RRC 2011 : Pharmacogénétique et médecine personnalisée du diabète
•
0 likes•830 views
This document discusses personalized medicine approaches for diabetes. It mentions that mutations in the MC4R gene can diminish the success of bariatric surgery for obesity. It also notes that around 5% of diabetes cases have a monogenic cause related to beta cell dysfunction, such as mutations in the KCNJ11/ABCC8 genes encoding the KATP channel, where patients can often be switched from insulin to sulfonylurea drugs. Finally, it states that most cases of type 2 diabetes have a polygenic cause involving interactions between many genes and the environment.
Report
Share
Report
Share
Recommended
CDD Seminar Presentation-JaeminLee
This document summarizes a study on the role of monoacyl glycerol lipase (MGL) in breast cancer proliferation. MGL degrades the endocannabinoid 2-AG, which inhibits cell proliferation when bound to cannabinoid receptors. The study found that inhibiting MGL in breast epithelial cells led to decreased phosphorylation of epidermal growth factor receptor (EGFR) and vascular endothelial growth factor (VEGF) secretion, both of which promote proliferation. This suggests inhibiting MGL may be a potential anti-breast cancer therapy by reducing EGFR and VEGF signaling and subsequent proliferation.
Pharmaceurtical role of nucleic acid
Nucleic acids have important pharmaceutical roles in treating cancer, cardiovascular, and autoimmune diseases. There are several approaches to gene therapy including inserting a normal gene to compensate for a nonfunctional one, changing gene regulation, or inserting an abnormal gene for normal function. Gene therapy can be somatic, affecting only the patient, or germline, passing genetic changes to offspring. It faces challenges like short-lived effects, potential immune responses, and difficulties treating multi-gene disorders. Successful gene therapy requires understanding disease processes, gene structure/function, efficient delivery methods, and control of expression and immune responses.
PPT Monoclonal antibodies in Endocrinology
Monoclonal antibodies (MABs) have various applications in endocrinology. MABs are used in immunoassays to detect hormones and proteins. They can also be radiolabeled for diagnostic imaging techniques. Therapeutically, burosumab treats X-linked hypophosphatemic rickets by targeting FGF-23. Romosozumab increases bone mineral density by inhibiting sclerostin. Teprotumumab treats thyroid eye disease. Alirocumab and evolocumab lower cholesterol by inhibiting PCSK9. Side effects of immune checkpoint inhibitors include hypophysitis due to removal of CTLA-4 mediated immune tolerance. Cases of type 1 diabetes have also been reported following anti
Recent advances in migraine management
Ubrogepant, erenumab, fremanezumab, and galcanezumab are monoclonal antibodies that target CGRP for the treatment of migraines. Ubrogepant is approved for acute treatment while the others are approved for prevention. Clinical trials showed they significantly reduced monthly migraine days compared to placebo. Common side effects include pain or redness at the injection site. They were approved by the FDA between 2018-2019 and cost approximately $6,000-7,000 per year.
Anti angiogenic activity of Annona muricata (guyabano) versus paclitaxel and ...
Anti angiogenic activity of Annona muricata (guyabano) versus paclitaxel and ...Mary Ondinee Manalo Igot
This study aimed to compare the antiangiogenic activity of guyabano compared with bevacizumab and paclitaxel, which are among the most common agents known to target angiogenesis in cancer patients.
Gene Therapy
Gene therapy is an experimental technique that uses genes to treat or prevent disease. There are two types of gene therapy - somatic gene therapy, which treats cells of the body but not reproductive cells, and germline gene therapy, which treats reproductive cells and can be passed to future generations. There are several techniques for gene therapy including gene augmentation therapy, which adds a functional gene to replace a non-functioning one; gene inhibition therapy, which inhibits or interferes with a disease-causing gene; and gene killing therapy, which inserts a "suicide gene" to kill specific diseased cells. A key challenge is safely delivering the new gene to the right cells and ensuring it is expressed without disrupting other genes or triggering
Epigenetics and type 2 diabetes
This document discusses the role of epigenetics in type 2 diabetes (T2D). It describes how environmental factors like undernutrition can induce chronic metabolic and hormonal changes through epigenetic mechanisms like DNA methylation and histone modification, enhancing the risk of T2D later in life. Specific genes involved in insulin production and secretion like INS and PPARGC1A show changes in DNA methylation and histone markers in pancreatic cells and tissues of T2D patients. Factors like obesity, diet, exercise and aging can also influence epigenetic changes linked to T2D risk and complications through various mechanisms. While research is still ongoing, epigenetics appears to play an important part in the development and pathology of
WHMS PGx Presentation
This document discusses the importance and benefits of pharmacogenetic testing for physicians and their patients. It notes that pharmacogenetic testing can help physicians determine the right drug, dose, and timing for each individual patient to reduce adverse drug reactions and improve outcomes. Not utilizing this testing could open physicians up to legal liability issues. The document provides several case studies demonstrating how pharmacogenetic testing could have helped identify the right treatment for patients and avoided negative health consequences or legal risks for physicians. It also addresses the ease of testing, billing, and reimbursement to make the case for integrating pharmacogenetics into medical practice.
Recommended
CDD Seminar Presentation-JaeminLee
This document summarizes a study on the role of monoacyl glycerol lipase (MGL) in breast cancer proliferation. MGL degrades the endocannabinoid 2-AG, which inhibits cell proliferation when bound to cannabinoid receptors. The study found that inhibiting MGL in breast epithelial cells led to decreased phosphorylation of epidermal growth factor receptor (EGFR) and vascular endothelial growth factor (VEGF) secretion, both of which promote proliferation. This suggests inhibiting MGL may be a potential anti-breast cancer therapy by reducing EGFR and VEGF signaling and subsequent proliferation.
Pharmaceurtical role of nucleic acid
Nucleic acids have important pharmaceutical roles in treating cancer, cardiovascular, and autoimmune diseases. There are several approaches to gene therapy including inserting a normal gene to compensate for a nonfunctional one, changing gene regulation, or inserting an abnormal gene for normal function. Gene therapy can be somatic, affecting only the patient, or germline, passing genetic changes to offspring. It faces challenges like short-lived effects, potential immune responses, and difficulties treating multi-gene disorders. Successful gene therapy requires understanding disease processes, gene structure/function, efficient delivery methods, and control of expression and immune responses.
PPT Monoclonal antibodies in Endocrinology
Monoclonal antibodies (MABs) have various applications in endocrinology. MABs are used in immunoassays to detect hormones and proteins. They can also be radiolabeled for diagnostic imaging techniques. Therapeutically, burosumab treats X-linked hypophosphatemic rickets by targeting FGF-23. Romosozumab increases bone mineral density by inhibiting sclerostin. Teprotumumab treats thyroid eye disease. Alirocumab and evolocumab lower cholesterol by inhibiting PCSK9. Side effects of immune checkpoint inhibitors include hypophysitis due to removal of CTLA-4 mediated immune tolerance. Cases of type 1 diabetes have also been reported following anti
Recent advances in migraine management
Ubrogepant, erenumab, fremanezumab, and galcanezumab are monoclonal antibodies that target CGRP for the treatment of migraines. Ubrogepant is approved for acute treatment while the others are approved for prevention. Clinical trials showed they significantly reduced monthly migraine days compared to placebo. Common side effects include pain or redness at the injection site. They were approved by the FDA between 2018-2019 and cost approximately $6,000-7,000 per year.
