This document discusses vision therapy techniques that emphasize the anti-gravity system and integration of multiple sensory systems. It begins with an overview of the tecto-pulvinar pathway and vestibular system, which are involved in vision and balance. Three specific vision therapy procedures are then described that incorporate these systems: 1) the Space Fixator, which requires coordinated eye and body movements; 2) Loaded Chart Saccades, where saccades are performed during movement; and 3) Bal-A-Vis-X exercises, which integrate visual, vestibular and auditory skills through ball/bag tossing routines. The goal is to enhance vision therapy by emphasizing elements that stimulate the anti-gravity system and cross
NeuroReport_Neural mechanisms of attentional modulation of perceptual groupin...John Chen, Jun
Psychophysical research showed that detection of an oriented visual target is facilitated when the target is grouped with collinear visual flankers. However, this collinear grouping effect is evident only when the flankers are attended. This study examined neural mechanisms underlying the interaction between attention and grouping by collinearity. Event-related potentials were recorded from study participants who judged whether oriented Gabor patches (i.e. visual elements consisting of a sinusoidal contrast modulation convolved with a Gaussian function) along the cued orientation were collinear or orthogonal. Event-related potentials showed an enhanced negativity over the posterior occipital cortex at 48-72 ms when collinear patches were congruent rather than incongruent with the cued orientation. A negative shift between 260 and 380 ms was observed over the occipital-parietal areas in the congruent rather than incongruent conditions. The long-latency effect, however, was evident only when the collinear patches were allocated along 45°. The event-related potential results suggest that the interaction between attention and collinear grouping may take place as early as in the primary visual cortex and is independent of global orientations of perceptual groups.
The discipline of Motor Control is the study of human movement and the systems that control it under normal and pathological conditions.
Depends upon -
Environmental result of the movement (Outcome)
Movement pattern
Neuromotor processes underlying movement
NeuroReport_Neural mechanisms of attentional modulation of perceptual groupin...John Chen, Jun
Psychophysical research showed that detection of an oriented visual target is facilitated when the target is grouped with collinear visual flankers. However, this collinear grouping effect is evident only when the flankers are attended. This study examined neural mechanisms underlying the interaction between attention and grouping by collinearity. Event-related potentials were recorded from study participants who judged whether oriented Gabor patches (i.e. visual elements consisting of a sinusoidal contrast modulation convolved with a Gaussian function) along the cued orientation were collinear or orthogonal. Event-related potentials showed an enhanced negativity over the posterior occipital cortex at 48-72 ms when collinear patches were congruent rather than incongruent with the cued orientation. A negative shift between 260 and 380 ms was observed over the occipital-parietal areas in the congruent rather than incongruent conditions. The long-latency effect, however, was evident only when the collinear patches were allocated along 45°. The event-related potential results suggest that the interaction between attention and collinear grouping may take place as early as in the primary visual cortex and is independent of global orientations of perceptual groups.
The discipline of Motor Control is the study of human movement and the systems that control it under normal and pathological conditions.
Depends upon -
Environmental result of the movement (Outcome)
Movement pattern
Neuromotor processes underlying movement
Does Event Related Desynchronization reveal anticipatory attention in the som...Onno Romijn
Attention that is directed at an upcoming stimulus is termed anticipatory attention. The extended thalamocortical gating model (Brunia, 1999) addresses the processes underlying anticipatory attention. According to this model, both the thalamic relay (TCR) nuclei and the reticular nucleus (RN) are involved in the selection (i.e. gating) of the relevant sensory modality. The TCR nuclei can fire in two modes. The tonic mode is associated with the transmission of afferent and subcortical input to the cortex and leads to desynchronization of 10 Hz rhythmic activity in the cortical projection area of the TCR nucleus. The burst mode is associated with a disruption in this transmission and results in the occurrence of 10 Hz rhythmic activity at the cortical projection area. This implies that event-related changes in 10 Hz activity in the scalp recorded EEG may give insight into the firing mode of the TCR nuclei and thus into the process of anticipatory attention. Event Related Desynchronization (ERD, Pfurtscheller & Aranibar, 1977) can quantify such changes. The extended thalamocortical model states that anticipatory attention is manifest as a prestimulus activation of the sensory cortex corresponding to the modality of the anticipated stimulus. Anticipatory attention to somatosensory stimuli would therefore be manifest as a 10 Hz ERD over the postcentral cortex, whereas anticipatory attention to visual stimuli would be manifest as a 10 Hz ERD over the occipital cortex. To test this hypothesis 9 subjects performed a time-estimation task. They received a Knowledge of Results (KR) stimulus 2 seconds after their manual response. ERD was recorded in the 10 Hz and 20 Hz frequency bands. An occipital ERD was present preceding visual KR stimuli, whereas no significant postcentral ERD was present prior to somatosensory KR stimuli. Nonetheless, the statistical analyses indicated that these differences between conditions were not significant. Therefore, these results do not support the extended thalamocortical gating model. It can be hypothesized that the postcentral ERD preceding somatosensory stimuli is masked by a postmovement Event Related Synchronization (ERS).
NDT, BOBATH TECHNIQUE, BASIC IDEA OF BOBATH, CONCEPT OF BOBATH, NEUROPHYSIOLOGY OF NDT, ICF MODEL, PRINCIPLES OF TREATMENT OF NDT IN STROKE AND CP, AUTOMATIC AND EQUILIBRIUM REACTIONS, KEY POINTS OF CONTROL, FACILITATION, INHIBITION AND HANDLING IN NDT
The manipulative physiotherapist will tell the patient that the problem is like a jigsaw puzzle, and it is her job to make 'all the pieces fit'. She needs his help to do this, and it is her ability to communicate that makes the difference between her being successful in helping him with his problem or not
Motor control and plasticity in psychologyZeenath Farzu
Theories of motor control and plasticity of brain and spinal cord.
