This document summarizes a study on the oral and maxillofacial manifestations of thalassemia from clinical and radiological studies in Pakistan. It finds that thalassemia can cause facial bone changes like high cheek bones and protruding teeth. Radiological imaging shows enlarged bone marrow spaces. Thalassemia is common in Pakistan and treatment is difficult due to high costs. Prevention through pre-marital screening and avoiding consanguineous marriages is important to reduce new thalassemia cases.
Prevalence of Tooth Agenesis in Orthodontic Patients at Arab Population in Is...Abu-Hussein Muhamad
This document reports on a study that assessed the prevalence of tooth agenesis (hypodontia) in orthodontic patients from the Arab population in Israel. The study reviewed panoramic radiographs of 500 patients between the ages of 12-39 years old. The results found a prevalence of hypodontia to be 2.6%, which is within the typical global range of 1.6-9.6%. The most commonly missing teeth were found to be the mandibular second premolars and maxillary lateral incisors. The study concludes that hypodontia is prevalent in this population, though further research with larger non-orthodontic samples is needed.
Tooth Agenesis in Orthodontic Patients at Arab Population in IsraelAbu-Hussein Muhamad
Non-syndromic tooth agenesis has been occasionally described in literature and data available for its prevalence is rare in Arabs population in Israel. The purpose of the present retrospective radiographic study was to provide data concerning the prevalence of non-syndromic hypodontia in patients reporting to the Center for Dentistry,Research & Aesthetics, Jatt, Almothalat, Israel
This document provides information about the film project "That Good Night" including:
- A 3 sentence synopsis of the film's plot about a terminally ill former film director who hires someone to end his life but his plan is disrupted.
- Details on the creative vision to adapt the story from a stage play to film while keeping the character-driven focus and filming in Portugal and Yorkshire.
- Bios of the director, writer/producer, and producer who have experience with independent films.
- Information on the production companies and investment opportunities for the film through tax schemes.
El documento presenta la propuesta de una nueva empresa de servicios generales llamada House Cleaners. La empresa ofrece servicios de limpieza, jardinería, fumigación y más, y está conformada por 4 socios. Detalla la misión, visión, ubicación, equipamiento inicial y costos de la empresa, así como su estrategia de marketing y segmentación de clientes potenciales.
El documento habla sobre la creación de un blog para el profesor Hugo Acosta del CONALEP Tlalnepantla 1. Se menciona publicar contenido en Slider Share.
Lucas Marsico observed a trial at the Philadelphia Courthouse of Common Pleas. He found the courthouse difficult to access and navigate. In the courtroom, the judge seemed intimidating and disrespectful towards others. The attorneys also disrespected each other at times. Marsico felt intimidated in the courthouse and courtroom. He believes policy changes should be made to reduce intimidation and better protect defendants' rights to due process.
Prevalence of Tooth Agenesis in Orthodontic Patients at Arab Population in Is...Abu-Hussein Muhamad
This document reports on a study that assessed the prevalence of tooth agenesis (hypodontia) in orthodontic patients from the Arab population in Israel. The study reviewed panoramic radiographs of 500 patients between the ages of 12-39 years old. The results found a prevalence of hypodontia to be 2.6%, which is within the typical global range of 1.6-9.6%. The most commonly missing teeth were found to be the mandibular second premolars and maxillary lateral incisors. The study concludes that hypodontia is prevalent in this population, though further research with larger non-orthodontic samples is needed.
Tooth Agenesis in Orthodontic Patients at Arab Population in IsraelAbu-Hussein Muhamad
Non-syndromic tooth agenesis has been occasionally described in literature and data available for its prevalence is rare in Arabs population in Israel. The purpose of the present retrospective radiographic study was to provide data concerning the prevalence of non-syndromic hypodontia in patients reporting to the Center for Dentistry,Research & Aesthetics, Jatt, Almothalat, Israel
This document provides information about the film project "That Good Night" including:
- A 3 sentence synopsis of the film's plot about a terminally ill former film director who hires someone to end his life but his plan is disrupted.
- Details on the creative vision to adapt the story from a stage play to film while keeping the character-driven focus and filming in Portugal and Yorkshire.
- Bios of the director, writer/producer, and producer who have experience with independent films.
- Information on the production companies and investment opportunities for the film through tax schemes.
El documento presenta la propuesta de una nueva empresa de servicios generales llamada House Cleaners. La empresa ofrece servicios de limpieza, jardinería, fumigación y más, y está conformada por 4 socios. Detalla la misión, visión, ubicación, equipamiento inicial y costos de la empresa, así como su estrategia de marketing y segmentación de clientes potenciales.
El documento habla sobre la creación de un blog para el profesor Hugo Acosta del CONALEP Tlalnepantla 1. Se menciona publicar contenido en Slider Share.
