis and gluconeogenesis.
3. If levels continue to drop, epinephrine is released to further increase glucose production from the liver while also breaking down glycogen in muscle and fat cells.
4. Prolonged low blood glucose can trigger the release of cortisol and growth hormone to mobilize more long-term energy stores and decrease glucose utilization in tissues.
Gluconeogenesis and Control of Blood Glucose.pptxAssiddiqah
Gluconeogenesis and Control of Blood Glucose discusses how glucose levels are maintained through a balance of input and output. Key processes include gluconeogenesis, which produces glucose from non-carbohydrate sources in the liver and kidneys. Hormones like insulin and glucagon tightly regulate blood glucose levels by controlling glucose uptake, storage, and output in tissues. The kidneys also help regulate levels by reabsorbing or excreting glucose to influence circulating amounts.
The document discusses endocrine disorders and focuses on diabetes mellitus. It defines the endocrine system and describes how hormones are secreted and transported. It then discusses the different types of diabetes (type 1, type 2, gestational), their causes and pathophysiology. Type 1 diabetes results from an autoimmune destruction of insulin-producing pancreatic beta cells, leading to little or no insulin production. This causes unchecked glucose production and fasting/postprandial hyperglycemia.
The pancreas contains both exocrine cells that secrete enzymes for digestion and endocrine cells clustered in islets of Langerhans that secrete hormones. The beta cells within the islets secrete insulin, which regulates blood glucose levels. Insulin binds to receptors on cells to promote glucose uptake and storage and regulate metabolism. Glucagon from alpha cells has opposing actions, raising blood glucose. Precise balance of insulin and glucagon maintains normal glucose homeostasis, while diabetes results from insufficient insulin.
1. Type 2 diabetes results from insulin resistance in the liver and peripheral tissues like muscle, as well as relative insulin deficiency. This leads to elevated hepatic glucose production and reduced glucose uptake in tissues.
2. Sustained hyperglycemia can cause glucotoxicity and further impair insulin secretion and action, exacerbating the disease. It also increases renal glucose reabsorption above normal levels, causing glucosuria.
3. Over time, this pathophysiology can damage target organs and increase the risk of diabetes complications if not properly treated. Treatment aims to reduce hyperglycemia through medications that increase insulin secretion and action or decrease hepatic glucose production.
1. Type 2 diabetes results from insulin resistance in the liver and peripheral tissues like muscle, as well as relative insulin deficiency. This leads to increased hepatic glucose production and reduced glucose uptake in tissues.
2. Sustained hyperglycemia can cause glucotoxicity and further impair insulin secretion and action, exacerbating the disease. It also increases renal glucose reabsorption beyond the renal threshold, causing glucosuria.
3. Over time, this pathophysiology can cause impaired counterregulatory hormone responses to hypoglycemia, increasing the risk of severe and prolonged hypoglycemic episodes with loss of symptomatic awareness.
This presentation is just an overview/summary of the vast topic insulin , its biosynthesis , mechanism of action , effects of insulin on body , related diseases and marketed preparations of insulin.
This document summarizes key aspects of insulin and glucagon regulation of blood glucose levels. It discusses that insulin and glucagon are polypeptide hormones secreted by the pancreas that have opposing functions. Insulin is produced in response to high blood glucose to promote glucose uptake and storage. Glucagon is produced in response to low blood glucose to promote glucose release from stores. The document also summarizes the different types of diabetes, their causes and treatments.
Endocrine function of pancrease.peyudrurudrdfSriRam071
The pancreas secretes two important hormones - insulin and glucagon. Insulin is produced by beta cells in the pancreas and regulates carbohydrate and fat metabolism. It causes cells to absorb glucose from the blood and store it as glycogen in the liver and muscles or as triglycerides in fat cells. Insulin is composed of two amino acid chains connected by disulfide bridges. It is synthesized as preproinsulin which is cleaved to form proinsulin and then insulin. Insulin secretion is increased by glucose, amino acids, and gastrointestinal hormones. Insulin promotes the storage and use of glucose, fatty acid synthesis and fat storage, and protein synthesis.
Integrating Ayurveda into Parkinson’s Management: A Holistic ApproachAyurveda ForAll
Explore the benefits of combining Ayurveda with conventional Parkinson's treatments. Learn how a holistic approach can manage symptoms, enhance well-being, and balance body energies. Discover the steps to safely integrate Ayurvedic practices into your Parkinson’s care plan, including expert guidance on diet, herbal remedies, and lifestyle modifications.
