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Using RELMA   Or… In Search of the Missing LOINC © 2007 Regenstrief Institute & James Case James T. Case MS, DVM, PhD Professor, Clinical Diagnostic Informatics California Animal Health and Food Safety Laboratory University of California, Davis Laboratory LOINC Meeting – June 2008
Acknowledgements ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],© 2007 Regenstrief Institute & James Case
What will we cover today? ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Goals of Health Information Standards ,[object Object],[object Object],[object Object]
Levels of Interoperability ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Comparability ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Potential Uses of Health Data are Constrained by Data Quality Factors ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
The Problem ,[object Object],Florence Nightingale - Notes on a Hospital, 1873
Why LOINC? ,[object Object],[object Object]
Test comparisons ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],LOINC Code = 5062-5 LOINC Code = 6321-4 What you see in the order list
LOINC ®  101
Anatomy of a LOINC Term 5193-8 LOINC Code Hepatitis B virus surface Ab ACnc Pt Ser Qn EIA Component Property Measured Timing System Scale Method There are six major LOINC axes 5193-8:Hepatitis B virus surface Ab:ACnc:Pt:Ser:Qn:EIA
What is NOT part of a LOINC Name? ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Component/Analyte The substance or entity that is measured, evaluated, or observed ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],5193-8: Hepatitis B virus surface Ab :ACnc:Pt:Ser:Qn:EIA
Component/Analyte  Structure ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],Analyte Name^Challenge^Adjustments
[object Object],[object Object],[object Object],[object Object],[object Object],Property* The characteristic or attribute of the analyte that is measured, evaluated, or observed the most difficult LOINC axis Major Categories 5193-8:Hepatitis B virus surface Ab: ACnc :Pt:Ser:Qn:EIA
[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],Property* the most difficult LOINC axis Combine Major Categories with Subtypes for Full Property 5193-8:Hepatitis B virus surface Ab: ACnc :Pt:Ser:Qn:EIA
Common Issues with LOINC Properties ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],Fraction (proportion) vs. Ratio a/a+b vs. a/b
[object Object],[object Object],[object Object],Timing* *non-Pt timings are usually associated with Ratio Property The interval of time over which the observation or measurement was made
System The system (context) or specimen type upon which the observation was made. Super System Second subpart (^). When not included, “patient” is the default. Used to indicated blood product unit (BPU), a bone marrow donor, or a fetus.
[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],Scale
Scale (Special) ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Method ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Mapping Terms to LOINC Things to Remember ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
RELMA ® Regenstrief LOINC Mapping Assistant
Purpose of Tutorial ,[object Object],[object Object],[object Object],[object Object],[object Object]
New in this Version (rel. 3.24) ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
New in this Version (rel. 3.24) ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
New in this Version (rel. 3.24) ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],RELMA Functions
 
Highlights ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],RELMA
RELMA Logic ,[object Object],[object Object],[object Object]
[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],RELMA Search logic
Additional RELMA Features  ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Installing RELMA®
Installation Steps ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Running RELMA®
Copyright Screen © 2006 Regenstrief Institute & James Case
Main Menu/Welcome Screen © 2006 Regenstrief Institute & James Case Click File, Set Preferred Language
Select Linguistic Variant(s)
LOINC Terms with Spanish Linguistic Variant Spanish!
Welcome Screen
Setting User Preferences
Select User Preferences From the File Menu Set User Preferences
Set User Preference Dialog © 2006 Regenstrief Institute & James Case User Name or Initials File Locations Startup Screen Preference RELMA Color Scheme
RELMA Color Schemes Predefined Schemes Create, Save, Delete custom color schemes Customize Colors
User Map Screen Preferences Click Map Screen Tab
Importing Local Terms into RELMA
4 Ways to Load LMOF Files ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Constructing a Local Dataset ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Creating Delimited ASCII File ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Entering New Local Terms  into RELMA
Manual Enter/Edit  © 2006 Regenstrief Institute & James Case View/Add/Edit Local Terms
Edit Term Dialog Add New Test Print Preview List Text alignment option Custom Export Format
Add Local Term Form Click to Add to Current Working File MICRO BUBPLAG BUBONIC PLAGUE – RRT PCR
Print Preview Local Term File
Text Alignment Truncated vs. Wrapped Truncated terms end with ellipsis
Custom Export Options Output Options
Exported as Excel File
Steps to Import Local Terms ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Example Delimited File © 2006 Regenstrief Institute & James Case
Importing Local Files © 2006 Regenstrief Institute & James Case Select Import Local Terms
Open File in RELMA © 2006 Regenstrief Institute & James Case Name your working set.  RELMA allows multiple sets in LMOF database Select your delimiter Import Button
Open File in RELMA © 2006 Regenstrief Institute & James Case
Fields Segregated © 2006 Regenstrief Institute & James Case Assign LMOF Attribute
Ready to Import © 2006 Regenstrief Institute & James Case Now you can click this button!