Presented by, zeenath farzu z, Soka Ikeda College, Psychology department, chennai, India.
Application of Affolter approach to occupational therapy intervention. The presentation ended with a case study of a patient management using affolter techniques.
CP-Care curriculum, training course and assessment mechanism (ECVET based)
Website: http://cpcare.eu/en/
This project (CP-CARE - 2016-1-TR01-KA202-035094) has been funded with support from the European Commission. This communication reflects the views only of the author, and the Commission cannot be held responsible for any use which may be made of the information contained therein.
How Neuro-Musculo-Skeletal care may help brain function.
Chiropractic is based on the now scientifically proven hypothesis that proper structure of the spine is required for proper function of the nervous system as it relates to the control and regulation of global physiology and health.”
Prevention and Management of Chronic PainMark Sexton
The Prevention and Managment of Chronic Pain. Slides for my 2012 lecture for the ICGP spring meeting.
Early identification of indications of neural sensitivity/adaptation key to appropriate early management and prevention.
این پاورپوینت خلاصه شده فصل شش یکی از کتابهای مربوط به علوم اعصاب است. این پاورپوینت در کارگاه تخصصی توانبخشی دیداری عصبی توسط دکتر علیزاده ارائه شده است.
Presented by Brad Aiken
Doctor and science-fiction writer Brad Aiken presents on new and upcoming technologies in neurological rehabilitation. Topics include breakthrough advances that can help people recover from stroke, brain injury, and spinal cord injury. Current, cutting-edge technologies will be discussed, as well as likely upcoming advances in this field.
Does Event Related Desynchronization reveal anticipatory attention in the som...Onno Romijn
Attention that is directed at an upcoming stimulus is termed anticipatory attention. The extended thalamocortical gating model (Brunia, 1999) addresses the processes underlying anticipatory attention. According to this model, both the thalamic relay (TCR) nuclei and the reticular nucleus (RN) are involved in the selection (i.e. gating) of the relevant sensory modality. The TCR nuclei can fire in two modes. The tonic mode is associated with the transmission of afferent and subcortical input to the cortex and leads to desynchronization of 10 Hz rhythmic activity in the cortical projection area of the TCR nucleus. The burst mode is associated with a disruption in this transmission and results in the occurrence of 10 Hz rhythmic activity at the cortical projection area. This implies that event-related changes in 10 Hz activity in the scalp recorded EEG may give insight into the firing mode of the TCR nuclei and thus into the process of anticipatory attention. Event Related Desynchronization (ERD, Pfurtscheller & Aranibar, 1977) can quantify such changes. The extended thalamocortical model states that anticipatory attention is manifest as a prestimulus activation of the sensory cortex corresponding to the modality of the anticipated stimulus. Anticipatory attention to somatosensory stimuli would therefore be manifest as a 10 Hz ERD over the postcentral cortex, whereas anticipatory attention to visual stimuli would be manifest as a 10 Hz ERD over the occipital cortex. To test this hypothesis 9 subjects performed a time-estimation task. They received a Knowledge of Results (KR) stimulus 2 seconds after their manual response. ERD was recorded in the 10 Hz and 20 Hz frequency bands. An occipital ERD was present preceding visual KR stimuli, whereas no significant postcentral ERD was present prior to somatosensory KR stimuli. Nonetheless, the statistical analyses indicated that these differences between conditions were not significant. Therefore, these results do not support the extended thalamocortical gating model. It can be hypothesized that the postcentral ERD preceding somatosensory stimuli is masked by a postmovement Event Related Synchronization (ERS).
NDT, BOBATH TECHNIQUE, BASIC IDEA OF BOBATH, CONCEPT OF BOBATH, NEUROPHYSIOLOGY OF NDT, ICF MODEL, PRINCIPLES OF TREATMENT OF NDT IN STROKE AND CP, AUTOMATIC AND EQUILIBRIUM REACTIONS, KEY POINTS OF CONTROL, FACILITATION, INHIBITION AND HANDLING IN NDT
The manipulative physiotherapist will tell the patient that the problem is like a jigsaw puzzle, and it is her job to make 'all the pieces fit'. She needs his help to do this, and it is her ability to communicate that makes the difference between her being successful in helping him with his problem or not
Motor control and plasticity in psychologyZeenath Farzu
Theories of motor control and plasticity of brain and spinal cord.
Presented by, zeenath farzu z, Soka Ikeda College, Psychology department, chennai, India.
Application of Affolter approach to occupational therapy intervention. The presentation ended with a case study of a patient management using affolter techniques.
CP-Care curriculum, training course and assessment mechanism (ECVET based)
Website: http://cpcare.eu/en/
This project (CP-CARE - 2016-1-TR01-KA202-035094) has been funded with support from the European Commission. This communication reflects the views only of the author, and the Commission cannot be held responsible for any use which may be made of the information contained therein.
How Neuro-Musculo-Skeletal care may help brain function.
Chiropractic is based on the now scientifically proven hypothesis that proper structure of the spine is required for proper function of the nervous system as it relates to the control and regulation of global physiology and health.”
Prevention and Management of Chronic PainMark Sexton
The Prevention and Managment of Chronic Pain. Slides for my 2012 lecture for the ICGP spring meeting.
Early identification of indications of neural sensitivity/adaptation key to appropriate early management and prevention.
