19 th Wonca World Conference - 2012 - Apresentação Dra. Catherine Moura
- Family Health Strategy in the National Health System in Brazil (SUS):
social, epidemiological and clinical context analysis for the cardiovascular risk intervention
1) The document examines how socioeconomic status predicts access to palliative care services.
2) A study analyzed referral data from 2004-2006 to a hospice at home service covering two areas with different socioeconomic profiles.
3) The results showed that wards with higher deprivation and lower socioeconomic status had significantly lower referral rates to the hospice at home service, even when controlling for cancer mortality rates. This suggests socioeconomic inequalities influence access to specialist palliative care.
NSM-NCD2013 Symposium 1 - NCD Risk Factors - A social determinant and ecologi...appfromlab
This document discusses analyzing non-communicable disease (NCD) risk factors using social determinants and ecological approaches in low and middle income countries. It covers an overview of social determinants, advantages and disadvantages of the approach, and expanding the analysis to include ecological factors. The utility of such analyses is that they address NCD risk factors through multi-dimensional, multi-sectoral lenses rather than individualistic approaches. This allows for more comprehensive policy solutions that consider diverse political and economic interests.
GHME 2013 Conference
Session: Global and national Burden of Disease III
Date: June 18
Presenter: Collin Payne
Institute:
University of Pennsylvania Population Studies Center
The assessment identified several priority health issues for the Clunes community, including cardiovascular disease, diabetes, mental health conditions, and obesity. Younger residents were more concerned with mental health and obesity, while older residents prioritized arthritis, mobility issues, and injuries from falls. Key needs included improved access to GPs, aged care services, mental health support, youth activities, and exercise programs. The report made recommendations to address these needs through partnerships between health services, local organizations, businesses, and the community.
Inequalities in induced abortion according to birthplace and educational atta...OPIK ikerketa taldea
This document summarizes a study examining inequalities in induced abortion according to birthplace and educational attainment in the Basque Country of Spain. The study found that immigrant women born in low-income countries were more likely to have induced abortions, repeat abortions, and abortions in the second trimester compared to women born in Spain, regardless of education level. While education generally reduced inequalities, the associations between birthplace and abortions were stronger among more educated immigrant women than native women. The conclusions indicate that cultural factors and lower socioeconomic status impact reproductive decisions for immigrant women more than education. Understanding these intersecting social factors is important for designing sexual health and abortion access programs and policies.
This document discusses health indicators and their uses. It defines health indicators as variables that reflect the health status of a community and are susceptible to direct measurement. It provides examples of health status indicators like life expectancy and disease rates, and health determinant indicators like diet and income. The document also outlines characteristics of good indicators, sources of health data, classifications of indicators, and how indicators can be used to measure, describe, compare and plan health in communities.
O documento fornece diretrizes para melhorar o atendimento telefônico no ambiente de trabalho. Ele discute fatores críticos como voz, respiração e escolha de palavras, e fornece dicas para preparar atendimentos, lidar com situações difíceis e avaliar a qualidade. O documento enfatiza a importância de identificar o cliente, ouvir atentamente e resolver problemas de forma diplomática.
O documento fornece diretrizes para atendimento telefônico profissional, enfatizando a importância de atender ligações de forma rápida, usar tom de voz apropriado, dar atenção total ao cliente, e sempre buscar solucionar problemas ou retornar com atualizações.
1) The document examines how socioeconomic status predicts access to palliative care services.
2) A study analyzed referral data from 2004-2006 to a hospice at home service covering two areas with different socioeconomic profiles.
3) The results showed that wards with higher deprivation and lower socioeconomic status had significantly lower referral rates to the hospice at home service, even when controlling for cancer mortality rates. This suggests socioeconomic inequalities influence access to specialist palliative care.