Lucas Marsico observed a trial at the Philadelphia Courthouse of Common Pleas. He found the courthouse difficult to access and navigate. In the courtroom, the judge seemed intimidating and disrespectful towards others. The attorneys also disrespected each other at times. Marsico felt intimidated in the courthouse and courtroom. He believes policy changes should be made to reduce intimidation and better protect defendants' rights to due process.
Este documento presenta información sobre una práctica realizada por un estudiante de informática en el Colegio de Educación Profesional Técnica del Estado de México, Plantel Tlalnepantla 1. El estudiante, Brandon Mónico Meza, pertenece al Grupo 102 y realizó la Práctica 8 bajo la supervisión del profesor Hugo Acosta Serna.
The document contains a single Spanish word: "delantal". This likely refers to an apron, as delantal is the Spanish word for apron. In just one word, the document conveys information about kitchen or cooking attire.
Licenciado em Engenharia Física e Doutorado em Física Tecnológica pela Universidade de Coimbra. É cofundador, presidente e CEO da ISA – Intelligent Sensing Anywhere, S.A., empresa de base tecnológica pioneira e líder mundial em telemetria e gestão remota aplicada aos mercados do Oil & Gas, Energia, Ambiente e Saúde. É Professor Convidado da Universidade de Coimbra na área do Empreendedorismo e Inovação Tecnológica, tendo anteriormente sido responsável pela regência de disciplinas nas áreas da Física, Eletrónica, Instrumentação e Processamento Digital de Sinal em tempo real. Foi investigador na Faculdade de Ciências e Tecnologia da Universidade de Coimbra e perito avaliador da Agência de Inovação, do IAPMEI, da Academia i-Techpartner e da Comissão Europeia na área dos real time embedded systems e da eficiência energética.
The document provides guidance on writing academic papers, including:
1) It outlines the typical structure of a paper, including the title, abstract, introduction, background, core contribution, conclusions, and references.
2) The abstract should state the problem, why it matters, the author's main idea, and implications.
3) The introduction sets the scope and context, states the problem and proposed solution, and outlines what follows.
4) The core contribution section makes the novel argument and presents results, backed by other work and methodology.
Using KPIs for Tracking Strategy and Driver Based Budgetingjarobertson2
This document discusses using key performance indicators (KPIs) for tracking strategy and driver-based budgeting. It outlines best practices for KPI design and implementation, including ensuring KPIs are defined and agreed upon, using both leading and lagging indicators, addressing measurability creatively, and updating KPIs as needed. The document also discusses integrating KPIs with driver-based planning and forecasting by linking KPIs to strategic objectives and cascading drivers from strategy to operations.
Credentialing is the process of verifying a practitioner's qualifications to participate in a healthcare organization. It involves primary source verification of licensure, education, training, experience and competence. Re-credentialing occurs every two years. There are three types of credentialing: primary source verification, centralized credentialing, and delegated credentialing which is performed by a third party organization. The credentialing process determines a practitioner's clinical privileges which specify the scope and limits of their approved practice within the organization. Privileges can have different statuses such as approved, temporary, emergency or have limitations. The goal of credentialing and privileging is to ensure quality care through oversight of practitioner competency.
This study examined the prevalence of tooth agenesis (hypodontia) in orthodontic patients from the Arab population in Israel. The researchers reviewed panoramic radiographs of 500 patients aged 12-39 years old. They found that 57 patients (2.6% prevalence) had hypodontia, missing a total of 167 permanent teeth. The most commonly missing tooth was the mandibular second premolar. This prevalence of hypodontia in the Arab population of Israel falls within the typical global range of 1.6-9.6%, and indicates hypodontia is present but not unusually high compared to other populations.
Prevalence of Tooth Agenesis in Orthodontic Patients at Arab Population in Is...Abu-Hussein Muhamad
This study examined the prevalence of tooth agenesis (hypodontia) in 500 orthodontic patients from the Arab population in Israel. The researchers reviewed panoramic radiographs and dental records to identify cases of one or more missing permanent teeth, excluding wisdom teeth. They found a prevalence of 2.6% hypodontia in this sample. The most commonly missing teeth were the mandibular second premolar and maxillary lateral incisor. This prevalence of hypodontia in the Arab population in Israel falls within the typical global range of 1.6-9.6%, providing baseline data on dental anomalies in this population.
1) The document summarizes a clinical study of oral and maxillofacial manifestations in 50 β-thalassemia patients in Karachi, Pakistan.
2) The most common extraoral findings were parietal bossing (88%), depressed nasal bridge (70%), and frontal bossing (54%). The most common intraoral findings were intraoral pigmentation (88%), gingivitis (82%), and pallor of the oral mucosa (84%).
