AMIA Knowledge and Semantics WG Webinar 	




                LOINC	
               An Introduction to the Universal Catalog of
                  Laboratory and Clinical Observations	


           Daniel J. Vreeman, PT, DPT, MSc	
                Assistant Research Professor, Indiana University School of Medicine	
               Associate Director for Terminology Services, Regenstrief Institute, Inc	




03.20.2012	
                          loinc@loinc.org	
                                    © 2012
Overview	

      1.        Origins and Evolution of LOINC	
      2.        LOINC Introduction	
      3.        Mapping Tools and Resources	
      4.        Closing Thoughts	



photo via Vernio77
Acknowledgements	
LOINC Development Team	
Clem McDonald, Kathy Mercer, Jaci Phillips, Jami
Deckard, David Baorto, Kelly Malott	
RELMA Development Team	
John Hook, Mark Fisher, Karen Ahmed, Anandhi
Sowmyan, James Dennis	
	



LOINC Committee 	
Supporters: NLM, Regenstrief Institute,
Regenstrief Foundation
Biomedical Informatics at
Regenstrief Institute	
Building data-rich systems for clinicians
Origins of LOINC	
The lingua franca of clinical observation exchange
40+ Years of
Canopy Computing	
making a forest out of individual trees of data	



 McDonald et al. Canopy Computing: using the Web in Clinical Practice. JAMA. 1998;280(15):1325-1329.
e rain forest canopy is a
seamless web through which
arboreal creatures efficiently
   move to reach the edible
 fruits without any attention
    to the individual trees.
                         photo via nosha
Arboreal Informatics Pioneers	
 40 years of EMR work	
 Indiana Network for Patient Care	
      	
	
 Nation’s most comprehensive and longest tenured HIE	


 Regenstrief 	
 – the neutral 3rd party convener
Fundamental challenge:	
local systems have different
ways of identifying the
same concept
A vocabulary standard
would serve as the
Rosetta Stone.	



                        Image © Hans Hillewaert / CC-BY-SA-3.0
Logical
           Observation
           Identifiers
           Names and
           Codes	
A universal code system that facilitates exchange,
        pooling, and processing of results
Established in 1994 by
Regenstrief Institute.	
	
Vocabulary standard for
observation identifiers.
Same or Different?	
                    what you see in the order list
                                                 	


Lab A	
                               Lab B	
Test Name: Lyme Disease Serology	
    Test Name: Lyme Disease Antibody	
Measures: B. burgdorferi Ab IgG	
     Measures: B. burgdorferi Ab IgM	
Method: ELISA	
                       Method: Immune blot	
Scale: quantitative	
                 Scale: qualitative	
e.g.: Titer 1:40	
                    e.g.: Positive	
	
                                    	
LOINC Code = 5062-5	
                  LOINC Code = 6321-4
Similar name, different meaning…	




                                            photo via Caption Time	


 meerkat	
 meerkat	
 mere cat	
 meerkat
If an observation is a question
and the observation value is
an answer…

  	
LOINC provides codes for
   	
questions

   	
Other vocabularies provide
   	
codes for the answers
What is my patient’s
hemoglobin level?	
718-7:Hemoglobin:MCnc:Pt:Bld:Qn
How fast does my
patient usually walk?	
41959-8:Walking speed:Vel:1W^mean:^Patient:Qn:Calculated




                                                 photo via Ed Yourdon
Indiana Network for Patient Care	
   HL7 v.2.X Message	
                                           !
MSH|^~&|HOSPITAL_A|SAMPLE_HOSPITAL_A|||$YearMonthDay|||||||||||||||!
PID|||$patientId$||$patientName$||||||||||||||||||||!
     LocalCode^LocalName^CodeSystem^LOINCcode^LOINCname^CodeSystem!
PV1|||||||$attendingDoctor$||$consultingDoctor$||||||||!
OBR|1|||012^CBC/Auto Diff^HSPA^57021-8^CBC ! Auto Diff^LN||$reqDate|||||||||!
                                           W
OBX|2|NM|123^WBC^HSP_A^26464-8^Leukocytes [#/volume] in Blood^LN||10.8|K/MM3|||||F|!
OBX|3|NM|234^RBC^HSP_A^26453-1^Erythrocytes [#/volume] in Blood^LN||4.82|MIL/MM3|||||F|!
OBX|4|NM|345^HGB^HSP_A^718-7^Hemoglobin [Mass/volume] in Blood^LN||15.7|GM/DL|||||F|!
OBX|5|NM|456^HCT^HSP_A^20570-8^Hematocrit [Volume Fraction] of Blood^LN||45|%|||||||F|!