NSM-NCD2013 Symposium 1 - NCD Risk Factors - A social determinant and ecologi...appfromlab
This document discusses analyzing non-communicable disease (NCD) risk factors using social determinants and ecological approaches in low and middle income countries. It covers an overview of social determinants, advantages and disadvantages of the approach, and expanding the analysis to include ecological factors. The utility of such analyses is that they address NCD risk factors through multi-dimensional, multi-sectoral lenses rather than individualistic approaches. This allows for more comprehensive policy solutions that consider diverse political and economic interests.
GHME 2013 Conference
Session: Global and national Burden of Disease III
Date: June 18
Presenter: Collin Payne
Institute:
University of Pennsylvania Population Studies Center
The assessment identified several priority health issues for the Clunes community, including cardiovascular disease, diabetes, mental health conditions, and obesity. Younger residents were more concerned with mental health and obesity, while older residents prioritized arthritis, mobility issues, and injuries from falls. Key needs included improved access to GPs, aged care services, mental health support, youth activities, and exercise programs. The report made recommendations to address these needs through partnerships between health services, local organizations, businesses, and the community.
Inequalities in induced abortion according to birthplace and educational atta...OPIK ikerketa taldea
This document summarizes a study examining inequalities in induced abortion according to birthplace and educational attainment in the Basque Country of Spain. The study found that immigrant women born in low-income countries were more likely to have induced abortions, repeat abortions, and abortions in the second trimester compared to women born in Spain, regardless of education level. While education generally reduced inequalities, the associations between birthplace and abortions were stronger among more educated immigrant women than native women. The conclusions indicate that cultural factors and lower socioeconomic status impact reproductive decisions for immigrant women more than education. Understanding these intersecting social factors is important for designing sexual health and abortion access programs and policies.
This document discusses health indicators and their uses. It defines health indicators as variables that reflect the health status of a community and are susceptible to direct measurement. It provides examples of health status indicators like life expectancy and disease rates, and health determinant indicators like diet and income. The document also outlines characteristics of good indicators, sources of health data, classifications of indicators, and how indicators can be used to measure, describe, compare and plan health in communities.
O documento fornece diretrizes para melhorar o atendimento telefônico no ambiente de trabalho. Ele discute fatores críticos como voz, respiração e escolha de palavras, e fornece dicas para preparar atendimentos, lidar com situações difíceis e avaliar a qualidade. O documento enfatiza a importância de identificar o cliente, ouvir atentamente e resolver problemas de forma diplomática.
O documento fornece diretrizes para atendimento telefônico profissional, enfatizando a importância de atender ligações de forma rápida, usar tom de voz apropriado, dar atenção total ao cliente, e sempre buscar solucionar problemas ou retornar com atualizações.
This systematic review examined the effectiveness of disease management and case management for people with diabetes. The review found:
1) Disease management was effective in improving glycemic control, screening for diabetic complications, and monitoring of lipid levels.
2) Case management was effective in improving both glycemic control and provider monitoring of glycemic control, particularly in managed care settings in the U.S. for adults with type 2 diabetes.
3) Case management delivered with disease management or additional interventions was also effective.
The document describes CASALUD, an innovative healthcare system in Mexico to control and prevent non-communicable diseases (NCDs) like diabetes and cardiovascular disease. It was created in response to Mexico facing a dramatic rise in NCDs due to aging populations and increasingly sedentary lifestyles. CASALUD leverages international best practices and innovative technology to deliver NCD care, control, and prevention through proactive strategies, expanded access to services, and ongoing professional education for healthcare providers. Initial implementation showed promising results, and the system is planned for wider adoption across Mexico in partnership with the Ministry of Health.
This document discusses the growing prevalence and economic impact of chronic diseases in the San Joaquin Valley region of California and San Joaquin County specifically. It finds that rates of chronic conditions like heart disease, diabetes, and obesity are higher in the region than statewide averages and are leading to premature death. The high costs of treating chronic diseases place a large burden on both the healthcare system and individuals' finances. Where people live determines their exposure to risks and opportunities for healthy living. Understanding current health issues is important to addressing them through public policy changes.