3) The results were generally consistent with previous international studies on oral manifestations of β-thalassemia, though some findings had higher or lower frequencies than other studies. The study aims to evaluate the oral complications experienced by thalassemia
revision and summary of Oral diseases: a global public health challenge.
Marco A Peres, Lorna M D Macpherson, Robert J Weyant, Blánaid Daly, Renato Venturelli, Manu R Mathur, Stefan Listl, Roger Keller Celeste, Carol C Guarnizo-Herreño, Cristin Kearns, Habib Benzian, Paul Allison, Richard G Watt
This document provides background information on a proposed rural dental center project for India. It discusses the high prevalence of oral diseases like dental caries and periodontal disease in India, especially in rural areas, due to lack of access to care, education and other socioeconomic factors. The proposed intervention has three parts: 1) an oral health education and fluoride rinse program in schools, 2) screening for dental diseases, and 3) increasing access to dental care through mobile clinics and rural dental centers. The goal is to comprehensively address oral health issues facing rural populations in India.
This systematic review and meta-analysis aimed to determine the global prevalence of apical periodontitis (AP) and factors influencing prevalence. The review identified 114 studies involving over 34,000 individuals and 639,000 teeth. It found that 52% of individuals had at least one tooth with AP. The prevalence of AP was higher in dental clinics (57%) and hospitals (51%) than the general population (40%). Prevalence was also higher in people with systemic conditions (63%) versus healthy individuals (48%). Half of adults worldwide have at least one tooth with AP, demonstrating the hidden burden of endodontic disease globally.
This case report describes a 9-year-old female patient with fibrous dysplasia of the maxilla and a port wine stain on her face. Clinical examination and radiographic imaging showed abnormal bone growth replacing the maxilla. A biopsy confirmed the diagnosis of fibrous dysplasia. The patient underwent surgical recontouring of the maxilla and was happy with the results at her 2-week follow up appointment. Fibrous dysplasia is a benign condition where abnormal bone growth replaces normal bone, usually becoming inactive in adulthood, though some cases like this one may continue progressing during childhood growth.
This document discusses dental management of patients with thalassemia. It provides background on a clinical and radiological study of oro-facial manifestations in thalassemia patients. The study aimed to evaluate oro-facial features and radiological changes in thalassemia patients and correlate them with disease duration. It also aimed to determine if oro-facial findings could aid in early diagnosis and provide clues about disease progression. The study examined 25 thalassemia patients and found various oro-facial changes including pallor, frontal bossing, and enlarged marrow spaces on radiographs. Results showed severity of changes depended on age, disease duration, transfusion timing, and whether the patient had a spleen
This document discusses thalassemia, a blood disorder characterized by reduced hemoglobin. It describes the two main types, alpha and beta thalassemia, and their genetic causes. Symptoms, tests, and management strategies are outlined, including blood transfusions, chelation therapy, and bone marrow transplantation. The high prevalence of thalassemia in Pakistan is noted, as well as the role of consanguineous marriages in increasing risk. Recent government efforts to require pre-marital screening are also mentioned.
This case report describes a rare case of a 56-year-old female patient who presented with four isolated gingival enlargements, one on each side of her upper and lower molars. Histopathological examination determined the lesions were epulides. This finding of four separate epulides was termed "Quadra Epulis". The epulides were surgically excised and antibiotics were prescribed. Follow up was recommended to minimize recurrence. This report describes a unique presentation of multiple epulis lesions not previously reported in the literature.
Prevalence of Missing Lateral Incisor Agenesis in an Or¬thodontic Arabs Popul...Abu-Hussein Muhamad
This study examined the prevalence of congenital absence (agenesis) of maxillary lateral incisors in 2,200 orthodontic patients of Arab descent in Israel. The researchers reviewed panoramic radiographs from 2006-2013 and found that 24 patients, or 1.1%, had agenesis of one or both maxillary lateral incisors. Specifically, 13 females (54.2%) and 11 males (45.8%) were missing their lateral incisors. This suggests the prevalence of maxillary lateral incisor agenesis in this population is 1.1%, providing data to compare to other studies on tooth agenesis frequencies.
Management of Thallasemia Patient of Dental SurgerySyed Muhammad Ali
1) Dr Syed Muhammad Ali is an oral surgery resident under the supervision of Prof Dr Syed Mahmood Haider at Karachi Medical and Dental College in Pakistan.
2) The document discusses thalassemia, including that it is a common autosomal recessive blood disease characterized by reduced hemoglobin. It also discusses the different types of thalassemia (alpha and beta) and their characteristics.
3) Management strategies before and after diagnosis are mentioned, including population screening, genetic counseling, and prenatal diagnosis to control the disease, as well as treatments like blood transfusions, bone marrow transplants, and genetic engineering.