Anti angiogenic activity of Annona muricata (guyabano) versus paclitaxel and ...
Anti angiogenic activity of Annona muricata (guyabano) versus paclitaxel and ...Mary Ondinee Manalo Igot
This study aimed to compare the antiangiogenic activity of guyabano compared with bevacizumab and paclitaxel, which are among the most common agents known to target angiogenesis in cancer patients.
Gene Therapy
Gene therapy is an experimental technique that uses genes to treat or prevent disease. There are two types of gene therapy - somatic gene therapy, which treats cells of the body but not reproductive cells, and germline gene therapy, which treats reproductive cells and can be passed to future generations. There are several techniques for gene therapy including gene augmentation therapy, which adds a functional gene to replace a non-functioning one; gene inhibition therapy, which inhibits or interferes with a disease-causing gene; and gene killing therapy, which inserts a "suicide gene" to kill specific diseased cells. A key challenge is safely delivering the new gene to the right cells and ensuring it is expressed without disrupting other genes or triggering
Epigenetics and type 2 diabetes
This document discusses the role of epigenetics in type 2 diabetes (T2D). It describes how environmental factors like undernutrition can induce chronic metabolic and hormonal changes through epigenetic mechanisms like DNA methylation and histone modification, enhancing the risk of T2D later in life. Specific genes involved in insulin production and secretion like INS and PPARGC1A show changes in DNA methylation and histone markers in pancreatic cells and tissues of T2D patients. Factors like obesity, diet, exercise and aging can also influence epigenetic changes linked to T2D risk and complications through various mechanisms. While research is still ongoing, epigenetics appears to play an important part in the development and pathology of
WHMS PGx Presentation
This document discusses the importance and benefits of pharmacogenetic testing for physicians and their patients. It notes that pharmacogenetic testing can help physicians determine the right drug, dose, and timing for each individual patient to reduce adverse drug reactions and improve outcomes. Not utilizing this testing could open physicians up to legal liability issues. The document provides several case studies demonstrating how pharmacogenetic testing could have helped identify the right treatment for patients and avoided negative health consequences or legal risks for physicians. It also addresses the ease of testing, billing, and reimbursement to make the case for integrating pharmacogenetics into medical practice.
Dna repair sara castrillon
The DNA repair mechanism plays an important role in maintaining DNA fidelity and avoiding lesions and mutations. The XPD protein functions like a scanner that travels along the DNA double helix, searching for signs of damage. When it finds damage, XPD stops and marks the DNA because the cell needs to fix it. This protein may be a solution for improving cancer treatments by helping researchers identify specific ways to use chemotherapy while decreasing risks and increasing patient survival. The KLF8 protein determines the possibility of tumor recurrence in breast and ovarian cancers by helping tumors regenerate, so stopping KLF8 could improve outcomes for many women with those cancers.
Targeted therapy in breast cancer
This document discusses targeted therapy for breast cancer. It begins by providing background on declining mortality rates for breast cancer over time. It then discusses how cancers develop multiple alterations that allow uncontrolled growth and outlines six essential alterations in cell physiology that contribute to malignancy. The document discusses molecular alterations that occur in breast cancer progression. It defines targeted therapy as drugs that target uniquely disrupted pathways in cancer cells. The document outlines several targeted therapies for breast cancer including hormonal therapies like tamoxifen, aromatase inhibitors, and fulvestrant. It discusses clinical trials demonstrating the benefits of these therapies. It also discusses therapies that target the HER2 receptor like trastuzumab and lapatinib. In summary, the document provides an overview of targeted
Methotrexate in treatment of rheumatoid arthritis
Methotrexate is considered the first-line treatment for rheumatoid arthritis and has been used to treat the disease since the 1980s. It works by reducing inflammation and immune system activity. While its exact mechanism is unknown, it likely involves effects on T cells, B cells, and cytokines like TNF-α, IL-6, and IL-1. Common side effects include liver and kidney toxicity. Future research seeks to develop targeted drug delivery methods to increase effectiveness and reduce side effects. Methotrexate remains a cornerstone therapy for rheumatoid arthritis treatment.
NCG poster BSH-ISH March 2016
We investigated whether thiamine deficiency was common in myeloproliferative neoplasms (MPN) and associated with different therapies. We measured thiamine levels in 92 MPN patients and correlated the results with disease subtypes and treatments. The median thiamine level was within normal range and showed no correlation with MPN subtype or treatment, including ruxolitinib. Thiamine deficiency does not appear to be a common problem in UK MPN patients. This suggests that thiamine deficiency leading to Wernicke's encephalopathy seen in patients treated with fedratinib was likely directly related to that drug.
Glut1 Abstract
This study investigated the efficacy of diazepam (DZP) and phenobarbital (PB) in terminating convulsive status epilepticus (CSE) in a mouse model of glucose transporter type 1 deficiency (G1D) syndrome. The researchers found that G1D mice were more susceptible to CSE induced by pilocarpine and less responsive to DZP and PB treatment compared to wild-type mice. Specifically, early treatment with DZP or PB stopped CSE in fewer G1D mice, and late treatment was ineffective. This suggests that drugs used to treat CSE, which inhibit glucose transporter function, may negatively impact outcomes for G1D patients experiencing CSE by exacerbating metabolic
Ppt ACC follow up
This presentation deals with the Endocrine aspects of following up in a case of ACC. It also a special mention about Mitotane.
Michael hutchinson - Natalizumab therapy for MS - 2009
Natalizumab is a monoclonal antibody approved for the treatment of relapsing-remitting multiple sclerosis. It works by blocking the alpha-4 integrin and preventing immune cells from migrating across the blood-brain barrier. Clinical trials showed it significantly reduced relapse rates and disability progression compared to placebo. However, it carries a risk of progressive multifocal leukoencephalopathy due to reactivation of the JC virus in some patients, especially after over 24 infusions. Careful monitoring is required for patients receiving natalizumab therapy.
Irm
This document discusses various topics related to immunosuppressive drugs used in renal transplantation. It begins by reviewing mTOR inhibitors used in combination with calcineurin inhibitors, noting their synergistic effect. It then discusses a study finding lower rates of discontinuation and better graft function with mTORi-CNI compared to MMF/MPA-CNI. Finally, it briefly touches on induction immunosuppression methods, tolerance without immunosuppression, and withdrawal of steroids and calcineurin inhibitors.
Genetic and epigenetic biomarkers for therapeutic monitoring in neurological ...
