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Clinical LOINC Meeting




     Clinical LOINC® Tutorial
                             Documents

             Daniel J. Vreeman, PT, DPT, MSc
        Assistant Research Professor, Indiana University School of Medicine
        Associate Director of Terminology Services, Regenstrief Institute, Inc




07.15.2010                                                           Copyright © 2010
Overview
•  Origins of a Document Ontology
•  HL7/LOINC Document Ontology Model
•  Evaluation, Evolution, Ongoing
   Development
  –  Empiric analyses
•  Future directions
Origins of a Document
Ontology
Rationale
•  As with other domains, local systems have
   idiosyncratic names for clinical documents
•  Need a common, controlled vocabulary
•  Needed for HL7 CDA standard
  –  HL7 v2 too
•  Timeline
  –  06/2000      Document Ontology Task Force
  –  09/2003      First axis values and LOINC codes
  –  ~2005        Expanded SMD domain
  –  10/2007      Revised axis value approval
Document Type Codes
•  Created to provide consistent semantics
   for names of documents exchanged b/w
   independent systems
•  Supported Uses
        –  Retrieval
        –  Organization
        –  Preparation of templates
        –  Display

Frazier P, Rossi-Mori A, Dolin RH, Alschuler L, Huff SM. The creation of an ontology of clinical document names. Stud Health Technol Inform. 2001;84(Pt 1):94-8.
What is a Document?
•  Document = Collection of information
  –  Sentences, sections
  –  Distinguished from “panels”, which have
     enumerated discrete contents of result elements
•  Formal Document Ontology model/rules apply
   to “clinical notes”
  –  Clinical document (per HL7 CDA), produced by
     clinicians spontaneously or in response to a request
     for consultation
  –  Does not apply to “reports”, produced in response to
     an order for a procedure
Approach
•  Started with empiric analysis of over 2000
   document names
  –  Mayo, 3M/Intermountain, VA in SLC, VA in
     Nashville
•  Find the level of granularity that best
   meets the exchange use case
Finding the Commonality
•  Ultra-specific local names:
  –  Dr. Evil’s Friday Afternoon Pain Clinic Note
•  Generalizable elements:
  –  Outpatient Pain Clinic Note
•  Local codes may still be needed
  –  Can send both local and universal codes in HL7
  –  Mapping to the universal code enables
     interoperability and aggregation
Document Ontology Model
Multi-axial / Poly-hierarchical
Names Based on Document Content
•  Names based on the expected
   information content
•  NOT based on the document format
  –  Text, scanned images, structured entry form,
     XML, etc would all have the same LOINC code
     if the information content was the same


 Assume that these other important attributes
would be sent in different fields of the message
What’s NOT in a Document Name
•    Specific author
•    Specific location of service or dictation
•    Date of service
•    Status (e.g. signed, unsigned)
•    Security/privacy flags (protected)
•    Updates/amendments to a document

  Assume that these other important attributes
 would be sent in different fields of the message
Model of Document Names
•  Subject Matter Domain
   –  E.g. Cardiology, Pediatric Cardiology, Physical Therapy

•  Role
   –  Author training/professional classification (not @ subspecialty)
   –  E.g. Physician, Nursing, Case Manager, Therapist, Patient

•  Setting
   –  Modest extension of CMS’s definition (not equivalent to location)
   –  E.g. Inpatient Hospital, Outpatient, Emergency Department

•  Type of Service
   –  Service or activity provided to/for the patient (or other subject)
   –  E.g. Consultation, History and Physical, Discharge Summary

•  Kind of Document
   –  General structure of the document
   –  E.g. Note, Letter, Consent
Rules for Constructing Names
      •  LOINC has enumerated value lists for axes
             –  Published in Users Guide
             –  Development edition at loinc.org
      •  Names need a Kind of Document value and at
         least one of the other four axes
Component	
                                               Prop	
     Time	
   System	
     Scale	
   Method	
  
<Type	
  of	
  Service>	
  <Kind	
  of	
  Document>	
     Find	
     Pt	
     <Se8ng>	
   Doc	
     <SMD>.<Role>	
  