Este documento presenta información sobre una práctica realizada por un estudiante de informática en el Colegio de Educación Profesional Técnica del Estado de México, Plantel Tlalnepantla 1. El estudiante, Brandon Mónico Meza, pertenece al Grupo 102 y realizó la Práctica 8 bajo la supervisión del profesor Hugo Acosta Serna.
The document contains a single Spanish word: "delantal". This likely refers to an apron, as delantal is the Spanish word for apron. In just one word, the document conveys information about kitchen or cooking attire.
Licenciado em Engenharia Física e Doutorado em Física Tecnológica pela Universidade de Coimbra. É cofundador, presidente e CEO da ISA – Intelligent Sensing Anywhere, S.A., empresa de base tecnológica pioneira e líder mundial em telemetria e gestão remota aplicada aos mercados do Oil & Gas, Energia, Ambiente e Saúde. É Professor Convidado da Universidade de Coimbra na área do Empreendedorismo e Inovação Tecnológica, tendo anteriormente sido responsável pela regência de disciplinas nas áreas da Física, Eletrónica, Instrumentação e Processamento Digital de Sinal em tempo real. Foi investigador na Faculdade de Ciências e Tecnologia da Universidade de Coimbra e perito avaliador da Agência de Inovação, do IAPMEI, da Academia i-Techpartner e da Comissão Europeia na área dos real time embedded systems e da eficiência energética.
The document provides guidance on writing academic papers, including:
1) It outlines the typical structure of a paper, including the title, abstract, introduction, background, core contribution, conclusions, and references.
2) The abstract should state the problem, why it matters, the author's main idea, and implications.
3) The introduction sets the scope and context, states the problem and proposed solution, and outlines what follows.
4) The core contribution section makes the novel argument and presents results, backed by other work and methodology.
Using KPIs for Tracking Strategy and Driver Based Budgetingjarobertson2
This document discusses using key performance indicators (KPIs) for tracking strategy and driver-based budgeting. It outlines best practices for KPI design and implementation, including ensuring KPIs are defined and agreed upon, using both leading and lagging indicators, addressing measurability creatively, and updating KPIs as needed. The document also discusses integrating KPIs with driver-based planning and forecasting by linking KPIs to strategic objectives and cascading drivers from strategy to operations.
Credentialing is the process of verifying a practitioner's qualifications to participate in a healthcare organization. It involves primary source verification of licensure, education, training, experience and competence. Re-credentialing occurs every two years. There are three types of credentialing: primary source verification, centralized credentialing, and delegated credentialing which is performed by a third party organization. The credentialing process determines a practitioner's clinical privileges which specify the scope and limits of their approved practice within the organization. Privileges can have different statuses such as approved, temporary, emergency or have limitations. The goal of credentialing and privileging is to ensure quality care through oversight of practitioner competency.
This study examined the prevalence of tooth agenesis (hypodontia) in orthodontic patients from the Arab population in Israel. The researchers reviewed panoramic radiographs of 500 patients aged 12-39 years old. They found that 57 patients (2.6% prevalence) had hypodontia, missing a total of 167 permanent teeth. The most commonly missing tooth was the mandibular second premolar. This prevalence of hypodontia in the Arab population of Israel falls within the typical global range of 1.6-9.6%, and indicates hypodontia is present but not unusually high compared to other populations.
Prevalence of Tooth Agenesis in Orthodontic Patients at Arab Population in Is...Abu-Hussein Muhamad
This study examined the prevalence of tooth agenesis (hypodontia) in 500 orthodontic patients from the Arab population in Israel. The researchers reviewed panoramic radiographs and dental records to identify cases of one or more missing permanent teeth, excluding wisdom teeth. They found a prevalence of 2.6% hypodontia in this sample. The most commonly missing teeth were the mandibular second premolar and maxillary lateral incisor. This prevalence of hypodontia in the Arab population in Israel falls within the typical global range of 1.6-9.6%, providing baseline data on dental anomalies in this population.
1) The document summarizes a clinical study of oral and maxillofacial manifestations in 50 β-thalassemia patients in Karachi, Pakistan.
2) The most common extraoral findings were parietal bossing (88%), depressed nasal bridge (70%), and frontal bossing (54%). The most common intraoral findings were intraoral pigmentation (88%), gingivitis (82%), and pallor of the oral mucosa (84%).
3) The results were generally consistent with previous international studies on oral manifestations of β-thalassemia, though some findings had higher or lower frequencies than other studies. The study aims to evaluate the oral complications experienced by thalassemia
revision and summary of Oral diseases: a global public health challenge.