Seminar held on Genetic and epigenetic biomarkers for therapeutic monitoring in neurological disorders.
Multiple Sclerosis, Alzheimer's Disease and Parkinson's Disease.
Biomarkers and epigenetic explained. New epigenetic drug targets.
Hipoglucemia post by pass gástrico
The document discusses hypoglycemia after gastric bypass surgery and various potential mechanisms and treatments. It notes a 0.2% incidence of hypoglycemia-related hospital admissions after gastric bypass. Various molecular mechanisms are proposed for how gastric bypass could lead to hypoglycemia, including increased insulin secretion and sensitivity as well as persistent beta cell mass expansion. The document outlines medical and surgical treatment options for hypoglycemia, including dietary changes, medications, increasing restriction or reversing the bypass, and pancreatectomy as a last resort.
TKI discontinuation in CML
1) Several studies have evaluated discontinuing tyrosine kinase inhibitor (TKI) treatment in chronic myeloid leukemia patients who have achieved a deep molecular response.
2) These studies found that 40-60% of patients were able to remain in treatment-free remission for varying periods of time after stopping TKI treatment.
3) Sustaining a complete molecular response for at least 2 years before discontinuing treatment appears important for treatment-free remission success rates. Close molecular monitoring after stopping treatment is also needed.
Cellular Therapy for multiple myeloma
This document summarizes cellular therapy approaches for multiple myeloma, including:
1) Allogeneic stem cell transplantation can exploit the graft-versus-myeloma effect but is associated with transplant-related mortality; reduced intensity conditioning regimens may improve outcomes.
2) Vaccine strategies targeting antigens like MAGE and idiotype have shown safety and immune responses in clinical trials but limited clinical responses so far.
3) Adoptive transfer of chimeric antigen receptor (CAR) T cells and natural killer (NK) cells show pre-clinical activity against myeloma and are being tested in early clinical trials.
4) Ex-vivo expanded cord blood NK cells are being tested in a clinical
Medicine journal updates
There was no significant difference in efficacy or side effects between clindamycin and tmp-smx for treating children and adults. Canagliflozin added to insulin improved glycemic control and decreased weight but increased genital infections and UTIs. A difference of over 10 mmHg in inter-arm blood pressure is linked to greater risk of future cardiovascular events.
10.29.07 Coumadin P Gx Jonas
The document discusses using genetic testing to guide warfarin therapy. It explains that genetic polymorphisms affect individuals' responses to medications like warfarin. Variants in CYP2C9 and VKORC1 genes influence warfarin dosing, with clinical trials showing genotype-guided dosing results in faster stabilization of anticoagulation and less risk of bleeding events. The author proposes a study at UNC to incorporate pharmacogenomic guidance in initial warfarin dosing to improve outcomes.
Plegable biologia molecular Maria Isabel Perez Palacio
The documents discuss two scientific studies:
1) A study found an enzyme in E. coli, called UvrD, that allows RNA polymerase to backtrack along DNA to expose errors, enabling DNA repair. A similar human repair mechanism involves the XPB protein. Understanding these mechanisms could help treat diseases caused by DNA mutations.
2) A study showed that the genetic disease myotonic dystrophy disrupts the MEF2 transcription factor, affecting microRNAs and other genes, particularly in heart tissue. MicroRNAs help regulate protein expression. Understanding microRNA involvement could help minimize myotonic dystrophy symptoms and improve patient quality of life.
Diabetic retinopathy
A physician's perspective on the importance of diagnosing, prognosing and treating diabetic retinopathy
Recherche translationnelle et maladies métaboliques - Philippe FROGUEL - Renc...
The document discusses the lack of personalized treatment approaches for diabetes over the past 30+ years and the potential for genetic sequencing and stem cell technologies to enable truly personalized diabetic care. Specifically:
- Currently, all diabetics receive metformin initially, but there are no agreed guidelines for alternative treatments if metformin fails.
- Recent advances in genetic sequencing allow for better characterization of familial diabetes cases and improved management.
- Sequencing the genome and using reprogrammed stem cells can help advance toward personalized diabetic medicine and understanding disease complications at the individual level.
Presentation on Gene Therapy for Cardiovascular Diseases.pptx
This document discusses how gene therapy can be used to treat cardiovascular diseases by replacing defective genes. It then focuses on three commonly prescribed cardiovascular drugs - statins, clopidogrel, and coumarin derivatives - and how patient responses to these drugs can vary due to genetic factors. Specifically, it describes genes like SLCO1B1, CYP2C19, CYP2C9, and VKORC1 that influence how effectively the body metabolizes and makes use of these drugs. Understanding a patient's genetic profile could allow doctors to select the most appropriate drug or dosage for that individual to maximize efficacy and safety.
UKPDS
1) The UKPDS trial compared intensive blood glucose control using sulfonylureas or insulin to conventional treatment in over 3,800 patients with newly diagnosed type 2 diabetes over 10 years.
2) Intensive treatment lowered A1C more but did not reduce macrovascular complications like heart disease. It did reduce microvascular complications like eye and kidney disease.
3) Intensive treatment was associated with more hypoglycemia.
Ndei Beta Cell Slide Kit Insulin Secretion
The document discusses beta cell dysfunction and failure in type 2 diabetes. It begins by presenting hypothetical relationships that determine glucose tolerance categories. It then discusses how beta cell adaptation and failure leads to the progression from normal glucose tolerance to impaired glucose tolerance to type 2 diabetes. The document also examines the progressive loss of beta cell function over time as type 2 diabetes develops and worsens.
Molecular basis of diabetes
This document discusses the molecular basis of diabetes. It begins by outlining worldwide trends showing increasing prevalence of diabetes. It then describes the main types of diabetes - type 1 resulting from autoimmune destruction of beta cells and type 2 from insulin resistance and relative beta cell dysfunction. Genetic and environmental factors contribute to both types. Later sections discuss specific genes involved like those coding for insulin, insulin receptor, and genes associated with maturity onset diabetes of young (MODY). The document outlines in detail the molecular mechanisms and genetic factors involved in various forms of diabetes.
RSSDI
Debate at RSSDI Cochin, 2010 on " Insulin should be the first drug in type 2 diabetes" . I spoke against the motion.
More Related Content
What's hot
Dna repair sara castrillon
The DNA repair mechanism plays an important role in maintaining DNA fidelity and avoiding lesions and mutations. The XPD protein functions like a scanner that travels along the DNA double helix, searching for signs of damage. When it finds damage, XPD stops and marks the DNA because the cell needs to fix it. This protein may be a solution for improving cancer treatments by helping researchers identify specific ways to use chemotherapy while decreasing risks and increasing patient survival. The KLF8 protein determines the possibility of tumor recurrence in breast and ovarian cancers by helping tumors regenerate, so stopping KLF8 could improve outcomes for many women with those cancers.
