Barrett’s esophagus (BE), a complication of chronic gastroesophageal reflux disease (GERD), is defined as the extension of salmoncolored mucosa into the tubular esophagus ≥1 cm proximal to the gastroesophageal junction (GEJ) with biopsy confirmation of intestinal metaplasia, defined by the presence of goblet cells histologically. Patients with BE are at increased risk of esophageal adenocarcinoma (EAC), and as such, need to undergo endoscopic surveillance with biopsy to detect dysplasia or earlyEAC. Histologic criteria for dysplasia in BE were well described in 1988 by Reidetal. and classified as BE with low grade dysplasia (LGD), BE with high grade dysplasia (HGD) and BE with changes indefinite for dysplasia (IND). Biopsies are classified as IND when the epithelial abnormalities are not sufficient to diagnose dysplasia or the nature of the epithelial abnormalities is uncertain due to inflammation or technical issues. Specific diagnostic criteria for indefinite for dysplasia (IND) are not well established and its clinical significance has not been well studied. Previous studies have focused on the higher end of neoplasia in BE and led to revolutionary changes and improvement in the management of BE with HGD and early EAC. Only recently, the lower end of dysplasia in BE attracted researchers’ interest. This reviewsummarizes the findings in most recent studies on the neoplastic risk and thus the management of BE IND.
Background: Arterial stiffness is an independent predictor of cardiovascular disease. Independent of aging and other cardiovascular risk factors, arterial stiffness increases from the proximal to the distal arterial compartments. The overall aim of this work is to establish a longitudinal mechanical mapping of the arterial tree in healthy individuals.
Methods: We report preliminary data quantifying stiffness of the abdominal aorta (AAA), common carotid artery (CCA) and brachial artery (BA) in adolescents. In group-1 subjects (from Melbourne, Australia), cine-loops of the AAA and CCA B-mode data were digitally recorded, whereas in group-2 (from Montreal, Canada), cine-loops of the CCA and BA B-mode data were acquired at the same clinical evaluation. Arterial wall elastic moduli (EIBM) were estimated off-line using our proprietary non-invasive imaging-based biomarker algorithm(ImBioMark).
Barrett’s esophagus (BE), a complication of chronic gastroesophageal reflux disease (GERD), is defined as the extension of salmoncolored mucosa into the tubular esophagus ≥1 cm proximal to the gastroesophageal junction (GEJ) with biopsy confirmation of intestinal metaplasia, defined by the presence of goblet cells histologically. Patients with BE are at increased risk of esophageal adenocarcinoma (EAC), and as such, need to undergo endoscopic surveillance with biopsy to detect dysplasia or earlyEAC. Histologic criteria for dysplasia in BE were well described in 1988 by Reidetal. and classified as BE with low grade dysplasia (LGD), BE with high grade dysplasia (HGD) and BE with changes indefinite for dysplasia (IND). Biopsies are classified as IND when the epithelial abnormalities are not sufficient to diagnose dysplasia or the nature of the epithelial abnormalities is uncertain due to inflammation or technical issues. Specific diagnostic criteria for indefinite for dysplasia (IND) are not well established and its clinical significance has not been well studied. Previous studies have focused on the higher end of neoplasia in BE and led to revolutionary changes and improvement in the management of BE with HGD and early EAC. Only recently, the lower end of dysplasia in BE attracted researchers’ interest. This reviewsummarizes the findings in most recent studies on the neoplastic risk and thus the management of BE IND.
Background: Arterial stiffness is an independent predictor of cardiovascular disease. Independent of aging and other cardiovascular risk factors, arterial stiffness increases from the proximal to the distal arterial compartments. The overall aim of this work is to establish a longitudinal mechanical mapping of the arterial tree in healthy individuals.