Marco A Peres, Lorna M D Macpherson, Robert J Weyant, Blánaid Daly, Renato Venturelli, Manu R Mathur, Stefan Listl, Roger Keller Celeste, Carol C Guarnizo-Herreño, Cristin Kearns, Habib Benzian, Paul Allison, Richard G Watt
This document provides background information on a proposed rural dental center project for India. It discusses the high prevalence of oral diseases like dental caries and periodontal disease in India, especially in rural areas, due to lack of access to care, education and other socioeconomic factors. The proposed intervention has three parts: 1) an oral health education and fluoride rinse program in schools, 2) screening for dental diseases, and 3) increasing access to dental care through mobile clinics and rural dental centers. The goal is to comprehensively address oral health issues facing rural populations in India.
This systematic review and meta-analysis aimed to determine the global prevalence of apical periodontitis (AP) and factors influencing prevalence. The review identified 114 studies involving over 34,000 individuals and 639,000 teeth. It found that 52% of individuals had at least one tooth with AP. The prevalence of AP was higher in dental clinics (57%) and hospitals (51%) than the general population (40%). Prevalence was also higher in people with systemic conditions (63%) versus healthy individuals (48%). Half of adults worldwide have at least one tooth with AP, demonstrating the hidden burden of endodontic disease globally.
This case report describes a 9-year-old female patient with fibrous dysplasia of the maxilla and a port wine stain on her face. Clinical examination and radiographic imaging showed abnormal bone growth replacing the maxilla. A biopsy confirmed the diagnosis of fibrous dysplasia. The patient underwent surgical recontouring of the maxilla and was happy with the results at her 2-week follow up appointment. Fibrous dysplasia is a benign condition where abnormal bone growth replaces normal bone, usually becoming inactive in adulthood, though some cases like this one may continue progressing during childhood growth.
This document discusses dental management of patients with thalassemia. It provides background on a clinical and radiological study of oro-facial manifestations in thalassemia patients. The study aimed to evaluate oro-facial features and radiological changes in thalassemia patients and correlate them with disease duration. It also aimed to determine if oro-facial findings could aid in early diagnosis and provide clues about disease progression. The study examined 25 thalassemia patients and found various oro-facial changes including pallor, frontal bossing, and enlarged marrow spaces on radiographs. Results showed severity of changes depended on age, disease duration, transfusion timing, and whether the patient had a spleen
This document discusses thalassemia, a blood disorder characterized by reduced hemoglobin. It describes the two main types, alpha and beta thalassemia, and their genetic causes. Symptoms, tests, and management strategies are outlined, including blood transfusions, chelation therapy, and bone marrow transplantation. The high prevalence of thalassemia in Pakistan is noted, as well as the role of consanguineous marriages in increasing risk. Recent government efforts to require pre-marital screening are also mentioned.
This case report describes a rare case of a 56-year-old female patient who presented with four isolated gingival enlargements, one on each side of her upper and lower molars. Histopathological examination determined the lesions were epulides. This finding of four separate epulides was termed "Quadra Epulis". The epulides were surgically excised and antibiotics were prescribed. Follow up was recommended to minimize recurrence. This report describes a unique presentation of multiple epulis lesions not previously reported in the literature.
Prevalence of Missing Lateral Incisor Agenesis in an Or¬thodontic Arabs Popul...Abu-Hussein Muhamad
This study examined the prevalence of congenital absence (agenesis) of maxillary lateral incisors in 2,200 orthodontic patients of Arab descent in Israel. The researchers reviewed panoramic radiographs from 2006-2013 and found that 24 patients, or 1.1%, had agenesis of one or both maxillary lateral incisors. Specifically, 13 females (54.2%) and 11 males (45.8%) were missing their lateral incisors. This suggests the prevalence of maxillary lateral incisor agenesis in this population is 1.1%, providing data to compare to other studies on tooth agenesis frequencies.
Management of Thallasemia Patient of Dental SurgerySyed Muhammad Ali
1) Dr Syed Muhammad Ali is an oral surgery resident under the supervision of Prof Dr Syed Mahmood Haider at Karachi Medical and Dental College in Pakistan.
2) The document discusses thalassemia, including that it is a common autosomal recessive blood disease characterized by reduced hemoglobin. It also discusses the different types of thalassemia (alpha and beta) and their characteristics.
3) Management strategies before and after diagnosis are mentioned, including population screening, genetic counseling, and prenatal diagnosis to control the disease, as well as treatments like blood transfusions, bone marrow transplants, and genetic engineering.
This document provides information on aggressive periodontitis, including its definition, classification, and etiology and pathogenesis. It discusses four main factors that contribute to aggressive periodontitis: microbiological, immunological, genetic, and environmental. The key microbiological factor is Aggregatibacter actinomycetemcomitans, which produces virulence factors like leukotoxin that damage tissues. Immunologically, patients exhibit both local and systemic immune responses, including elevated inflammatory mediators and antibodies against periodontal bacteria. Genetic factors are also significant, as the disease demonstrates familial aggregation and certain gene polymorphisms may impair immune responses.