The document discusses strategies that will reshape the healthcare industry landscape in the future. It predicts that healthcare delivery will transform due to epidemiological, demographic, technological and quality pressures as well as emerging infections and consumerism. Specifically, it anticipates a growth in ambulatory and day care due to lower costs, more emphasis on outsourcing services by hospitals, and a focus on technology, efficiency and value-based care. Universal health coverage is also discussed as a goal to ensure all people can access needed health services without financial hardship.
Health sector challenges to climate change adaptation in Australiaredwanrahman
This document discusses the impacts of climate change on health in Australia and Queensland. It outlines how temperature and precipitation are projected to increase in the coming decades. This will increase health risks like heatwaves, floods, storms and diseases. The health sector faces challenges in dealing with these impacts due to vulnerabilities in the system. Adaptation measures are needed like improving surveillance, communication, and infrastructure. Coordination is required across government levels and sectors to effectively address climate change and health risks.
A study on awareness of diabetic complications among type 2 diabetes patientsiosrjce
IOSR Journal of Dental and Medical Sciences is one of the speciality Journal in Dental Science and Medical Science published by International Organization of Scientific Research (IOSR). The Journal publishes papers of the highest scientific merit and widest possible scope work in all areas related to medical and dental science. The Journal welcome review articles, leading medical and clinical research articles, technical notes, case reports and others.
This document discusses how health informatics can help reduce health disparities. It begins by defining key terms like informatics, health disparities, and how informatics turns data into useful information. It then provides examples of how clinicians can use informatics tools like electronic medical records to improve access to health information for diverse patient populations and help eliminate gaps in care. Specific ways highlighted include providing culturally appropriate patient education resources, facilitating communication across languages, and allowing remote patient monitoring. The conclusion reinforces that optimizing information sharing between patients and providers through advanced health informatics approaches is essential for delivering equitable care.
This document discusses strategies for preventing and managing diabetes in populations. It notes the high prevalence of comorbidities like obesity and hypertension in diabetic patients and the large health expenditures and resources required to treat diabetes. The document advocates for educating consumers about treatment costs and assessing patient health through healthcare policies, legislation, and definitive care plans. Challenges include genetics, the uninsured, demographics, social factors, and disease prevention. Data from epidemiology, managed care information, and disease registries can help healthcare managers make decisions and anticipate future trends to better address issues surrounding population health.
Non-invasive Diagnostic Tools: Cardiometabolic Risk Assessment and Predictionasclepiuspdfs
Cardiometabolic risks (CMRs) have rapidly increased to epidemic proportions worldwide in the past three decades. Cardiovascular disease (CVD) remains the number one killer. No country has reduced, reversed, or prevented the increase in the incidence or prevalence of chronic metabolic diseases. Framingham Heart Study group described the modifiable risk factors that promote the development of CVD. They also developed risk calculators, for the prediction of acute vascular events such as heart attacks and stroke. The risk predictor algorithms were fine-tuned, as and when additional risk factors were discovered. However, at the time of this writing, there is no such calculator for assessment, stratification, and management of CMRs. On the other hand, numbers of non-invasive diagnostic devices have been developed for continuous monitoring of blood pressure and glucose profiles. We have described in our earlier articles, non-invasive diagnostic platform developed by LD-Technologies,
What are the differences in publishing diabetes epidemiological manuscripts.pdfPubrica
The scientific and medical research papers produced by Pubrica's team of researchers and writers may be an invaluable tool for authors and practitioners.
The proposed federal budget would significantly cut funding to major public health agencies and programs like the CDC, NIH, Medicaid, and EPA. The CDC budget would be cut by 17% which a former CDC director said would force them to fight epidemics and health threats with both hands tied behind their back while wearing a blindfold. The budget also cuts Medicaid by $800 billion over 10 years which could impact access to care. Several state marketplaces also proposed substantial premium increases for plans purchased under the Affordable Care Act.
