This document provides an overview of the RELMA tool for mapping local laboratory terms to standardized LOINC codes. It discusses the goals of health information standards including interoperability and comparability. It then reviews key aspects of the RELMA tool including installing RELMA, loading and preparing local terms for mapping, searching LOINC hierarchies, mapping terms, and exporting mapped terms. The presentation emphasizes best practices for accurate mapping including understanding what is being measured versus reported and ensuring all aspects of the LOINC code are appropriately represented.
The document provides an overview of a Laboratory LOINC Meeting held in June 2010. It discusses the goals of health information standards to improve interoperability, comparability and data quality. The meeting covered installing and using the RELMA tool to map local lab terms to standardized LOINC codes. This process helps laboratories exchange data in a common format and allows comparison of test results across different sites.
This document describes a single-laboratory validation study of a combustion method for determining total sulfur content in fertilizers. The method involves combusting samples at 1150°C, converting sulfur species to SO2, and measuring SO2 levels using a thermal conductivity detector. Eleven fertilizer samples with sulfur content ranging from 1.47-91% were analyzed over multiple days. Recoveries ranged from 94.3-125.9% and precision was good, suggesting the method is accurate and precise for determining total sulfur in fertilizers. Further collaborative study is recommended to validate the method.
The document characterizes emissions of dioxins and furans from ethylene dichloride, vinyl chloride monomer and polyvinyl chloride facilities in the United States. Testing was conducted on various process streams including water, stack emissions, and products. Testing showed detectable levels of dioxins and furans in many samples, with concentrations varying depending on the specific facility and process stream. The highest levels were generally found in stack emissions from combustion devices used at ethylene dichloride and vinyl chloride facilities. Overall, the study estimated total emissions of dioxins and furans to the environment from these facilities to be about 12 grams per year.
The role of process analytical technology (pat) in green chemistry and green ...dominev
This document discusses the use of process analytical technology (PAT) tools in green chemistry and engineering. It presents case studies on using Fourier transform infrared spectroscopy (FTIR) and reaction calorimetry to monitor and develop continuous bioprocesses and chemical reactions. Specifically, it examines how FTIR was used to monitor a biotransformation reaction and develop a continuous multi-step synthesis. It also explores how reaction calorimetry helped classify reaction kinetics and screen conditions to optimize reactions. The document emphasizes how PAT tools can advance green chemistry principles by enabling real-time process monitoring, improving reaction understanding, and facilitating continuous process development and scale-up.
2012 02 16 - Clinical LOINC Tutorial - Collections - Panels Forms and Assessm...dvreeman
This document summarizes a presentation on using LOINC (Logical Observation Identifiers Names and Codes) to standardize patient assessments. It discusses how LOINC provides a uniform model for representing standardized questions, answers, and panels/forms. The presentation covers the iterative development of LOINC's assessment model over 10 years, current assessment content in LOINC, and lessons learned regarding variation, data modeling, and intellectual property issues.
2011 05 26 - Lab LOINC Tutorial - Chicago - Handout version - fulldvreeman
The document provides information about an upcoming Laboratory LOINC Workshop in Chicago, Illinois. It includes an agenda for the workshop covering topics such as the origins of LOINC, using the RELMA mapping tool, searching and mapping local terms to LOINC codes, and hands-on practice mapping terms. The workshop will be led by Daniel Vreeman from Indiana University and Clem McDonald from the National Library of Medicine.
Presentation by Daniel J. Vreeman, PT, DPT, MSc for the AMIA KRS Working Group. Title: LOINC - An Introduction to the Universal Catalog of Laboratory and Clinical Observations.
This document provides an overview of the RELMA tool for mapping local laboratory terms to standardized LOINC codes. It discusses the goals of health information standards including interoperability and comparability. It then reviews key aspects of the RELMA tool including installing RELMA, loading and preparing local terms for mapping, searching LOINC hierarchies, mapping terms, and exporting mapped terms. The presentation emphasizes best practices for accurate mapping including understanding what is being measured versus reported and ensuring all aspects of the LOINC code are appropriately represented.