این پاورپوینت خلاصه شده فصل شش یکی از کتابهای مربوط به علوم اعصاب است. این پاورپوینت در کارگاه تخصصی توانبخشی دیداری عصبی توسط دکتر علیزاده ارائه شده است.
Presented by Brad Aiken
Doctor and science-fiction writer Brad Aiken presents on new and upcoming technologies in neurological rehabilitation. Topics include breakthrough advances that can help people recover from stroke, brain injury, and spinal cord injury. Current, cutting-edge technologies will be discussed, as well as likely upcoming advances in this field.
این پاورپوینت در کارگاه توانبخشی شناختی در اختلالات یادگیری توسط دکتر فائزه دهقان ارائه شده است
برای مشاهده مطالب بیشتر در این زمینه، به وب سایت فروردین مراجعه نمایید.
IOSR Journal of Nursing and health Science is ambitious to disseminate information and experience in education, practice and investigation between medicine, nursing and all the sciences involved in health care.
Nursing & Health Sciences focuses on the international exchange of knowledge in nursing and health sciences. The journal publishes peer-reviewed papers on original research, education and clinical practice.
By encouraging scholars from around the world to share their knowledge and expertise, the journal aims to provide the reader with a deeper understanding of the lived experience of nursing and health sciences and the opportunity to enrich their own area of practice
Role of various systems to maintain balance.
Role of sensory systems-vision,proprioceptors,vestibular
Role of Musculoskeletal system
Biomechanics in balance
Contextual factors in balance
Role of nervous system
Strategies-ankle, hip,stepping
Theoretical framework of infant physiotherapyAnwesh Pradhan
MPT class- Theoretical framework of infant physiotherapy. Require 3 class. Help us to decide the paediatric physiotherapy approach for paediatric patient.
Topic- "The Binocular Continuum"
Speaker: Dr Paul Harris
Hello Everyone, Namaste!!
We would like to notify you all that Mero Eye Foundation is going to conduct an "EYE TALKS-Webinar", and we will be having our session live broadcasted on YouTube (Session No. 97)
DATE – Sun, 08:00 p.m NPT, 07:45 p.m IST, 10:15 a.m EDT, 9th August 2020
YouTube Live- https://youtu.be/T4-tn6LKt1w
Learn More - https://www.paulharrisod.com/papers
The presentation includes physiological mechanism of different functional classes of eye movements such as horizontal & vertical eye movements, saccades, persuits, vestibuloocular reflex, Bell's phenomenon and it also includes different disorders that causes abnormal supranuclear eye movements e.g. skew deviation, Perinaud syndrome, INO.
Understanding the various theories of motor control- reflex-hierarchal theory, ecological theory, dynamic systems theory and it's clinical application; also forming the basis of neurological rehabilitation techniques like Task-orient approach, Constraint induced movement therapy (CIMT), NDT (Neurodevelopmental Facilitation).
Title: Sense of Taste
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the structure and function of taste buds.
Describe the relationship between the taste threshold and taste index of common substances.
Explain the chemical basis and signal transduction of taste perception for each type of primary taste sensation.
Recognize different abnormalities of taste perception and their causes.
Key Topics:
Significance of Taste Sensation:
Differentiation between pleasant and harmful food
Influence on behavior
Selection of food based on metabolic needs
Receptors of Taste:
Taste buds on the tongue
Influence of sense of smell, texture of food, and pain stimulation (e.g., by pepper)
Primary and Secondary Taste Sensations:
Primary taste sensations: Sweet, Sour, Salty, Bitter, Umami
Chemical basis and signal transduction mechanisms for each taste
Taste Threshold and Index:
Taste threshold values for Sweet (sucrose), Salty (NaCl), Sour (HCl), and Bitter (Quinine)
Taste index relationship: Inversely proportional to taste threshold
Taste Blindness:
Inability to taste certain substances, particularly thiourea compounds
Example: Phenylthiocarbamide
Structure and Function of Taste Buds:
Composition: Epithelial cells, Sustentacular/Supporting cells, Taste cells, Basal cells
Features: Taste pores, Taste hairs/microvilli, and Taste nerve fibers
Location of Taste Buds:
Found in papillae of the tongue (Fungiform, Circumvallate, Foliate)
Also present on the palate, tonsillar pillars, epiglottis, and proximal esophagus
Mechanism of Taste Stimulation:
Interaction of taste substances with receptors on microvilli
Signal transduction pathways for Umami, Sweet, Bitter, Sour, and Salty tastes
Taste Sensitivity and Adaptation:
Decrease in sensitivity with age
Rapid adaptation of taste sensation
Role of Saliva in Taste:
Dissolution of tastants to reach receptors
Washing away the stimulus
Taste Preferences and Aversions:
Mechanisms behind taste preference and aversion
Influence of receptors and neural pathways
Impact of Sensory Nerve Damage:
Degeneration of taste buds if the sensory nerve fiber is cut
Abnormalities of Taste Detection:
Conditions: Ageusia, Hypogeusia, Dysgeusia (parageusia)
Causes: Nerve damage, neurological disorders, infections, poor oral hygiene, adverse drug effects, deficiencies, aging, tobacco use, altered neurotransmitter levels
Neurotransmitters and Taste Threshold:
Effects of serotonin (5-HT) and norepinephrine (NE) on taste sensitivity
Supertasters:
25% of the population with heightened sensitivity to taste, especially bitterness
Increased number of fungiform papillae
New Drug Discovery and Development .....NEHA GUPTA
The "New Drug Discovery and Development" process involves the identification, design, testing, and manufacturing of novel pharmaceutical compounds with the aim of introducing new and improved treatments for various medical conditions. This comprehensive endeavor encompasses various stages, including target identification, preclinical studies, clinical trials, regulatory approval, and post-market surveillance. It involves multidisciplinary collaboration among scientists, researchers, clinicians, regulatory experts, and pharmaceutical companies to bring innovative therapies to market and address unmet medical needs.