The document discusses health disparities between urban and rural areas. It notes that urban areas tend to have more socioeconomic diversity and higher rates of chronic diseases, while rural areas have higher rates of poverty, smoking, and uninsured residents with limited access to healthcare. The document also examines factors like availability of health professionals, distribution of resources, and accessibility of social services that influence these disparities. Racial and ethnic minorities also face barriers in accessing healthcare for cancer screening, treatment, and prevention.
Lectura complementaria. Social determinants of health and COVID-19 infection ...AlexcisAguirre
Socioeconomic factors influenced the evolution and impact of the COVID-19 pandemic in Brazil. The study found that 59.8% of the variation in COVID-19 incidence rates across Brazilian states was explained by income inequality, high population density, and mortality rates. Similarly, those same factors explained 57.9% of the variation in COVID-19 mortality rates across states. States with higher levels of socioeconomic vulnerability tended to have higher COVID-19 incidence and mortality. Comprehensive actions are needed to support economic conditions and strengthen health systems for vulnerable populations.
This document discusses a module developed through a collaboration between the Brody School of Medicine at East Carolina University and the Centers for Disease Control and Prevention (CDC) to enhance population health education. It acknowledges the individuals and institutions involved in developing the module. The module aims to discuss key topics related to population health determinants, health status, leading causes of death, health disparities, and use of Healthy People objectives in public health planning. It was made possible through a cooperative agreement between the CDC and the Association for Prevention Teaching and Research.
Role of Biostatistician and Biostatistical Programming in Epidemiological Stu...PEPGRA Healthcare
Pepgra experts provide regulatory biostatistics and epidemiology statistical programming support to all phases of clinical trial process development and commercialization. Our Epidemiological statistical services is are located globally & trained in current methods and standards to support the successful execution of your projects.
Continue Reading: http://bit.ly/2OBq9EZ
Youtube: https://youtu.be/2NORssElgFg
Contact Us:
Website : https://bit.ly/33Fwsye
Email us: sales.cro@pepgra.com
India: +91 9884350006
United Kingdom: +44- 74248 10299
This document discusses health care spending and social services spending in the United States compared to other countries. It finds that while the US spends more on health care as a percentage of GDP, it spends less on social services. Countries that spend more on social services relative to health care experience better health outcomes. Within the US, states and counties that devote a greater portion of their budgets to social services also tend to have lower rates of health issues like mortality, obesity, and mental health problems. The document advocates for increasing social services spending to improve population health.
King Holmes, MD, PhD. University Consortium for Global Health. Sept. 15, 2009.UWGlobalHealth
The document discusses the state of global health in 2009 and opportunities for universities to help address global health challenges through collaboration. It outlines five major global health agendas, including communicable diseases, maternal and child health, injuries and violence, chronic diseases, and environmental health issues related to climate change. There are many workforce and infrastructure needs in developing countries that universities could help meet by training skilled professionals. New opportunities exist through partnerships, technologies, and increased resources and interest from different sectors. The Consortium of Universities for Global Health aims to leverage these opportunities by promoting effective interdisciplinary collaboration between universities and other institutions.
This document summarizes a seminar given by Rachel Nugent on the links between agriculture and health. Some key points from the seminar include:
- The relationship between agriculture and health has focused on issues like pesticide exposure, food safety, and how nutrition interventions can impact development.
- Recent conferences and projects have sought to broaden the view to consider the full range of agricultural and health outcomes.
- Non-communicable diseases (NCDs) impose large health and economic burdens globally, especially in low and middle income countries. Dietary risks are major contributors to NCDs independently of obesity.
- There is a need for more research on the quality and measurement of diets, food reform
Desenho Técnico e Funcional PCE para Atenção Primária à SaúdeGesaworld do Brasil
O documento propõe um projeto de coordenação de serviços de saúde em três microrregiões de São Paulo para melhorar o acesso, qualidade e eficiência do sistema por meio da integração de unidades de saúde, linhas de cuidado e prontuário eletrônico centralizado.