Definition of hormones
Pancreas
Intro of insulin
Chemistry
Biosynthesis
Action of insulin
Metabolic effect on insulin
Factors effect insulin secretion
Disorders related to insulin hormone
Treatment
Brand name of insulin in market
Diabetes mellitus is characterized by hyperglycemia due to insufficient insulin production or ineffective insulin. There are two main types - type 1 diabetes results from autoimmune destruction of insulin-producing pancreatic beta cells, while type 2 diabetes involves insulin resistance along with relative insulin deficiency. Insulin regulates carbohydrate, fat, and protein metabolism, maintaining blood glucose levels. Glucagon has opposing effects, promoting gluconeogenesis and glycolysis to increase glucose levels. Tight regulation of insulin and glucagon secretion is needed to keep glucose within its narrow physiological range.
The document discusses various aspects of antidiabetic drugs including:
- Insulin is produced in the pancreatic beta cells and helps regulate blood glucose levels. It exists as two chains and is processed from proinsulin. Insulin secretion is stimulated by glucose and other factors.
- Other pancreatic hormones that regulate blood glucose include glucagon, somatostatin, pancreatic peptide, and ghrelin.
- Diabetes mellitus occurs when there is not enough insulin or when cells ignore insulin signals. The main types are type 1 caused by beta cell destruction and type 2 caused by insulin resistance and relative deficiency.
- Common antidiabetic drug classes include insulin, sulfonylureas, me
Glucose is the main sugar found in the blood. The body get glucose from the food we eat.
This sugar is an important source of energy and provides nutrients to the body’s organs, muscles and nervous system.
Blood sugar concentration, or glucose level, refers to the amount of glucose present in the blood of a human.
Insulin is a hormone produced by the pancreas that regulates glucose metabolism and favors the storage and synthesis of carbohydrates, proteins, and fats in cells. It binds to insulin receptors on cells, triggering a signaling cascade that increases the translocation of GLUT-4 glucose transporters to cell membranes. This allows glucose uptake into cells, where it is used or stored as glycogen in the liver and muscle or converted to triglycerides for storage in adipose tissue. Insulin also inhibits the breakdown of glycogen, triglycerides, and proteins, favoring their synthesis and storage over degradation.
The document discusses the pancreas and its role in producing digestive enzymes and peptide hormones like insulin, glucagon, and somatostatin. It describes the four types of diabetes, focusing on type 1 diabetes which results from an absolute deficiency of insulin due to destruction of beta cells in the pancreas. Signs and symptoms of type 1 diabetes include polydipsia, polyphagia, polyuria, and weight loss. Treatment involves administering exogenous insulin through injections to control blood glucose levels.
The endocrine system consists of ductless glands that secrete hormones directly into the the blood stream and are carried to the target organs through blood
The document discusses hormonal regulation of blood glucose levels. It explains that insulin, glucagon, and epinephrine work to keep blood glucose within a narrow range. Insulin is released when glucose is high and signals cells to take up and store glucose. Glucagon is released when glucose is low and signals the liver to produce glucose through gluconeogenesis and glycogen breakdown. Epinephrine prepares the body for activity by stimulating glycogen and fat breakdown. Diabetes results from defects in insulin production or action, leading to high blood glucose and ketone production. Prolonged fasting relies on gluconeogenesis and ketone bodies for fuel. Alcohol excess can cause hypoglycemia by inhibiting gluconeogenesis in the liver.
The document discusses endocrine physiology, focusing on the pancreas and its role in regulating blood glucose levels. It describes:
1) The pancreas contains islets of Langerhans that produce hormones like insulin and glucagon which regulate fuel storage and use.
2) Insulin is produced by beta cells, lowers blood glucose, and promotes fuel storage in liver, muscle and fat tissues.
3) Glucagon is produced by alpha cells, raises blood glucose levels by promoting glycogenolysis and gluconeogenesis in the liver.
4) Diabetes mellitus results from low insulin levels and high blood glucose. The two primary types are type 1 caused by beta cell destruction and type 2
Insulin is a hormone produced by the pancreas that regulates blood sugar levels. It is composed of two chains of amino acids and functions by promoting the uptake and storage of glucose in the liver, muscle and fat cells. Diabetes occurs when the pancreas produces little or no insulin (Type 1) or the body does not respond properly to insulin (Type 2), resulting in high blood sugar levels. The main types of diabetes are juvenile onset (Type 1) and maturity onset (Type 2) diabetes.
1. Blood glucose levels are normally maintained within a narrow range through the rates of glucose entering and leaving the bloodstream.