NVBDCP.pptx Nation vector borne disease control programSapna Thakur
NVBDCP was launched in 2003-2004 . Vector-Borne Disease: Disease that results from an infection transmitted to humans and other animals by blood-feeding arthropods, such as mosquitoes, ticks, and fleas. Examples of vector-borne diseases include Dengue fever, West Nile Virus, Lyme disease, and malaria.
Prix Galien International 2024 Forum ProgramLevi Shapiro
June 20, 2024, Prix Galien International and Jerusalem Ethics Forum in ROME. Detailed agenda including panels:
- ADVANCES IN CARDIOLOGY: A NEW PARADIGM IS COMING
- WOMEN’S HEALTH: FERTILITY PRESERVATION
- WHAT’S NEW IN THE TREATMENT OF INFECTIOUS,
ONCOLOGICAL AND INFLAMMATORY SKIN DISEASES?
- ARTIFICIAL INTELLIGENCE AND ETHICS
- GENE THERAPY
- BEYOND BORDERS: GLOBAL INITIATIVES FOR DEMOCRATIZING LIFE SCIENCE TECHNOLOGIES AND PROMOTING ACCESS TO HEALTHCARE
- ETHICAL CHALLENGES IN LIFE SCIENCES
- Prix Galien International Awards Ceremony
Lung Cancer: Artificial Intelligence, Synergetics, Complex System Analysis, S...Oleg Kshivets
RESULTS: Overall life span (LS) was 2252.1±1742.5 days and cumulative 5-year survival (5YS) reached 73.2%, 10 years – 64.8%, 20 years – 42.5%. 513 LCP lived more than 5 years (LS=3124.6±1525.6 days), 148 LCP – more than 10 years (LS=5054.4±1504.1 days).199 LCP died because of LC (LS=562.7±374.5 days). 5YS of LCP after bi/lobectomies was significantly superior in comparison with LCP after pneumonectomies (78.1% vs.63.7%, P=0.00001 by log-rank test). AT significantly improved 5YS (66.3% vs. 34.8%) (P=0.00000 by log-rank test) only for LCP with N1-2. Cox modeling displayed that 5YS of LCP significantly depended on: phase transition (PT) early-invasive LC in terms of synergetics, PT N0—N12, cell ratio factors (ratio between cancer cells- CC and blood cells subpopulations), G1-3, histology, glucose, AT, blood cell circuit, prothrombin index, heparin tolerance, recalcification time (P=0.000-0.038). Neural networks, genetic algorithm selection and bootstrap simulation revealed relationships between 5YS and PT early-invasive LC (rank=1), PT N0—N12 (rank=2), thrombocytes/CC (3), erythrocytes/CC (4), eosinophils/CC (5), healthy cells/CC (6), lymphocytes/CC (7), segmented neutrophils/CC (8), stick neutrophils/CC (9), monocytes/CC (10); leucocytes/CC (11). Correct prediction of 5YS was 100% by neural networks computing (area under ROC curve=1.0; error=0.0).
CONCLUSIONS: 5YS of LCP after radical procedures significantly depended on: 1) PT early-invasive cancer; 2) PT N0--N12; 3) cell ratio factors; 4) blood cell circuit; 5) biochemical factors; 6) hemostasis system; 7) AT; 8) LC characteristics; 9) LC cell dynamics; 10) surgery type: lobectomy/pneumonectomy; 11) anthropometric data. Optimal diagnosis and treatment strategies for LC are: 1) screening and early detection of LC; 2) availability of experienced thoracic surgeons because of complexity of radical procedures; 3) aggressive en block surgery and adequate lymph node dissection for completeness; 4) precise prediction; 5) adjuvant chemoimmunoradiotherapy for LCP with unfavorable prognosis.
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New Directions in Targeted Therapeutic Approaches for Older Adults With Mantl...i3 Health
i3 Health is pleased to make the speaker slides from this activity available for use as a non-accredited self-study or teaching resource.
This slide deck presented by Dr. Kami Maddocks, Professor-Clinical in the Division of Hematology and
Associate Division Director for Ambulatory Operations
The Ohio State University Comprehensive Cancer Center, will provide insight into new directions in targeted therapeutic approaches for older adults with mantle cell lymphoma.
STATEMENT OF NEED
Mantle cell lymphoma (MCL) is a rare, aggressive B-cell non-Hodgkin lymphoma (NHL) accounting for 5% to 7% of all lymphomas. Its prognosis ranges from indolent disease that does not require treatment for years to very aggressive disease, which is associated with poor survival (Silkenstedt et al, 2021). Typically, MCL is diagnosed at advanced stage and in older patients who cannot tolerate intensive therapy (NCCN, 2022). Although recent advances have slightly increased remission rates, recurrence and relapse remain very common, leading to a median overall survival between 3 and 6 years (LLS, 2021). Though there are several effective options, progress is still needed towards establishing an accepted frontline approach for MCL (Castellino et al, 2022). Treatment selection and management of MCL are complicated by the heterogeneity of prognosis, advanced age and comorbidities of patients, and lack of an established standard approach for treatment, making it vital that clinicians be familiar with the latest research and advances in this area. In this activity chaired by Michael Wang, MD, Professor in the Department of Lymphoma & Myeloma at MD Anderson Cancer Center, expert faculty will discuss prognostic factors informing treatment, the promising results of recent trials in new therapeutic approaches, and the implications of treatment resistance in therapeutic selection for MCL.