Targeted therapy in breast cancer
This document discusses targeted therapy for breast cancer. It begins by providing background on declining mortality rates for breast cancer over time. It then discusses how cancers develop multiple alterations that allow uncontrolled growth and outlines six essential alterations in cell physiology that contribute to malignancy. The document discusses molecular alterations that occur in breast cancer progression. It defines targeted therapy as drugs that target uniquely disrupted pathways in cancer cells. The document outlines several targeted therapies for breast cancer including hormonal therapies like tamoxifen, aromatase inhibitors, and fulvestrant. It discusses clinical trials demonstrating the benefits of these therapies. It also discusses therapies that target the HER2 receptor like trastuzumab and lapatinib. In summary, the document provides an overview of targeted
Methotrexate in treatment of rheumatoid arthritis
Methotrexate is considered the first-line treatment for rheumatoid arthritis and has been used to treat the disease since the 1980s. It works by reducing inflammation and immune system activity. While its exact mechanism is unknown, it likely involves effects on T cells, B cells, and cytokines like TNF-α, IL-6, and IL-1. Common side effects include liver and kidney toxicity. Future research seeks to develop targeted drug delivery methods to increase effectiveness and reduce side effects. Methotrexate remains a cornerstone therapy for rheumatoid arthritis treatment.
NCG poster BSH-ISH March 2016
We investigated whether thiamine deficiency was common in myeloproliferative neoplasms (MPN) and associated with different therapies. We measured thiamine levels in 92 MPN patients and correlated the results with disease subtypes and treatments. The median thiamine level was within normal range and showed no correlation with MPN subtype or treatment, including ruxolitinib. Thiamine deficiency does not appear to be a common problem in UK MPN patients. This suggests that thiamine deficiency leading to Wernicke's encephalopathy seen in patients treated with fedratinib was likely directly related to that drug.
Glut1 Abstract
This study investigated the efficacy of diazepam (DZP) and phenobarbital (PB) in terminating convulsive status epilepticus (CSE) in a mouse model of glucose transporter type 1 deficiency (G1D) syndrome. The researchers found that G1D mice were more susceptible to CSE induced by pilocarpine and less responsive to DZP and PB treatment compared to wild-type mice. Specifically, early treatment with DZP or PB stopped CSE in fewer G1D mice, and late treatment was ineffective. This suggests that drugs used to treat CSE, which inhibit glucose transporter function, may negatively impact outcomes for G1D patients experiencing CSE by exacerbating metabolic
Ppt ACC follow up
This presentation deals with the Endocrine aspects of following up in a case of ACC. It also a special mention about Mitotane.
Michael hutchinson - Natalizumab therapy for MS - 2009
Natalizumab is a monoclonal antibody approved for the treatment of relapsing-remitting multiple sclerosis. It works by blocking the alpha-4 integrin and preventing immune cells from migrating across the blood-brain barrier. Clinical trials showed it significantly reduced relapse rates and disability progression compared to placebo. However, it carries a risk of progressive multifocal leukoencephalopathy due to reactivation of the JC virus in some patients, especially after over 24 infusions. Careful monitoring is required for patients receiving natalizumab therapy.
Irm
This document discusses various topics related to immunosuppressive drugs used in renal transplantation. It begins by reviewing mTOR inhibitors used in combination with calcineurin inhibitors, noting their synergistic effect. It then discusses a study finding lower rates of discontinuation and better graft function with mTORi-CNI compared to MMF/MPA-CNI. Finally, it briefly touches on induction immunosuppression methods, tolerance without immunosuppression, and withdrawal of steroids and calcineurin inhibitors.
Genetic and epigenetic biomarkers for therapeutic monitoring in neurological ...
Seminar held on Genetic and epigenetic biomarkers for therapeutic monitoring in neurological disorders.
Multiple Sclerosis, Alzheimer's Disease and Parkinson's Disease.
Biomarkers and epigenetic explained. New epigenetic drug targets.
Hipoglucemia post by pass gástrico
The document discusses hypoglycemia after gastric bypass surgery and various potential mechanisms and treatments. It notes a 0.2% incidence of hypoglycemia-related hospital admissions after gastric bypass. Various molecular mechanisms are proposed for how gastric bypass could lead to hypoglycemia, including increased insulin secretion and sensitivity as well as persistent beta cell mass expansion. The document outlines medical and surgical treatment options for hypoglycemia, including dietary changes, medications, increasing restriction or reversing the bypass, and pancreatectomy as a last resort.
TKI discontinuation in CML
1) Several studies have evaluated discontinuing tyrosine kinase inhibitor (TKI) treatment in chronic myeloid leukemia patients who have achieved a deep molecular response.
2) These studies found that 40-60% of patients were able to remain in treatment-free remission for varying periods of time after stopping TKI treatment.
3) Sustaining a complete molecular response for at least 2 years before discontinuing treatment appears important for treatment-free remission success rates. Close molecular monitoring after stopping treatment is also needed.
Cellular Therapy for multiple myeloma
This document summarizes cellular therapy approaches for multiple myeloma, including:
1) Allogeneic stem cell transplantation can exploit the graft-versus-myeloma effect but is associated with transplant-related mortality; reduced intensity conditioning regimens may improve outcomes.
2) Vaccine strategies targeting antigens like MAGE and idiotype have shown safety and immune responses in clinical trials but limited clinical responses so far.
3) Adoptive transfer of chimeric antigen receptor (CAR) T cells and natural killer (NK) cells show pre-clinical activity against myeloma and are being tested in early clinical trials.
4) Ex-vivo expanded cord blood NK cells are being tested in a clinical
Medicine journal updates
There was no significant difference in efficacy or side effects between clindamycin and tmp-smx for treating children and adults. Canagliflozin added to insulin improved glycemic control and decreased weight but increased genital infections and UTIs. A difference of over 10 mmHg in inter-arm blood pressure is linked to greater risk of future cardiovascular events.
10.29.07 Coumadin P Gx Jonas
The document discusses using genetic testing to guide warfarin therapy. It explains that genetic polymorphisms affect individuals' responses to medications like warfarin. Variants in CYP2C9 and VKORC1 genes influence warfarin dosing, with clinical trials showing genotype-guided dosing results in faster stabilization of anticoagulation and less risk of bleeding events. The author proposes a study at UNC to incorporate pharmacogenomic guidance in initial warfarin dosing to improve outcomes.
Plegable biologia molecular Maria Isabel Perez Palacio
The documents discuss two scientific studies:
1) A study found an enzyme in E. coli, called UvrD, that allows RNA polymerase to backtrack along DNA to expose errors, enabling DNA repair. A similar human repair mechanism involves the XPB protein. Understanding these mechanisms could help treat diseases caused by DNA mutations.
2) A study showed that the genetic disease myotonic dystrophy disrupts the MEF2 transcription factor, affecting microRNAs and other genes, particularly in heart tissue. MicroRNAs help regulate protein expression. Understanding microRNA involvement could help minimize myotonic dystrophy symptoms and improve patient quality of life.