          A	
  




                        Message Processor	
                       A	
  



                                                     Institutional Repository
Result with a Coded Value	

   Data type of
result (OBX-5) is a      This code is          This code is
 coded element	
         from LOINC	
        from SNOMED	


 OBX||CE|6609-2^Listeria ID^LN||36094007^L. monocytogenes^SCT




 Code identifying this
     observation 	
                Code identifying the
(what are these results?        result (L. monocytogenes)	
   Listeria culture)
Laboratory LOINC
Clinical LOINC
Laboratory LOINC Committee Chair:
         Clem McDonald, MD	
                  	
                  	
                  	
  Clinical LOINC Committee Chair:	
            Stan Huff, MD
The LOINC Community	
Open. Nimble. Pragmatic.
Open Development	
Worldwide distribution at no cost	
End-user content additions	
Welcome all comers	
Volunteers
Funding Support	
Principal current sources are:	
     U.S. National Library of Medicine
     Regenstrief Foundation	
	
Prior support from	
     Several other U.S. federal agencies, 	
     John A. Hartford Foundation
Regenstrief Institute	
Steward	
Developer of content	
Developer of tools	
Developer of community	
Distributor	
Voice
5/




               0!
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                                                                                           Doubled in 19 months!




 3/       !
    2/
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 5/
                                                                                                                              loinc.org members	




    2/
       11
          !
 7/
    2/
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          !
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       11
11        !
   /2
      /1
        1!
                      14 new members per day	




 1/
    2/
       12
          !
                    410 new members per month
16,300+ users in 145 countries
The LOINC Distribution
Major releases
twice per year
(June and December)	

                        photo via striatic
LOINC Codes Over Time By Release	
80,000	
            LOINC Codes	
            Lab Codes	
70,000	
                                             Slope = 2200	
60,000	

50,000	
                    Slope = 600	
40,000	

30,000	

20,000	

10,000	
                                            laboratory terms only	
      0
Lots Cooking…	
Always more lab tests	
Genetic reporting	
Flow cytometry	
Lots of survey instruments, forms, and assessments 	
More radiology reports	
Structured document titles	
…	
	
	
                                                      photo via liber
loinc.org/terms-of-use
photo via 917press
Just kidding.

Copyright is a good thing for
standards.

It’s the licensing part that is
interesting.
No cost	
Worldwide	
In perpetuity
Use	
Copy	
Distribute
Any purpose:	
 	
commercial	
 	
non-commercial	
               photo via Refracted Moments™
Cannot use any
Licensed Material to
develop or promulgate
a different standard
for orders or
observations.
That would defeat
 the purpose of
having a standard!
International Adoption	
participation, translation, implementation
LOINC Submitters	




            Since 2009	
79 organizations from 14 countries
LOINC Translators	




   19 organizations
Chinese	
  (CHINA)	
  	
  
Dra$	
  Portuguese	
  (BRAZIL)	
  	
  
English	
  (UNITED	
  STATES)	
  	
  
Estonian	
  (ESTONIA)	
  	
  
French	
  (CANADA)	
  	
  
French	
  (FRANCE)	
  	
  
French	
  (SWITZERLAND)	
  	
  
German	
  (GERMANY)	
  	
  
German	
  (SWITZERLAND)	
  	
  
Greek	
  (GREECE)	
  	
  
Italian	
  (ITALY)	
  	
  
Italian	
  (SWITZERLAND)	
  	
  
Korean	
  (KOREA,	
  REPUBLIC	
  OF)	
  	
  
Spanish	
  (ARGENTINA)	
  	
  
Spanish	
  (SPAIN)	
  	