Target Audience
Hematology/oncology fellows, attending faculty, and other health care professionals involved in the treatment of patients with mantle cell lymphoma (MCL).
Learning Objectives
1.) Identify clinical and biological prognostic factors that can guide treatment decision making for older adults with MCL
2.) Evaluate emerging data on targeted therapeutic approaches for treatment-naive and relapsed/refractory MCL and their applicability to older adults
3.) Assess mechanisms of resistance to targeted therapies for MCL and their implications for treatment selection
These simplified slides by Dr. Sidra Arshad present an overview of the non-respiratory functions of the respiratory tract.
Learning objectives:
1. Enlist the non-respiratory functions of the respiratory tract
2. Briefly explain how these functions are carried out
3. Discuss the significance of dead space
4. Differentiate between minute ventilation and alveolar ventilation
5. Describe the cough and sneeze reflexes
Study Resources:
1. Chapter 39, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 34, Ganong’s Review of Medical Physiology, 26th edition
3. Chapter 17, Human Physiology by Lauralee Sherwood, 9th edition
4. Non-respiratory functions of the lungs https://academic.oup.com/bjaed/article/13/3/98/278874
Knee anatomy and clinical tests 2024.pdfvimalpl1234
This includes all relevant anatomy and clinical tests compiled from standard textbooks, Campbell,netter etc..It is comprehensive and best suited for orthopaedicians and orthopaedic residents.
The prostate is an exocrine gland of the male mammalian reproductive system
It is a walnut-sized gland that forms part of the male reproductive system and is located in front of the rectum and just below the urinary bladder
Function is to store and secrete a clear, slightly alkaline fluid that constitutes 10-30% of the volume of the seminal fluid that along with the spermatozoa, constitutes semen
A healthy human prostate measures (4cm-vertical, by 3cm-horizontal, 2cm ant-post ).
It surrounds the urethra just below the urinary bladder. It has anterior, median, posterior and two lateral lobes
It’s work is regulated by androgens which are responsible for male sex characteristics
Generalised disease of the prostate due to hormonal derangement which leads to non malignant enlargement of the gland (increase in the number of epithelial cells and stromal tissue)to cause compression of the urethra leading to symptoms (LUTS
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Ve...kevinkariuki227
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
Title: Sense of Smell
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the primary categories of smells and the concept of odor blindness.
Explain the structure and location of the olfactory membrane and mucosa, including the types and roles of cells involved in olfaction.
Describe the pathway and mechanisms of olfactory signal transmission from the olfactory receptors to the brain.
Illustrate the biochemical cascade triggered by odorant binding to olfactory receptors, including the role of G-proteins and second messengers in generating an action potential.
Identify different types of olfactory disorders such as anosmia, hyposmia, hyperosmia, and dysosmia, including their potential causes.
Key Topics:
Olfactory Genes:
3% of the human genome accounts for olfactory genes.
400 genes for odorant receptors.
Olfactory Membrane:
Located in the superior part of the nasal cavity.
Medially: Folds downward along the superior septum.
Laterally: Folds over the superior turbinate and upper surface of the middle turbinate.
Total surface area: 5-10 square centimeters.
Olfactory Mucosa:
Olfactory Cells: Bipolar nerve cells derived from the CNS (100 million), with 4-25 olfactory cilia per cell.
Sustentacular Cells: Produce mucus and maintain ionic and molecular environment.
Basal Cells: Replace worn-out olfactory cells with an average lifespan of 1-2 months.
Bowman’s Gland: Secretes mucus.
Stimulation of Olfactory Cells:
Odorant dissolves in mucus and attaches to receptors on olfactory cilia.
Involves a cascade effect through G-proteins and second messengers, leading to depolarization and action potential generation in the olfactory nerve.
Quality of a Good Odorant:
Small (3-20 Carbon atoms), volatile, water-soluble, and lipid-soluble.
Facilitated by odorant-binding proteins in mucus.
Membrane Potential and Action Potential:
Resting membrane potential: -55mV.
Action potential frequency in the olfactory nerve increases with odorant strength.
Adaptation Towards the Sense of Smell:
Rapid adaptation within the first second, with further slow adaptation.
Psychological adaptation greater than receptor adaptation, involving feedback inhibition from the central nervous system.
Primary Sensations of Smell:
Camphoraceous, Musky, Floral, Pepperminty, Ethereal, Pungent, Putrid.
Odor Detection Threshold:
Examples: Hydrogen sulfide (0.0005 ppm), Methyl-mercaptan (0.002 ppm).
Some toxic substances are odorless at lethal concentrations.
Characteristics of Smell:
Odor blindness for single substances due to lack of appropriate receptor protein.
Behavioral and emotional influences of smell.
Transmission of Olfactory Signals:
From olfactory cells to glomeruli in the olfactory bulb, involving lateral inhibition.
Primitive, less old, and new olfactory systems with different path
1. Journal of Behavioral OptometryVolume 23/2012/Number2/Page 40
Dynamic Vision: Vision Therapy
through the Anti-Gravity System
Tanner Gates, OD
Madonna Rehabiliation Hospital
Lincoln, Nebraska
Abstract
In the four circle model, AM Skeffington proposed the idea of the anti-gravity system as one of the building blocks of
vision. While the anti-gravity system is highly active in many vision therapy techniques, conditions can be arranged
to ensure full engagement. This paper will briefly discuss the tecto-pulvinar pathway and vestibular system and ex-
plain how they play a role in vision therapy as it relates to the anti-gravity system. Specific vision therapy procedures
emphasizing the anti-gravity system will be discussed.