Alternative (best) Way ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Generate Local term file from HL7 messages   Select Import Terms from HL7 File
Select File to Import Select HL7 File
Specify HL7 File Name and Sample Size Name the Local Term File (working set)
HL7 Messages Data Statistics © 2006 Regenstrief Institute & James Case
New Terms added to LMOF New Battery Code Sample Data
[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],Lenny L’OINC says: “ Load the Sample Files Into RELMA now!”
Cleaning your data
Preparing your Data for Mapping ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Preparing your Data for Mapping ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
RELMA Cleaning Tools Use this tool to find unknown terms
Scanning Local Terms
Replace Local Terms © 2006 Regenstrief Institute & James Case Assign LMOF Attribute Replacement  Options
RELMA Cleaning Tools Use this tool to make global substitutions
Term Substitution Save this global substitution for only this working set
Mapping Local Terms
Mapping Local Terms ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Standard Mapping Window Features ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Mapping Screen  View or edit local term
View Local Term Details © 2006 Regenstrief Institute & James Case
Standard Mapping Screen Begin a  search
Initial Mapping Results Click to show words used in search EEK!  What’ll I do?!
Initial Mapping Results Use term checkbox Number of LOINC terms containing keyword Battery terms included in search
Revised Mapping Results Number of matching records found Match units selected by default
Re-revised Mapping Results Number of matching records found Match units unselected
Standard Mapping Screen Clear all input fields
Cleared Mapping Screen Enter keywords here CANINE DISTEMPER VIRUS IF
Ad hoc  term search
Standard Mapping Screen Navigate through the local terms Show entire local term file
Show all terms Displays printed report format
© 2006 Regenstrief Institute & James Case
Additional Search Screen Options Navigate to viewed screens View Mode: Grid (default) or Tree (new)
Tree View ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Tree View Cannot map to these Can map to these
Assigning a LOINC Map Highlight correct term Click “Map” Button  (or doubleclick)
Adding Mapping Comments If comments option is selected, prompt appears Check with Frank in Chemistry
Assigning a LOINC Map LOINC Term Assigned
View LOINC Term Details Right clicking on a LOINC term brings up a Task Menu View details for a specific LOINC Term
LOINC Term Details Can scroll through returned subset of terms Change to expanded details view  Change text size Can scroll down a single formatted page
Expanded Details View
Expanded Details View
Using Wildcards in Searches ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Other Search Qualifiers ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Limiting Searches
Setting Search Limits ,[object Object],[object Object],[object Object],[object Object],[object Object]
RELMA - Search Constraints ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Setting Search Limits Click Hierarchy & Search Limits Button
Setting search limits ,[object Object],Toggle Buttons
Search Constraints Predefined, general search constraints Attribute trees Local Unit Constraint: Now defaults to “ON”
Terms Consistent with Units Only terms consistent with mmol/L appear
Setting Search Limits Specimen constraints
Terms Consistent with Specimen  CSF Enter default Specimen
Terms Consistent with Specimen  Only CSF Terms are returned
Setting Search Limits Methodless Terms Restriction Override Methodless Terms Restriction
Limit to Methodless Terms
Limit to Methodless Terms Only Methodless Terms Appear
More on Methodless Terms ,[object Object],[object Object],[object Object]
Methodless Only Unchecked All terms returned
Methodless Only Checked Only Methodless terms returned
Conditional Methodless More terms returned
Setting Search Limits Limit to Lab Tests Only  (No Clinical LOINC Terms)
Setting Search Limits Limit to lab tests that comprise 99.8% of INPC volume
Setting Search Limits Limit Number of Words in the Component Attribute