  
Spanish	
  (SWITZERLAND)	
  	
  
Vreeman DJ et al. Enabling international adoption of LOINC through translation. J Biomed Inform (2012), doi:10.1016/j.jbi.2012.01.005
In-progress	
Catalan	
Dutch	
French	
Russian	
Turkish
Adopted as National Standard	
Brazil	
Canada	
France	
Germany	
The Netherlands	
Mexico	
Rwanda	
Thailand
Large Implementations	
SIGA Saúde project 	
Canada Health Infoway	
ePSOS	
Assistance publique - Hôpitaux de Paris	
Red Agrolab	
BiTAC	
Hong Kong Hospital Authority	
              Many more…
US Adoption	
A few key highlights
Some Key US Adoptions	
All the big labs	
All health-related federal agencies 	
Lots of care organizations	
HIE’s	
Insurance companies	
EHR vendors	
Instrument manufacturers (nascent)
EHR Incentive
   Program
a.k.a. “Meaningful Use”
LOINC adopted for:	
1.  View, download, transmit data to third party	
2.  Cancer case reporting to state registry	
3.  Send/receive electronic lab results in
    ambulatory settings	
4.  Provide a care summary at care transition	
5.  Provide clinical summaries for patients	
6.  Submit reportable lab results to public health
LOINC Names	
Introduction to LOINC Naming
Conventions
Anatomy of a LOINC Term	
       5193-8:Hepatitis B virus surface Ab:ACnc:Pt:Ser:Qn:EIA	

         5193-8	
                                          LOINC Code	

Hepatitis B virus surface Ab	
                            Component
                                                                  	
          ACnc
             	
                                   Property Measured	
            Pt
             	
                                                   Timing	

           Ser
             	
                                                   System	
           Qn	
                                                     Scale	

           EIA	
                                              Method	


  There are six major LOINC axes
NOT part of a LOINC Name	
Reason for the test (disease it diagnoses)	
Testing instrument	
Specific details about the specimen	
Priority (e.g. STAT)	
Where testing was done	
Who did the test	
Test interpretation	
Anything not part of naming the test	
Stuff carried in other parts of HL7 message
Component	
    The substance or entity that is measured,
             evaluated, or observed	
Sodium	
Glucose	
Brucella sp. organism	
Influenza A Virus antigen	
Cytomegalovirus antibody	
Lipids.total	
    5193-8:Hepatitis B virus surface Ab:ACnc:Pt:Ser:Qn:EIA
Component Structure                                        	


       Analyte Name^Challenge^Adjustments
                                        	

Formal analyte name	
                                 Calcium	
     Specify “subanalytes”	
                   Coronavirus Ag	
     May have subclasses	
                     Calcium.ionized	
  	
                                                          	
Challenge	
                    1H post 100 g Glucose PO	
     Two parts separated        <time delay>post<challenge type>	
     by “post”	
                                                	
	
                                                              	
Adjustments	
                           Adjusted to pH 7.4
Property	
                       * the most difficult LOINC axis	




 The characteristic or attribute of the analyte that
       is measured, evaluated, or observed.	
Major Categories:	
 	
mass	
 	
substance	
 	
catalytic activity	
 	
arbitrary	
 	
number	
     5193-8:Hepatitis B virus surface Ab:ACnc:Pt:Ser:Qn:EIA
Property	
                       * the most difficult LOINC axis	




Fully Named Properties	
MCnc	
 mass concentration	
                                 mg/dL	
SCnc	
 substance concentration	
                           umol/L	
MCnt	
 mass content 	
                                       mg/g	
CCnc	
 catalytic concentration	
                              U/L	
Prid	
  presence or identity	
Imp	
   impression	
Type	
 “kind of”	

    Property is related to units of measure	
     5193-8:Hepatitis B virus surface Ab:ACnc:Pt:Ser:Qn:EIA
Timing	
The interval of time over which the observation
          or measurement was made	

Pt	
           point in time	
12H	
          12 hour collection	
24H	
          24 hour collection	

        Non-Pt timings are often 	
        5193-8:Hepatitis B virus surface Ab:ACnc:Pt:Ser:Qn:EIA	
        found with Rate Property
System	
The system (context) or specimen type upon which the
               observation was made.	

