This document summarizes different mechanisms of sex determination in animals. It discusses chromosomal sex determination mechanisms including XX-XO type (found in grasshoppers and aphids), XX-XY type (found in humans), ZZ-ZW type (found in birds), and haplodiploid type. It also covers environmental sex determination influenced by factors like temperature (in crocodiles and turtles) and location (in Bonellia viridis). Sex determination in Drosophila depends on the ratio of X chromosomes to autosomes. The document concludes that the key to maleness and femaleness ultimately lies in the control of gene expression.