What's hot (15)
Michael hutchinson - Natalizumab therapy for MS - 2009
Michael hutchinson - Natalizumab therapy for MS - 2009
Genetic and epigenetic biomarkers for therapeutic monitoring in neurological ...
Genetic and epigenetic biomarkers for therapeutic monitoring in neurological ...
Plegable biologia molecular Maria Isabel Perez Palacio
Plegable biologia molecular Maria Isabel Perez Palacio
Similar to RRC 2011 : Pharmacogénétique et médecine personnalisée du diabète
Diabetic retinopathy
A physician's perspective on the importance of diagnosing, prognosing and treating diabetic retinopathy
Recherche translationnelle et maladies métaboliques - Philippe FROGUEL - Renc...
The document discusses the lack of personalized treatment approaches for diabetes over the past 30+ years and the potential for genetic sequencing and stem cell technologies to enable truly personalized diabetic care. Specifically:
- Currently, all diabetics receive metformin initially, but there are no agreed guidelines for alternative treatments if metformin fails.
- Recent advances in genetic sequencing allow for better characterization of familial diabetes cases and improved management.
- Sequencing the genome and using reprogrammed stem cells can help advance toward personalized diabetic medicine and understanding disease complications at the individual level.
Presentation on Gene Therapy for Cardiovascular Diseases.pptx
This document discusses how gene therapy can be used to treat cardiovascular diseases by replacing defective genes. It then focuses on three commonly prescribed cardiovascular drugs - statins, clopidogrel, and coumarin derivatives - and how patient responses to these drugs can vary due to genetic factors. Specifically, it describes genes like SLCO1B1, CYP2C19, CYP2C9, and VKORC1 that influence how effectively the body metabolizes and makes use of these drugs. Understanding a patient's genetic profile could allow doctors to select the most appropriate drug or dosage for that individual to maximize efficacy and safety.
UKPDS
1) The UKPDS trial compared intensive blood glucose control using sulfonylureas or insulin to conventional treatment in over 3,800 patients with newly diagnosed type 2 diabetes over 10 years.
2) Intensive treatment lowered A1C more but did not reduce macrovascular complications like heart disease. It did reduce microvascular complications like eye and kidney disease.
3) Intensive treatment was associated with more hypoglycemia.
Ndei Beta Cell Slide Kit Insulin Secretion
The document discusses beta cell dysfunction and failure in type 2 diabetes. It begins by presenting hypothetical relationships that determine glucose tolerance categories. It then discusses how beta cell adaptation and failure leads to the progression from normal glucose tolerance to impaired glucose tolerance to type 2 diabetes. The document also examines the progressive loss of beta cell function over time as type 2 diabetes develops and worsens.
Molecular basis of diabetes
This document discusses the molecular basis of diabetes. It begins by outlining worldwide trends showing increasing prevalence of diabetes. It then describes the main types of diabetes - type 1 resulting from autoimmune destruction of beta cells and type 2 from insulin resistance and relative beta cell dysfunction. Genetic and environmental factors contribute to both types. Later sections discuss specific genes involved like those coding for insulin, insulin receptor, and genes associated with maturity onset diabetes of young (MODY). The document outlines in detail the molecular mechanisms and genetic factors involved in various forms of diabetes.
RSSDI
Debate at RSSDI Cochin, 2010 on " Insulin should be the first drug in type 2 diabetes" . I spoke against the motion.
Should all diabetics with TB be on insulin?
1. Rifampicin, a potent inducer of cytochrome P450, lowers the levels of sulfonylureas and metformin, requiring increased doses of these oral hypoglycemic agents.
2. Diabetics with tuberculosis have impaired immune function and pulmonary dysfunction, worsening tuberculosis infection and treatment outcomes. Tight glycemic control is important.
3. Insulin is preferable to oral agents for treating diabetes in tuberculosis due to drug interactions and the need for tight glycemic control through diet. Indications for insulin include severe or uncontrolled diabetes, contraindications for oral agents, and during tuberculosis treatment.
Membranous Nephropathy
Membranous nephropathy is a common cause of nephrotic syndrome in adults. It has variable natural history, with about 1/3 of patients achieving spontaneous remission, 1/3 having persistent proteinuria but stable renal function, and 1/3 progressing to end-stage renal disease over 5-10 years. Several factors predict poorer prognosis, including older age, nephrotic syndrome, lower serum albumin and higher proteinuria levels. Studies show immunosuppressive therapy may alter the natural history for patients at high risk of progression, but risks of treatment must be weighed against the likelihood of spontaneous remission.
Pharmacogenomics in Cardiovascular Diseases
- Pharmacogenomics uses genetic information to guide treatment for cardiovascular diseases. Variations in genes like SLCO1B1, CYP2C19, and VKORC1 influence patient responses to common cardiovascular drugs like statins, clopidogrel, and coumarins. Testing for these genetic biomarkers can optimize drug therapy, reducing adverse effects and improving outcomes. Considering a patient's genetic profile may help select the most effective statin or coumarin dosage and avoid less effective clopidogrel treatment. Pharmacogenomics holds promise for more personalized medicine that cures disease while minimizing health risks.
TKI Resistance Mechanisms in Chronic Myeloid Leukemia(CML)
The Mechanisms of TKI Resistance in CML.
BCR-ABL dependent and Independent mechanisms.
Newer therapies for TKI resistant CML.
ELN 2020 recommendations
Role of early basal insulin initiation of t2 dm
1) The document discusses guidelines for initiating basal insulin therapy in patients with type 2 diabetes, including benefits such as lowering HbA1c and reducing cardiovascular risk.
2) It compares different basal insulin options like glargine, detemir, and NPH insulin, finding that the long-acting analogs glargine and detemir have advantages like lower rates of hypoglycemia and weight gain compared to NPH.
3) Studies show that early initiation of basal insulin can help preserve beta-cell function and provide better long-term glycemic control for patients with type 2 diabetes.
Role of early basal insulin initiation of t2 dm
This document discusses the benefits of early initiation of basal insulin in managing type 2 diabetes. It recommends starting with low doses of long-acting basal insulin, which can help lower HbA1c and reduce complications by providing consistent insulin levels throughout the day. Basal insulin is preferred over premix insulins when first adding insulin. Clinical guidelines support initiating basal insulin when oral medications fail to control blood sugar levels. Studies show basal insulin improves beta-cell function and glycemic control long-term compared to late insulin initiation.
3. DM.pptx
This document provides an overview of diabetes mellitus (DM), including the different types of DM, pathophysiology, clinical presentation, diagnosis, treatment goals, and pharmacotherapy options. It discusses type 1 DM, type 2 DM, and gestational diabetes. For type 2 DM, it outlines non-pharmacologic treatment including lifestyle changes and describes pharmacologic options including metformin, sulfonylureas, and insulin therapy. The goals of treatment for type 2 DM are also summarized.