Ser	
         serum	
Ser/Plas	
    serum or plasma	
Bld	
         whole blood 	
Ur	
          urine	
Flu	
         body fluid	
                                   photo via AlishaV	




Tiss	
        tissue	
XXX	
         specified elsewhere 	
     5193-8:Hepatitis B virus surface Ab:ACnc:Pt:Ser:Qn:EIA
System Structure	
                 System^Super System	

Super System	
Patient is the default	
Used to indicate: 	
      	
blood product unit, bone marrow donor, fetus	



               818-5:A Ag:ACnc:Pt:RBC^BPU:Ord: 	
 11670-7:Blood flow.mean:Vel:Pt:Aortic arch^fetus:Qn:US.doppler
Scale	
Qn	
     Quantitative	
	
           continuous numeric	
	
           can have operators	
Ord	
 Ordinal	
	
           Ranked set (1+, 2+, 3+)	
                      photo via puuikibeach 	


Nom	
 Nominal	
	
           unranked collection	
	
           Taxonomy (e.g. bacteria)	
Nar	
 Narrative	
       5193-8:Hepatitis B virus surface Ab:ACnc:Pt:Ser:Qn:EIA
Method	
Only needed if interpretation affected	
  Different normal ranges	
  Test sensitivity	
Listed at the generic level	
  Agglutination	
  Enzyme Immunoassay	
  Probe with target amplification	


    5193-8:Hepatitis B virus surface Ab:ACnc:Pt:Ser:Qn:EIA
LOINC Collections	
Panels, forms, surveys, and other patient
assessments	




                                        photo via LuzA
Standardized Assessments and Collections	




Vreeman DJ, McDonald CJ, Huff SM. Representing patient assessments in LOINC®. AMIA Annu Symp Proc. 2010;832-836. PMID: 21347095 .	
Vreeman DJ, McDonald CJ, Huff SM. LOINC® - A Universal Catalog of Individual Clinical Observations and Uniform Representation of Enumerated Collections.
     Int J Funct Inform Personal Med. 2010;3(4):273-291.
Iteratively expanded the
base lab panel model to
accommodate more
complex attributes
Hierarchy of a Panel in LOINC
Purpose	
Assessments are widely used…	




…and not unlike other clinical observations
LOINC could be a
       	
           	
 master question file
          and
uniform representation
Panels/Forms Available as
   Separate Download
Tools for
Implementers	

            photo via Robert S Donovan
photo via SMcGarigle
loinc.org/usage
A Few Tests Give Most Results	
                                                 100%	
Cumulative Laboratory Observation Volume (%)	




                                                  90%	

                                                  80%	

                                                  70%	

                                                  60%	

                                                  50%	

                                                  40%	

                                                  30%	

                                                  20%	

                                                  10%	

                                                   0%	
                                                          0	
   500	
 1000	
 1500	
 2000	
 2500	
 3000	
 3500	
                                       4000	
                                                                 Number of Laboratory Observation Codes (N)	
                         Vreeman DJ, Finnell JT, Overhage JM. A Rationale for Parsimonious Laboratory Term Mapping by Frequency. AMIA Annu Symp Proc. 2007;:771-775.
loinc.org/usage	




“Top 2000 Results”
search.loinc.org	
If you want to poke around…start here!
search.loinc.org
Alternate Language Search
Alternate Language Search
RELMA®	
REgenstrief LOINC Mapping Assistant
What’s it Good For?	
Browse LOINC	
Map local terms to LOINC	
   	
import/export	
   	
translate local words to LOINC-speak	
   	
manual/automated mapping
Search Window
Mapping Screen	




                Navigate through the local terms
                                               	




Begin a search 	
(or hit “enter”)
LOINC Term Details
LOINC Terms with Spanish Linguistic Variant	



                         All Spanish!
Closing Themes	
General recommendations for health data
exchange with LOINC	




                                          photo via janeandd
Not just an IT problem
Don’t Assume	
Units of measure are critical.	
	