Methods: We report preliminary data quantifying stiffness of the abdominal aorta (AAA), common carotid artery (CCA) and brachial artery (BA) in adolescents. In group-1 subjects (from Melbourne, Australia), cine-loops of the AAA and CCA B-mode data were digitally recorded, whereas in group-2 (from Montreal, Canada), cine-loops of the CCA and BA B-mode data were acquired at the same clinical evaluation. Arterial wall elastic moduli (EIBM) were estimated off-line using our proprietary non-invasive imaging-based biomarker algorithm(ImBioMark).
To describe the frequency, type, and clinical course
of hearing loss in Wegener’s granulomatosis and assess hearing
loss as an indicator of disease activity.
The Effect of Demographic Data and Hemoglobin A 1c on Treatment Outcomes in P...asclepiuspdfs
Objective: Diabetes mellitus, the most common cause of non-traumatic foot amputations, is a life-threatening condition due to its high mortality and morbidity. In our study, we retrospectively evaluated our patients with diabetic foot syndrome in our clinic. Materials and Methods: The demographic data, duration of diabetes, Wagner classification, haemoglobin A 1c (HbA1c) levels, white blood cell, C-reactive protein sedimentation levels, hospital stay, and treatment results were evaluated retrospectively in 14 patients with diabetic foot between January 2017 and December 2018. Results: The mean age of the patients was 62.43 ± 7.7 years. Of the 14 patients, 3 were females and 11 were males. All 14 patients were type 2 diabetes mellitus. When diabetic foot Wagner classification was performed, 6 patients were evaluated as Wagner 2, five patients were Wagner 3, and three patients were evaluated as Wagner 4. Nine patients had complete amputation and 3 had vascular surgery. Conclusion: Although the level of HbA1c is below the target level, the risk of diabetic foot is increased when there is no adequate diabetes mellitus foot training. Inadequate diabetic patient education and hospitalization of patients after infection progress the amputation rate.
Clinical Profile of Patients with Coronary Tortuosity and its Relation with C...Premier Publishers
Coronary tortuosity is a common angiographic finding. This study was done to observe the clinical profile of patients with coronary tortuosity (CT) and its relation with coronary artery disease (CAD). Method: A total 224 patients undergoing angiography for suspected CAD were included in the study. Coronary tortuosity was defined by the presence of ≥3 consecutive bends of > 45 degree, measured at end-diastole in an epicardial artery ≥2 mm in diameter. Coronary tortuosity was present in 45(20.1%) patients (CT group) in the study and another 45 patients without coronary tortuosity was randomly selected as control (NCT group). Clinical profile of CT and NCT group was compared. Results: Incidence of coronary tortuosity was significantly higher in females (p=0.000) and hypertensives (p=0.001) patients. Coronary tortuosity was most commonly seen in Left circumflex coronary artery. Incidence of CAD was significantly lower in CT group as compare to NCT group (0.02). Risk factors for CAD was associated with reduced incidence of Coronary tortuosity. Majority (88.5%) patient with CT without CAD presented with chronic stable angina out of which (65.2%) had an objective evidence of myocardial ischemia. Conclusion: Coronary tortuosity is more commonly seen females and hypertensive patients. It has negative correlation with CAD but can lead to myocardial ischemia. Risk factors of CAD do not predict CT.
To describe the frequency, type, and clinical course
of hearing loss in Wegener’s granulomatosis and assess hearing
loss as an indicator of disease activity.
The Effect of Demographic Data and Hemoglobin A 1c on Treatment Outcomes in P...asclepiuspdfs
Objective: Diabetes mellitus, the most common cause of non-traumatic foot amputations, is a life-threatening condition due to its high mortality and morbidity. In our study, we retrospectively evaluated our patients with diabetic foot syndrome in our clinic. Materials and Methods: The demographic data, duration of diabetes, Wagner classification, haemoglobin A 1c (HbA1c) levels, white blood cell, C-reactive protein sedimentation levels, hospital stay, and treatment results were evaluated retrospectively in 14 patients with diabetic foot between January 2017 and December 2018. Results: The mean age of the patients was 62.43 ± 7.7 years. Of the 14 patients, 3 were females and 11 were males. All 14 patients were type 2 diabetes mellitus. When diabetic foot Wagner classification was performed, 6 patients were evaluated as Wagner 2, five patients were Wagner 3, and three patients were evaluated as Wagner 4. Nine patients had complete amputation and 3 had vascular surgery. Conclusion: Although the level of HbA1c is below the target level, the risk of diabetic foot is increased when there is no adequate diabetes mellitus foot training. Inadequate diabetic patient education and hospitalization of patients after infection progress the amputation rate.