UKPDS overview
The UK Prospective Diabetes Study was a 20-year multicenter randomized controlled trial that investigated the effects of intensive glucose control and tight blood pressure control on diabetes complications. Over 5,000 patients with newly diagnosed type 2 diabetes were recruited between 1977-1991 and followed for a median of 10 years. The study found that intensive glucose control reduced the risk of diabetes complications, particularly microvascular complications, by 10-25%. The blood pressure control study found that tight blood pressure control reduced the risk of diabetes-related endpoints by 24% and strokes by 44% compared to less tight control.
A Glimpse at Precision Medicine in AML.
Precision medicine is a rapidly growing field of medicine that proposes individually customized diagnostics and therapeutics based upon molecular and genetic profile of individual patients. The main goal of precision medicine is to minimize harmful side effects and maximize benefits. In particular, hematological malignancies were seen as the most direct candidates of the most promising applications of precision medicine. However, Precision medicine approaches face multiple challenges. Despite these challenges and limitations, continuous effort is carried out to use these molecular findings as disease biomarkers and targets for therapeutic intervention. In the last decade the hemato-oncology witnessed a major revolution in the understanding of the molecular pathogenesis of hematological malignancies. While the therapeutic research for hematologic malignancies is continuously expanding, some medicines have been approved in hematological malignancies patients’ therapeutic algorithm and many are still under investigation.
Membranous Nephropathy
This document summarizes a nephrology morning session on membranous nephropathy. Membranous nephropathy is one of the most common causes of nephrotic syndrome in adults, accounting for about 1/3 of biopsy diagnoses. It can be idiopathic or secondary. The main clinical features are nephrotic syndrome with preserved kidney function. Treatment involves non-immunosuppressive measures like ACE inhibitors and immunosuppressive regimens like the Ponticelli regimen for patients meeting certain criteria. The prognosis depends on achieving remission, with about 1/3 of patients achieving remission, 1/3 continuing heavy proteinuria, and 1/3 progressing
Pathophysiology and Classification of diabetes by Dr Selim
Pathophysiology and Classification of diabetes by Dr SelimBangabandhu Sheikh Mujib Medical University
This document discusses diabetes mellitus (DM), including its definition, etiology, pathogenesis, classification, clinical manifestations, and complications. DM is defined as a chronic condition of hyperglycemia resulting from defects in insulin secretion or insulin action. It discusses the two main types of DM - type 1 characterized by pancreatic beta cell destruction and absolute insulin deficiency, and type 2 characterized by insulin resistance and relative insulin deficiency. The document outlines the clinical differences between the two types and describes the potential complications affecting multiple organ systems that can develop from long-term hyperglycemia if DM is not adequately controlled.Targeted therapy for Hodgkin’s Lymphoma
Larry W. Kwak discusses ongoing research for targeted therapy of Hodgkin's lymphoma. The goals are to [1] improve remission rates and decrease risk of death, [2] minimize side effects and maintain or prolong remissions, and [3] develop additional options for relapsed or refractory disease. Research is exploring targeted agents like HDAC inhibitors, OX40 receptor ligation, and oral panobinostat to alter the tumor microenvironment and induce apoptosis. Brentuximab vedotin, an anti-CD30 antibody-drug conjugate, has shown durable responses in refractory Hodgkin's lymphoma with manageable toxicity. Introduction of targeted therapies into frontline treatment, such as brentuxim
Targeted therapy for Hodgkin’s Lymphoma
Larry W. Kwak discusses ongoing research goals and therapeutic options for Hodgkin's lymphoma, including improving remission rates and minimizing side effects. He describes targeted therapies under investigation, such as deacetylase inhibitors that induce cell cycle arrest and apoptosis as well as alter the tumor microenvironment. Kwak also discusses the use of oral HDAC inhibitors like mocetinostat, which have shown clinical activity in Hodgkin's lymphoma. Finally, he examines the efficacy of the antibody-drug conjugate brentuximab vedotin in treating relapsed and refractory Hodgkin's lymphoma.
Similar to RRC 2011 : Pharmacogénétique et médecine personnalisée du diabète (20)
Recherche translationnelle et maladies métaboliques - Philippe FROGUEL - Renc...
Recherche translationnelle et maladies métaboliques - Philippe FROGUEL - Renc...
Presentation on Gene Therapy for Cardiovascular Diseases.pptx
Presentation on Gene Therapy for Cardiovascular Diseases.pptx
TKI Resistance Mechanisms in Chronic Myeloid Leukemia(CML)
TKI Resistance Mechanisms in Chronic Myeloid Leukemia(CML)
Pathophysiology and Classification of diabetes by Dr Selim
Pathophysiology and Classification of diabetes by Dr Selim
More from EuroHealthNet
Pdf_atelier mobile_health_pharmasuccess
The document discusses the benefits of exercise for mental health. Regular physical activity can help reduce anxiety and depression and improve mood and cognitive functioning. Exercise causes chemical changes in the brain that may help protect against developing mental illness and improve symptoms for those who already have a condition.
Netvibes user guide
This document provides an overview of the Netvibes dashboard platform, including descriptions of key features like dashboards, widgets, contacts, activities, and customization settings. It covers the sign up and account management process, and explains how to add and organize content on the dashboard using drag and drop. Sections are also dedicated to public dashboards, the widget viewing interface, and keyboard shortcuts.
Atelier 2 : Essais cliniques internationaux quels sont les facteurs clés de s...
This document summarizes information about Merck & Co., a large pharmaceutical company, and RPS, a clinical research organization. It discusses Merck's revenues, R&D investments, therapeutic areas, and a merger in 2009. It then provides details about RPS's history, operations in 45 countries, and growth. The remainder discusses changes in pharmaceutical R&D and outsourcing strategies, differences in conducting global versus local clinical trials, and key factors for successful international monitoring.
More from EuroHealthNet (20)
RRC 2011 : Recherche clinique et Maladie d'Alzheimer
RRC 2011 : Recherche clinique et Maladie d'Alzheimer
Atelier 3 : Être ARC industriel en 2011 : quelles évolutions des profils de f...
Atelier 3 : Être ARC industriel en 2011 : quelles évolutions des profils de f...
Atelier 2 : Essais cliniques internationaux quels sont les facteurs clés de s...
Atelier 2 : Essais cliniques internationaux quels sont les facteurs clés de s...
Atelier 1: Le moniteur acteur clé de la qualité. Focus sur AQ audits et inspe...
Atelier 1: Le moniteur acteur clé de la qualité. Focus sur AQ audits et inspe...
Recently uploaded
#cALL# #gIRLS# In Dehradun ꧁❤8107221448❤꧂#cALL# #gIRLS# Service In Dehradun W...