Key Words
anti-gravity, Bal-A-Vis-X, central-peripheral organization, Hart chart saccades, sensory integration, space fixator,
tecto-pulvinar pathway, vestibular system, vision therapy
In school, I remember learning about the incredible detail
and complex processes that go into making vision possible.
During that time, the concepts focused on the neurophysiology
of light and how the information was sent to the brain as useful
pieces of life and information. The whole process was remark-
able, but I seldom found clinical and real life applicability to
what I was learning. I was taught an appreciation for how visu-
al information was sent to specific areas of the brain resulting
in visual processes like accommodation, vergence, saccades,
pursuits, visual-spatial organization, and visual-vestibular in-
tegration. But, what if these visual processes do not function at
their most optimal levels? What I wanted to know were vision
therapy techniques that could help to turn on these visual path-
ways and lead to efficient visual processing and purposeful
movements through space. I propose to integrate multiple neu-
rological systems into vision therapy procedures to enhance
the therapy. The goal of this paper is to provide a condensed
explanation of the tecto-pulvinar pathway and vestibular sys-
tem and integrate them into several vision therapy procedures.
There is little argument that vision is our dominant sense;
its integration with other neurological systems and pathways
shows that without an efficient visual system, we are at an ex-
treme disadvantage when attempting to derive meaning from
our surroundings. These neurological pathways process a wide
range of visual tasks to keep our bodies in a state of clarity and
equilibrium, as well as process information for all our senses.1
It is how we integrate this total system that allows for efficient,
purposeful vision and movement.
Skeffington proposed his four circles model of vision and
explained the importance of gravity on vision. It is described
as the ‘Where am I’ aspect for the person and ‘Where is my
body in relationship to my surroundings.’1
We know there are
specific neurons that are solely devoted to helping the body
maintain balance, posture, and movement through space. The
less effective the anti-gravity system, the more energy is re-
quired to establish proper balance. This results in less freedom
to manipulate visual processes adequately. It has been found
that visual input makes up nearly one-third of the sensory in-
formation that is used for balance and equilibrium.2
This can
be appreciated by merely standing with your feet heel-to-toe
and trying to balance with your eyes closed. An action that is
generally easy to perform when the eyes are open, now be-
comes a challenging task without visual input. Pertinent to
this paper are two pathways that contribute to the anti-gravity
system and help maintain the stability of the body’s visual en-
vironment by compensating for the effects body movements
have on the position of images on the retina.
A pathway known commonly as the tecto-pulvinar, su-
perior collicular, or extrastriate (reflecting the regions of the
brain involved in processing) does not travel to the primary
visual cortex (V1) for processing. This pathway relays visual
neuronal information to the extrastriate visual cortical areas
for processing of orientation, motion, and speed. This visual
pathway bypasses the lateral genticulate nucleus (LGN) and
V1 completely and coordinates visual-motor tasks, body, and
head movements for stability of fixation. This pathway also
integrates with the vestibular, tactile, proprioceptive, and au-
ditory systems as well as other areas of the cortex.3
There is
much in common with the magnocellular pathway, which is
primarily involved in location and movement of objects with
an emphasis on stimuli in peripheral space.
Another system that is highly involved in vision and bal-
ance is the vestibular system. The vestibular system serves
to stabilize eye position and movement during changes in
head position. The vestibular apparatus located in the inner
ear consists of semicircular canals to monitor rotational and
angular head movements. The orientation of the semicircular
canals mirrors the actions of the extra-ocular muscles of the
eye. The vestibular ocular reflex (VOR) plays a pivotal role
in the vestibular system. It helps to maintain bifoveal fixation
by managing compensatory eye movements to head and body
movements. Each semicircular canal is connected to one ipsi-
lateral and one contralateral extra-ocular muscle. For the eyes
to move horizontally, a signal generated in the horizontal semi-
2. Volume 23/2011/Number 2/Page 41Journal of Behavioral Optometry
circular canal goes to the vestibular nuclei in the brain stem.
From there it travels to the contralateral abducens nerve (CN
VI) nucleus and ipsilateral oculomotor nerve (CN III) nucleus
by way of the medial longitudinal fasciculus. This innervation
creates a subsequent eye turn to the right in response to a head
turn to the left.2
For therapy to be at an optimal level, integration of multiple
senses and systems must take place. The term sensory integra-
tion is defined as the ability of the central nervous system to
take in, sort out, and interrelate information received from the
body and the environment to allow for purposeful responses.4
The idea of sensory integration is closely related to the Gestalt
concept of Figure-Ground. The primary focus (Figure) is dis-
tinguished from, but still integrated with, whatever is periph-
erally attended to (Ground), thus producing multi-awareness.
Proper sensory integration is pivotal for efficient action, and so
the collaboration of vision therapy with other therapies can be
beneficial. Proper testing is needed to ensure a reliable referral
when necessary.5
Many patients come to vision therapy practices with visual
issues manifesting from disruptions in the anti-gravity system.
It is important that we understand this integration between vi-
sion and the other senses; this integration is crucial for proper
development. Specific procedures can be used and certain con-
ditions can be arranged to elicit the optimal response. The anti-
gravity system can be added into vision therapy procedures to
ensure integration and increase the degrees of freedom, allow-
ing for full patient potential.
Movement, balance, and auditory stimulation can be incor-
porated into vision therapy, integrating multiple systems.6
The
manner in which variables in techniques can be manipulated
is truly limitless. These procedures are not intended to replace
others, but merely to serve as additional ways to arrange con-
ditions differently to create opportunities for learning. Because
the scope of this paper is limited, three vision therapy proce-
dures that incorporate the integration of these sensory systems
will be discussed.