PROSTHODONTIC MANAGEMENT OF PATIENTS WITH AMELOGENESIS IMPERFECTA: A CASE REP...Abu-Hussein Muhamad
This document discusses the prosthodontic management of patients with amelogenesis imperfecta (AI), a hereditary condition affecting the structure and appearance of enamel. It provides background on AI, including classification, genetic causes, clinical implications such as sensitivity and rapid wear, and impact on growth. Treatment considerations are outlined for the primary, mixed, and permanent dentitions. The focus case describes a patient with AI who was rehabilitated using full-mouth zirconium oxide ceramic fixed bridges over 3 years, leaving the patient satisfied with function, esthetics, and speech.
This study analyzed the prevalence and patterns of congenital malformations in Duhok City, Iraq between 2006-2010. A total of 369 cases of congenital anomalies were identified among 79,227 live births, for a prevalence of 4.65 per 1,000 live births. The most common types of anomalies were central nervous system defects (44.98%), congenital heart diseases (14.09%), and chromosomal abnormalities (8.67%). Hydrocephalus, myelomeningocele, and microcephaly were the most frequent central nervous system defects. Ventricular septal defect was the most common heart defect. Down syndrome was the leading chromosomal abnormality. The study aims to inform strategies to prevent birth
This case report describes a rare occurrence of "mirror image impacted rosette molars" or "kissing molars" in a 26-year-old male patient. Panoramic x-ray and CT imaging revealed bilaterally impacted third molars along with an impacted left second molar that was contacting the third molar from above in a rosette formation. The patient underwent surgical extraction of all four impacted teeth. Kissing molars are a very rare impaction where two teeth contact each other within the same follicular space. The etiology is still unknown but it may be associated with certain medical conditions or developmental abnormalities.
Epidemiological Trends of Oral Diseases in IndiaHaritha RK
A brief look at the recent epidemiological trends of dental caries, periodontal disease, oral cancer and malocclusion in India as of available research in March 2021
Basavarajeeyam is a Sreshta Sangraha grantha (Compiled book ), written by Neelkanta kotturu Basavaraja Virachita. It contains 25 Prakaranas, First 24 Chapters related to Rogas& 25th to Rasadravyas.
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Muktapishti is a traditional Ayurvedic preparation made from Shoditha Mukta (Purified Pearl), is believed to help regulate thyroid function and reduce symptoms of hyperthyroidism due to its cooling and balancing properties. Clinical evidence on its efficacy remains limited, necessitating further research to validate its therapeutic benefits.
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Adhd Medication Shortage Uk - trinexpharmacy.comreignlana06
The UK is currently facing a Adhd Medication Shortage Uk, which has left many patients and their families grappling with uncertainty and frustration. ADHD, or Attention Deficit Hyperactivity Disorder, is a chronic condition that requires consistent medication to manage effectively. This shortage has highlighted the critical role these medications play in the daily lives of those affected by ADHD. Contact : +1 (747) 209 – 3649 E-mail : sales@trinexpharmacy.com
Local Advanced Lung Cancer: Artificial Intelligence, Synergetics, Complex Sys...Oleg Kshivets
Overall life span (LS) was 1671.7±1721.6 days and cumulative 5YS reached 62.4%, 10 years – 50.4%, 20 years – 44.6%. 94 LCP lived more than 5 years without cancer (LS=2958.6±1723.6 days), 22 – more than 10 years (LS=5571±1841.8 days). 67 LCP died because of LC (LS=471.9±344 days). AT significantly improved 5YS (68% vs. 53.7%) (P=0.028 by log-rank test). Cox modeling displayed that 5YS of LCP significantly depended on: N0-N12, T3-4, blood cell circuit, cell ratio factors (ratio between cancer cells-CC and blood cells subpopulations), LC cell dynamics, recalcification time, heparin tolerance, prothrombin index, protein, AT, procedure type (P=0.000-0.031). Neural networks, genetic algorithm selection and bootstrap simulation revealed relationships between 5YS and N0-12 (rank=1), thrombocytes/CC (rank=2), segmented neutrophils/CC (3), eosinophils/CC (4), erythrocytes/CC (5), healthy cells/CC (6), lymphocytes/CC (7), stick neutrophils/CC (8), leucocytes/CC (9), monocytes/CC (10). Correct prediction of 5YS was 100% by neural networks computing (error=0.000; area under ROC curve=1.0).