2. When blood glucose levels drop, glucagon is secreted to stimulate glucose production and release from the liver through glycogenolysis and gluconeogenesis.
3. If levels continue to drop, epinephrine is released to further increase glucose production from the liver while also breaking down glycogen in muscle and fat cells.
4. Prolonged low blood glucose can trigger the release of cortisol and growth hormone to mobilize more long-term energy stores and decrease glucose utilization in tissues.
Gluconeogenesis and Control of Blood Glucose.pptxAssiddiqah
Gluconeogenesis and Control of Blood Glucose discusses how glucose levels are maintained through a balance of input and output. Key processes include gluconeogenesis, which produces glucose from non-carbohydrate sources in the liver and kidneys. Hormones like insulin and glucagon tightly regulate blood glucose levels by controlling glucose uptake, storage, and output in tissues. The kidneys also help regulate levels by reabsorbing or excreting glucose to influence circulating amounts.
The document discusses endocrine disorders and focuses on diabetes mellitus. It defines the endocrine system and describes how hormones are secreted and transported. It then discusses the different types of diabetes (type 1, type 2, gestational), their causes and pathophysiology. Type 1 diabetes results from an autoimmune destruction of insulin-producing pancreatic beta cells, leading to little or no insulin production. This causes unchecked glucose production and fasting/postprandial hyperglycemia.
The pancreas contains both exocrine cells that secrete enzymes for digestion and endocrine cells clustered in islets of Langerhans that secrete hormones. The beta cells within the islets secrete insulin, which regulates blood glucose levels. Insulin binds to receptors on cells to promote glucose uptake and storage and regulate metabolism. Glucagon from alpha cells has opposing actions, raising blood glucose. Precise balance of insulin and glucagon maintains normal glucose homeostasis, while diabetes results from insufficient insulin.
1. Type 2 diabetes results from insulin resistance in the liver and peripheral tissues like muscle, as well as relative insulin deficiency. This leads to elevated hepatic glucose production and reduced glucose uptake in tissues.
2. Sustained hyperglycemia can cause glucotoxicity and further impair insulin secretion and action, exacerbating the disease. It also increases renal glucose reabsorption above normal levels, causing glucosuria.
3. Over time, this pathophysiology can damage target organs and increase the risk of diabetes complications if not properly treated. Treatment aims to reduce hyperglycemia through medications that increase insulin secretion and action or decrease hepatic glucose production.
1. Type 2 diabetes results from insulin resistance in the liver and peripheral tissues like muscle, as well as relative insulin deficiency. This leads to increased hepatic glucose production and reduced glucose uptake in tissues.
2. Sustained hyperglycemia can cause glucotoxicity and further impair insulin secretion and action, exacerbating the disease. It also increases renal glucose reabsorption beyond the renal threshold, causing glucosuria.
3. Over time, this pathophysiology can cause impaired counterregulatory hormone responses to hypoglycemia, increasing the risk of severe and prolonged hypoglycemic episodes with loss of symptomatic awareness.
This presentation is just an overview/summary of the vast topic insulin , its biosynthesis , mechanism of action , effects of insulin on body , related diseases and marketed preparations of insulin.
This document summarizes key aspects of insulin and glucagon regulation of blood glucose levels. It discusses that insulin and glucagon are polypeptide hormones secreted by the pancreas that have opposing functions. Insulin is produced in response to high blood glucose to promote glucose uptake and storage. Glucagon is produced in response to low blood glucose to promote glucose release from stores. The document also summarizes the different types of diabetes, their causes and treatments.
Endocrine function of pancrease.peyudrurudrdfSriRam071
The pancreas secretes two important hormones - insulin and glucagon. Insulin is produced by beta cells in the pancreas and regulates carbohydrate and fat metabolism. It causes cells to absorb glucose from the blood and store it as glycogen in the liver and muscles or as triglycerides in fat cells. Insulin is composed of two amino acid chains connected by disulfide bridges. It is synthesized as preproinsulin which is cleaved to form proinsulin and then insulin. Insulin secretion is increased by glucose, amino acids, and gastrointestinal hormones. Insulin promotes the storage and use of glucose, fatty acid synthesis and fat storage, and protein synthesis.
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Local Advanced Lung Cancer: Artificial Intelligence, Synergetics, Complex Sys...Oleg Kshivets
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Histololgy of Female Reproductive System.pptxAyeshaZaid1
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Basavarajeeyam is a Sreshta Sangraha grantha (Compiled book ), written by Neelkanta kotturu Basavaraja Virachita. It contains 25 Prakaranas, First 24 Chapters related to Rogas& 25th to Rasadravyas.