      •  Combinations from within an axis
             –  Allowed where they make sense (SMD, Service)
             –  Represented with a plus (+)
      •  LOINC Class = DOC.CLINRPT
Example LOINC Codes
Component	
                                 Prop	
   Time	
   System	
                    Scale	
   Method	
  
Group	
  counseling	
  note	
               Find	
     Pt	
     InpaBent	
  Hospital	
   Doc	
      {Provider}	
  
EvaluaBon	
  and	
  management	
  note	
   Find	
      Pt	
     OutpaBent	
               Doc	
     {Provider}	
  

EvaluaBon	
  and	
  management	
  note	
   Find	
      Pt	
     {Se8ng}	
                 Doc	
     {Provider}	
  
History	
  and	
  physical	
  note	
        Find	
     Pt	
     {Se8ng}	
                 Doc	
     {Provider}	
  
IniBal	
  evaluaBon	
  note	
               Find	
     Pt	
     {Se8ng}	
                 Doc	
     Physician	
  
Subsequent	
  evaluaBon	
  note	
           Find	
     Pt	
     {Se8ng}	
                 Doc	
     Nurse	
  PracBBoner	
  



         {curly braces} notation: send that content as a
         separate item in the message (field or segment)
Hierarchy in LOINC
•  Constructed a first-pass Component hierarchy
   based on the Type of Service axis
  –  Ignored Kind of Document
•  Multi-axial hierarchy is generated based on the
   component hierarchy
  –  (available as separate download)
•  Could imagine construction of other
   hierarchies, like context-specific use cases
Hierarchy in LOINC
Evaluation, Evolution, and
Development
We’re not done yet
Ontology Evolution and Refinement
  •  Ongoing evaluation and evolution
  •  Exceptional contributions from Columbia
     University and the VA
  •  In particular, expanded original SMD value
     list with ABMS specialty names and
     iterative discussion



Shapiro	
  JS,	
  Bakken	
  S,	
  Hyun	
  S,	
  Melton	
  GB,	
  Schlegel	
  C,	
  Johnson	
  SB.	
  Document	
  ontology:	
  supporting	
  narrative	
  documents	
  in	
  electronic	
  health	
  records.	
  
      AMIA	
  Annu	
  Symp	
  Proc.	
  2005:684-­‐8.	
  
Iterative Evaluation Case Study:
                                                                                                  NYPH-CUMC
                      SMD	
   Role	
   Se8ng	
   Type	
  of	
  Service	
   Kind	
  of	
  Document	
     Overall	
   Dis?nct	
  	
  
Original	
  CDO	
     26.7%	
     99.9%	
     99.9%	
       43.5%	
                   100%	
              23.4%	
  	
     7.9%	
  
                                                                                                         (n=894)	
  

Expanded	
  CDO	
     98.6%	
     100%	
      100%	
        99.9%	
                   99.9%	
             98.5%	
         39.1%	
  
                                                                                                         (n=935)	
  


        •  Hyun	
  S,	
  Shapiro	
  JS,	
  Melton	
  G,	
  Schlegel	
  C,	
  Stetson	
  PD,	
  Johnson	
  SB,	
  
           Bakken	
  S.	
  Iterative	
  evaluation	
  of	
  the	
  Health	
  Level	
  7-­‐-­‐Logical	
  
           Observation	
  IdentiOiers	
  Names	
  and	
  Codes	
  Clinical	
  Document	
  Ontology	
  
           for	
  representing	
  clinical	
  document	
  names:	
  a	
  case	
  report.	
  J	
  Am	
  Med	
  
           Inform	
  Assoc.	
  2009	
  May-­‐Jun;16(3):395-­‐9.	
  