Limit Number of Component Words Without Limit Applied: 698 terms returned
Limit Number of Component Words With Limit Applied:  64 terms returned Restriction appears on Toggle Bar  (cannot toggle off)
Setting Search Limits Include Deprecated LOINC Codes with Returned Terms
Include Deprecated LOINC Terms Deprecated LOINC Terms appear as Strikethrough Text with a “Do Not” Symbol
Favor Property Restriction Favor one type of property over others
Order/Observation Restriction Order or Observation preference
LOINC Hierarchies – Class Tree Three top-level branches Tree Navigation Buttons
Before Class Restriction Large number of candidate terms Many terms have class of “CHAL”
Search Trees chal Restrict eligible tests to non-challenge chemistry tests only
Following Class Restriction Only Non-Challenge Chemistry tests returned
Improvements to Trees Continued reorganization to provide a Specimen hierarchy
Improved Hierarchy for Component Show the LOINC Codes associated with these components
Show Associated LOINCs Click on details for more information about the selection
Details Screen
Tree Export Tools Save tree data to a file Export tree data to Excel Send Tree data as email
RELMA - Tree Features ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Navigating through the Mapping Process
[object Object],[object Object],[object Object],LOINC Mapping Tactics
Vreeman DJ, Finnell JT, Overhage JM. A Rationale for Parsimonious Laboratory Term Mapping by Frequency.  AMIA Annu Symp Proc . 2007;:771-775.
More LOINC Mapping Tactics ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Common Mapping Issues ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Using your Mapped Terms ,[object Object],[object Object]
Intelligent Mapper  ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Picking the Intelligent Mapper
Intelligent Mapper Start Screen
Intelligent Mapper - Mapping Screen
Exporting Mapped Terms Export Terms to Delimited File
Export Terms Dialog Check Fields you wish to export Select Delimiter
Output File © 2006 Regenstrief Institute & James Case Mapped terms include LOINC code
Other RELMA ®  Features
Panels, Forms and Survey Review New Menu Function: Review Panels, Forms and Surveys
Government Forms Form Name Component LOINC terms
Laboratory panels Expand category to see panels  Double-click panel name to see components
Expanded Panel Detail
Expanded Clinical Panel © 2006 Regenstrief Institute & James Case
Clinical Panels New Feature: Find where a term has been used
LOINC Term Usage 35089-2, 35090-0
LOINC Term Panel Usage
Other Survey Instruments
HIPAA Attachments View Various HIPAA Attachments
HIPPA Attachment Tree
Expanded Attachment Data
Can’t find the term you want?
Search Hints and Tips ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Proposing New LOINC Terms
Proposing New Terms ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Propose new LOINC terms Select Propose a LOINC
Propose new LOINC terms Navigate through proposed terms Create new term, save current term or Exit form
Preview Proposed Terms Review your new terms
Preview Proposed Terms All proposed terms fully editable Choose whether to send or postpone X X X X
Use Existing Terms as Template Select your closest match Click the Propose Term button
Use Existing Terms as Template All required components filled in
Using LOINC and SNOMED Together
Where do LOINC and SNOMED Fit? ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],Remember:
Where do LOINC and SNOMED Fit? ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
OBX: With a Coded Value OBX||CE|6609-2^Listeria  ID^LN||36094007^L. monocytogenes^SCT The code is from SNOMED The code is from LOINC OBX-5: Data A code for L. monocytogenes A code that identifies the data type in  OBX-5 as a coded element OBX-3:A code that identifies the data in OBX-5 (Listeria culture)
HL7 2.5 Example (ER-7 format) ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],First Order OBR (Culture and ID) First Result Value (SNOMED) First Result Description OBX (LOINC) Second Order OBR (Susceptibility)
Q and A Session
Exercise Map your own data
Need RELMA?   http://tinyurl.com/2vrms7

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