Clinical Profile of Patients with Coronary Tortuosity and its Relation with C...Premier Publishers
Coronary tortuosity is a common angiographic finding. This study was done to observe the clinical profile of patients with coronary tortuosity (CT) and its relation with coronary artery disease (CAD). Method: A total 224 patients undergoing angiography for suspected CAD were included in the study. Coronary tortuosity was defined by the presence of ≥3 consecutive bends of > 45 degree, measured at end-diastole in an epicardial artery ≥2 mm in diameter. Coronary tortuosity was present in 45(20.1%) patients (CT group) in the study and another 45 patients without coronary tortuosity was randomly selected as control (NCT group). Clinical profile of CT and NCT group was compared. Results: Incidence of coronary tortuosity was significantly higher in females (p=0.000) and hypertensives (p=0.001) patients. Coronary tortuosity was most commonly seen in Left circumflex coronary artery. Incidence of CAD was significantly lower in CT group as compare to NCT group (0.02). Risk factors for CAD was associated with reduced incidence of Coronary tortuosity. Majority (88.5%) patient with CT without CAD presented with chronic stable angina out of which (65.2%) had an objective evidence of myocardial ischemia. Conclusion: Coronary tortuosity is more commonly seen females and hypertensive patients. It has negative correlation with CAD but can lead to myocardial ischemia. Risk factors of CAD do not predict CT.
WordPress, muito além de um software para blogsCayo Medeiros
A idéia da palestra é falar um pouco do WordPress, suas características e funcionalidades, e depois explicar as vantagens em utilizá-lo como um CMS mostrando alguns cases. Termino fugindo do foco dando várias dicas de plugins que servem para resolver os mais variados problemas.
Palestra que inicialmente foi ministrada no 1º Encontro de Tecnologia Simonsen e depois alterada para apresentação no 1º In Net.
UFMG Prova única 1972 caderno par - Conteúdo vinculado ao blog http://fi...Rodrigo Penna
Provas antigas do vestibular da UFMG, gentilmente cedidas pelo Prof. Dr. José Guilherme. Que foi meu professor de Física I e é ex-presidente da Copeve. Lembrar que é preciso citar a fonte, caso vá utilizar as questões. Todo o conteúdo vinculado a este arquivo está descrito, organizado e lincado no nosso blog:
http://fisicanoenem.blogspot.com/
Journal of Blood Disorders is a peer-reviewed, open access journal published by Austin Publishers. It provides easy access to high quality Manuscripts in the branch of internal medicine, physiology, pathology, pediatrics covering etiology, diagnosis, staging, treatment, prognosis, and follow-up the diseased caused in either the three components of the blood namely red blood cells, white blood cells, platelets or sometimes even cause in the liquid portion of blood, plasma. This journal also focuses upon the study of blood diseases, blood malignancies, etiology, diagnosis, staging, treatment, drugs, epidemiology, and awareness.
Austin Publishing Group is a successful host of more than hundred peer reviewed, open access journals in various fields of science and technology with intent to bridge the gap between academia and research access.
Journal of Blood Disorders accepts original research articles, review articles, case reports, mini reviews, rapid communication, opinions and editorials on all the related aspects of hematology, blood diseases and blood malignancies.