Sample results can help identify
the correct LOINC Scale.	
	
Local experts, package inserts can
be very informative.
Clean water act	




                    photo via Fishking_1
ivdconnectivity.org
A journey. 	
Not a destination.
Ongoing Journey	

Plan for updating as your testing
changes (less common), or your
local code identifiers change
(more common).
Ongoing Journey	

Replace mappings to deprecated
terms with new LOINC releases. 	
	
(RELMA can help)
Prioritization	
Local or national policies may help
prioritize mapping subsets.	
	
For example:	
   	
common results	
   	
+ panel elements	
   	
+ public health reportable tests
Jump In!	




             photo via Justin Ornellas
The Race is On!	




Happy LOINCing!	
                    photo via ryarwood
photo via milos milosevic

2012 03 20 - LOINC Introduction - AMIA KRS-WG

  • 1.
    AMIA Knowledge andSemantics WG Webinar LOINC An Introduction to the Universal Catalog of Laboratory and Clinical Observations Daniel J. Vreeman, PT, DPT, MSc Assistant Research Professor, Indiana University School of Medicine Associate Director for Terminology Services, Regenstrief Institute, Inc 03.20.2012 loinc@loinc.org © 2012
  • 2.
    Overview 1.  Origins and Evolution of LOINC 2.  LOINC Introduction 3.  Mapping Tools and Resources 4.  Closing Thoughts photo via Vernio77
  • 3.
    Acknowledgements LOINC Development Team ClemMcDonald, Kathy Mercer, Jaci Phillips, Jami Deckard, David Baorto, Kelly Malott RELMA Development Team John Hook, Mark Fisher, Karen Ahmed, Anandhi Sowmyan, James Dennis LOINC Committee Supporters: NLM, Regenstrief Institute, Regenstrief Foundation
  • 4.
    Biomedical Informatics at RegenstriefInstitute Building data-rich systems for clinicians
  • 5.
    Origins of LOINC Thelingua franca of clinical observation exchange
  • 6.
    40+ Years of CanopyComputing making a forest out of individual trees of data McDonald et al. Canopy Computing: using the Web in Clinical Practice. JAMA. 1998;280(15):1325-1329.
  • 7.
    e rain forestcanopy is a seamless web through which arboreal creatures efficiently move to reach the edible fruits without any attention to the individual trees. photo via nosha
  • 8.
    Arboreal Informatics Pioneers 40 years of EMR work Indiana Network for Patient Care Nation’s most comprehensive and longest tenured HIE Regenstrief – the neutral 3rd party convener
  • 11.
    Fundamental challenge: local systemshave different ways of identifying the same concept
  • 12.
    A vocabulary standard wouldserve as the Rosetta Stone. Image © Hans Hillewaert / CC-BY-SA-3.0
  • 13.
    Logical Observation Identifiers Names and Codes A universal code system that facilitates exchange, pooling, and processing of results
  • 14.
    Established in 1994by Regenstrief Institute. Vocabulary standard for observation identifiers.
  • 16.
    Same or Different? what you see in the order list Lab A Lab B Test Name: Lyme Disease Serology Test Name: Lyme Disease Antibody Measures: B. burgdorferi Ab IgG Measures: B. burgdorferi Ab IgM Method: ELISA Method: Immune blot Scale: quantitative Scale: qualitative e.g.: Titer 1:40 e.g.: Positive LOINC Code = 5062-5 LOINC Code = 6321-4
  • 17.
    Similar name, differentmeaning… photo via Caption Time meerkat meerkat mere cat meerkat
  • 18.
    If an observationis a question and the observation value is an answer… LOINC provides codes for questions Other vocabularies provide codes for the answers
  • 19.
    What is mypatient’s hemoglobin level? 718-7:Hemoglobin:MCnc:Pt:Bld:Qn