        •  Summary	
  
            •  More	
  documents	
  could	
  be	
  fully	
  speciOied	
  in	
  with	
  the	
  expanded	
  CDO	
  
            •  Many	
  documents	
  map	
  to	
  one	
  LOINC	
  code	
  –	
  factor	
  of	
  local	
  names	
  
                   and	
  suitable	
  LOINC	
  values	
  
            •  Inter-­‐rater	
  reliability	
  was	
  very	
  good	
  
Nursing
                                     SMD	
   Role	
   Se8ng	
   Type	
  of	
  Service	
   Kind	
  of	
  Document	
                                                                                        Overall	
   Dis?nct	
  	
  
SMD-­‐enhanced	
                       74%	
             100%	
               100%	
                               100%	
                                             100%	
                                  74.5%	
                     33%	
  
CDO	
  (2005)	
                                                                                                                                                                                               (n=94)	
  

Hyun	
  S,	
  Shapiro	
  JS,	
  Melton	
  G,	
  Schlegel	
  C,	
  Stetson	
  PD,	
  Johnson	
  SB,	
  Bakken	
  S.	
  Iterative	
  evaluation	
  of	
  the	
  Health	
  Level	
  7-­‐-­‐Logical	
  Observation	
  IdentiOiers	
  Names	
  and	
  Codes	
  
        Clinical	
  Document	
  Ontology	
  for	
  representing	
  clinical	
  document	
  names:	
  a	
  case	
  report.	
  J	
  Am	
  Med	
  Inform	
  Assoc.	
  2009	
  May-­‐Jun;16(3):395-­‐9.	
  




            •  In	
  a	
  separate	
  analysis,	
  38%	
  of	
  the	
  section	
  headings	
  
               (n=308)	
  from	
  nursing	
  documents	
  could	
  be	
  
               mapped	
  to	
  existing	
  LOINC	
  codes	
  
                         •  Hyun	
  S,	
  Bakken	
  S.	
  Toward	
  the	
  creation	
  of	
  an	
  ontology	
  for	
  nursing	
  
                            document	
  sections:	
  mapping	
  section	
  names	
  to	
  the	
  LOINC	
  semantic	
  
                            model.	
  AMIA	
  Annu	
  Symp	
  Proc.	
  2006:364-­‐8.	
  
German University Hospital
•  Used LOINC v2.24 (original DocOnt terms)
•  Of 86 the document types for 1.2 million
   documents:
           –  44% mapped to LOINC
           –  44% had available mapping deemed not specific
              enough
           –  12% had no LOINC match
•  A LOINC code existed for 93.1% of documents in
   their set (by volume)

Dugas	
  M,	
  Thun	
  S,	
  Frankewitsch	
  T,	
  Heitmann	
  KU.	
  LOINC	
  codes	
  for	
  hospital	
  information	
  systems	
  documents:	
  a	
  case	
  study.	
  J	
  Am	
  Med	
  
     Inform	
  Assoc.	
  2009	
  May-­‐Jun;16(3):400-­‐3.	
  
Ongoing Development
Ongoing Development
•  A work-in-progress
•  LOINC Users’ Guide is the definitive
   source for current policy
  –  Always available at http://loinc.org
•  Collaboration/discussion
  –  Clinical LOINC meetings, HL7 SDTC
  –  LOINC website
  –  LOINC Users’ Forum: http:/forum.loinc.org
Future Directions
Future Directions
•  Continued harmonization of v1 and v2
   axis values
•  Axis definitions
•  Extension/refinement to other Kind of
   Documents
•  Empiric analysis of document contents

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2010 07 15 - Clinical LOINC Tutorial - Documents