The document provides an overview of a Laboratory LOINC Meeting held in June 2010. It discusses the goals of health information standards to improve interoperability, comparability and data quality. The meeting covered installing and using the RELMA tool to map local lab terms to standardized LOINC codes. This process helps laboratories exchange data in a common format and allows comparison of test results across different sites.
This document describes a single-laboratory validation study of a combustion method for determining total sulfur content in fertilizers. The method involves combusting samples at 1150°C, converting sulfur species to SO2, and measuring SO2 levels using a thermal conductivity detector. Eleven fertilizer samples with sulfur content ranging from 1.47-91% were analyzed over multiple days. Recoveries ranged from 94.3-125.9% and precision was good, suggesting the method is accurate and precise for determining total sulfur in fertilizers. Further collaborative study is recommended to validate the method.
The document characterizes emissions of dioxins and furans from ethylene dichloride, vinyl chloride monomer and polyvinyl chloride facilities in the United States. Testing was conducted on various process streams including water, stack emissions, and products. Testing showed detectable levels of dioxins and furans in many samples, with concentrations varying depending on the specific facility and process stream. The highest levels were generally found in stack emissions from combustion devices used at ethylene dichloride and vinyl chloride facilities. Overall, the study estimated total emissions of dioxins and furans to the environment from these facilities to be about 12 grams per year.
The role of process analytical technology (pat) in green chemistry and green ...dominev
This document discusses the use of process analytical technology (PAT) tools in green chemistry and engineering. It presents case studies on using Fourier transform infrared spectroscopy (FTIR) and reaction calorimetry to monitor and develop continuous bioprocesses and chemical reactions. Specifically, it examines how FTIR was used to monitor a biotransformation reaction and develop a continuous multi-step synthesis. It also explores how reaction calorimetry helped classify reaction kinetics and screen conditions to optimize reactions. The document emphasizes how PAT tools can advance green chemistry principles by enabling real-time process monitoring, improving reaction understanding, and facilitating continuous process development and scale-up.
2012 02 16 - Clinical LOINC Tutorial - Collections - Panels Forms and Assessm...dvreeman
This document summarizes a presentation on using LOINC (Logical Observation Identifiers Names and Codes) to standardize patient assessments. It discusses how LOINC provides a uniform model for representing standardized questions, answers, and panels/forms. The presentation covers the iterative development of LOINC's assessment model over 10 years, current assessment content in LOINC, and lessons learned regarding variation, data modeling, and intellectual property issues.
2011 05 26 - Lab LOINC Tutorial - Chicago - Handout version - fulldvreeman
The document provides information about an upcoming Laboratory LOINC Workshop in Chicago, Illinois. It includes an agenda for the workshop covering topics such as the origins of LOINC, using the RELMA mapping tool, searching and mapping local terms to LOINC codes, and hands-on practice mapping terms. The workshop will be led by Daniel Vreeman from Indiana University and Clem McDonald from the National Library of Medicine.
Presentation by Daniel J. Vreeman, PT, DPT, MSc for the AMIA KRS Working Group. Title: LOINC - An Introduction to the Universal Catalog of Laboratory and Clinical Observations.
The document provides an overview of the Regenstrief LOINC Mapping Assistant (RELMA) tool. It discusses RELMA's features for installing the tool, setting preferences, loading local observation files, searching for and mapping local terms to LOINC codes, and proposing new LOINC terms. The goal is to help laboratories map their local test names and codes to standardized LOINC codes to improve data interoperability, comparability and quality.
The LOINC name does not include the instrument used in testing, specific details about the specimen, priority (e.g. STAT), where testing was done, who did the test, test interpretation, or anything else that is not an intrinsic part of the name of the result.
The document discusses a presentation on LOINC (Logical Observation Identifiers Names and Codes) given at the 2011 Public Health Informatics conference in Atlanta, GA. The presentation provides an introduction to LOINC and covers topics such as the origins of LOINC, common elements in LOINC terms, LOINC collections like forms and surveys, and domain-specific approaches to mapping standards and terminologies in areas like microbiology. It also discusses LOINC tools and resources for mapping terms and codes.
