4. Basic life Process and Their Function
1.Metabolism
2.Responsiveness
3. Movement
4. Growth
5. Differentiation
6. Reproduction
5. Metabolism
It is the sum of all the chemical process that occur in
the body
(a) Catabolism :- breakdown of complex chemical
substances into simpler components
(b) Anabolism :- the building up complex substance
from smaller, simpler components
E.g.:- digestive processes catabolize protein in food into
amino acid. These amino acid then used to anabolise
(build) new proteins that make up body structure such
as muscle and bone.
6. Responsiveness
The body’s ability to detect and respond to changes.
Example
1. increase in the body temperature represent a change in
internal environment
2. turning head toward the sound is a response of external
environment.
Nerve cells response by generating electrical signals known as
nerve impulse
Muscle cells response by contracting which generate force to move
body parts.
7. Movement
• It means motion of the whole body.
Example
1. Coordination action of legs.
2. When body tissue damage WBC move from blood
into affected tissue to help repair area.
.
8. Growth
•Increase in body size that result from an increase
in the size of existing cells, tissue some time
increase in size because the amount of material
between the cells increase.
9. Differentiation
The development of cell from an unspecialized to specialized state.
Example
A fertilized egg (ovum) develops into an embryo, then into foetus, an
infants, child, finally adult
11. Body Fluid
• Intera cellular fluid (ICF) :- the watery solution containing dissolved
chemical that are found inside cells as well as surrounding them.
• Extra Cellular fluid (ECF):- the fluid outside the body cells.
• Interstitial fluid :- ECF that fill the narrow space between cell of tissue
12. Body Fluid
• ECF with blood vessel is called blood plasma
• ECF with in lymphatic vessel is called Lymph
• ECF around the brain and spinal cord is called Cerebro spinal fluid
(CSF)
• ECF in joint is Synovial Fluid
• ECF in eye is called Aqueous Humor or Vitreous body
13. REFERENCES
• Essentials of Medical Physiology by K. Sembulingam and P. Sembulingam. Jaypee
Brothers Medical Publishers, New Delhi.
• Anatomy and Physiology in Health and Illness by Kathleen J.W. Wilson, Churchill
Livingstone, New York.
• Physiological basis of Medical Practice-Best and Tailor. Williams and Wilkins
Co, Riverview, MI USA.
• Text book of Medical Physiology- Arthur C, Guyton and John.E. Hall. Miamisburg,
OH, U.S.A.
• Principles of Anatomy and Physiology by Tortora Grabowski. Palmetto, GA, U.S.A.
• Human Physiology (vol 1 and 2) by Dr. C.C. Chatterrje, Academic Publishers Kolkata.
Firstly, we are going to start by looking at the definition of validation and the different types that are used.
Secondly, we will discuss documents associated with validation, and review the key stages of the validation process.
Thirdly, we shall look at a model approach for process validation in the context of the WHO documentation.
Finally, we are going to look at where validation has got to in your country and talk about the barriers that need to be overcome.
This module will deal with the very fundamentals of validation but it will only provide an overview. It will not be an in-depth review of the subject. The subject is very important and requires a lot of careful thought. It will be a major topic of discussion with companies that you inspect and also within the inspectorate.
It is important to remember that validation does not improve bad processes.