  • 1. Clinical LOINC Meeting Clinical LOINC® Tutorial Documents Daniel J. Vreeman, PT, DPT, MSc Assistant Research Professor, Indiana University School of Medicine Associate Director of Terminology Services, Regenstrief Institute, Inc 07.15.2010 Copyright © 2010
  • 2. Overview •  Origins of a Document Ontology •  HL7/LOINC Document Ontology Model •  Evaluation, Evolution, Ongoing Development –  Empiric analyses •  Future directions
  • 3. Origins of a Document Ontology
  • 4. Rationale •  As with other domains, local systems have idiosyncratic names for clinical documents •  Need a common, controlled vocabulary •  Needed for HL7 CDA standard –  HL7 v2 too •  Timeline –  06/2000 Document Ontology Task Force –  09/2003 First axis values and LOINC codes –  ~2005 Expanded SMD domain –  10/2007 Revised axis value approval
  • 5. Document Type Codes •  Created to provide consistent semantics for names of documents exchanged b/w independent systems •  Supported Uses –  Retrieval –  Organization –  Preparation of templates –  Display Frazier P, Rossi-Mori A, Dolin RH, Alschuler L, Huff SM. The creation of an ontology of clinical document names. Stud Health Technol Inform. 2001;84(Pt 1):94-8.
  • 6. What is a Document? •  Document = Collection of information –  Sentences, sections –  Distinguished from “panels”, which have enumerated discrete contents of result elements •  Formal Document Ontology model/rules apply to “clinical notes” –  Clinical document (per HL7 CDA), produced by clinicians spontaneously or in response to a request for consultation –  Does not apply to “reports”, produced in response to an order for a procedure
  • 7. Approach •  Started with empiric analysis of over 2000 document names –  Mayo, 3M/Intermountain, VA in SLC, VA in Nashville •  Find the level of granularity that best meets the exchange use case
  • 8. Finding the Commonality •  Ultra-specific local names: –  Dr. Evil’s Friday Afternoon Pain Clinic Note •  Generalizable elements: –  Outpatient Pain Clinic Note •  Local codes may still be needed –  Can send both local and universal codes in HL7 –  Mapping to the universal code enables interoperability and aggregation
  • 10. Names Based on Document Content •  Names based on the expected information content •  NOT based on the document format –  Text, scanned images, structured entry form, XML, etc would all have the same LOINC code if the information content was the same Assume that these other important attributes would be sent in different fields of the message
  • 11. What’s NOT in a Document Name •  Specific author •  Specific location of service or dictation •  Date of service •  Status (e.g. signed, unsigned) •  Security/privacy flags (protected) •  Updates/amendments to a document Assume that these other important attributes would be sent in different fields of the message
  • 12. Model of Document Names •  Subject Matter Domain –  E.g. Cardiology, Pediatric Cardiology, Physical Therapy •  Role –  Author training/professional classification (not @ subspecialty) –  E.g. Physician, Nursing, Case Manager, Therapist, Patient •  Setting –  Modest extension of CMS’s definition (not equivalent to location) –  E.g. Inpatient Hospital, Outpatient, Emergency Department •  Type of Service –  Service or activity provided to/for the patient (or other subject) –  E.g. Consultation, History and Physical, Discharge Summary •  Kind of Document –  General structure of the document –  E.g. Note, Letter, Consent
  • 13. Rules for Constructing Names •  LOINC has enumerated value lists for axes –  Published in Users Guide –  Development edition at loinc.org •  Names need a Kind of Document value and at least one of the other four axes Component   Prop   Time   System   Scale   Method   <Type  of  Service>  <Kind  of  Document>   Find   Pt   <Se8ng>   Doc   <SMD>.<Role>   •  Combinations from within an axis –  Allowed where they make sense (SMD, Service) –  Represented with a plus (+) •  LOINC Class = DOC.CLINRPT