  • 20.
    How fast doesmy patient usually walk? 41959-8:Walking speed:Vel:1W^mean:^Patient:Qn:Calculated photo via Ed Yourdon
  • 21.
    Indiana Network forPatient Care HL7 v.2.X Message ! MSH|^~&|HOSPITAL_A|SAMPLE_HOSPITAL_A|||$YearMonthDay|||||||||||||||! PID|||$patientId$||$patientName$||||||||||||||||||||! LocalCode^LocalName^CodeSystem^LOINCcode^LOINCname^CodeSystem! PV1|||||||$attendingDoctor$||$consultingDoctor$||||||||! OBR|1|||012^CBC/Auto Diff^HSPA^57021-8^CBC ! Auto Diff^LN||$reqDate|||||||||! W OBX|2|NM|123^WBC^HSP_A^26464-8^Leukocytes [#/volume] in Blood^LN||10.8|K/MM3|||||F|! OBX|3|NM|234^RBC^HSP_A^26453-1^Erythrocytes [#/volume] in Blood^LN||4.82|MIL/MM3|||||F|! OBX|4|NM|345^HGB^HSP_A^718-7^Hemoglobin [Mass/volume] in Blood^LN||15.7|GM/DL|||||F|! OBX|5|NM|456^HCT^HSP_A^20570-8^Hematocrit [Volume Fraction] of Blood^LN||45|%|||||||F|! A   Message Processor A   Institutional Repository
  • 22.
    Result with aCoded Value Data type of result (OBX-5) is a This code is This code is coded element from LOINC from SNOMED OBX||CE|6609-2^Listeria ID^LN||36094007^L. monocytogenes^SCT Code identifying this observation Code identifying the (what are these results? result (L. monocytogenes) Listeria culture)
  • 23.
  • 24.
  • 25.
    Laboratory LOINC CommitteeChair: Clem McDonald, MD Clinical LOINC Committee Chair: Stan Huff, MD
  • 26.
    The LOINC Community Open.Nimble. Pragmatic.
  • 27.
    Open Development Worldwide distributionat no cost End-user content additions Welcome all comers Volunteers
  • 28.
    Funding Support Principal currentsources are: U.S. National Library of Medicine Regenstrief Foundation Prior support from Several other U.S. federal agencies, John A. Hartford Foundation
  • 29.
    Regenstrief Institute Steward Developer ofcontent Developer of tools Developer of community Distributor Voice
  • 31.
    5/ 0! 10,000! 12,000! 14,000! 16,000! 18,000! 2,000! 4,000! 6,000! 8,000! 2/ 08 ! 7/ 2/ 08 ! 9/ 2/ 08 11 ! /2 /0 8! 1/ 2/ 09 3/ ! 2/ 09 ! 5/ 2/ 09 ! 7/ 2/ 09 ! 9/ 2/ 09 11 ! /2 /0 9! 1/ 2/ 10 3/ ! 2/ 10 ! 5/ 2/ 10 ! 7/ 2/ 10 ! 9/ 2/ 10 11 ! /2 /1 0! 1/ 2/ 11 Doubled in 19 months! 3/ ! 2/ 11 ! 5/ loinc.org members 2/ 11 ! 7/ 2/ 11 ! 9/ 2/ 11 11 ! /2 /1 1! 14 new members per day 1/ 2/ 12 ! 410 new members per month
  • 32.
    16,300+ users in145 countries
  • 33.
  • 34.
    Major releases twice peryear (June and December) photo via striatic
  • 35.
    LOINC Codes OverTime By Release 80,000 LOINC Codes Lab Codes 70,000 Slope = 2200 60,000 50,000 Slope = 600 40,000 30,000 20,000 10,000 laboratory terms only 0
  • 36.
    Lots Cooking… Always morelab tests Genetic reporting Flow cytometry Lots of survey instruments, forms, and assessments More radiology reports Structured document titles … photo via liber
  • 37.
  • 38.
  • 39.
    Just kidding. Copyright isa good thing for standards. It’s the licensing part that is interesting.
  • 40.
  • 41.
  • 42.
    Any purpose: commercial non-commercial photo via Refracted Moments™
  • 43.
    Cannot use any LicensedMaterial to develop or promulgate a different standard for orders or observations.
  • 44.
    That would defeat the purpose of having a standard!
  • 45.
  • 46.
    LOINC Submitters Since 2009 79 organizations from 14 countries
  • 47.
    LOINC Translators 19 organizations
  • 48.