O documento discute a importância de se incluir critérios de sustentabilidade no plano diretor de uma organização de saúde. Ele descreve os pilares do desenvolvimento sustentável e como hospitais consomem muitos recursos. O plano diretor deve orientar o desenvolvimento sustentável considerando necessidades atuais e futuras, impactos socioambientais, e fluxos de circulação.
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This systematic review examined the effectiveness of disease management and case management for people with diabetes. The review found:
1) Disease management was effective in improving glycemic control, screening for diabetic complications, and monitoring of lipid levels.
2) Case management was effective in improving both glycemic control and provider monitoring of glycemic control, particularly in managed care settings in the U.S. for adults with type 2 diabetes.
3) Case management delivered with disease management or additional interventions was also effective.
The document describes CASALUD, an innovative healthcare system in Mexico to control and prevent non-communicable diseases (NCDs) like diabetes and cardiovascular disease. It was created in response to Mexico facing a dramatic rise in NCDs due to aging populations and increasingly sedentary lifestyles. CASALUD leverages international best practices and innovative technology to deliver NCD care, control, and prevention through proactive strategies, expanded access to services, and ongoing professional education for healthcare providers. Initial implementation showed promising results, and the system is planned for wider adoption across Mexico in partnership with the Ministry of Health.
This document discusses the growing prevalence and economic impact of chronic diseases in the San Joaquin Valley region of California and San Joaquin County specifically. It finds that rates of chronic conditions like heart disease, diabetes, and obesity are higher in the region than statewide averages and are leading to premature death. The high costs of treating chronic diseases place a large burden on both the healthcare system and individuals' finances. Where people live determines their exposure to risks and opportunities for healthy living. Understanding current health issues is important to addressing them through public policy changes.
The document discusses strategies that will reshape the healthcare industry landscape in the future. It predicts that healthcare delivery will transform due to epidemiological, demographic, technological and quality pressures as well as emerging infections and consumerism. Specifically, it anticipates a growth in ambulatory and day care due to lower costs, more emphasis on outsourcing services by hospitals, and a focus on technology, efficiency and value-based care. Universal health coverage is also discussed as a goal to ensure all people can access needed health services without financial hardship.
Health sector challenges to climate change adaptation in Australiaredwanrahman
This document discusses the impacts of climate change on health in Australia and Queensland. It outlines how temperature and precipitation are projected to increase in the coming decades. This will increase health risks like heatwaves, floods, storms and diseases. The health sector faces challenges in dealing with these impacts due to vulnerabilities in the system. Adaptation measures are needed like improving surveillance, communication, and infrastructure. Coordination is required across government levels and sectors to effectively address climate change and health risks.
A study on awareness of diabetic complications among type 2 diabetes patientsiosrjce
IOSR Journal of Dental and Medical Sciences is one of the speciality Journal in Dental Science and Medical Science published by International Organization of Scientific Research (IOSR). The Journal publishes papers of the highest scientific merit and widest possible scope work in all areas related to medical and dental science. The Journal welcome review articles, leading medical and clinical research articles, technical notes, case reports and others.
This document discusses how health informatics can help reduce health disparities. It begins by defining key terms like informatics, health disparities, and how informatics turns data into useful information. It then provides examples of how clinicians can use informatics tools like electronic medical records to improve access to health information for diverse patient populations and help eliminate gaps in care. Specific ways highlighted include providing culturally appropriate patient education resources, facilitating communication across languages, and allowing remote patient monitoring. The conclusion reinforces that optimizing information sharing between patients and providers through advanced health informatics approaches is essential for delivering equitable care.
This document discusses strategies for preventing and managing diabetes in populations. It notes the high prevalence of comorbidities like obesity and hypertension in diabetic patients and the large health expenditures and resources required to treat diabetes. The document advocates for educating consumers about treatment costs and assessing patient health through healthcare policies, legislation, and definitive care plans. Challenges include genetics, the uninsured, demographics, social factors, and disease prevention. Data from epidemiology, managed care information, and disease registries can help healthcare managers make decisions and anticipate future trends to better address issues surrounding population health.