  • 14. Example LOINC Codes Component   Prop   Time   System   Scale   Method   Group  counseling  note   Find   Pt   InpaBent  Hospital   Doc   {Provider}   EvaluaBon  and  management  note   Find   Pt   OutpaBent   Doc   {Provider}   EvaluaBon  and  management  note   Find   Pt   {Se8ng}   Doc   {Provider}   History  and  physical  note   Find   Pt   {Se8ng}   Doc   {Provider}   IniBal  evaluaBon  note   Find   Pt   {Se8ng}   Doc   Physician   Subsequent  evaluaBon  note   Find   Pt   {Se8ng}   Doc   Nurse  PracBBoner   {curly braces} notation: send that content as a separate item in the message (field or segment)
  • 15. Hierarchy in LOINC •  Constructed a first-pass Component hierarchy based on the Type of Service axis –  Ignored Kind of Document •  Multi-axial hierarchy is generated based on the component hierarchy –  (available as separate download) •  Could imagine construction of other hierarchies, like context-specific use cases
  • 18. Ontology Evolution and Refinement •  Ongoing evaluation and evolution •  Exceptional contributions from Columbia University and the VA •  In particular, expanded original SMD value list with ABMS specialty names and iterative discussion Shapiro  JS,  Bakken  S,  Hyun  S,  Melton  GB,  Schlegel  C,  Johnson  SB.  Document  ontology:  supporting  narrative  documents  in  electronic  health  records.   AMIA  Annu  Symp  Proc.  2005:684-­‐8.  
  • 19. Iterative Evaluation Case Study: NYPH-CUMC SMD   Role   Se8ng   Type  of  Service   Kind  of  Document   Overall   Dis?nct     Original  CDO   26.7%   99.9%   99.9%   43.5%   100%   23.4%     7.9%   (n=894)   Expanded  CDO   98.6%   100%   100%   99.9%   99.9%   98.5%   39.1%   (n=935)   •  Hyun  S,  Shapiro  JS,  Melton  G,  Schlegel  C,  Stetson  PD,  Johnson  SB,   Bakken  S.  Iterative  evaluation  of  the  Health  Level  7-­‐-­‐Logical   Observation  IdentiOiers  Names  and  Codes  Clinical  Document  Ontology   for  representing  clinical  document  names:  a  case  report.  J  Am  Med   Inform  Assoc.  2009  May-­‐Jun;16(3):395-­‐9.   •  Summary   •  More  documents  could  be  fully  speciOied  in  with  the  expanded  CDO   •  Many  documents  map  to  one  LOINC  code  –  factor  of  local  names   and  suitable  LOINC  values   •  Inter-­‐rater  reliability  was  very  good  
  • 20. Nursing SMD   Role   Se8ng   Type  of  Service   Kind  of  Document   Overall   Dis?nct     SMD-­‐enhanced   74%   100%   100%   100%   100%   74.5%   33%   CDO  (2005)   (n=94)   Hyun  S,  Shapiro  JS,  Melton  G,  Schlegel  C,  Stetson  PD,  Johnson  SB,  Bakken  S.  Iterative  evaluation  of  the  Health  Level  7-­‐-­‐Logical  Observation  IdentiOiers  Names  and  Codes   Clinical  Document  Ontology  for  representing  clinical  document  names:  a  case  report.  J  Am  Med  Inform  Assoc.  2009  May-­‐Jun;16(3):395-­‐9.   •  In  a  separate  analysis,  38%  of  the  section  headings   (n=308)  from  nursing  documents  could  be   mapped  to  existing  LOINC  codes   •  Hyun  S,  Bakken  S.  Toward  the  creation  of  an  ontology  for  nursing   document  sections:  mapping  section  names  to  the  LOINC  semantic   model.  AMIA  Annu  Symp  Proc.  2006:364-­‐8.  
  • 21. German University Hospital •  Used LOINC v2.24 (original DocOnt terms) •  Of 86 the document types for 1.2 million documents: –  44% mapped to LOINC –  44% had available mapping deemed not specific enough –  12% had no LOINC match •  A LOINC code existed for 93.1% of documents in their set (by volume) Dugas  M,  Thun  S,  Frankewitsch  T,  Heitmann  KU.  LOINC  codes  for  hospital  information  systems  documents:  a  case  study.  J  Am  Med   Inform  Assoc.  2009  May-­‐Jun;16(3):400-­‐3.  
  • 23. Ongoing Development •  A work-in-progress •  LOINC Users’ Guide is the definitive source for current policy –  Always available at http://loinc.org •  Collaboration/discussion –  Clinical LOINC meetings, HL7 SDTC –  LOINC website –  LOINC Users’ Forum: http:/forum.loinc.org
  • 24.
  • 26. Future Directions •  Continued harmonization of v1 and v2 axis values •  Axis definitions •  Extension/refinement to other Kind of Documents •  Empiric analysis of document contents