TEST BANK For Basic and Clinical Pharmacology, 14th Edition by Bertram G. Kat...rightmanforbloodline
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23 mahmood haider- 175-178
1. HAIDER AND ALI (2015), FUUAST J. BIOL., 5(1): 175-178
REVIEW OF CLINICAL AND RADIOLOGICAL STUDIES OF ORAL AND
MAXILLO-FACIAL MANIFESTATION IN THALASSEMIA FROM
PAKISTAN
1
SYED MAHMOOD HAIDER AND 2
SYED MOHAMMAD ALI
1
Department of Oral Surgery Karachi Medical and Dental College.2
Faculty of Medicine,
University of Karachi, Karachi, Pakistan
2
Department of Oral Surgery Karachi Medical and Dental College, Karachi, Pakistan
Corresponding author e-mail: alidentist84@yahoo.com
Abstract
Oral and maxillofacial manifestation in thalassemia has been discussed from Pakistan.
Introduction
Thalassemia is an inherited single gene recessive, autosomal, blood disease , where totally or partially
hemoglobin is produced(Cooley & Lee 1925; Rund & Rachmilewitz, 2005; Verma et al., 2011). It is very
common in Mediterranean region Flint et al. (1998). Hemoglobin is composed of four protein chains, two α-
globin and two β- globin chains arranged into a hetro-tetramer Thein (2005). Patients suffering from
thalassemia, defects occur in either the α or β- globin chain which produced abnormal red blood cells (Rund &
Rachmilewitz , 2005)
Kinds of thallassemia
β –Thalassemia:-
In β-thalassemia mutations occur in the HB β gene at chromosome No.11, and severity of the disease depends
on the nature of the mutation. According to severity it is classified in three subclasses. 1) Thalassemia major;
2) Thalassemia intermedia; 3) Thalassemia minor. Severity of disease depends upon the amount of α-globin,
however in each sub class tetramer do not form and they bind to the red blood cell membranes, producing
damage to membrane, further more at high concentrations they form toxic compounds. (Khan et al., 2000;
Raihan, et al., 2009; Galanello & Origa, 2010; Khan et al., 2012; Bejaoui & Guirat, 2013; Kang et al., 2013).
α- Thalassemia: In α-thalassemia two genes HB α1 and HB α 2 at chomosome16are involved and inherited in
a recessive manner. The cause of. α - thalassemia is decreased in production of α- globin resulting excess of β
chains in adults and excess γ chains in new born babies. The excess β- chains form unstable tetramers, which are
characterized by abnormal oxygen dissociation curves. (Bridge, 1998; Rund & Rachmilewitz, 2005; Patil, 2006)
Delta (Δ) Thalassemia: Generally hemoglobin, is mainly composed of α and β –chains, however about 3% of
adult hemoglobin is made of α and Δ chains. Mutations also effect the production of Δ- chains (Patil, 2006)
General Manifestation in Thalassemia: Patients suffering in thalassemia due to lack of total or partial
production of α or β globins, causes serious effects on their bodies, details of effects has been fully discussed by
many worker. (Van dis & Langlias, 1986; Rund & Rachmilewitz, 2005; Raihan et al., 2009; Galanello & Origa,
2010; Verma et al., 2011; Abdel-Malak et al., 2012)
β –thalassemia is also responsible of causing various manifestations and complications of various degrees
on different organs of patients. Initially it start by anemia and for treatment of it, regular blood transfusion is
necesssory, which not only causes iron overloading but infections are also transmitted which causes serious
effects on different organs of patients. Thus a disease that starts just as hemolytic anemia change to a chronic
disease with involving many system with various deformities. It effects on bones, liver, kidneys, eyes, spleen,
bones of face, maxilla, mandible, pharynx and esophagus-aperture etc. (Cooley & Lee 1925; Chakraborty &
Basu,1971, Logothetis et al., 1971; Abu-Alhaija et al., 2002; Seyyedi & Nabavizadeh, 2003; Cunningham et al.,
2004; Hazza & Al-Jamal, 2006; Amini et al., 2007; Mehdizadeh et al., 2008; Hashemipour & Ebrahimi, 2008;
Rashi et al., 2010).
Oral and Maxillofacial Manifestation in Thalassemia: In β thalassemia, bones of face are also involved
resulting in severe disfigurement face has been reported in several reports. ( Poyton & Davey, 1968;
Chakraborty & Basu, 1971; Logothetis et al., 1971; Van dis & Langlias,1986; Well et al.,1987; Bassimiti et
al.,1996; Abu Alhaija et al., 2002; Baig et al., 2006; Amini et al., 2007; Hashemipour& Ebrahimi, 2008).
2. HAIDER AND ALI (2015), FUUAST J. BIOL., 5(1): 175-178 176
Changes occur are high and bulging cheek bones, retraction of the upper lip, protrusion of the anterior teeth,
spacing of other teeth, over- bite or open-bite, and various degrees of malocclusion. The skeletal changes are
due to proliferation of the bone marrow in the facial skeleton (Chakraborty &. Basu, 1971).This proliferated
bone marrow is extensively used as an ancillary hematopoietic organ to compensate for the chronic hemolysis.