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2. Overview
• Four major organs play a
dominant role in fuel
metabolism: liver, adipose
tissue, muscle and brain.
• Communication between
tissues is mediated by the
nervous system, by the
availability of circulating
substrates and by variation
in the levels of plasma
hormones.
3. • Changes in the circulating levels of these hormones
allow the body to:
a) Store energy when food is available in abundance,
b) Make stored energy available, for example, during
severe injury, and “fight-or-flight” situations.
• The integration of energy metabolism is controlled
primarily by the actions of two peptide hormones:
insulin and glucagon, with the catecholamines;
(epinephrine & norepinephrine); have a supporting
role.
Overview
4. INSULIN HORMONE
• Insulin is a polypeptide hormone produced by the
β cells of islets of Langerhans.
• The islets of Langerhans are about 1-2% of the
total cells of the pancreas.
• Insulin is the most important hormone
coordinating the use of fuels by tissues.
• Its metabolic effects are anabolic, i.e., favoring
synthesis of glycogen, TAGs and proteins.
5. • Insulin is composed of 51 amino
acids arranged in two
polypeptide chains, A and B,
which are linked together by two
disulfide bridges.
• Insulin molecule contains also
one intra-molecular disulfide
bridge between amino acid
residues of the A chain.
Structure Of Insulin
6. Synthesis of Insulin:
The biosynthesis involves two inactive precursors, pre-
pro-insulin and pro-insulin, which are sequentially
cleaved to form the active hormone “ insulin” and the
connecting or the C-peptide.
7. • The C-peptide is essential for proper insulin folding.
• The C-peptide has a long half-life in the plasma, so, it
is a good indicator of insulin production and
secretion in early diabetes.
• Insulin is stored in the cytosol in granules. Proper
stimulus of these granules causes release of insulin by
exocytosis.
• Insulin is degraded by insulinase enzyme which is
present in liver and to a lesser extent in the kidneys.
• Insulin has a plasma half-life of approximately 6 minutes.
8. Regulation of Insulin Secretion
1- Stimulation of Insulin Secretion
l Insulin secretion by the β-cells of the pancreas is
closely coordinated with the release of glucagon
by α-cells of islets of Langerhans.
l The relative amounts of insulin and glucagon
released by the pancreas are regulated so that the
rate of hepatic glucose production is kept equal
to the use of glucose by peripheral tissues.
9. Changes in blood levels of glucose, insulin, and
glucagon after ingestion of a carbohydrate-rich meal
10. A - Glucose:
• Glucose is the most important stimulus for insulin
secretion.
• β-cells are the most important glucose-sensing cells in
the body. Like the liver, β-cells contain GLUT-2 and have
glucokinase activity.
• So, they can uptake and phosphorylate glucose in
amounts proportional to its actual concentration in the
blood.
• Ingestion of glucose or a carbohydrate-rich meal leads
to a rise in blood glucose level, which is a signal for
increased insulin secretion and a decreased glucagon
synthesis and release.
12. SGLT: sodium-glucose linked transporter
• SGLT are a family of glucose transporter found in
the intestinal mucosa (enterocytes), (SGLT1) and
the proximal tubule of the nephron (SGLT2 in S1
and S2 segments of PCT and SGLT1 in S3 segment
of PCT).
• They contribute to renal glucose reabsorption.
• In the kidneys, 100% of the filtered glucose in
the glomerulus is reabsorbed along the nephron
(98% in PCT, via SGLT2).
13. SGLT: sodium-glucose linked transporter
• In case of too high plasma glucose concentration
(hyperglycemia), glucose is excreted in urine
(glucosuria); because SGLT are saturated with
the filtered glucose
• Glucose is never secreted by the nephron.
14. B - Amino acids:
• Ingestion of protein causes a transient rise in
plasma amino acid levels, which in turn, induces
the immediate secretion of insulin.
• Elevated plasma arginine is a particularly potent
stimulus for insulin synthesis and secretion.
Stimulation of Insulin Secretion
15. C - Gastrointestinal hormones:
• Most gastrointestinal hormones favor insulin release.
• The intestinal peptides Cholecystokinin and Gastric-
Inhibitory Polypeptide increase insulin secretion in
response to oral glucose.
• This may explain why the same amount of glucose
given orally induces a much greater secretion of
insulin than if it is given intravenously.
Stimulation of Insulin Secretion
16. • The synthesis and release of insulin are decreased
when there is a decrease of dietary fuels and also
during periods of stress (for example: fever,
infection ......etc)
• These effects are mediated primarily by
epinephrine, which is secreted by the adrenal
medulla in response to stress, trauma or extreme
muscular exercise.