Space Fixator
Materials: Space Fixator, Translucent Occluder, Metronome
This procedure is deeply rooted in the integration of mul-
tiple sensory processes.7
The incorporation of visual, vestibu-
lar, tactile, auditory, and proprioceptive awareness can be ac-
complished with proper use. You will see an increased ability
in the eyes to move quickly, accurately, and efficiently from
one target to another. The device is ostensibly designed to be
unsteady, but this element creates a need for accurate spatial
judgments along the z-axis. This swivel and instability re-
quire precise tactile and visual-spatial movement to succeed
in the task. A coherence of central-peripheral organization is
also stressed in this procedure by requiring the patient both
to localize the target accurately and to be peripherally aware
of the next target prior to movement. A sense of “leading with
eyes and brain” is encouraged to obtain efficiency in saccadic
and spatial eye movements. The use of a metronome set at 60
beats per minute for each instructional set requires the patient
to direct the body in a rhythmic and coordinated manner. Cog-
nitive loading can be accomplished through simple dialogue
regarding the patient’s history or even math problems aimed at
creating a new demand for the procedure.
The first level of the procedure begins with creating an un-
derstanding of peripheral awareness to lead the eyes in move-
ment from point to point along the spatial plane. As the center
target is fixated upon, an ‘awareness’ of the 3 o’clock posi-
tion should be appreciated before a quick, precise saccade is
performed. When efficient central-peripheral organization has
been consistently observed, the integration of multiple sensory
processing is required for accurate and rhythmic eye move-
ments in conjunction with hand movements along the pat-
terned board (Figure 1a). As the level set increases, efficient
eye movements combined with homolateral and contralateral
hand and foot movements bring an integration of multiple sen-
sory systems (Figure 1b). Appendix A describes various levels
of training with the Space Fixator.
Loaded Chart Saccades
Materials: Letter/Number Chart(s), Balance Board, Metro-
nome
The possibilities for variation and loading are extensive in
this technique. To incorporate multiple pathways and systems
such as the tecto-pulvinar and vestibular, the addition of a
balance board, or movement forward and backward, can be
used. It is amazing how much additional cognitive attention is
necessary to perform saccades and fixations while keeping a
consistent walking pace. A metronome can be added to assist
in visual-auditory integration and reinforce the need for coor-
dinated and rhythmic movement and speech. To add cognitive
load to the procedure, one could direct the patient to change
directions of movement (if multiple charts are used) –clock-
wise & counterclockwise–upon vowels (Figure 2). The patient
could also be instructed to keep a running count of numbers in
multiples of three, upon vowels, or any letter predetermined.
If the charts contain numbers, the patient could be instructed
to raise his right hand on even numbers and left hand on odd
numbers. While loading the procedure with different cognitive
demands, precise, rhythmic saccades are continually empha-
sized as the patient reads through the charts. The possibility for
Figure 1. a) One of the early levels of the Space Fixator se-
quence being performed using hands only. b) More advanced
level now using hand and contralateral foot movement
3. Journal of Behavioral OptometryVolume 23/2012/Number2/Page 42
many variations makes this an effective and engaging activity
for the patient.
Bal-A-Vis-X (Balance Auditory Vision
eXercises)
Materials: Bal-A-Vis-X set including Information Book and/
or DVD set
Sensory integration is at the center of this activity. There
are over 300 different exercises listed, each consisting of spe-
cially designed ways of integrating the visual, vestibular, and
auditory systems for an overall awareness of body movements
in space. This is used in occupational therapy settings, and
schools, and certainly would be of benefit in vision therapy
because of one of its fundamental principles: the eyes are at the
forefront in creating smooth movements in space. Each level
includes the use of bean bags or racquetballs.
The first level involves two people working together in
a self-rhythmic pattern tossing one bag with the right hand,
catching it with the left, and clapping the bag over their mid-
line to the right hand before tossing again. Emphasis is placed
on the eyes maintaining a steady fixation of the bag through-
out the activity. Smooth, accurate pursuits are necessary when
tossing and catching, in addition to saccades when the bag is
crossed over the midline. The addition of another bag creates
a higher demand and requires more accurate timing and syn-
chronizing (Figure 3). The same instructions mentioned above
are performed with two bags being tossed simultaneously in
the air. The same activities can be done with balls, placing an
emphasis on visual space and where to bounce the ball so your
partner can easily catch it. The standard pattern is to toss with
the right hand and catch with the left, but a direction change
of tossing with the left and catching with the right can be used
to load. A more advanced level includes the use of three bags
or balls and requires efficient central-peripheral organization.
The two balls or bags are directed “outside” of the one allow-
ing for an alternate exchange between central attention for the
one, and peripheral attention for the two. Because the tech-
niques are very detailed and have specific directives, it is best to
refer to the website at http://www.bal-a-vis-x.com/index.htm,
where more information on each level set including instruc-
tions can be found.
Conclusion
As previously noted, this is merely scratching the surface
of what can be done with any vision therapy technique. The
possibilities to vary procedures are limitless, and to be able to
emphasize elements of procedures for each individual is quite
beneficial. To some, the introduction of these procedures may
seem unrelated to vision therapy, but that could not be further
from the truth. Utilizing balance and movement supports the
idea that every human being is a dynamic balancing system
and must create and maintain degrees of freedom to balance,
first and foremost with gravity. The more efficient and smooth
our anti-gravity system, the more efficient our total visual sys-
tem will be.