Usually the mandible becomes less enlarged than the maxilla. The dense cortical plates of the mandible
apparently prevent expansion and they may occur early in life and tend to persist, particularly in skull (Bassimiti
et al., 1996; Abu-Alhaji et al., 2002; Amini et al., 2007; Aminabadi et al., 2006). In addition to, a tint of lemon
color is also observed in oral mucosa due to existing bilirubin produced by the decomposition of red cells.
Radiological changes are also occur but not evident up to first year of age. These include large bone
marrow spaces, one of the most important and diagnostic radiographic features of Thalassemia. This
enlargement is due to the fact that, when ineffective erythropoiesis damages the membrane of RBC ( red blood
cells) causing severe anemia, and thus body responds by increasing the production of RBC, resulting expansion
of the bone marrow up to 15-30 times the normal amount. Small maxillary sinuses are also due to bone marrow
expansion, classical “Chipmunk facies” with depressed cranial vault, maxillary expansion, frontal bossing,
retracted upper lip and saddle nose, yellowish tinge at the junction of hard and soft palate, yellow tinged finger
nails and spaces with widened trabeculae ( Hashemipour & Ebrahimi, 2008). In thalassemic patients, radiograph
of The skull shows the increased diploid space and arrangement of trabeculae in the vertical rows, causing “hair
on end” appearance.( Hazza & Jamal, 2006). In OPG images, thinning of cortical borders and short spiky roots
causing hyperplasia of the alveolar processes of maxilla at the cost of the sinuses normal volume may be visible.
Further more cortex, spiky shaped short root, faint lamina Dura and absence of inferior alveolar canals become
evident. (Patil, 2006).
Thalassemia in Pakistan and Azad Kashmir: The Population of Pakistan was recorded 18.2490721 millions
(Anonyms, 2012). Thalassemia is a major health concern in Pakistan and is the most prevalent genetically
transmitted blood disorder with a carrier rate of 5-8 %.f this disease. 5000 children in Pakistan are diagnosed
with thalassemia every year. (Anonym, 2012, 2013). The total number of thalassemic major children in Pakistan
are 60000-100,000 (Anonym, 2013). It is prevalent in all provinces of Pakistan but total numbers of patient are
more in Punjab since its population is 50% of all Pakistan. Further more South Punjab literacy rate is low (Baig,
2006).
The Pakistan Institute of Medical Sciences (PIMS) has diagnosed around 160 new cases of thalassemia
major during the last four years (2008-2012). Furthermore 277 patients have been transfused for thalassemia by
Pediatric department of the hospital during (2011-2012).
In Azad Kashmir the people suffering from thalassemia are 5% with only one blood bank in public sector
which is insufficient for a large population, (Gilani et al., 2012).
Treatment: Prevention against thalassemia in developing countries is very challenging. (Mehrnoush, 2011).
In big cities of Pakistan treatment facilities in public sector are available however they are insufficient. Some
private sectors and ANGO‟S are also working. For optimum treatment every thalassemic child needs frequent
transfusion of screened packed red cells and regular iron chelation therapy. This cost more than Rs.15,000/ per
month ( Karnon et al.,1991, Anonyms, 2013). Thalassemia major patients required at least Rs, 12.0 billion each
year, which is out of reach of health budget. Bone marrow transplantation is also a costly methods which cost 1-
1.5 millions (Anonyms, 2013). This situation leaves only one alternative:- stop birth of thalassemic children.
This is only possible by screening of thalassemia before marriages and stop consigenous marrariges. (Jaber et
al., 1998; Hussain, 2000; Naidu et al., 2010). Literature survey revealed that work on oral and maxillofacial
manifestation in thalassemia has been extensively carried out through out the world ( Bassimiti et al.,1996; Abu-
Alhaiji et al.,2002; Amini et al., 2007; Aminabadi et al., 2006;). In India this type of work has also been
carried (Patil, 2006 ). In Pakistan no work of oral and-maxillo-facial manifestation in thalassemia is carried out,
however work on other aspect of thalassemia were carried out in Pakistan (Baig, 2006; Jafry, 2007; Gilani et al.,
2012). Therefore it is necessary to do work on this aspect in Pakistan.
Acknowledgement
Syed Mohammad Ali thanks his supervisor Prof, Dr. Syed Mahmood Haider for suggesting and guiding
him for the research topic „Clinical and radiological studies of oral and maxillofacial manifestation in
thalassemia from Population of Karachi, Pakistan‟ for M.S. Degree from Karachi University in 2012-2016
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