#cALL# #gIRLS# In Dehradun ꧁❤8107221448❤꧂#cALL# #gIRLS# Service In Dehradun W...chandankumarsmartiso
#cALL# #gIRLS# In Dehradun ꧁❤8107221448❤꧂#cALL# #gIRLS# Service In Dehradun Women Seeking Service
The Best Ayurvedic Antacid Tablets in India
Treat the symptoms of indigestion, heartburn and stomach reflux with the 10 Best Ayurvedic Antacid Tablets in India.
TEST BANK For Community Health Nursing A Canadian Perspective, 5th Edition by...
TEST BANK For Community Health Nursing A Canadian Perspective, 5th Edition by Stamler, Verified Chapters 1 - 33, Complete Newest Version Community Health Nursing A Canadian Perspective, 5th Edition by Stamler, Verified Chapters 1 - 33, Complete Newest Version Community Health Nursing A Canadian Perspective, 5th Edition by Stamler Community Health Nursing A Canadian Perspective, 5th Edition TEST BANK by Stamler Test Bank For Community Health Nursing A Canadian Perspective, 5th Edition Pdf Chapters Download Test Bank For Community Health Nursing A Canadian Perspective, 5th Edition Pdf Download Stuvia Test Bank For Community Health Nursing A Canadian Perspective, 5th Edition Study Guide Test Bank For Community Health Nursing A Canadian Perspective, 5th Edition Ebook Download Stuvia Test Bank For Community Health Nursing A Canadian Perspective, 5th Edition Questions and Answers Quizlet Test Bank For Community Health Nursing A Canadian Perspective, 5th Edition Studocu Test Bank For Community Health Nursing A Canadian Perspective, 5th Edition Quizlet Test Bank For Community Health Nursing A Canadian Perspective, 5th Edition Stuvia Community Health Nursing A Canadian Perspective, 5th Edition Pdf Chapters Download Community Health Nursing A Canadian Perspective, 5th Edition Pdf Download Course Hero Community Health Nursing A Canadian Perspective, 5th Edition Answers Quizlet Community Health Nursing A Canadian Perspective, 5th Edition Ebook Download Course hero Community Health Nursing A Canadian Perspective, 5th Edition Questions and Answers Community Health Nursing A Canadian Perspective, 5th Edition Studocu Community Health Nursing A Canadian Perspective, 5th Edition Quizlet Community Health Nursing A Canadian Perspective, 5th Edition Stuvia Community Health Nursing A Canadian Perspective, 5th Edition Test Bank Pdf Chapters Download Community Health Nursing A Canadian Perspective, 5th Edition Test Bank Pdf Download Stuvia Community Health Nursing A Canadian Perspective, 5th Edition Test Bank Study Guide Questions and Answers Community Health Nursing A Canadian Perspective, 5th Edition Test Bank Ebook Download Stuvia Community Health Nursing A Canadian Perspective, 5th Edition Test Bank Questions Quizlet Community Health Nursing A Canadian Perspective, 5th Edition Test Bank Studocu Community Health Nursing A Canadian Perspective, 5th Edition Test Bank Quizlet Community Health Nursing A Canadian Perspective, 5th Edition Test Bank Stuvia
share - Lions, tigers, AI and health misinformation, oh my!.pptx
• Pitfalls and pivots needed to use AI effectively in public health
• Evidence-based strategies to address health misinformation effectively
• Building trust with communities online and offline
• Equipping health professionals to address questions, concerns and health misinformation
• Assessing risk and mitigating harm from adverse health narratives in communities, health workforce and health system
Histololgy of Female Reproductive System.pptx
Dive into an in-depth exploration of the histological structure of female reproductive system with this comprehensive lecture. Presented by Dr. Ayesha Irfan, Assistant Professor of Anatomy, this presentation covers the Gross anatomy and functional histology of the female reproductive organs. Ideal for students, educators, and anyone interested in medical science, this lecture provides clear explanations, detailed diagrams, and valuable insights into female reproductive system. Enhance your knowledge and understanding of this essential aspect of human biology.
Part II - Body Grief: Losing parts of ourselves and our identity before, duri...
Learn about body grief and ways to cope with it. We will also explore methods to heal from this challenging experience.
Cell Therapy Expansion and Challenges in Autoimmune Disease
There is increasing confidence that cell therapies will soon play a role in the treatment of autoimmune disorders, but the extent of this impact remains to be seen. Early readouts on autologous CAR-Ts in lupus are encouraging, but manufacturing and cost limitations are likely to restrict access to highly refractory patients. Allogeneic CAR-Ts have the potential to broaden access to earlier lines of treatment due to their inherent cost benefits, however they will need to demonstrate comparable or improved efficacy to established modalities.
In addition to infrastructure and capacity constraints, CAR-Ts face a very different risk-benefit dynamic in autoimmune compared to oncology, highlighting the need for tolerable therapies with low adverse event risk. CAR-NK and Treg-based therapies are also being developed in certain autoimmune disorders and may demonstrate favorable safety profiles. Several novel non-cell therapies such as bispecific antibodies, nanobodies, and RNAi drugs, may also offer future alternative competitive solutions with variable value propositions.
Widespread adoption of cell therapies will not only require strong efficacy and safety data, but also adapted pricing and access strategies. At oncology-based price points, CAR-Ts are unlikely to achieve broad market access in autoimmune disorders, with eligible patient populations that are potentially orders of magnitude greater than the number of currently addressable cancer patients. Developers have made strides towards reducing cell therapy COGS while improving manufacturing efficiency, but payors will inevitably restrict access until more sustainable pricing is achieved.
Despite these headwinds, industry leaders and investors remain confident that cell therapies are poised to address significant unmet need in patients suffering from autoimmune disorders. However, the extent of this impact on the treatment landscape remains to be seen, as the industry rapidly approaches an inflection point.
Identification and nursing management of congenital malformations .pptx
Identification and nursing management of congenital malformations .pptxMGM SCHOOL/COLLEGE OF NURSING
Identification and nursing management of congenital malformations Does Over-Masturbation Contribute to Chronic Prostatitis.pptx
In some case, your chronic prostatitis may be related to over-masturbation. Generally, natural medicine Diuretic and Anti-inflammatory Pill can help mee get a cure.
ABDOMINAL TRAUMA in pediatrics part one.
Abdominal trauma in pediatrics refers to injuries or damage to the abdominal organs in children. It can occur due to various causes such as falls, motor vehicle accidents, sports-related injuries, and physical abuse. Children are more vulnerable to abdominal trauma due to their unique anatomical and physiological characteristics. Signs and symptoms include abdominal pain, tenderness, distension, vomiting, and signs of shock. Diagnosis involves physical examination, imaging studies, and laboratory tests. Management depends on the severity and may involve conservative treatment or surgical intervention. Prevention is crucial in reducing the incidence of abdominal trauma in children.