Non-invasive Diagnostic Tools: Cardiometabolic Risk Assessment and Predictionasclepiuspdfs
Cardiometabolic risks (CMRs) have rapidly increased to epidemic proportions worldwide in the past three decades. Cardiovascular disease (CVD) remains the number one killer. No country has reduced, reversed, or prevented the increase in the incidence or prevalence of chronic metabolic diseases. Framingham Heart Study group described the modifiable risk factors that promote the development of CVD. They also developed risk calculators, for the prediction of acute vascular events such as heart attacks and stroke. The risk predictor algorithms were fine-tuned, as and when additional risk factors were discovered. However, at the time of this writing, there is no such calculator for assessment, stratification, and management of CMRs. On the other hand, numbers of non-invasive diagnostic devices have been developed for continuous monitoring of blood pressure and glucose profiles. We have described in our earlier articles, non-invasive diagnostic platform developed by LD-Technologies,
What are the differences in publishing diabetes epidemiological manuscripts.pdfPubrica
The scientific and medical research papers produced by Pubrica's team of researchers and writers may be an invaluable tool for authors and practitioners.
The proposed federal budget would significantly cut funding to major public health agencies and programs like the CDC, NIH, Medicaid, and EPA. The CDC budget would be cut by 17% which a former CDC director said would force them to fight epidemics and health threats with both hands tied behind their back while wearing a blindfold. The budget also cuts Medicaid by $800 billion over 10 years which could impact access to care. Several state marketplaces also proposed substantial premium increases for plans purchased under the Affordable Care Act.
The document discusses health disparities between urban and rural areas. It notes that urban areas tend to have more socioeconomic diversity and higher rates of chronic diseases, while rural areas have higher rates of poverty, smoking, and uninsured residents with limited access to healthcare. The document also examines factors like availability of health professionals, distribution of resources, and accessibility of social services that influence these disparities. Racial and ethnic minorities also face barriers in accessing healthcare for cancer screening, treatment, and prevention.
Lectura complementaria. Social determinants of health and COVID-19 infection ...AlexcisAguirre
Socioeconomic factors influenced the evolution and impact of the COVID-19 pandemic in Brazil. The study found that 59.8% of the variation in COVID-19 incidence rates across Brazilian states was explained by income inequality, high population density, and mortality rates. Similarly, those same factors explained 57.9% of the variation in COVID-19 mortality rates across states. States with higher levels of socioeconomic vulnerability tended to have higher COVID-19 incidence and mortality. Comprehensive actions are needed to support economic conditions and strengthen health systems for vulnerable populations.
This document discusses a module developed through a collaboration between the Brody School of Medicine at East Carolina University and the Centers for Disease Control and Prevention (CDC) to enhance population health education. It acknowledges the individuals and institutions involved in developing the module. The module aims to discuss key topics related to population health determinants, health status, leading causes of death, health disparities, and use of Healthy People objectives in public health planning. It was made possible through a cooperative agreement between the CDC and the Association for Prevention Teaching and Research.
Role of Biostatistician and Biostatistical Programming in Epidemiological Stu...PEPGRA Healthcare
Pepgra experts provide regulatory biostatistics and epidemiology statistical programming support to all phases of clinical trial process development and commercialization. Our Epidemiological statistical services is are located globally & trained in current methods and standards to support the successful execution of your projects.
Continue Reading: http://bit.ly/2OBq9EZ
Youtube: https://youtu.be/2NORssElgFg
Contact Us:
Website : https://bit.ly/33Fwsye
Email us: sales.cro@pepgra.com
India: +91 9884350006
United Kingdom: +44- 74248 10299
This document discusses health care spending and social services spending in the United States compared to other countries. It finds that while the US spends more on health care as a percentage of GDP, it spends less on social services. Countries that spend more on social services relative to health care experience better health outcomes. Within the US, states and counties that devote a greater portion of their budgets to social services also tend to have lower rates of health issues like mortality, obesity, and mental health problems. The document advocates for increasing social services spending to improve population health.