    Chinese  (CHINA)     Dra$  Portuguese  (BRAZIL)     English  (UNITED  STATES)     Estonian  (ESTONIA)     French  (CANADA)     French  (FRANCE)     French  (SWITZERLAND)     German  (GERMANY)     German  (SWITZERLAND)     Greek  (GREECE)     Italian  (ITALY)     Italian  (SWITZERLAND)     Korean  (KOREA,  REPUBLIC  OF)     Spanish  (ARGENTINA)     Spanish  (SPAIN)     Spanish  (SWITZERLAND)    
  • 50.
    Vreeman DJ etal. Enabling international adoption of LOINC through translation. J Biomed Inform (2012), doi:10.1016/j.jbi.2012.01.005
  • 51.
  • 52.
    Adopted as NationalStandard Brazil Canada France Germany The Netherlands Mexico Rwanda Thailand
  • 53.
    Large Implementations SIGA Saúdeproject Canada Health Infoway ePSOS Assistance publique - Hôpitaux de Paris Red Agrolab BiTAC Hong Kong Hospital Authority Many more…
  • 55.
    US Adoption A fewkey highlights
  • 56.
    Some Key USAdoptions All the big labs All health-related federal agencies Lots of care organizations HIE’s Insurance companies EHR vendors Instrument manufacturers (nascent)
  • 57.
    EHR Incentive Program a.k.a. “Meaningful Use”
  • 61.
    LOINC adopted for: 1. View, download, transmit data to third party 2.  Cancer case reporting to state registry 3.  Send/receive electronic lab results in ambulatory settings 4.  Provide a care summary at care transition 5.  Provide clinical summaries for patients 6.  Submit reportable lab results to public health
  • 62.
    LOINC Names Introduction toLOINC Naming Conventions
  • 63.
    Anatomy of aLOINC Term 5193-8:Hepatitis B virus surface Ab:ACnc:Pt:Ser:Qn:EIA 5193-8 LOINC Code Hepatitis B virus surface Ab Component ACnc Property Measured Pt Timing Ser System Qn Scale EIA Method There are six major LOINC axes
  • 64.
    NOT part ofa LOINC Name Reason for the test (disease it diagnoses) Testing instrument Specific details about the specimen Priority (e.g. STAT) Where testing was done Who did the test Test interpretation Anything not part of naming the test Stuff carried in other parts of HL7 message
  • 65.
    Component The substance or entity that is measured, evaluated, or observed Sodium Glucose Brucella sp. organism Influenza A Virus antigen Cytomegalovirus antibody Lipids.total 5193-8:Hepatitis B virus surface Ab:ACnc:Pt:Ser:Qn:EIA
  • 66.
    Component Structure Analyte Name^Challenge^Adjustments Formal analyte name Calcium Specify “subanalytes” Coronavirus Ag May have subclasses Calcium.ionized Challenge 1H post 100 g Glucose PO Two parts separated <time delay>post<challenge type> by “post” Adjustments Adjusted to pH 7.4
  • 67.
    Property * the most difficult LOINC axis The characteristic or attribute of the analyte that is measured, evaluated, or observed. Major Categories: mass substance catalytic activity arbitrary number 5193-8:Hepatitis B virus surface Ab:ACnc:Pt:Ser:Qn:EIA
  • 68.
    Property * the most difficult LOINC axis Fully Named Properties MCnc mass concentration mg/dL SCnc substance concentration umol/L MCnt mass content mg/g CCnc catalytic concentration U/L Prid presence or identity Imp impression Type “kind of” Property is related to units of measure 5193-8:Hepatitis B virus surface Ab:ACnc:Pt:Ser:Qn:EIA
  • 69.
    Timing The interval oftime over which the observation or measurement was made Pt point in time 12H 12 hour collection 24H 24 hour collection Non-Pt timings are often 5193-8:Hepatitis B virus surface Ab:ACnc:Pt:Ser:Qn:EIA found with Rate Property
  • 70.
    System The system (context)or specimen type upon which the observation was made. Ser serum Ser/Plas serum or plasma Bld whole blood Ur urine Flu body fluid photo via AlishaV Tiss tissue XXX specified elsewhere 5193-8:Hepatitis B virus surface Ab:ACnc:Pt:Ser:Qn:EIA