Basavarajeeyam - Ayurvedic heritage book of Andhra pradesh
Basavarajeeyam is an important text for ayurvedic physician belonging to andhra pradehs. It is a popular compendium in various parts of our country as well as in andhra pradesh. The content of the text was presented in sanskrit and telugu language (Bilingual). One of the most famous book in ayurvedic pharmaceutics and therapeutics. This book contains 25 chapters called as prakaranas. Many rasaoushadis were explained, pioneer of dhatu druti, nadi pareeksha, mutra pareeksha etc. Belongs to the period of 15-16 century. New diseases like upadamsha, phiranga rogas are explained.
The Electrocardiogram - Physiologic Principles
These lecture slides, by Dr Sidra Arshad, offer a quick overview of the physiological basis of a normal electrocardiogram.
Learning objectives:
1. Define an electrocardiogram (ECG) and electrocardiography
2. Describe how dipoles generated by the heart produce the waveforms of the ECG
3. Describe the components of a normal electrocardiogram of a typical bipolar lead (limb II)
4. Differentiate between intervals and segments
5. Enlist some common indications for obtaining an ECG
6. Describe the flow of current around the heart during the cardiac cycle
7. Discuss the placement and polarity of the leads of electrocardiograph
8. Describe the normal electrocardiograms recorded from the limb leads and explain the physiological basis of the different records that are obtained
9. Define mean electrical vector (axis) of the heart and give the normal range
10. Define the mean QRS vector
11. Describe the axes of leads (hexagonal reference system)
12. Comprehend the vectorial analysis of the normal ECG
13. Determine the mean electrical axis of the ventricular QRS and appreciate the mean axis deviation
14. Explain the concepts of current of injury, J point, and their significance
Study Resources:
1. Chapter 11, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 9, Human Physiology - From Cells to Systems, Lauralee Sherwood, 9th edition
3. Chapter 29, Ganong’s Review of Medical Physiology, 26th edition
4. Electrocardiogram, StatPearls - https://www.ncbi.nlm.nih.gov/books/NBK549803/
5. ECG in Medical Practice by ABM Abdullah, 4th edition
6. Chapter 3, Cardiology Explained, https://www.ncbi.nlm.nih.gov/books/NBK2214/
7. ECG Basics, http://www.nataliescasebook.com/tag/e-c-g-basics
Role of Mukta Pishti in the Management of Hyperthyroidism
Muktapishti is a traditional Ayurvedic preparation made from Shoditha Mukta (Purified Pearl), is believed to help regulate thyroid function and reduce symptoms of hyperthyroidism due to its cooling and balancing properties. Clinical evidence on its efficacy remains limited, necessitating further research to validate its therapeutic benefits.
Top 10 Best Ayurvedic Kidney Stone Syrups in India
we have mentioned the best 10 ayurvedic Kidney Stone Syrups. You can check all these products and choose the best one for yourself.
How STIs Influence the Development of Pelvic Inflammatory Disease.pptx
STIs may cause PID. For the both disease, herbal medicine Fuyan Pill can be a solution.
Recently uploaded (20)
#cALL# #gIRLS# In Dehradun ꧁❤8107221448❤꧂#cALL# #gIRLS# Service In Dehradun W...
#cALL# #gIRLS# In Dehradun ꧁❤8107221448❤꧂#cALL# #gIRLS# Service In Dehradun W...
TEST BANK For Community Health Nursing A Canadian Perspective, 5th Edition by...
TEST BANK For Community Health Nursing A Canadian Perspective, 5th Edition by...
share - Lions, tigers, AI and health misinformation, oh my!.pptx
share - Lions, tigers, AI and health misinformation, oh my!.pptx
Part II - Body Grief: Losing parts of ourselves and our identity before, duri...
Part II - Body Grief: Losing parts of ourselves and our identity before, duri...
Cell Therapy Expansion and Challenges in Autoimmune Disease
Cell Therapy Expansion and Challenges in Autoimmune Disease
CHEMOTHERAPY_RDP_CHAPTER 6_Anti Malarial Drugs.pdf
CHEMOTHERAPY_RDP_CHAPTER 6_Anti Malarial Drugs.pdf
Identification and nursing management of congenital malformations .pptx
Identification and nursing management of congenital malformations .pptx
Does Over-Masturbation Contribute to Chronic Prostatitis.pptx
Does Over-Masturbation Contribute to Chronic Prostatitis.pptx
Basavarajeeyam - Ayurvedic heritage book of Andhra pradesh
Basavarajeeyam - Ayurvedic heritage book of Andhra pradesh
Tests for analysis of different pharmaceutical.pptx
Tests for analysis of different pharmaceutical.pptx
Thyroid Gland- Gross Anatomy by Dr. Rabia Inam Gandapore.pptx
Thyroid Gland- Gross Anatomy by Dr. Rabia Inam Gandapore.pptx
Muscles of Mastication by Dr. Rabia Inam Gandapore.pptx
Muscles of Mastication by Dr. Rabia Inam Gandapore.pptx
Role of Mukta Pishti in the Management of Hyperthyroidism
Role of Mukta Pishti in the Management of Hyperthyroidism
Top 10 Best Ayurvedic Kidney Stone Syrups in India
Top 10 Best Ayurvedic Kidney Stone Syrups in India
How STIs Influence the Development of Pelvic Inflammatory Disease.pptx
How STIs Influence the Development of Pelvic Inflammatory Disease.pptx
RRC 2011 : Pharmacogénétique et médecine personnalisée du diabète
- 1. Pharmacogénétique et médecine personnalisée du diabète
- 3. What are the effects of mutations in MC4R on Obesity bariatric surgery outcome ?
- 4. EEEEEEEEEEEEEEEEEE EEEEEEEEEE Obesity Surgery success rate is diminished by MC4R mutations
- 5. 6th of October 2011
- 7. 5% of diabetic cases have a monogenic cause Monogenic T2D is due to primary -cell dysfunction…
- 8. Role of the ATP-sensitive potassium channel subunits Kir6.2 and ABCC8/SUR1 in insulin secretion K ATP channels close Membrane depolarization Ca 2+ influx Insulin secretion ATP/ADP Glucose entering Gloyn et al., N Eng J Med, 2004 Babenko et al., N Eng J Med, 2006 SUR1 = sulfonylurea receptor
- 9. Most KCNJ11/ABCC8 NDM patients can be switched from insulin to oral anti diabetic drug sulfonylurea NDM patients newly treated with glibenclamide n=28 Success : n =27 96.4% Failure n = 1 3.6% Glibenclamide alone n=24 89% Insulin + glibenclamide n = 3 11%
- 12. >95% of Type 2 Diabetes cases are polygenic And interaction Genes Environment Environment Gene 4 Gene 3 Gene 5 Gene 13 Gene 9 Gene 12 Gene 11 Gene 8 Gene 7 Gene 10 Gene 6 Gene 2 Gene 14 Gene 1 Gene n Epistatic interaction between genes? Low penetrance Type 2 Diabetes
- 13. “ The optimal management of type 2 diabetes should take into consideration the heterogeneity of the disorder which requires individualized therapies tailored to patient's individual needs” “
Editor's Notes
- Environmental compenent - sedentary lifestyle