King Holmes, MD, PhD. University Consortium for Global Health. Sept. 15, 2009.UWGlobalHealth
The document discusses the state of global health in 2009 and opportunities for universities to help address global health challenges through collaboration. It outlines five major global health agendas, including communicable diseases, maternal and child health, injuries and violence, chronic diseases, and environmental health issues related to climate change. There are many workforce and infrastructure needs in developing countries that universities could help meet by training skilled professionals. New opportunities exist through partnerships, technologies, and increased resources and interest from different sectors. The Consortium of Universities for Global Health aims to leverage these opportunities by promoting effective interdisciplinary collaboration between universities and other institutions.
This document summarizes a seminar given by Rachel Nugent on the links between agriculture and health. Some key points from the seminar include:
- The relationship between agriculture and health has focused on issues like pesticide exposure, food safety, and how nutrition interventions can impact development.
- Recent conferences and projects have sought to broaden the view to consider the full range of agricultural and health outcomes.
- Non-communicable diseases (NCDs) impose large health and economic burdens globally, especially in low and middle income countries. Dietary risks are major contributors to NCDs independently of obesity.
- There is a need for more research on the quality and measurement of diets, food reform
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Cell Therapy Expansion and Challenges in Autoimmune DiseaseHealth Advances
There is increasing confidence that cell therapies will soon play a role in the treatment of autoimmune disorders, but the extent of this impact remains to be seen. Early readouts on autologous CAR-Ts in lupus are encouraging, but manufacturing and cost limitations are likely to restrict access to highly refractory patients. Allogeneic CAR-Ts have the potential to broaden access to earlier lines of treatment due to their inherent cost benefits, however they will need to demonstrate comparable or improved efficacy to established modalities.
In addition to infrastructure and capacity constraints, CAR-Ts face a very different risk-benefit dynamic in autoimmune compared to oncology, highlighting the need for tolerable therapies with low adverse event risk. CAR-NK and Treg-based therapies are also being developed in certain autoimmune disorders and may demonstrate favorable safety profiles. Several novel non-cell therapies such as bispecific antibodies, nanobodies, and RNAi drugs, may also offer future alternative competitive solutions with variable value propositions.
Widespread adoption of cell therapies will not only require strong efficacy and safety data, but also adapted pricing and access strategies. At oncology-based price points, CAR-Ts are unlikely to achieve broad market access in autoimmune disorders, with eligible patient populations that are potentially orders of magnitude greater than the number of currently addressable cancer patients. Developers have made strides towards reducing cell therapy COGS while improving manufacturing efficiency, but payors will inevitably restrict access until more sustainable pricing is achieved.
Despite these headwinds, industry leaders and investors remain confident that cell therapies are poised to address significant unmet need in patients suffering from autoimmune disorders. However, the extent of this impact on the treatment landscape remains to be seen, as the industry rapidly approaches an inflection point.
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Overall life span (LS) was 1671.7±1721.6 days and cumulative 5YS reached 62.4%, 10 years – 50.4%, 20 years – 44.6%. 94 LCP lived more than 5 years without cancer (LS=2958.6±1723.6 days), 22 – more than 10 years (LS=5571±1841.8 days). 67 LCP died because of LC (LS=471.9±344 days). AT significantly improved 5YS (68% vs. 53.7%) (P=0.028 by log-rank test). Cox modeling displayed that 5YS of LCP significantly depended on: N0-N12, T3-4, blood cell circuit, cell ratio factors (ratio between cancer cells-CC and blood cells subpopulations), LC cell dynamics, recalcification time, heparin tolerance, prothrombin index, protein, AT, procedure type (P=0.000-0.031). Neural networks, genetic algorithm selection and bootstrap simulation revealed relationships between 5YS and N0-12 (rank=1), thrombocytes/CC (rank=2), segmented neutrophils/CC (3), eosinophils/CC (4), erythrocytes/CC (5), healthy cells/CC (6), lymphocytes/CC (7), stick neutrophils/CC (8), leucocytes/CC (9), monocytes/CC (10). Correct prediction of 5YS was 100% by neural networks computing (error=0.000; area under ROC curve=1.0).