References
1. Birnbaum MH. Optometric Management of Nearpoint Vision Disorders.
Boston, MA: Butterworth-Heinemann, 1993.
2. Meija GA. Vision and balance the optometrist’s role in managing patients
with dizziness and vestibular dysfunction. J Behav Optom 2008;19:97-
102.
3. Braddick OJ, O’Brien JM, Wattam-Bell J, Atkinson J, et al. Brain areas
sensitive to coherent visual motion. Perception 2001;30: 61-72.
4. Appelbaum SA. Sensory Integration: Optometric and Occupational Thera-
py Perspectives. Santa Ana, CA: Optometric Extension Program, 1988.
5. Pepper RC, Nordgren MJ. Stress-Point Learning: A Multi-sensory Ap-
proach to Processing Information. Santa Ana, CA: Optometric Extension
Program, 2006.
6. Hoopes AM, Appelbaum SA. Eye Power: A Cutting Edge Report on Vision
Therapy. Lexington, KY: 2010.
7. Sanet RB. Powerful Vision Therapy Seminar. San Diego, CA: 2011.
Corresponding author:
Tanner Gates, OD
Madonna Rehabilitation Hospital
5445 South Street
Lincoln, Nebraska USA 08506
tannercgates@gmail.com
Date submitted for pulication: 27 March 2011
Date accepted for publication: 27 April 2011
Figure 2. Multiple chart saccades displayed for use with clock-
wise/counterclockwise sequence
Figure 3. Bal-A-Vis-X performed using two bags displaying
accuracy, timing, and visual skills necessary
4. Volume 23/2011/Number 2/Page 43Journal of Behavioral Optometry
Appendix A.
(Adapted from the work of Robert Sanet, OD)
Level I – Eye Control and Peripheral Awareness
1. Patient stands approximately sixteen inches (40 cm.) away at eye level with one eye occluded.
2. Patient is asked to look at the center fixation target to his left and while using his peripheral vision to locate the 3 o’clock position and
then shift his eyes quickly and accurately to that target. The patient is to shift his eyes back and forth between the two fixation targets
at five-second intervals with the doctor/therapist observing for over or undershooting.
3. When this step is mastered, the patient repeats all of the above using the 9 o’clock target, and so on until all targets have been com-
pleted. The entire sequence is repeated using the other eye.
Level II – Eye-Hand
1. Patient stands approximately sixteen inches (40 cm.) away at eye level with one eye occluded.
2. The following sequence is first demonstrated by the doctor/therapist and then practiced by the patient.
a) “Look” –patient maintains peripheral awareness of all dots and moves his eyes from the center dot to the 12 o’clock target.
b) “Ready” – patient maintains fixation and raises right hand to right temple in a “salute.”
c) ”Touch” – maintaining fixation, the patient touches the target with the index finger of his right hand, emphasizing an accurate spatial
judgment on the “z” axis.
d) “Back” – patient returns fixation to the center target and right hand returns to the side.
3. Patient continues sequence on all dots in a clockwise pattern. With practice, a metronome set at 60bpm is used and the patient calls out and
executes the commands in rhythm with the metronome.
4. Repeat entire sequence using the left hand. Then repeat with left eye, then both eyes.
Level III – Alternate Hands
1. Patient repeats Level II but now alternates hands.
Level IV – Homolateral Hand-Feet
1. Patient repeats all steps in Level II but using a homolateral pattern. When the right hand is used on the “touch” command, the right hand
will touch the target and the right foot will step forward touching the toe to the floor; when the left hand is used, the left foot steps forward.
On the“back” command, both the hand and foot return to starting position.
Level V – Contralateral Hand-Feet
1. Repeat all steps in Level IV using a contralateral pattern.
Level VI – Change Eye Movement-Homolateral
1. Patient begins in homolateral pattern, alternating hands. When a clicker sounds, the patient completes the sequence for the target he is on,
and for the next target changes direction of eye movement (clockwise – counter-clockwise). He will continue with that until the clicker
sounds again, at which point he will change eye movement direction again.
Level VII – Change Eye Movement-Contralateral
1. Repeat Level VI using the contralateral pattern.
Level VIII – Change Homolateral-Contralateral
1. Patient proceeds using the homolateral pattern in a clockwise pattern. When the clicker sounds, the patient completes the sequence for
the target he is on, and for the next target switches to the contralateral pattern. He will continue with that until the clicker sounds again,
at which point he will switch back to the homolateral pattern. The patient does not change direction of eye movement, only the pattern of
hand and foot.
Level IX – Change Eye Direction & Homolateral-Contralateral
1. Patient is instructed on how to respond to two different cues:
a) When the clicker sounds, he is to change the direction of eye movement only.
b) When the doctor/therapist says “SAME” the patient uses a homolateral pattern, and when the doctor/therapist says “OPPOSITE”
the patient switches to contralateral. If “SAME” is said while performing a homolateral pattern or “OPPOSITE” while performing a
contralateral pattern, the pattern does not need to a change.
Level X – Peripheral Touch
1. All of the above levels can be practiced using a variation of the “Look-Ready-Touch-Back” sequence. The variation is:
a) “Locate” – while maintaining fixation on the center target, the patient locates the 12 o’clock target using peripheral awareness.
b) “Touch” – maintaining fixation on the center target, the patient touches the 12 o’clock target, using peripheral awareness and localiza-
tion to guide him.
c) “Look” – patient shifts fixation to target to verify accuracy of touch.
d) “Back” – arm returns to patient’s side and eye returns to center dot.
2. Repeat using eye movement, pattern changes, and verbal cues as described above.