This document provides an overview of RELMA (Regenstrief LOINC Mapping Assistant), a software tool for mapping local laboratory test names and codes to standardized LOINC codes. It discusses installing and using RELMA to facilitate mapping of a local observation file to LOINC codes. The goals are to improve data quality, interoperability and comparability by implementing standardized terminology.
2009 12 07 - LOINC Introduction and Overviewdvreeman
This document provides an overview and introduction to LOINC (Logical Observation Identifiers Names and Codes). It discusses the origins and growth of LOINC as a universal standard for identifying laboratory and clinical observations. Key points include: LOINC was created in 1994 by Regenstrief Institute to facilitate information exchange; it has over 80,000 codes covering many clinical domains and is used internationally; and adoption has increased steadily with over 800 downloads per month and participation from many organizations globally and within the US.
This document provides an overview of how to use RELMA (Regenstrief LOINC Mapping Assistant) to map local laboratory test names and codes to standardized LOINC codes. It discusses loading a local observation file containing local test data into RELMA, searching for LOINC terms, mapping local terms to LOINC codes, and exporting the mapped terms. The goal is to improve data interoperability, comparability and quality by standardizing test names and codes using the LOINC system.
The document discusses an introduction and tutorial about LOINC® and RELMA® given to the CDC Vocabulary Team Meeting. It provides an overview of the origins and growth of LOINC, which was created in 1994 to serve as a universal standard for identifying clinical observations. It aims to facilitate information exchange. The presentation describes LOINC's role in coding questions like lab test names rather than answers like numeric results. It also reviews the international adoption of LOINC across organizations in many countries.
Traditional methods of diagnosing infectious diseases like isolation, serology, and direct detection have limitations that influence their clinical utility. Molecular methods using nucleic acid detection and characterization have advantages like faster results, increased sensitivity and specificity, and ability to adapt to new instrumentation. Introducing molecular diagnostic testing requires evaluating needs, identifying suitable changes, developing protocols, providing resources, educating staff, and ensuring continuous quality improvement.
This document discusses methods for diagnosing infectious diseases. Traditional methods like isolation, serology, and direct detection have limitations in clinical utility due to factors like time, viability of organisms, and technical skill required. Molecular methods using nucleic acid detection and manipulation offer advantages like faster results, increased sensitivity and specificity, and adaptation to instrumentation. Introducing molecular diagnostic testing requires evaluating needs, identifying changes, developing protocols, providing resources, educating staff and clients, and ongoing evaluation and improvement. Key steps include specimen collection, nucleic acid extraction, PCR, detection, and reporting results.
This file includes the SLAS2013 presentations of Paul A. Johnston of University of Pittsburgh; Douglas Auld of Novartis Institutes for Biomedical Research; and Lisa Minor of In Vitro Strategies, LLC.
A proposal for interoperable health information exchange with two Esperantos: ICF and LOINC. Presented at the 2010 NAAC ICF Conference: Enhancing our Understanding of the ICF.
Application of adverse outcome pathways in chemical risk assessment, Dan Vill...OECD Environment
On 30 April 2019, the OECD organised a webinar on the Adverse Outcome Pathway (AOP) framework. The AOP framework is a collaborative tool that applies an innovative approach for collecting mechanistic knowledge from various sources that can eventually support chemical safety assessment.
The following questions were addressed:
What is the AOP framework and why should you care?
Why are we developing AOPs?
Why collaborations are encouraged and why should scientific societies be brought in?
What are the opportunities for collaboration in AOP development?
DIAGNOSTIC TEST AND INVESTIGATION IN PERIODONTOLOGY (1).pptxDr K. Abhilasha
This document provides an overview of investigations used in dental diagnosis. It begins by defining diagnosis and the role of laboratory investigations. It then classifies investigations based on where they are performed (chairside or laboratory), their specificity/sensitivity, the type of hospital laboratory service used, and frequency of dental use. The remainder of the document discusses various chairside and laboratory investigations in hematology, biochemistry, microbiology, and imaging that are used in dentistry.