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1. Family Health Strategy in the National Health System in
Brazil (SUS):
social, epidemiological and clinical context analysis for the
cardiovascular risk intervention
19 th WONCAWORLD CONFERENCE
19 – 23 May, 2010, Cancun - Mexico
Authors: Catherine M. F. Pinto (Gesaworld), Diego da Silveira, Roberson J.
Kanamura, Juliana Vasconcelos, Gisele C. M. Sugai, Rosimeire R. Oliveira, Dalia
A. Nogueira, Angela M. B. de Oliveira, Rodrigo F. M. Leite (OS ACSC)
Speaker: Catherine M. F. Pinto
cmoura@gesaworld.com.br
2. Family Health Strategy: PHC
BRAZIL
STATE OF SÃO PAULO
CITY OF SÃO
PAULO
ESF/ACS/SB
ESF/ACS
ACS
SEM ESF, ACS E ESB
0% 0 a 25% 25 a 50% 50 a 75%75 a 100%
Population : 10.940.311 inhabitants
•Area – 1.523 km²
•Population density– 7.113 inhabitants/km²
3. City of São Paulo: South Side
Municipality of São Paulo, South side
• Population 2.486.258 inhabitants
• Largest population living in substandard residences (slum) 21,4%
•Largest cluster of children under 10 years old -19%
•Second cluster in numbers of teenage pregnancies - 16,2%
•Fountainhead area with two Indian villages
• Highest rate of homicides in Sao Paulo (25,4 deaths/1000.00
inhabitants)
Management Contract: Public sector + Social
Health Organizations
• Jointly responsible for managing health services
in many territories of the city of São Paulo
(hospitals,
emergency
services,
primary
healthcare services and specialized healthcare
services)
4. Local scenarium – Partnership Model
In the management model adopted by the municipality is the partnership model with
Social Health Organizations (OS), nonprofit organizations - that meets the
requirements of municipal legislation for this purpose, which requires its rules and
qualifications to manage health care services.
The management model determines territorial integration between the different
levels of care.
The work is developed on the basis on the health needs of the population in a
given area and observing the relationship between the different health care services.
The focus is the effectiveness of public health policies to expand access,
resolution and quality of services and health actions.
The model is regulated and controlled by a “Management Agreement” outlining the
commitments of partnership between the government (municipality or state) and the
OS.
5. Cidade Ademar - Microregion
20 Primary Health Care services, with 11
services
with
the
Family
Health
Strategy
implemented
06 Emergency services
01 Psychosocial support centers
01 Home Care
01 Specialist support team to family healthcare
strategy
02 Support services of diagnostic imaging
01 Dentistry specialized service
02 Medical specialized services
9. Project: Cardiovascular Risk Guideline
An approach for the
identification of cardiovascular
Identification and classification
risk parameters based on
flowchart with cardiovascular risk
epidemiological, clinical and
parameters based on social,
social factors.
epidemiological and clinical studies
(Framingham scale).
Consider cardiovascular risk through programs of diagnosis
and treatment of hypertension and diabetes mellitus using
clinical, epidemiological and social data.
17. Conclusions
Greater identification of high risk cases influenced by the social factor
Provide a greater treatment for patients with cardiovascular risk, according to the
level of social, epidemiological and clinical risks
Promote a holistic care of patients covering the social, epidemiological and clinical
parameters
Organize the services (PHC) and the family health workers teams in order to
increase the quality of the assistance to the population in this micro region of the
city of São Paulo
Contribute for the family health development