Inhibition of Insulin Secretion
17. • In these conditions, epinephrine is largely
controlled by the nervous system.
• Epinephrine has a direct effect on energy
metabolism, causing a rapid mobilization of
energy-yielding fuels, including glucose from the
liver ( by glycogenolysis or gluconeogenesis) and
fatty acids from adipose tissue.
Inhibition of Insulin Secretion
18. • In addition, epinephrine can override the normal glucose
- stimulated release of insulin.
• Thus, in emergency situations, the CNS (sympathetic
nervous system) largely replaces the plasma glucose
concentration as the controlling influence over β - cell
secretion.
21. Metabolic effects of Insulin
Effects on metabolism:
The effects of insulin on glucose metabolism:
• Promote its storage and are most prominent in
three tissues: liver, muscle and adipose tissue”.
• Increase glucose uptake
• Increase glycogen synthesis.
• Increase protein synthesis.
• Increase Lipid synthesis.
• Inhibition of glycogenolysis and gluconeogenesis.
24. Receptor regulation:
• Binding of insulin is followed by internalization
of the hormone–receptor complex. Once inside
the cell, insulin is degraded in the lysosomes.
• The receptors may be degraded but most are
recycled to the cell surface.
• Elevated levels of insulin promote the
degradation of receptors, thus decreasing the
number of surface receptors.
• This is one type of “down-regulation.”
25. Glucagon Hormone
• Glucagon is a polypeptide hormone secreted by
the α cells of the islets of Langerhans of the
pancreas.
• Glucagon, along with epinephrine, cortisol and
growth hormone oppose many of the actions of
insulin.
• Glucagon acts to maintain blood glucose levels at
normal values between meals by the activation
of hepatic glycogenolysis and gluconeogenesis.
28. Stimulation of Glucagon Secretion
1- Low blood glucose:
During an overnight or prolonged fast, elevated
glucagon levels prevent hypoglycemia.
2- Amino acids:
A meal containing proteins stimulates the release of
both glucagon and insulin.
Glucagon effectively prevents hypoglycemia that
would otherwise occurs as a result of increased
insulin secretion that occurs after a protein meal.
29. 3- Epinephrine:
• Elevated levels of circulating epinephrine produced by
the adrenal medulla, or norepinephrine produced by
sympathetic nervous system of the pancreas, or both,
stimulate the release of glucagon.
• Thus, during periods of stress, trauma, or severe
exercise, in these situations—regardless of the
concentration of blood glucose, glucagon levels are
elevated in anticipation of increased glucose use.
• In contrast, insulin levels are depressed.
Stimulation of Glucagon Secretion
30. Metabolic effects of glucagon
Effects on carbohydrate metabolism:
• Increase in the breakdown of liver (not muscle)
glycogen and an increase in gluconeogenesis.
Effects on lipid metabolism:
• Activates lipolysis in adipose tissue.
Effects on protein metabolism:
• Increases uptake of amino acids by the liver,
resulting in increased availability of carbon
skeletons for gluconeogenesis. So, plasma levels
of amino acids are decreased.
32. Diabetes Mellitus (DM)
• Normal plasma glucose 70-110 mg/dL.
• Type 1 diabetes: or insulin dependent diabetes is a
chronic condition in which the pancreas produces little or
no insulin. Usually diagnosed in children & young adults.
• Type 2 diabetes: characterized by high blood sugar,
insulin resistance and relative lack of insulin.
• About 90% of cases of diabetes.
• Caused by a combination of lifestyle & genetic factors.
• Gestational diabetes: is a rare disorder that happens
in pregnancy, usually in the third trimester.
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33. Diagnosis of Diabetes Mellitus (DM)
ØThe American Diabetes Association defines the
normal glucose reference ranges as below:
- Fasting plasma glucose 70-99 (≤ 110) mg/dL .
- Two-hour postprandial plasma glucose levels: Give
the patient a 75 g glucose orally and after 2hrs
measure plasma glucose; level ≤ 140mg/dL.
- Random plasma glucose level of ≤ 140 mg/dL.
- HbA1c level: normal range less than 6%.
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35. Diagnosis of Diabetes Mellitus (DM)
HbA1c
Ø According to the American Diabetes Association (ADA)
guidelines regarding to the HbA1c level:
a) HbA1c <7.5% = well controlled DM.
b) HbA1c 7.5% & ≤ 9% = fairly controlled DM.
c) HbA1c >9% = poorly controlled DM.
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