Public Laboratory LOINC Workshop and Committee Meeting documents the origins and growth of LOINC as a universal standard for clinical observations and laboratory results. It discusses how LOINC provides a common language for information exchange and how its open model has led to widespread international adoption and translations. Large healthcare organizations around the world have implemented LOINC to facilitate interoperability across hundreds of systems.
Luke Lightning presented on pre-clinical drug development and ADME (absorption, distribution, metabolism, excretion) studies. He discussed why ADME is important for assessing a compound's developability. He provided examples of his experience conducting ADME studies at Alquest Therapeutics and a previous company. The presentation covered regulatory considerations for ADME studies, in vitro and in vivo study types and costs, and options for conducting studies in-house or outsourcing them. An example ADME work plan was presented, along with a summary of key points and future directions for ADME research.
Lisa Grimm has over 15 years of experience developing, optimizing, and validating various immunoassays, cell-based assays, and coagulation assays. She has worked in immunology, oncology, haemostasis, and biologics at several pharmaceutical companies. Currently she is a research scientist at Tandem Labs developing and validating immunoassays like ADA and neutralizing antibody assays under GLP regulations.
Pasteur Institute User Story - Cheminfo Stories 2020 Day 5ChemAxon
Here, we present an updated version of iPPI-DB, our manually curated database of PPI modulators. In this release, the data model, the graphical interface and the tools to query the database have been completely redesigned. We used Chemaxon MarvinJS and JChem library to support this development. We added new PPI modulators, new PPI targets, and extended our focus to stabilizers of PPIs as well. Finally, we introduce a web application relying on crowdsourcing for the maintenance of the database. This application can be used outside of our group to collaboratively maintain iPPI-DB within a community of curators.
Here are the suggested dimensions for the interior of a laboratory:
- Work benches: 3-4 feet wide by 10-12 feet long. Allow at least 3 feet of clear space between benches.
- Stools: Provide at least 1 stool per 2 linear feet of bench space. Stools should be adjustable in height from sitting to standing positions.
- Fume hoods: Provide at least 1 linear foot of fume hood space per 2 workers if volatile chemicals will be used. Minimum dimensions are 4 feet wide by 2 feet deep by 7 feet high.
- Storage: Allow at least 10 square feet per worker for chemical and equipment storage in ventilated cabinets and on shelves above benches. Flammable materials should
Ontology-Driven Clinical Intelligence: A Path from the Biobank to Cross-Disea...Remedy Informatics
The discovery of clinical insights through effective management and reuse of data requires several conditions to be optimized: Data need to be digital, data need to be structured, and data need to be standardized in terms of metadata and ontology. This presentation describes a bioinformatics system that combines a next-generation biobank management model mapped to applicable international standards and guidelines with a master ontology that controls all input and output and is able to add unique properties to meet the specialized needs of clinicians for cross-disease research.
Diagnostic test and investigation in periodontology Dr Abhilasha
This document provides an overview of investigations used in dental diagnosis. It begins by defining diagnosis and the role of laboratory investigations. It then classifies investigations based on where they are performed (chairside or laboratory), their specificity/sensitivity, the type of hospital laboratory service used, and frequency of dental use. The remainder of the document discusses various chairside and laboratory investigations in hematology, biochemistry, microbiology, and imaging that are used in dentistry.
This document discusses the origins and development of the LOINC Clinical Document Ontology (CDO), which provides a standardized terminology for clinical document names. It describes how the CDO was created based on empirical analysis of over 2000 local document names. The CDO uses a multi-axial model with domains like subject matter, role, setting, type of service, and kind of document. Iterative evaluations found the expanded CDO better mapped local names than the original. Ongoing work involves adding new content and harmonizing with other clinical terminologies.
2012 02 10 - Vreeman - Possibilities and Implications of ICF-powered Health I...dvreeman
The document discusses the possibilities and implications of using the International Classification of Functioning (ICF) to power health information technology. It describes how incorporating standardized vocabularies like ICF and LOINC into electronic health records could allow for data reuse across settings, clinical decision support, and a more seamless exchange of health information. This would help realize the vision of a healthcare system with coordinated, consumer-centered care enabled by digital tools.
