20140711 NIST ERCC 2.0 Workshop

1. ERCC
2.0
Workshop
Day
2
July
11,
2014
Sarah
Munro
and
Marc
Salit

2. WELCOME

3. Charge
to
the
Workshop
• Develop
consensus
on…
– Concept
• Shared
interests
– PorDolio
• Controls
• Analysis
• Documentary
Standards
• Develop
consorGum
structure…
– Working
groups
– Steering
commiHee

4. What
we
heard
yesterday…
• Stage
in
complexity
• PrioriGze
clinical
applicaGons
• PrioriGes
we
heard
yesterday…
– Update
formulaGons
of
ERCC
1.0
controls
– Refinement
of
“monolithic”
transcripts
– Cancer
fusion
transcripts
– Transcript
isoforms
• Allele
specific
expression
could
be
included
applicaGon
– miRNAs
– Use
of
controls
in
FFPE
samples
– Allele
specific
expression
is
an
important
applicaGon
to
consider
• Not
combined
in
one
mixture
or
product
• Nothing
is
off
the
table
• Establish
principles
for
growing
porDolio
Blue
text
added
during
discussion

5. Agenda
• ParGcipant
PresentaGons
– James
Willey
– Tyson
Clark
– Elizabeth
Tseng
– Joel
Myerson
• Open
Pitch
Session
• Break:
10:30
–
11:00am
• Planning
our
work
• Steering
CommiHee
SelecGon
• MeeGng
Summary
Discussion
&
Next
Steps

6. PARTICIPANT
PRESENTATIONS

7. OPEN
PITCH
SESSION

8. MEETING
SUMMARY
DISCUSSION
&
NEXT
STEPS