Implication of preoperative glycosylated hemoglobin level on short term outco...Dr.Debmalya Saha
ABSTRACT
Background: Diabetes mellitus is one of the significant risk factors for adverse outcomes after coronary artery bypass surgery. The glycosylated haemoglobin i.e. HbA1c is a reliable diagnostic test to know the long-term glycemic status. The objective of the study is to investigate the implication of preoperative HbA1c level on short term outcomes after coronary artery bypass grafting (CABG).
Method: Total 218 patients were studied, and the data were collected retrospectively. Patients are distributed into group 1 with HbA1c≤7 (good glycemic control) and group 2 with HbA1c>7 (poor glycemic control). The parameters studied for short term outcomes were revision due to bleeding, duration of mechanical ventilation, cerebrovascular accident (CVA), atrial fibrillation (AF), renal failure requiring dialysis, infective complications like sternal and leg wound infection, mediastinitis, pneumonia, urinary tract infection (UTI), sepsis; length of ICU stay and in-hospital mortality.
Result: In comparison to group 1, patients of group 2 showed statistically significant more morbidity in view of short-term outcomes in this study.
Conclusion: HbA1c>7 is associated with statistically significant adverse short-term outcomes after CABG.
Correlation between vascular endothelial growth factor-A expression and tumor...UniversitasGadjahMada
Vascular endothelial growth factor-A (VEGF-A) has been observed as the predominant angiogenic factor in colorectal cancer (CRC) and the assessment of microvessel density (MVD) has been used to quantify tumor neoangiogenesis. This study aimed to determine clinicopathological and prognostic significance of both angiogenic markers in the local CRC patients. We analyzed tissue samples obtained from 81 cases with CRC. VEGF-A expression and MVD counts were immunohistochemically detected using anti VEGF-A and CD31. The assessments of both markers were classified as low and high. Correlation between VEGF-A expression and MVD value and clinicopathological characteristics were examined using Chi-square test. The overall survival (OS) was plotted using the Kaplan-Meier method. The results indicated a high VEGF-A expression was found more frequently in the rectal location (P=0.042) and T4 tumors (P=0.041) compared to their counterparts. Older patients tended to show a higher MVD value compared to younger cases (P=0.062). In addition, survival analysis showed that males had a worse OS compared to females (P=0.029), and VEGF-A expression and MVD count did not correlate with patients’ survival. In conclusion, there were significant differences of VEGF-A expression according to tumor location and T invasion. Sex, but not angiogenic markers, had an influence on the survival of CRC patients.
Lung Poorly differentiated Adenocarcinoma with Cerebral Metastasesasclepiuspdfs
A 61-year-old man was transferred to our hospital with dizziness and gait disturbance that had progressed over the preceding 2 weeks. Four weeks before presentation, he had presented to fever clinics with hemoptysis and fever and received a diagnose of mild Coronavirus disease 2019 pneumonia by nucleic acid test. Chest computed tomography (CT) scan showed the neoplasm in the left upper lung [Figure 1a and b], and findings on CT-guided percutaneous lung biopsy were consistent with poorly differentiated adenocarcinoma, which was one of non-small cell lung cancer (NSCLC).
Red cell alloimmunization in blood transfusion dependent Patients with Sickle...iosrjce
IOSR Journal of Dental and Medical Sciences is one of the speciality Journal in Dental Science and Medical Science published by International Organization of Scientific Research (IOSR). The Journal publishes papers of the highest scientific merit and widest possible scope work in all areas related to medical and dental science. The Journal welcome review articles, leading medical and clinical research articles, technical notes, case reports and others.
Serum interleukin - 6 level among sudanese patients with chronic kidney disease
Authors:Safaa I.A Nasr , Rbab A.M Adam , Hala M.M Ibrahim , Afra S.A Abdelgadir , Ibrahim Alkider , Solomon M. Gamde , Simon P. Abriba
Int J Biol Med Res. 2023; 14(4): 7652-7654 | Abstract | PDF File
Similar to Persistent monocytosis and CAL in Kawasaki disease, Ho-Chang Kuo, MD (郭和昌醫師 川崎症) (20)