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The document provides an overview of the Regenstrief LOINC Mapping Assistant (RELMA) tool. It discusses RELMA's features for installing the tool, setting preferences, loading local observation files, searching for and mapping local terms to LOINC codes, and proposing new LOINC terms. The goal is to help laboratories map their local test names and codes to standardized LOINC codes to improve data interoperability, comparability and quality.
The LOINC name does not include the instrument used in testing, specific details about the specimen, priority (e.g. STAT), where testing was done, who did the test, test interpretation, or anything else that is not an intrinsic part of the name of the result.
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This document provides an overview and introduction to LOINC (Logical Observation Identifiers Names and Codes). It discusses the origins and growth of LOINC as a universal standard for identifying laboratory and clinical observations. Key points include: LOINC was created in 1994 by Regenstrief Institute to facilitate information exchange; it has over 80,000 codes covering many clinical domains and is used internationally; and adoption has increased steadily with over 800 downloads per month and participation from many organizations globally and within the US.
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Traditional methods of diagnosing infectious diseases like isolation, serology, and direct detection have limitations that influence their clinical utility. Molecular methods using nucleic acid detection and characterization have advantages like faster results, increased sensitivity and specificity, and ability to adapt to new instrumentation. Introducing molecular diagnostic testing requires evaluating needs, identifying suitable changes, developing protocols, providing resources, educating staff, and ensuring continuous quality improvement.
This document discusses methods for diagnosing infectious diseases. Traditional methods like isolation, serology, and direct detection have limitations in clinical utility due to factors like time, viability of organisms, and technical skill required. Molecular methods using nucleic acid detection and manipulation offer advantages like faster results, increased sensitivity and specificity, and adaptation to instrumentation. Introducing molecular diagnostic testing requires evaluating needs, identifying changes, developing protocols, providing resources, educating staff and clients, and ongoing evaluation and improvement. Key steps include specimen collection, nucleic acid extraction, PCR, detection, and reporting results.
This file includes the SLAS2013 presentations of Paul A. Johnston of University of Pittsburgh; Douglas Auld of Novartis Institutes for Biomedical Research; and Lisa Minor of In Vitro Strategies, LLC.
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What is the AOP framework and why should you care?
Why are we developing AOPs?
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What are the opportunities for collaboration in AOP development?
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This document provides an overview of investigations used in dental diagnosis. It begins by defining diagnosis and the role of laboratory investigations. It then classifies investigations based on where they are performed (chairside or laboratory), their specificity/sensitivity, the type of hospital laboratory service used, and frequency of dental use. The remainder of the document discusses various chairside and laboratory investigations in hematology, biochemistry, microbiology, and imaging that are used in dentistry.
Public Laboratory LOINC Workshop and Committee Meeting documents the origins and growth of LOINC as a universal standard for clinical observations and laboratory results. It discusses how LOINC provides a common language for information exchange and how its open model has led to widespread international adoption and translations. Large healthcare organizations around the world have implemented LOINC to facilitate interoperability across hundreds of systems.
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The document provides an introduction and overview of LOINC (Logical Observation Identifiers Names and Codes), including:
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This document provides an overview and introduction to LOINC (Logical Observation Identifiers Names and Codes). It describes the structure and components of LOINC codes, including the six primary axes used to systematically name clinical observations. It provides examples of LOINC codes for different clinical concepts and discusses how LOINC codes are used for clinical documents and attachments in health information exchange.
Cell Therapy Expansion and Challenges in Autoimmune DiseaseHealth Advances
There is increasing confidence that cell therapies will soon play a role in the treatment of autoimmune disorders, but the extent of this impact remains to be seen. Early readouts on autologous CAR-Ts in lupus are encouraging, but manufacturing and cost limitations are likely to restrict access to highly refractory patients. Allogeneic CAR-Ts have the potential to broaden access to earlier lines of treatment due to their inherent cost benefits, however they will need to demonstrate comparable or improved efficacy to established modalities.