  • 71.
    System Structure System^Super System Super System Patient is the default Used to indicate: blood product unit, bone marrow donor, fetus 818-5:A Ag:ACnc:Pt:RBC^BPU:Ord: 11670-7:Blood flow.mean:Vel:Pt:Aortic arch^fetus:Qn:US.doppler
  • 72.
    Scale Qn Quantitative continuous numeric can have operators Ord Ordinal Ranked set (1+, 2+, 3+) photo via puuikibeach Nom Nominal unranked collection Taxonomy (e.g. bacteria) Nar Narrative 5193-8:Hepatitis B virus surface Ab:ACnc:Pt:Ser:Qn:EIA
  • 73.
    Method Only needed ifinterpretation affected Different normal ranges Test sensitivity Listed at the generic level Agglutination Enzyme Immunoassay Probe with target amplification 5193-8:Hepatitis B virus surface Ab:ACnc:Pt:Ser:Qn:EIA
  • 74.
    LOINC Collections Panels, forms,surveys, and other patient assessments photo via LuzA
  • 75.
    Standardized Assessments andCollections Vreeman DJ, McDonald CJ, Huff SM. Representing patient assessments in LOINC®. AMIA Annu Symp Proc. 2010;832-836. PMID: 21347095 . Vreeman DJ, McDonald CJ, Huff SM. LOINC® - A Universal Catalog of Individual Clinical Observations and Uniform Representation of Enumerated Collections. Int J Funct Inform Personal Med. 2010;3(4):273-291.
  • 76.
    Iteratively expanded the baselab panel model to accommodate more complex attributes
  • 77.
    Hierarchy of aPanel in LOINC
  • 78.
    Purpose Assessments are widelyused… …and not unlike other clinical observations
  • 79.
    LOINC could bea master question file and uniform representation
  • 81.
    Panels/Forms Available as Separate Download
  • 82.
    Tools for Implementers photo via Robert S Donovan
  • 83.
  • 84.
  • 85.
    A Few TestsGive Most Results 100% Cumulative Laboratory Observation Volume (%) 90% 80% 70% 60% 50% 40% 30% 20% 10% 0% 0 500 1000 1500 2000 2500 3000 3500 4000 Number of Laboratory Observation Codes (N) Vreeman DJ, Finnell JT, Overhage JM. A Rationale for Parsimonious Laboratory Term Mapping by Frequency. AMIA Annu Symp Proc. 2007;:771-775.
  • 86.
  • 88.
    search.loinc.org If you wantto poke around…start here!
  • 89.
  • 90.
  • 91.
  • 92.
  • 93.
    What’s it GoodFor? Browse LOINC Map local terms to LOINC import/export translate local words to LOINC-speak manual/automated mapping
  • 94.
  • 95.
    Mapping Screen Navigate through the local terms Begin a search (or hit “enter”)
  • 96.
  • 97.
    LOINC Terms withSpanish Linguistic Variant All Spanish!
  • 98.
    Closing Themes General recommendationsfor health data exchange with LOINC photo via janeandd
  • 99.
    Not just anIT problem
  • 100.
    Don’t Assume Units ofmeasure are critical. Sample results can help identify the correct LOINC Scale. Local experts, package inserts can be very informative.
  • 101.
    Clean water act photo via Fishking_1
  • 102.
  • 103.
    A journey. Nota destination.
  • 104.
    Ongoing Journey Plan forupdating as your testing changes (less common), or your local code identifiers change (more common).
  • 105.
    Ongoing Journey Replace mappingsto deprecated terms with new LOINC releases. (RELMA can help)
  • 107.
    Prioritization Local or nationalpolicies may help prioritize mapping subsets. For example: common results + panel elements + public health reportable tests
  • 108.
    Jump In! photo via Justin Ornellas
  • 109.
    The Race isOn! Happy LOINCing! photo via ryarwood
  • 110.
    photo via milosmilosevic