In addition to infrastructure and capacity constraints, CAR-Ts face a very different risk-benefit dynamic in autoimmune compared to oncology, highlighting the need for tolerable therapies with low adverse event risk. CAR-NK and Treg-based therapies are also being developed in certain autoimmune disorders and may demonstrate favorable safety profiles. Several novel non-cell therapies such as bispecific antibodies, nanobodies, and RNAi drugs, may also offer future alternative competitive solutions with variable value propositions.
Widespread adoption of cell therapies will not only require strong efficacy and safety data, but also adapted pricing and access strategies. At oncology-based price points, CAR-Ts are unlikely to achieve broad market access in autoimmune disorders, with eligible patient populations that are potentially orders of magnitude greater than the number of currently addressable cancer patients. Developers have made strides towards reducing cell therapy COGS while improving manufacturing efficiency, but payors will inevitably restrict access until more sustainable pricing is achieved.
Despite these headwinds, industry leaders and investors remain confident that cell therapies are poised to address significant unmet need in patients suffering from autoimmune disorders. However, the extent of this impact on the treatment landscape remains to be seen, as the industry rapidly approaches an inflection point.
Summer is a time for fun in the sun, but the heat and humidity can also wreak havoc on your skin. From itchy rashes to unwanted pigmentation, several skin conditions become more prevalent during these warmer months.
Are you looking for a long-lasting solution to your missing tooth?
Dental implants are the most common type of method for replacing the missing tooth. Unlike dentures or bridges, implants are surgically placed in the jawbone. In layman’s terms, a dental implant is similar to the natural root of the tooth. It offers a stable foundation for the artificial tooth giving it the look, feel, and function similar to the natural tooth.
Test bank for karp s cell and molecular biology 9th edition by gerald karp.pdfrightmanforbloodline
Test bank for karp s cell and molecular biology 9th edition by gerald karp.pdf
Test bank for karp s cell and molecular biology 9th edition by gerald karp.pdf
Test bank for karp s cell and molecular biology 9th edition by gerald karp.pdf
Promoting Wellbeing - Applied Social Psychology - Psychology SuperNotesPsychoTech Services
A proprietary approach developed by bringing together the best of learning theories from Psychology, design principles from the world of visualization, and pedagogical methods from over a decade of training experience, that enables you to: Learn better, faster!
These lecture slides, by Dr Sidra Arshad, offer a simplified look into the mechanisms involved in the regulation of respiration:
Learning objectives:
1. Describe the organisation of respiratory center
2. Describe the nervous control of inspiration and respiratory rhythm
3. Describe the functions of the dorsal and respiratory groups of neurons
4. Describe the influences of the Pneumotaxic and Apneustic centers
5. Explain the role of Hering-Breur inflation reflex in regulation of inspiration
6. Explain the role of central chemoreceptors in regulation of respiration
7. Explain the role of peripheral chemoreceptors in regulation of respiration
8. Explain the regulation of respiration during exercise
9. Integrate the respiratory regulatory mechanisms
10. Describe the Cheyne-Stokes breathing
Study Resources:
1. Chapter 42, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 36, Ganong’s Review of Medical Physiology, 26th edition
3. Chapter 13, Human Physiology by Lauralee Sherwood, 9th edition
Lecture 6 -- Memory 2015.pptlearning occurs when a stimulus (unconditioned st...AyushGadhvi1
learning occurs when a stimulus (unconditioned stimulus) eliciting a response (unconditioned response) • is paired with another stimulus (conditioned stimulus)
10 Benefits an EPCR Software should Bring to EMS Organizations Traumasoft LLC
The benefits of an ePCR solution should extend to the whole EMS organization, not just certain groups of people or certain departments. It should provide more than just a form for entering and a database for storing information. It should also include a workflow of how information is communicated, used and stored across the entire organization.
How to Control Your Asthma Tips by gokuldas hospital.Gokuldas Hospital
Respiratory issues like asthma are the most sensitive issue that is affecting millions worldwide. It hampers the daily activities leaving the body tired and breathless.
The key to a good grip on asthma is proper knowledge and management strategies. Understanding the patient-specific symptoms and carving out an effective treatment likewise is the best way to keep asthma under control.